JP2002500618A5 - - Google Patents

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Publication number
JP2002500618A5
JP2002500618A5 JP1997525183A JP52518397A JP2002500618A5 JP 2002500618 A5 JP2002500618 A5 JP 2002500618A5 JP 1997525183 A JP1997525183 A JP 1997525183A JP 52518397 A JP52518397 A JP 52518397A JP 2002500618 A5 JP2002500618 A5 JP 2002500618A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1997525183A
Other languages
English (en)
Japanese (ja)
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JP2002500618A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1996/017995 external-priority patent/WO1997025033A1/en
Publication of JP2002500618A publication Critical patent/JP2002500618A/ja
Publication of JP2002500618A5 publication Critical patent/JP2002500618A5/ja
Withdrawn legal-status Critical Current

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JP52518397A 1995-10-31 1996-10-30 抗血栓性ジアミン Withdrawn JP2002500618A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US712095P 1995-10-31 1995-10-31
US60/007,120 1995-10-31
US2825296P 1996-10-09 1996-10-09
US60/028,252 1996-10-09
PCT/US1996/017995 WO1997025033A1 (en) 1995-10-31 1996-10-30 Antithrombotic diamines

Publications (2)

Publication Number Publication Date
JP2002500618A JP2002500618A (ja) 2002-01-08
JP2002500618A5 true JP2002500618A5 (US06251921-20010626-C00244.png) 2004-10-28

Family

ID=26676549

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52518397A Withdrawn JP2002500618A (ja) 1995-10-31 1996-10-30 抗血栓性ジアミン

Country Status (9)

Country Link
US (3) US6025382A (US06251921-20010626-C00244.png)
EP (1) EP0863755B1 (US06251921-20010626-C00244.png)
JP (1) JP2002500618A (US06251921-20010626-C00244.png)
AT (1) ATE284690T1 (US06251921-20010626-C00244.png)
AU (1) AU7725596A (US06251921-20010626-C00244.png)
CA (1) CA2236007A1 (US06251921-20010626-C00244.png)
DE (1) DE69634045T2 (US06251921-20010626-C00244.png)
ES (1) ES2233982T3 (US06251921-20010626-C00244.png)
WO (1) WO1997025033A1 (US06251921-20010626-C00244.png)

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JPH10130258A (ja) * 1996-10-10 1998-05-19 Eli Lilly & Co ベンゾ[b]チオフェン化合物、中間体、製剤、および方法
ES2232946T3 (es) 1997-04-30 2005-06-01 Eli Lilly And Company Agentes antitromboticos.
US6172100B1 (en) 1997-04-30 2001-01-09 Eli Lilly And Company Antithrombotic agents
JP2002513415A (ja) 1997-04-30 2002-05-08 イーライ・リリー・アンド・カンパニー 抗血栓剤
WO1998048794A1 (en) * 1997-04-30 1998-11-05 Eli Lilly And Company Antithrombotic agents
ATE268768T1 (de) * 1997-04-30 2004-06-15 Lilly Co Eli Antithrombosemittel
EP1019047B1 (en) 1997-05-01 2003-11-05 Eli Lilly And Company Antithrombotic agents
US7008950B1 (en) 1997-06-05 2006-03-07 Takeda Chemical Industries, Ltd. Benzofurans as suppressors of neurodegeneration
US6017914A (en) * 1997-09-03 2000-01-25 Eli Lilly And Company Benzo[b]thiophene compounds, intermediates, formulations, and methods
US6284756B1 (en) 1998-04-30 2001-09-04 Eli Lilly And Company Antithrombotic agents
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
ATE229520T1 (de) * 1998-10-28 2002-12-15 Lilly Co Eli Benzothiophenderivate als antithrombotische mitteln und zwischenprodukte
ES2213984T3 (es) 1998-10-30 2004-09-01 Eli Lilly And Company Derivados de azaindol y su uso como agentes antitrombicos.
US6620837B1 (en) * 1999-11-19 2003-09-16 Eli Lilly And Company Antithrombotic agents
DK1401446T3 (da) 2001-05-22 2005-05-23 Lilly Co Eli Tetrahydroquinolinderivater til inhiberingen af sygdomme forbundet med estrogenmangel eller med en urelgelmæssig fysiologisk reaktion til endogent estrogen
ATE321754T1 (de) 2001-05-22 2006-04-15 Lilly Co Eli 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren
JP5082033B2 (ja) 2001-12-21 2012-11-28 エグゼリクシス パテント カンパニー エルエルシー Lxrのモジュレーター
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
AU2003253129B2 (en) * 2002-07-22 2008-12-11 Eli Lilly And Company Selective estrogen receptor modulators containing a phenylsulfonyl group
US7296361B2 (en) * 2003-07-31 2007-11-20 University Of Pittsburgh Measuring device and method of measuring
LT2896397T (lt) 2003-08-01 2017-11-27 Mitsubishi Tanabe Pharma Corporation Nauji junginiai, turintys inhibitorinį aktyvumą prieš nuo natrio priklausomą gliukozės transporterį
US8785403B2 (en) 2003-08-01 2014-07-22 Mitsubishi Tanabe Pharma Corporation Glucopyranoside compound
WO2006084338A1 (en) 2005-02-14 2006-08-17 Bionomics Limited Novel tubulin polymerisation inhibitors
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
UY30730A1 (es) 2006-12-04 2008-07-03 Mitsubishi Tanabe Pharma Corp Forma cristalina del hemihidrato de 1-(b (beta)-d-glucopiranosil) -4-metil-3-[5-(4-fluorofenil) -2-tienilmetil]benceno
MY162628A (en) 2007-09-10 2017-06-30 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
PT2488515T (pt) 2009-10-14 2017-04-11 Janssen Pharmaceutica Nv Processo para a preparação de compostos úteis como inibidores de sglt2
KR101931209B1 (ko) 2010-05-11 2018-12-20 얀센 파마슈티카 엔.브이. Sglt의 억제제로서 1-(베타-d-글루코피라노실)-2-티에닐-메틸벤젠 유도체를 포함하는 약학 제형
ME02469B (me) 2011-04-13 2017-02-20 Janssen Pharmaceutica Nv Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 (2s,3r,4r,5s,6r)-2-(3-((5-(4-氟苯基)噻吩-2-基)甲基)-4-甲基苯基)-6-(羥甲基)四氫-2h-哌喃-3,4,5-三醇之l-脯胺酸及檸檬酸共晶體
CA2862981C (en) 2011-12-15 2020-02-25 Bayer Pharma Aktiengesellschaft Substituted benzothienyl-pyrrolotriazines and uses thereof in the treatment cancer
US9475815B2 (en) 2012-02-23 2016-10-25 Bayer Intelletual Property Gmbh Substituted benzothienyl-pyrrolotriazines and uses thereof
KR20170118687A (ko) * 2015-02-19 2017-10-25 제이엔씨 주식회사 벤조티오펜을 가지는 액정성 화합물, 액정 조성물 및 액정 표시 소자
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
CN109311848B (zh) 2016-06-07 2022-02-01 北京加科思新药研发有限公司 可用作shp2抑制剂的新型杂环衍生物
US10988466B2 (en) 2017-03-23 2021-04-27 Jacobio Pharmaceuticals Co., Ltd. Heterocyclic derivatives useful as SHP2 inhibitors

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US3274213A (en) * 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
US3293263A (en) * 1963-12-09 1966-12-20 Upjohn Co Diphenylbenzocycloalkenes
GB1456323A (en) * 1974-06-06 1976-11-24 Labaz Benzothiophenes process for preparing them and pharmaceutical compositions containing the same
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
AU8868991A (en) 1990-11-15 1992-06-11 Pentapharm Ag Meta-substituted phenyl alanine derivatives
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5371091A (en) * 1992-08-31 1994-12-06 Bristol-Myers Squibb Company Heteroaromatic amine thrombin inhibitors
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5441965A (en) * 1993-12-21 1995-08-15 Eli Lilly And Company Methods of inhibiting thrombin
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
CA2218756A1 (en) 1996-10-25 1998-04-25 Kristin Sue Marron Substituted benzo¢b!thiophene compounds having activity as selective estrogen receptor modulators
US5929090A (en) 1997-09-12 1999-07-27 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods

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