JP2002500183A5 - - Google Patents
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- Publication number
- JP2002500183A5 JP2002500183A5 JP2000527238A JP2000527238A JP2002500183A5 JP 2002500183 A5 JP2002500183 A5 JP 2002500183A5 JP 2000527238 A JP2000527238 A JP 2000527238A JP 2000527238 A JP2000527238 A JP 2000527238A JP 2002500183 A5 JP2002500183 A5 JP 2002500183A5
- Authority
- JP
- Japan
- Prior art keywords
- obesity treatment
- alkyl group
- poly
- carbons
- hydrophobic region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000008589 Obesity Diseases 0.000 description 27
- 235000020824 obesity Nutrition 0.000 description 27
- 238000000034 method Methods 0.000 description 24
- 230000002209 hydrophobic effect Effects 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 13
- 125000000217 alkyl group Chemical group 0.000 description 11
- 150000001412 amines Chemical class 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 125000006165 cyclic alkyl group Chemical group 0.000 description 4
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 description 4
- 208000001162 steatorrhea Diseases 0.000 description 4
- 239000004367 Lipase Substances 0.000 description 3
- 102000004882 Lipase Human genes 0.000 description 3
- 108090001060 Lipase Proteins 0.000 description 3
- 229940086609 Lipase inhibitor Drugs 0.000 description 3
- 206010041969 Steatorrhoea Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 235000019421 lipase Nutrition 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 2
- KUDUQBURMYMBIJ-UHFFFAOYSA-N 2-prop-2-enoyloxyethyl prop-2-enoate Chemical group C=CC(=O)OCCOC(=O)C=C KUDUQBURMYMBIJ-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000003431 cross linking reagent Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 229940126585 therapeutic drug Drugs 0.000 description 2
- MYWOJODOMFBVCB-UHFFFAOYSA-N 1,2,6-trimethylphenanthrene Chemical compound CC1=CC=C2C3=CC(C)=CC=C3C=CC2=C1C MYWOJODOMFBVCB-UHFFFAOYSA-N 0.000 description 1
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 1
- UABZBFJRDPRXJR-UHFFFAOYSA-N 2-methylidenebutanoate;trimethylazanium Chemical compound C[NH+](C)C.CCC(=C)C([O-])=O UABZBFJRDPRXJR-UHFFFAOYSA-N 0.000 description 1
- VFZKVQVQOMDJEG-UHFFFAOYSA-N 2-prop-2-enoyloxypropyl prop-2-enoate Chemical compound C=CC(=O)OC(C)COC(=O)C=C VFZKVQVQOMDJEG-UHFFFAOYSA-N 0.000 description 1
- XOJWAAUYNWGQAU-UHFFFAOYSA-N 4-(2-methylprop-2-enoyloxy)butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCOC(=O)C(C)=C XOJWAAUYNWGQAU-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- JHWGFJBTMHEZME-UHFFFAOYSA-N 4-prop-2-enoyloxybutyl prop-2-enoate Chemical compound C=CC(=O)OCCCCOC(=O)C=C JHWGFJBTMHEZME-UHFFFAOYSA-N 0.000 description 1
- ZWAPMFBHEQZLGK-UHFFFAOYSA-N 5-(dimethylamino)-2-methylidenepentanamide Chemical compound CN(C)CCCC(=C)C(N)=O ZWAPMFBHEQZLGK-UHFFFAOYSA-N 0.000 description 1
- SIKWOTFNWURSAY-UHFFFAOYSA-N Lipstatin Natural products CCCCCCC1C(CC(CC=CCC=CCCCCC)C(=O)OC(CC(C)C)NC=O)OC1=O SIKWOTFNWURSAY-UHFFFAOYSA-N 0.000 description 1
- AHLBNYSZXLDEJQ-UHFFFAOYSA-N N-formyl-L-leucylester Natural products CCCCCCCCCCCC(OC(=O)C(CC(C)C)NC=O)CC1OC(=O)C1CCCCCC AHLBNYSZXLDEJQ-UHFFFAOYSA-N 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 description 1
- FHLPGTXWCFQMIU-UHFFFAOYSA-N [4-[2-(4-prop-2-enoyloxyphenyl)propan-2-yl]phenyl] prop-2-enoate Chemical compound C=1C=C(OC(=O)C=C)C=CC=1C(C)(C)C1=CC=C(OC(=O)C=C)C=C1 FHLPGTXWCFQMIU-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- QUZSUMLPWDHKCJ-UHFFFAOYSA-N bisphenol A dimethacrylate Chemical compound C1=CC(OC(=O)C(=C)C)=CC=C1C(C)(C)C1=CC=C(OC(=O)C(C)=C)C=C1 QUZSUMLPWDHKCJ-UHFFFAOYSA-N 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- UYMKPFRHYYNDTL-UHFFFAOYSA-N ethenamine Chemical compound NC=C UYMKPFRHYYNDTL-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 208000006575 hypertriglyceridemia Diseases 0.000 description 1
- OQMAKWGYQLJJIA-CUOOPAIESA-N lipstatin Chemical group CCCCCC[C@H]1[C@H](C[C@H](C\C=C/C\C=C/CCCCC)OC(=O)[C@H](CC(C)C)NC=O)OC1=O OQMAKWGYQLJJIA-CUOOPAIESA-N 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- RNTIBYGPJVJCCJ-UHFFFAOYSA-N n,n-dimethylmethanamine;ethyl 2-methylprop-2-enoate Chemical compound CN(C)C.CCOC(=O)C(C)=C RNTIBYGPJVJCCJ-UHFFFAOYSA-N 0.000 description 1
- WGESLFUSXZBFQF-UHFFFAOYSA-N n-methyl-n-prop-2-enylprop-2-en-1-amine Chemical compound C=CCN(C)CC=C WGESLFUSXZBFQF-UHFFFAOYSA-N 0.000 description 1
- CHDKQNHKDMEASZ-UHFFFAOYSA-N n-prop-2-enoylprop-2-enamide Chemical compound C=CC(=O)NC(=O)C=C CHDKQNHKDMEASZ-UHFFFAOYSA-N 0.000 description 1
- DYUWTXWIYMHBQS-UHFFFAOYSA-N n-prop-2-enylprop-2-en-1-amine Chemical compound C=CCNCC=C DYUWTXWIYMHBQS-UHFFFAOYSA-N 0.000 description 1
- ZBKXCYSJSMCLHH-UHFFFAOYSA-N n-propylprop-2-enimidate;trimethylazanium Chemical compound C[NH+](C)C.CCCN=C([O-])C=C ZBKXCYSJSMCLHH-UHFFFAOYSA-N 0.000 description 1
- HMZGPNHSPWNGEP-UHFFFAOYSA-N octadecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C(C)=C HMZGPNHSPWNGEP-UHFFFAOYSA-N 0.000 description 1
- FSAJWMJJORKPKS-UHFFFAOYSA-N octadecyl prop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)C=C FSAJWMJJORKPKS-UHFFFAOYSA-N 0.000 description 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 1
- 229960001243 orlistat Drugs 0.000 description 1
- 229920000083 poly(allylamine) Polymers 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US496398A | 1998-01-09 | 1998-01-09 | |
| US09/166,453 US6264937B1 (en) | 1998-01-09 | 1998-10-05 | Fat-binding polymers |
| US09/004,963 | 1998-10-05 | ||
| US09/166,453 | 1998-10-05 | ||
| PCT/US1999/000028 WO1999034787A2 (en) | 1998-01-09 | 1999-01-04 | Fat-binding polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002500183A JP2002500183A (ja) | 2002-01-08 |
| JP2002500183A5 true JP2002500183A5 (enExample) | 2006-02-23 |
Family
ID=26673719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000527238A Pending JP2002500183A (ja) | 1998-01-09 | 1999-01-04 | 脂肪結合性ポリマー |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1043981B1 (enExample) |
| JP (1) | JP2002500183A (enExample) |
| KR (2) | KR100773625B1 (enExample) |
| CN (1) | CN1212123C (enExample) |
| AT (1) | ATE237349T1 (enExample) |
| AU (2) | AU740233B2 (enExample) |
| BR (1) | BR9907234A (enExample) |
| CA (1) | CA2318417A1 (enExample) |
| DE (1) | DE69906928T2 (enExample) |
| ES (1) | ES2200493T3 (enExample) |
| HU (1) | HUP0100890A3 (enExample) |
| IL (1) | IL137096A (enExample) |
| MX (1) | MX222446B (enExample) |
| NO (1) | NO20003510L (enExample) |
| NZ (2) | NZ505294A (enExample) |
| PL (1) | PL193452B1 (enExample) |
| RU (1) | RU2222335C2 (enExample) |
| WO (1) | WO1999034787A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| IL147361A0 (en) * | 1999-07-14 | 2002-08-14 | Geltex Pharma Inc | Fat-binding polymers, optionally combined with lipase inhibitors |
| CA2386036A1 (en) * | 1999-10-01 | 2001-04-12 | Yasukazu Nagato | Antiobesity agent |
| RU2241462C2 (ru) | 2000-07-28 | 2004-12-10 | Ф. Хоффманн-Ля Рош Аг | Новая фармацевтическая композиция |
| KR20040018359A (ko) * | 2001-04-18 | 2004-03-03 | 젠자임 코포레이션 | 지방족 폴리아민으로 ｘ 증후군을 치료하는 방법 |
| US8372430B2 (en) | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
| SE0302253D0 (sv) * | 2003-08-21 | 2003-08-21 | Forskarpatent I Syd Ab | Lipase-colipase inhibitor |
| CN106176800B (zh) * | 2016-07-11 | 2019-12-06 | 韩源平 | 多聚阳离子树脂的制药应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7017227A (enExample) * | 1969-12-27 | 1971-06-29 | ||
| US4211765A (en) * | 1971-10-12 | 1980-07-08 | Monsanto Company | Method for controlling obesity |
| US4432968A (en) * | 1980-10-20 | 1984-02-21 | The Dow Chemical Company | Weight control with fat imbibing polymers |
| CA1213397A (en) * | 1980-10-20 | 1986-10-28 | Judith L. Page | Weight control with alkyl styrene polymers |
| JPH02503205A (ja) * | 1988-02-12 | 1990-10-04 | ドゥ ツァープフェル，ブリギット | 医用及びパラメディカル用の架橋親水性コポリマー |
| RU2066185C1 (ru) * | 1993-01-11 | 1996-09-10 | Институт пищевых веществ РАН | Гиполипидемический энтеросорбент |
| JP3507523B2 (ja) * | 1993-05-12 | 2004-03-15 | 積水化学工業株式会社 | 糖質吸収抑制剤 |
-
1999
- 1999-01-04 RU RU2000120918/14A patent/RU2222335C2/ru not_active IP Right Cessation
- 1999-01-04 BR BR9907234-3A patent/BR9907234A/pt not_active Application Discontinuation
- 1999-01-04 HU HU0100890A patent/HUP0100890A3/hu unknown
- 1999-01-04 AT AT99900369T patent/ATE237349T1/de not_active IP Right Cessation
- 1999-01-04 NZ NZ505294A patent/NZ505294A/xx unknown
- 1999-01-04 IL IL137096A patent/IL137096A/en active IP Right Grant
- 1999-01-04 PL PL343898A patent/PL193452B1/pl unknown
- 1999-01-04 JP JP2000527238A patent/JP2002500183A/ja active Pending
- 1999-01-04 DE DE69906928T patent/DE69906928T2/de not_active Expired - Fee Related
- 1999-01-04 KR KR1020007007608A patent/KR100773625B1/ko not_active Expired - Fee Related
- 1999-01-04 CA CA002318417A patent/CA2318417A1/en not_active Abandoned
- 1999-01-04 NZ NZ523301A patent/NZ523301A/en unknown
- 1999-01-04 ES ES99900369T patent/ES2200493T3/es not_active Expired - Lifetime
- 1999-01-04 CN CNB998020311A patent/CN1212123C/zh not_active Expired - Fee Related
- 1999-01-04 KR KR1020067021186A patent/KR20060111741A/ko not_active Ceased
- 1999-01-04 WO PCT/US1999/000028 patent/WO1999034787A2/en not_active Ceased
- 1999-01-04 EP EP99900369A patent/EP1043981B1/en not_active Expired - Lifetime
- 1999-01-04 AU AU19505/99A patent/AU740233B2/en not_active Ceased
-
2000
- 2000-07-06 MX MXPA00006681 patent/MX222446B/es active IP Right Grant
- 2000-07-07 NO NO20003510A patent/NO20003510L/no not_active Application Discontinuation
-
2002
- 2002-02-01 AU AU2002014755A patent/AU2002014755A1/xx not_active Withdrawn
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