JP2002501077A5 - - Google Patents

Info

Publication number

JP2002501077A5

JP2002501077A5 JP2000528581A JP2000528581A JP2002501077A5 JP 2002501077 A5 JP2002501077 A5 JP 2002501077A5 JP 2000528581 A JP2000528581 A JP 2000528581A JP 2000528581 A JP2000528581 A JP 2000528581A JP 2002501077 A5 JP2002501077 A5 JP 2002501077A5

Authority

JP

Japan

Prior art keywords

polypeptide

seq

amino acids

amino acid

acid sequence

Prior art date

1999-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 229920001184 polypeptide Polymers 0.000 description 71
• 102000004196 processed proteins & peptides Human genes 0.000 description 71
• 108090000765 processed proteins & peptides Proteins 0.000 description 71
• 150000001413 amino acids Chemical class 0.000 description 57
• 125000003275 alpha amino acid group Chemical group 0.000 description 49
• 239000002157 polynucleotide Substances 0.000 description 39
• 108091033319 polynucleotide Proteins 0.000 description 38
• 102000040430 polynucleotide Human genes 0.000 description 38
• 239000002299 complementary DNA Substances 0.000 description 24
• 239000002773 nucleotide Substances 0.000 description 18
• 125000003729 nucleotide group Chemical group 0.000 description 18
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 16
• 102100032635 A disintegrin and metalloproteinase with thrombospondin motifs 8 Human genes 0.000 description 16
• 101000730038 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 8 Proteins 0.000 description 16
• 102100027398 A disintegrin and metalloproteinase with thrombospondin motifs 1 Human genes 0.000 description 14
• 101000936405 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 1 Proteins 0.000 description 14
• 102000039446 nucleic acids Human genes 0.000 description 12
• 108020004707 nucleic acids Proteins 0.000 description 12
• 150000007523 nucleic acids Chemical class 0.000 description 12
• -1 Amino acids Chemical class 0.000 description 10
• 239000002253 acid Substances 0.000 description 10
• 238000006467 substitution reaction Methods 0.000 description 6
• 238000000034 method Methods 0.000 description 4
• 238000012986 modification Methods 0.000 description 4
• 230000004048 modification Effects 0.000 description 4
• 238000004590 computer program Methods 0.000 description 3
• 239000011159 matrix material Substances 0.000 description 3
• 230000000295 complement effect Effects 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 108091026890 Coding region Proteins 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 101100401199 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SAM2 gene Proteins 0.000 description 1
• 230000033115 angiogenesis Effects 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 238000010188 recombinant method Methods 0.000 description 1