JP2002500897A - 電子的核酸検出の増幅 - Google Patents

電子的核酸検出の増幅

Info

Publication number
JP2002500897A
JP2002500897A JP2000528725A JP2000528725A JP2002500897A JP 2002500897 A JP2002500897 A JP 2002500897A JP 2000528725 A JP2000528725 A JP 2000528725A JP 2000528725 A JP2000528725 A JP 2000528725A JP 2002500897 A JP2002500897 A JP 2002500897A
Authority
JP
Japan
Prior art keywords
probe
nucleic acid
primer
sequence
etm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000528725A
Other languages
English (en)
Japanese (ja)
Inventor
ジョン・フェイズ・ケイイェム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Micro Sensors Inc
Original Assignee
Clinical Micro Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/014,304 external-priority patent/US6063573A/en
Application filed by Clinical Micro Sensors Inc filed Critical Clinical Micro Sensors Inc
Publication of JP2002500897A publication Critical patent/JP2002500897A/ja
Pending legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D24/00Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof
    • B01D24/02Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof with the filter bed stationary during the filtration
    • B01D24/10Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof with the filter bed stationary during the filtration the filtering material being held in a closed container
    • B01D24/105Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof with the filter bed stationary during the filtration the filtering material being held in a closed container downward filtration without specifications about the filter material supporting means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D17/00Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02Separation of non-miscible liquids
    • B01D17/0208Separation of non-miscible liquids by sedimentation
    • B01D17/0214Separation of non-miscible liquids by sedimentation with removal of one of the phases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D17/00Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02Separation of non-miscible liquids
    • B01D17/04Breaking emulsions
    • B01D17/045Breaking emulsions with coalescers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D24/00Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof
    • B01D24/46Regenerating the filtering material in the filter
    • B01D24/4631Counter-current flushing, e.g. by air
    • B01D24/4642Counter-current flushing, e.g. by air with valves, e.g. rotating valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D24/00Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof
    • B01D24/48Filters comprising loose filtering material, i.e. filtering material without any binder between the individual particles or fibres thereof integrally combined with devices for controlling the filtration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D35/00Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/12Devices for taking out of action one or more units of multi- unit filters, e.g. for regeneration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • CCHEMISTRY; METALLURGY
    • C02TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02FTREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00Treatment of water, waste water, or sewage
    • C02F1/28Treatment of water, waste water, or sewage by sorption
    • C02F1/283Treatment of water, waste water, or sewage by sorption using coal, charred products, or inorganic mixtures containing them
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Thermal Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Hydrology & Water Resources (AREA)
  • Materials Engineering (AREA)
  • Water Supply & Treatment (AREA)
  • Environmental & Geological Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000528725A 1998-01-27 1999-01-27 電子的核酸検出の増幅 Pending JP2002500897A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US09/014,304 US6063573A (en) 1998-01-27 1998-01-27 Cycling probe technology using electron transfer detection
US7301198P 1998-01-29 1998-01-29
US7810298P 1998-03-16 1998-03-16
US8442598P 1998-05-06 1998-05-06
US8450998P 1998-05-06 1998-05-06
US13518398A 1998-08-17 1998-08-17
US09/135,183 1998-08-17
US60/078,102 1998-08-17
US60/084,425 1998-08-17
US60/084,509 1998-08-17
US60/073,011 1998-08-17
US09/014,304 1998-08-17
PCT/US1999/001705 WO1999037819A2 (en) 1998-01-27 1999-01-27 Amplification of nucleic acids with electronic detection

Publications (1)

Publication Number Publication Date
JP2002500897A true JP2002500897A (ja) 2002-01-15

Family

ID=27555780

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000528725A Pending JP2002500897A (ja) 1998-01-27 1999-01-27 電子的核酸検出の増幅

Country Status (6)

Country Link
US (1) US7090804B2 (US07090804-20060815-C00019.png)
EP (1) EP1051517A2 (US07090804-20060815-C00019.png)
JP (1) JP2002500897A (US07090804-20060815-C00019.png)
AU (1) AU764926B2 (US07090804-20060815-C00019.png)
CA (1) CA2319170A1 (US07090804-20060815-C00019.png)
WO (1) WO1999037819A2 (US07090804-20060815-C00019.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501922A (ja) * 2009-08-07 2013-01-17 オームクス コーポレーション 酵素による酸化還元変化化学的脱離(e−trace)免疫学的検定法

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
EP0988534B1 (en) 1997-06-12 2011-02-16 Clinical Micro Sensors, Inc. Electronic methods and apparatus for the detection of analytes
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20030087228A1 (en) * 1998-05-06 2003-05-08 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
DE59915204D1 (de) 1998-08-28 2010-10-28 Febit Holding Gmbh Verfahren zur herstellung von biochemischen reaktionsträgern
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) * 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
JP2003530822A (ja) * 1999-07-20 2003-10-21 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子的核酸検出の増幅
US7935481B1 (en) 1999-07-26 2011-05-03 Osmetech Technology Inc. Sequence determination of nucleic acids using electronic detection
ES2225264T3 (es) * 1999-11-12 2005-03-16 Clinical Micro Sensors, Inc. Tecnicas de aceleracion de union para la deteccion de analitos.
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
GB9928232D0 (en) * 1999-12-01 2000-01-26 Skelton Stephen Detection system
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
GB0002859D0 (en) * 2000-02-08 2000-03-29 Molecular Sensing Plc Process for characterising nucleic acids in solution
US20020034744A1 (en) * 2000-03-27 2002-03-21 Creager Stephen E. Compositions and methods for detecting redox-active molecules in solution
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US7585682B2 (en) 2000-10-03 2009-09-08 Minerva Biotechologies Corporation Magnetic in situ dilution
DE10051396A1 (de) 2000-10-17 2002-04-18 Febit Ferrarius Biotech Gmbh Verfahren und Vorrichtung zur integrierten Synthese und Analytbestimmung an einem Träger
US20050009101A1 (en) * 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
WO2003008624A2 (en) * 2001-07-15 2003-01-30 Keck Graduate Institute Nucleic acid amplification using nicking agents
CA2492007A1 (en) * 2001-07-15 2003-01-30 Keck Graduate Institute Amplification of nucleic acid fragments using nicking agents
US20050208495A1 (en) * 2002-09-17 2005-09-22 Joseph Richard A Real-time detection of nucleic acid reactions
US8394944B2 (en) * 2002-09-20 2013-03-12 Siemens Healthcare Diagnostics Inc. Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation
WO2004029217A2 (en) * 2002-09-26 2004-04-08 Vanderbilt University Method for screening molecular interactions
US8277762B2 (en) * 2003-08-01 2012-10-02 Tioga Research, Inc. Apparatus and methods for evaluating the barrier properties of a membrane
US7341837B2 (en) * 2003-09-02 2008-03-11 Lawton Robert L Soluble analyte detection and amplification
WO2006131892A2 (en) * 2005-06-09 2006-12-14 Koninklijke Philips Electronics N.V. Amplification of nucleic acids with magnetic detection
DK1991694T3 (da) * 2006-02-13 2016-08-01 Fluidigm Canada Inc Genekspressionsanalyse med grundstoftagget oligonukleotid
EP2021514A2 (en) 2006-05-10 2009-02-11 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
US7635566B2 (en) * 2007-06-29 2009-12-22 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
EP2220102B1 (en) 2007-11-06 2014-04-16 Clinical Micro Sensors, Inc. Baseless nucleotide analogues and uses thereof
CN102159722B (zh) 2008-08-22 2014-09-03 桑格摩生物科学股份有限公司 用于靶向单链切割和靶向整合的方法和组合物
DK2414544T3 (da) 2009-04-01 2014-06-16 Dxterity Diagnostics Inc Probe-amplifikations-afhængig kemisk ligering
CN102625850B (zh) 2009-04-03 2014-11-26 蒂莫西·Z·刘 多重核酸检测方法和系统
US8673627B2 (en) * 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
EP2710145B1 (en) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Methods and compositions for detecting target nucleic acids
EP3427830B1 (en) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
US9222623B2 (en) 2013-03-15 2015-12-29 Genmark Diagnostics, Inc. Devices and methods for manipulating deformable fluid vessels
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
CN106879252B (zh) 2014-06-10 2020-07-17 德克斯特里蒂诊断公司 用于收集和稳定生物样品的装置及方法
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
AU2015346527A1 (en) 2014-11-11 2017-06-29 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
EP3234576B1 (en) 2014-12-18 2023-11-22 Life Technologies Corporation High data rate integrated circuit with transmitter configuration
WO2016160877A1 (en) * 2015-03-31 2016-10-06 Rapid Pathogen Screening, Inc. Non-enzymatic nucleic acid detection using an oligonucleotide linker with a large cell gap
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
WO2019040769A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS
CN110565100B (zh) * 2019-07-12 2021-05-07 西北工业大学 一种二茂钴阳离子基缓蚀剂及制备方法和使用方法

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
DE3479522D1 (en) 1983-12-16 1989-09-28 Medisense Inc Assay for nucleic acids
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4943523A (en) 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4952685A (en) 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4707352A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US5002885A (en) 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US5013831A (en) 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
GB8417301D0 (en) * 1984-07-06 1984-08-08 Serono Diagnostics Ltd Assay
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5112974A (en) 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
GB8507706D0 (en) 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1254945A (en) 1986-02-27 1989-05-30 Marco F. Cardosi Application of tetrathiafulvalenes in bioelectrochemical processes
US4704193A (en) 1986-05-14 1987-11-03 Gte Laboratories Incorporated Covalently coupled cofactor modified electrodes and methods of synthesis and use
US5175270A (en) 1986-09-10 1992-12-29 Polyprobe, Inc. Reagents for detecting and assaying nucleic acid sequences
ZA877772B (en) 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
JPS63238166A (ja) 1987-03-26 1988-10-04 Mitsubishi Electric Corp 有機電子素子材料
US4787963A (en) 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
CA1340807C (en) 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5089112A (en) 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
DE4039677A1 (de) 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5180968A (en) 1991-03-01 1993-01-19 Research Foundation Of State University Of New York Method and apparatus for compensation of double layer charging current in electrochemical cells
JPH04278450A (ja) 1991-03-04 1992-10-05 Adam Heller バイオセンサー及び分析物を分析する方法
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
US5846717A (en) 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5849486A (en) 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
DK0567635T3 (da) 1991-11-15 2000-09-25 Igen Int Inc Hurtige assays for amplifikationsprodukter
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5391272A (en) 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
EP0566751B1 (en) 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag DNA detection method
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
CA2094785A1 (en) 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
JPH0641183A (ja) 1992-07-23 1994-02-15 Mitsubishi Kasei Corp オリゴヌクレオチド単分子膜
IL102930A (en) 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes
US5312527A (en) 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
JPH06153997A (ja) 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
DE69333991T2 (de) 1992-11-27 2006-12-14 Canon K.K. Verfahren und Sonde zum Nachweis von Nukleinsäuren
EP0690983A4 (en) 1993-03-05 1998-01-28 Univ Wollongong PULSE ELECTROCHEMICAL DETECTION BY ELECTRODES WITH ELECTROACTIVE POLYMER
FR2703359B1 (fr) 1993-03-31 1995-06-23 Cis Bio Int Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation .
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5616464A (en) 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
RU2041261C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
RU2041262C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
EP0716713A1 (en) 1993-08-18 1996-06-19 Id Biomedical Corporation Compositions and methods for detecting target nucleic acid sequences utilizing adjacent sequence-enzyme molecules
WO1995008626A1 (en) 1993-09-20 1995-03-30 The Regents Of The University Of Colorado Strategy for the production of rna from immobilized templates
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
FR2720832A1 (fr) 1994-04-22 1995-12-08 Francis Garnier Electrodes et membranes électroactives à base de peptides bioactifs, pour la reconnaissance, l'extraction ou le relargage d'espèces biologiquement actives.
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5601982A (en) 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
DE19515552A1 (de) 1995-04-27 1996-10-31 Europ Lab Molekularbiolog Simultane Sequenzierung von Nukleinsäuren
DE19533093C1 (de) * 1995-09-07 1996-12-05 Deutsches Krebsforsch Metallocen-Phosphoramidit-Konjugate, Verfahren zu ihrer Herstellung sowie deren Verwendung
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5795453A (en) 1996-01-23 1998-08-18 Gilmartin; Markas A. T. Electrodes and metallo isoindole ringed compounds
US5851772A (en) 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
US6107080A (en) 1996-04-25 2000-08-22 Mcgill University Biosensor device and method
CA2270633A1 (en) * 1996-11-05 1998-05-14 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6060327A (en) 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
EP0988534B1 (en) * 1997-06-12 2011-02-16 Clinical Micro Sensors, Inc. Electronic methods and apparatus for the detection of analytes
US6203758B1 (en) 1997-11-10 2001-03-20 Bio-Pixel Ltd. Micro-circuit system with array of functionalized micro-electrodes
US6060023A (en) 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501922A (ja) * 2009-08-07 2013-01-17 オームクス コーポレーション 酵素による酸化還元変化化学的脱離(e−trace)免疫学的検定法

Also Published As

Publication number Publication date
AU764926B2 (en) 2003-09-04
WO1999037819A3 (en) 1999-10-14
CA2319170A1 (en) 1999-07-29
AU2473799A (en) 1999-08-09
EP1051517A2 (en) 2000-11-15
WO1999037819A2 (en) 1999-07-29
US7090804B2 (en) 2006-08-15
US20020006643A1 (en) 2002-01-17

Similar Documents

Publication Publication Date Title
JP2002500897A (ja) 電子的核酸検出の増幅
US6686150B1 (en) Amplification of nucleic acids with electronic detection
JP3926625B2 (ja) 電子検出を用いる核酸の配列決定
US6063573A (en) Cycling probe technology using electron transfer detection
JP4072206B2 (ja) 導電性オリゴマーを介して核酸に連結させた電極
US7160678B1 (en) Compositions for the electronic detection of analytes utilizing monolayers
US6090933A (en) Methods of attaching conductive oligomers to electrodes
US6238870B1 (en) Nucleic acid mediated electron transfer
US6096273A (en) Electrodes linked via conductive oligomers to nucleic acids
US6177250B1 (en) Nucleic acid mediated electron transfer
US6258545B1 (en) Nucleic acid mediated electron transfer
AU763494B2 (en) Electronic methods for the detection of analytes utilizing monolayers
US7045285B1 (en) Electronic transfer moieties attached to peptide nucleic acids
AU765597B2 (en) Electronic detection of nucleic acids using monolayers
US20030087228A1 (en) Electronic detection of nucleic acids using monolayers
JP2003530822A (ja) 電子的核酸検出の増幅
US20050053962A1 (en) Amplification of nucleic acids with electronic detection
CA2444186A1 (en) Nucleic acid reactions using labels with different redox potentials
AU2003271352A1 (en) Electronic detection of nucleic acids using monolayers

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060126

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081111

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090407