JP2002356413A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation effective for preventing and ameliorating pigmentation/fleckles or the like after sunburn and having high skin whitening effect. SOLUTION: This skin care preparation is obtained by compounding at least one kind of ingredient selected from collagen, hydrolyzates thereof, salts thereof and derivatives thereof, and plant-derived peptides with the amino acid composition resembling that of collagen, and an extract from a mandarin-based plant, and optionally, at least one kind of ingredient selected from anti-inflammatory agent, antioxidant and skin whitening agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin which is effective in preventing and improving pigmentation, spots, freckles and the like after sunburn and has a high skin whitening effect.

[0002]

2. Description of the Related Art Conventionally, darkening of skin by ultraviolet rays,
In order to prevent or improve pigmentation of the skin, such as spots and freckles, components having an action of inhibiting melanin production or reducing the produced melanin pigment have been screened and formulated into skin external preparations. For example, ascorbic acid, cysteine, hydroquinone, placenta extract, 2-
Hydroxy acids and their derivatives, extracts from plants and algae and the like are used.

[0003] However, ascorbic acid, cysteine and hydroquinone are susceptible to oxidation-reduction reactions and are unstable, and 2-hydroxy acids may cause skin irritation when an effective amount is added, and placental extracts, plants and algae However, when an effective amount is added to the extract, there is a problem that an unpleasant odor or color may be imparted to the external preparation for skin.

[0004]

DISCLOSURE OF THE INVENTION The present invention solves the above problems and is effective in preventing and improving pigmentation, spots, freckles, etc. after sunburn, and has a high skin whitening effect. The aim was to get.

[0005]

In order to solve the above-mentioned problems, various studies were conducted to select collagen, its hydrolysates, salts and derivatives thereof, and plant-derived peptides having a similar amino acid composition to collagen. One or two or more of the above, and an extract obtained from a plant of the genus Citrus, and one or more selected from an inflammatory agent, an antioxidant, and a whitening agent are combined with the external preparation for skin. As a result, the present inventors have found that a skin external preparation which synergistically enhances the whitening effect and has no safety problems such as skin irritation and skin sensitization can be obtained, and has completed the present invention.

That is, the present invention relates to one or more selected from collagen and its hydrolyzate, and salts and derivatives thereof, and peptides derived from plants having an amino acid composition similar to collagen, An object of the present invention is to provide a skin external preparation containing one or more selected from an obtained extract and an anti-inflammatory agent, an antioxidant, and a whitening agent.

[0007]

Embodiments of the present invention will be described.

[0008] Collagen or their derivatives, hydrolysates and salts thereof used in the present invention include collagen and their hydrolysates, solubilized derivatives having a hydrophilic group introduced therein, or hydrophobic groups introduced therein. One or more selected from hydrophobized derivatives and salts thereof can be used. Further, the plant-derived peptide having a similar amino acid composition to collagen is not particularly limited as long as it is a peptide containing hydroxyproline as an essential component and has a similar amino acid composition to animal collagen. Such collagen-like peptides include carrots
( Daucus carota L.). An appropriate amount is about 0.0001 to 5.0% by weight.

In the present invention, in addition to one or two or more selected from the above-mentioned collagen and its hydrolyzate, and salts and derivatives thereof, and plant-derived peptides having an amino acid composition similar to collagen, citrus ( Citrus
L.) An extract obtained from a plant is incorporated.

[0010] Citrus L. plants are of the Citrus family ( Ru).
taceae ), which is an evergreen fruit tree of any kind, for example, lime ( Citrus aurantifolia Swingl
e), Tahitian lime ( Citrus latifolia Tanaka), Sweet lime ( Citrus limettioides Tanaka), Bergamot
(Citrus bergamia Risso et Poit.) , Citron (Citrus
medica L.), lemon (Citrus limon Burm.), sweet lemon (Citrus limetta Risso), Rough Lemon (Citrus jamb
hiri Lush.) 、 Meier lemon ( Citrus meyeri Y.Tanak)
a), Pomelo ( Citrus grandis Osbeck), Oyu ( Citrus p
seudogulgul Hort.ex Shirai), grapefruit ( Citr
us paradisi Macf.), Kinukawa ( Citrus glaberrima Hor)
t. ex Tanaka), Yamamikan ( Citrus intermedia Hort.
ex Tanaka), Hassaku ( Citrus hassaku Hort. ex Tanak)
a), Naruto ( Citrus medioglobosa Hort. ex Tanaka),
Natsumikan ( Citrus natsudaidai Hayata), Kinkouji
(Citrus obovoidea Hort. Ex Takahashi) , Ootachibana (Citrus otachibana Hort. ExY. Tanaka ), Sanpoukan (Citrus sulcata Hort. Ex Takahashi) , bitter orange
( Citrus aurantium L.), Chinot ( Citrus myritifolia
Rafin.), Satsuma Kikoku ( Citrus neoaurantium Hort. E)
x Tanaka), Sweet Orange ( Citrus sinensis Osbec)
k), Funadoko ( Citrus funadoko Hort. ex Y. Tanaka),
Tankan ( Citrus tankan Hayata), Iyokan ( Citrus iy
o Hort. ex Tanaka), Hyuganatsu ( Citrus tamurana H
ort. ex Tanaka), Shunkokan ( Citurs shunkokan H)
ort. ex Tanaka), echanchi ( Citrus ichangensis)
Swingle), Yuzu ( Citrus junos Sieb.ex Tanaka), Hanayu ( Citrus hanaju Hort. Ex Shirai), Sudachi ( Citrus s
udachi Hort. ex Shirai), Yuko ( Citurs yuko Hort. e)
x Tanaka), Naoshi ( Citrus takuma-sudachi Hort. ex
Tanaka), Cabos ( Citrus sphaerocarpa Hort. Ex Tanak)
a), King ( Citrus nobilis Lour.), Unshu Mandarin
( Citrus unshiu Mar.), Yatsushiro ( Citrus yatsushiro H
ort. ex Tanaka), Keraj ( Citrus keraji Hort. ex Tan)
aka), Ponkan ( Citrus reticulata Blanco), Chicken Mandarin ( Citrus deliciosa Tenore), Dancy Tangerine ( Citrus tangerina Hort. exTanaka), Alzerian ( Citrus clementina Hort. ex Tanaka), Benikoji ( Citrus benikoji Hort. ex Tanaka), Mankitsu ( C
itrus tardiferax Hort. ex Tanaka), Tachibana ( Citrus
tachibana Tanaka), Citrus kinokuni
Hort. Ex Tanaka), Sunki ( Citrus sunki Hort. Ex
Tanaka), Cleopatra ( Citrus reshni Hort. Ex Tanak)
a), Humutia Tenga ( Citrus indica Tanaka), Shiikuwasha ( Citrus depressa Hayata), Koji ( Citrus le
iocarpa Hort. ex Tanaka), Fukuromikan ( Citrus tumi )
da Hort. ex Tanaka), Toukinkan ( Citrus madurensi )
s Lour.) and the like are exemplified, and among these citrus plants Lemon (Citruslimon Burm.), sweet orange (Citrus
sinensis Osbeck) and Citrus unshi
u Mar.) is preferably used.

An extract from a Citrus L. plant is used in a state where one or more parts such as fruits, pericarp, seeds, leaves, bark, roots, flowers, and branches are raw or dried. .

In the present invention, Citrus L.
The plant may be subjected to extraction as it is, but in consideration of extraction efficiency, it is preferable to perform extraction after performing processing such as shredding, drying, and pulverization. The extraction is performed by immersion in an extraction solvent.
Stirring may be performed to increase the extraction efficiency, or homogenization may be performed in an extraction solvent. It is appropriate that the extraction temperature is set to a temperature of about 5 ° C. to the boiling point of the extraction solvent or lower. The extraction time varies depending on the type of the extraction solvent and the extraction temperature, but is suitably about 4 hours to 2 weeks.

As an extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin; ethers such as ethyl ether and propyl ether; esters such as ethyl acetate and butyl acetate And polar organic solvents such as ketones such as acetone and ethyl methyl ketone, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. The ratio of the plant to the solvent at the time of extraction is not particularly limited, but the solvent is preferably 0.1 to 1000 times by weight, particularly 0.5 to 100 times by weight, from the viewpoint of the extraction operation and efficiency with respect to the plant 1.

The extract of the Citrus L. plant with the above solvent can be used as it is, but the concentrated and dried extract may be redissolved in water or a polar solvent, or may impair the effects of the present invention. It may be used after performing a purification treatment such as decolorization, deodorization, and desalting within a range that does not exist, or after performing a fractionation treatment by column chromatography. For preservation, it can be freeze-dried after the purification treatment and dissolved in a solvent before use. Further, it can also be used by being encapsulated in vesicles such as liposomes, microcapsules and the like.

In the present invention, one or more selected from an anti-inflammatory agent, an antioxidant, and a whitening agent can be added.

Such anti-inflammatory agents are not particularly limited as long as they are commonly used in external preparations for the skin, and they may be of any type and origin. Cortisone, hydrocortisone, prednisolone,
Methylprednisolone, dexamethasone, betamethasone, triamcinolone, triamcinolone acetonide,
Steroidal anti-inflammatory agents such as fluocinolone acetonide, fluocinonide, beclomethasone and their phosphates, propionates, acetates, and succinates; salicylic acid derivatives such as salicylic acid and aspirin, salicylamide, ethenzamide, methyl salicylate; Indomethacin,
Indoleacetic acid derivatives such as sulindac, pyrazolidinedione derivatives such as phenylbutazone and oxyphenbutazone, anthranilic acid derivatives such as mefenamic acid and flufenamic acid, propionic acid derivatives such as ibuprofen, ketoprofen and naproxen, diclofenac and fenbufen Non-steroidal anti-inflammatory agents such as phenylacetic acid derivatives, benzothiazine derivatives such as piroxicam,
Salts and derivatives of glycyrrhizic acid and dipotassium glycyrrhizinate, monoammonium glycyrrhizinate,
Salts and derivatives of glycyrrhetinic acid and stearyl glycyrrhetinate, glycyrrhetinyl stearate, disodium 3-succinyloxyglycyrrhetinate, azulene derivatives such as guaiazulene, ethyl guaiazulene sulphonate, sodium guaiazulene sulphonate and camazulene, allantoin, aloin, aloe emodin, shikonin And derivatives such as isobutyl shikonin, acetyl shikonin, isovaleryl shikonin and the like, ginsenosides such as ginsenoside R _a1 , ginsenoside R _a2 , ginsenoside R _b1 ,
And 20-ginsenoside derivatives such as glucosides Gin Seno glucoside R _f, paeoniflorin, paeonol and Peonoshido, like paeonol derivatives such Peonorido.

[0017] as anti-inflammatory agents in the present invention, lithospermum (Lithospermi Radix), carrots (Ginseng Radi
x), peony (Paeoniae Radix), moutan bark (Mouta
Herbal extracts used as anti-inflammatory agents, such as n Cortex ) and kujin ( Sophorae Radix ), can also be used.

The antioxidant used in the present invention may be of any type and origin as long as it is generally used in external preparations for the skin. For example, carotenoids, flavonoids,
Tannins and gallic acid and salts and esters thereof,
Tocopherol and its derivatives, superoxide dismutase, hydroquinone and its salts or derivatives, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like are used.

Regarding the carotenoids used in the present invention, irrespective of their type and origin, α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein (xanthophyll), zeaxanthin, rhodoxanthin, crocetin Etc. are exemplified. In addition, these carotenoids may be used as they are, or derivatives such as glycosides and esters may be used.

The flavonoids used in the present invention, irrespective of their types and bases, are flavones and flavone glycosides such as flavone, chrysin, primetine, apigenin and luteolin, galangin, kaempferol, fisetin, quercetin, myricetin Flavonols and flavonol glycosides, such as sucrose, rutin, isoflavones and isoflavone glycosides, such as daidzein and genistein, flavanone, pinocembrin, naringenin, sachranetin,
Flavanones and flavanone glycosides such as hesperetin, eriodictyol and matisinol; flavanonols and flavanonol glycosides such as flavanonol, pinobanksin, aromadendrin, fustin, taxifolin, amperoptin, chalcone, butein, and carcono cartamidine , Pedicin, pedicinin, etc., chalcone and chalcone glycosides, benzalcumaranone, sulfretin, leptosidine, auredin, etc., benzalkumaranone and benzalkumaranone glycosides, pelargonidin,
Anthocyan and anthocyan glycosides such as cyanidin and delphinidin are exemplified.

The tannins used in the present invention are tannic acids in a broad sense, which are present in many plants, particularly bark of beech family plants such as oak and oak, leaves of gourd plants such as goby, nulde and urushi, and fruits of kariloku. It is also called gallotannin, gallotannic acid or the like. Tannins are a generic term for these complex aromatic compounds having a large number of phenolic hydroxyl groups widely distributed in the plant kingdom. Phenols and phenol carboxylic acids are obtained by alkali decomposition. In the present invention, these plant-derived tannins can be used as they are or purified, and artificially synthesized tannins can also be used. Further, gallic acid and its salts, which are constituents of tannin, and esters thereof can also be used. Among these tannins,
It is most preferable to use the hamameli tannin contained in the hamamelis extract.

The tocopherol and derivatives thereof used in the present invention are not particularly limited, and α-tocopherol, β-tocopherol, γ-tocopherol, d-δ-tocopherol, tocopherol acetate, nicotinic acid DL-
α-tocopherol, DL-α-tocopherol succinate and the like are exemplified.

In the present invention, as other antioxidant components, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like can be blended.

In the present invention, one selected from the above antioxidant components can be used alone or in combination of two or more. The amount of these antioxidants to be added to the skin external preparation depends on the antioxidant activity of each antioxidant, but is generally 0.0001 to 5% by weight, preferably 0.1% by weight.
001 to 5% by weight is suitable.

The whitening agents used in the present invention include:
If it is usually used for skin external preparations,
Regardless of the base, for example, L-ascorbic acid and its salts or derivatives thereof, hinokitiol and its derivatives,
2-hydroxycarboxylic acid and salts or derivatives thereof,
Hydroquinone and its derivatives, cysteine and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, placenta extract, plants having skin whitening action
One or more selected from algal extracts are exemplified.

Examples of L-ascorbic acid and salts and derivatives thereof used as whitening agents include L-ascorbic acid, sodium L-ascorbate, magnesium L-ascorbate, potassium L-ascorbate,
Calcium L-ascorbate, L-ascorbic acid monostearate, L-ascorbic acid monopalmitate, L-ascorbic acid monooleate, L-ascorbic acid-2-sulfate, L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid dioleate, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-
Ascorbic acid trioleate, L-ascorbic acid phosphate, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid calcium phosphate Salts and the like can be mentioned. Among these L-ascorbic acid and salts or derivatives thereof, particularly preferred are L-ascorbic acid, L-ascorbic acid phosphate and magnesium salts thereof.

The hinokitiol and its derivatives used as whitening agents are not particularly limited.
Examples include hinokitiol zinc complexes, hinokitiol glycosides, and the like.

The 2-hydroxycarboxylic acid and salts or derivatives thereof used as whitening agents are not particularly limited, but are preferably 2-hydroxycarboxylic acids having 2 to 22 carbon atoms, and more preferably 2-hydroxycarboxylic acids having 2 to 6 carbon atoms. Hydroxycarboxylic acid is preferably used in view of the effects of the present invention. For example, 2-hydroxyacetic acid, lactic acid, malic acid, tartaric acid,
Pyruvic acid, citric acid and salts thereof, and alkyl esters, cholesterol esters, glycosides, phosphatidyl esters, and L-arginine salts of 2-hydroxycarboxylic acid, which have improved skin affinity of 2-hydroxycarboxylic acid, and the like. .

Hydroquinone and its derivatives used as whitening agents are not particularly limited, but hydroquinone glycosides are preferably used. For example, hydroquinone-α-D-glucose, hydroquinone-β-D-glucose, hydroquinone-α- L-glucose, hydroquinone-β-L-glucose, hydroquinone-α-
Hexasaccharide glycosides such as D-galactose, hydroquinone-β-D-galactose, hydroquinone-α-L-galactose, hydroquinone-β-L-galactose, hydroquinone-α-D-ribose, hydroquinone-β
-D-ribose, hydroquinone-α-L-ribose,
Hydroquinone-β-L-ribose, hydroquinone-
Pentose sugar glycosides such as α-D-arabinose, hydroquinone-β-D-arabinose, hydroquinone-α-L-arabinose, hydroquinone-β-L-arabinose, hydroquinone-α-D-glucosamine, hydroquinone-β- D-glucosamine, hydroquinone-α-
L-glucosamine, hydroquinone-β-L-glucosamine, hydroquinone-α-D-galactosamine, hydroquinone-β-D-galactosamine, hydroquinone-α-L-galactosamine, hydroquinone-β-L-
Amino sugar glycosides such as galactosamine, hydroquinone-
α-D-glucuronic acid, hydroquinone-β-D-glucuronic acid, hydroquinone-α-L-glucuronic acid, hydroquinone-β-L-glucuronic acid, hydroquinone-α-D-galacturonic acid, hydroquinone-β-D-
Examples thereof include uronic acid glycosides such as galacturonic acid, hydroquinone-α-L-galacturonic acid, and hydroquinone-β-L-galacturonic acid. Examples of the derivative include an ester such as an acetylated product and an ether such as a methylated product. Among them, hydroquinone-β-D-glucose is most preferable from the viewpoint of the effect of the present invention.

The cysteine and its derivatives used as whitening agents are not particularly restricted but include, for example, cysteine or phospholipid esters of cysteine, esters with sphingosine and its derivatives, glycolipid esters, sugar esters, sterol esters and C 8 carbon atoms. To 20 alkyl or alkenyl esters.

Glucosamine and its derivatives used as whitening agents are not particularly limited, and include, for example, glucosamine, glucosamine esters such as acetylglucosamine, and glucosamine ethers such as glucosamine methyl ether.

Azelaic acid and derivatives thereof used as a whitening agent are not particularly limited. Examples thereof include azelaic acid, azelaic acid monoesters such as azelaic acid monoalkyl ester, and azelaic acid diesters such as azelaic acid dialkyl ester. No.

The placenta extract used as a whitening agent includes:
Any base can be used as long as it is used for a normal skin external preparation.

In the present invention, extracts from plants and algae known to have a whitening effect can also be used as whitening agents. Such plants and algae include mulberry ( Morus alba)
L.), Paeonia ( Paeonia lactiflora Pall.), Button ( Paeonia suffruticosa Andr.), Scarabae ( Suc
tellaria baicalensis Georg.), Adlay ( Coix lach )
ryma-jobi L. var. ma-yuen (Roman.) Stapf), Spinach ( Coptis japonica (Thunb.) Makino), Saxifraga ( Saxifraga stolonifera Meerb.), Jinko ( Aquila )
ria agallocha Roxb.), tea ( Camellia sinensis )
(L.) O. Kuntze) and its variants, Polygonum
cuspidatum Sieb. et Zucc.), Melissa ( Melissa off )
icinalis L.), time (Thymus vulgaris L.), Artemisia capillaris (Artemisia capillaris Thunb.), yarrow (Achillea milleifolium L.), St. John's wort (Hypericum erectum Thunb.), western fairy Li (Hypericum perforatum L.), peony (Paeonia l
actiflora Pall.), Spanish liquorice ( Glycyrrhiza g)
labra L.), Licorice ( Glycyrrhiza urarensis Fisc)
h.), Datura moss ( Drosera routundifolia L.), Uwaurushi ( Arctostaphylos uva-ursi (L.) Spreng.),
Herayahazu ( Dictyopteris prolifera ), Haramiji ( Dictyota spinulosa ), Hijiki ( Hizikia fusiformi)
s ), Sozo sp. ( Laurencia sp.), Fushigaya ( Lomenta )
ria catenata ), whisker ( Myelophycus caespitosu )
s ), duls ( Palmaria palmata ), willow moku (sarmosum: Sargassum ringgoldianum ), ezononemoku ( Sargassum yezoense ), fushijimoku ( Sargassum co )
nfusum ), Ishimozuku ( Sphaerotrichia divaricata )
One or more plants and algae selected from the group consisting of

Further, components obtained by purifying and fractionating from these plant extracts can be blended. Examples of such components include flavonoids contained in an oil-soluble extract component of licorice, in particular, glabridine, hispagrabridine, (-)-epicatechin contained in an extract of a plant belonging to the genus Polygonum.

The amount of one or more components selected from these anti-inflammatory agents, antioxidants and whitening agents in the external preparation for skin is determined in view of its effect, odor and color tone when added. Considering this, the concentration is desirably in the range of 0.0001 to 10% by weight.

The external preparation for skin of the present invention may optionally contain
Oils and fats, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, thickeners usually used in pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics, and cleansers , Drugs, fragrances, resins, alcohols and the like can be appropriately compounded. The dosage form of the external preparation for skin of the present invention is arbitrary. For example, it can be provided as a solubilizing system such as a lotion, an emulsifying system such as a cream or an emulsion, or a dispersion system such as a calamine lotion. You may take the form of a filled aerosol.

[0038]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

[Examples 1 to 5 and Comparative Examples 1 to 6] Liquid skin external preparations Examples 1 to 5 and Comparative Examples 1 to 5 were prepared using the formulations shown in Tables 1 and 2. A liquid skin external preparation according to Example 6 was prepared. Liquid skin external preparations were prepared by mixing, dissolving, and homogenizing all components. In the ingredients, marine collagen manufactured by Brooks as hydrolyzed collagen,
As a collagen-like peptide, a carrot-derived collagen-like peptide (trade name: EXTENSIN) manufactured by Koken Co., Ltd.
, And as a lemon extract, a lemon extra liquid manufactured by Ichimaru Falcos was used.

[0040]

[Table 1]

[0041]

[Table 2]

Examples 1 to 3 of the present invention prepared according to the above formula
Example 5 and Comparative Examples 1 to 6 were evaluated for the effect of improving pigmentation symptoms. The effect of improving pigmentation symptoms is
A group of 20 female panelers having pigmentation symptoms such as spots and freckles due to remarkable sunburn was prepared as a group.
Example 5 and Comparative Examples 1 to 6 were each used twice a day in a blind for 1 month, and the state of pigmentation of the skin after 1 month was observed and compared with that before use. . The state of pigmentation was evaluated according to the criterion shown in Table 3, and the average value of 20 persons was calculated and shown in Table 4.

[0043]

[Table 3]

[0044]

[Table 4]

As is evident from Table 4, in all the groups using the examples according to the present invention, remarkable improvement of the pigmentation symptom was observed in all the groups. After the use test, slight or slight pigmentation was observed. Symptoms had improved to the extent that they were only noticeable. On the other hand, in the comparative group using the active ingredient of the present invention alone, the degree of improvement in pigmentation was clearly smaller than in the corresponding group using the examples.

In Examples 1 to 5 of the present invention, no change in the state of the preparation such as precipitation, separation, aggregation, discoloration, and discoloration of the components was found during the use test period. In addition, in each group used in Examples, there was no paneler showing a skin irritating reaction or a skin sensitizing reaction.

Another embodiment of the present invention will be described.

Example 6 Beauty Essence (1) Glycerin 40.0 (wt%) (2) Carboxyvinyl polymer (1 wt% aqueous solution) 20.0 (3) Ethanol 10.0 (4) Succinyl atelocollagen solution 2 % 1.0 (Atelocollagen SS (2%) manufactured by Koken Co., Ltd.) (5) Chimney extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) 1.0 (6) Potassium hydroxide (10% by weight aqueous solution) 0.6 (7) Purified water 27 .4 Production method: Mix and homogenize all components of (1) to (7).

Example 7 Oil-in-water Emulsified Essence (1) Squalane 5.0 (% by weight) (2) White Vaseline 1.5 (3) Beeswax 0.5 (4) Sorbitan Sesquioleate 0.8 (5) Polyoxyethylene oleyl ether (20EO) 1.2 (6) Orange oil (manufactured by GOLDEN GEM GROWERS) 1.0 (7) Methyl parahydroxybenzoate 0.1 (8) Propylene glycol 5.0 (9) Hydrolyzed collagen solution 1.0 (Promois W-42K manufactured by Seiwa Kasei Co., Ltd.) (10) Purified water 59.3 (11) Carboxyvinyl polymer (1.0% by weight aqueous solution) 20.0 (12) Potassium hydroxide 0 1 (13) Ethanol 5.0 (14) Oil-soluble licorice extract powder (manufactured by Maruzen Pharmaceutical Co., Ltd.) 0.5 Production method: The oil phase components of (1) to (6) are mixed and heated to 75 ° C. for dissolution. Make uniform. On the other hand, the aqueous phase components (7) to (10) are mixed,
Dissolve and heat to 75 ° C., pre-emulsify by gradually adding the oil phase component. After adding (11), the mixture is uniformly emulsified with a homomixer, and the pH is adjusted by adding (11). After cooling, add (13) and (14) at 40 ° C, mix and homogenize.

Example 8 Toner (1) Methyl paraoxybenzoate 0.1 (% by weight) (2) Fragrance 0.2 (3) Ethanol 10.0 (4) 1,3-butylene glycol 3.0 (5) Lemon extra liquid (Ichimaru Falcos) 0.5 (6) Xanthan gum (1% by weight aqueous solution) 10.0 (7) Hydrolyzed collagen 1.0 (Marine collagen Brooks) (8) Purified water 74 0.7 (9) Dipotassium glycyrrhizinate 0.5 Production method: After dissolving (1) and (2) in (3), the components (4) to (9) are sequentially added, mixed and homogenized.

Example 9 Skin Emulsion (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid paraffin 7.0 (5) Polyoxy Ethylene (10EO) monooleate 1.5 (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Purified water 78.8 (9) Yeast-derived superoxide dismutase 0.5 (10) Hydrolysis Degraded Collagen 1.0 (Marine Collagen Brooks) (11) Chimney Extract (Maruzen Pharmaceutical Co., Ltd.) 0.5 Production Method: The oil phase components (1) to (5) are mixed, heated and uniformly dissolved. Keep at ° C. On the other hand, the aqueous phase components (6) to (8) are mixed and heated to be uniform, and the temperature is set to 70 ° C. The oil phase component is gradually added to the aqueous phase component with stirring, emulsified, cooled, and the components (9) to (11) are added at 40 ° C. and mixed.

Example 10 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic type Glyceryl monostearate 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (7) Propylene glycol 5.0 (8) Purified water 36.0 (9) Collagen-like peptide 0.5 ( (EXTENSIN BG manufactured by Koken Co., Ltd.) (10) Lemon extra liquid (manufactured by Ichimaru Falcos) 0.5 (11) Knotweed extract 0.5 Manufacturing method: Mix and dissolve the oil phase components (1) to (6) Heat to 75 ° C. On the other hand, the aqueous phase components (7) and (8) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. Cool with stirring, add (9)-(11) at 40 ° C., mix and homogenize.

[Example 11] Whitening lotion (1) Purified water 20.0 (% by weight) (2) Glycerin 15.0 (3) 1,3-butylene glycol 3.0 (4) Xanthan gum (1% by weight) (Aqueous solution) 10.0 (5) Carboxyvinyl polymer (1% by weight aqueous solution) 5.0 (6) Polyglyceryl monolaurate 0.1 (7) L-arginine (10% by weight aqueous solution) 0.9 (8) Diethylenetriaminepentaacetic acid Pentasodium 0.2 (9) Methyl parahydroxybenzoate 0.05 (9) Collagen-like peptide 0.1 (EXTENSIN BG manufactured by Koken) (10) Gentian extract 0.1 (Infran-ATF Technoble) (11) Peony extract 0.1 (Peony extract liquid manufactured by Maruzen Pharmaceutical Co., Ltd.) (12) Button extract 0.1 (Button extract liquid manufactured by Maruzen Pharmaceutical Co.) (13) Yokuinin extract 0.1 (Yokuinin extract liquid manufactured by Maruzen Pharmaceutical Co., Ltd.) ) (14) Lemon extract 0.1 (Lemon extra liquid manufactured by Ichimaru Falcos) (15) Magnesium phosphate ascorbate 30.0 (10% by weight aqueous solution) (16) Citric acid (10% by weight aqueous solution) ) Sodium hydroxide (10% by weight aqueous solution) Appropriate amount (18) Purified water Amount based on the total amount of 100 Production method: After the components (2) to (15) are added to (1) in order and mixed and homogenized, (16) After adjusting the pH to 8.0 with the components () and (17), the total amount is adjusted to 100 with purified water.

Example 12 Whitening Essence (1) Polyglyceryl Distearate 2.5 (% by Weight) (2) Tri-2-ethylhexane Sanglyceryl 8.0 (3) Bacyl Alcohol 0.5 (4) Hydrogen Added soybean phospholipids 0.4 (5) Glycerin 5.0 (6) 1,3-butylene glycol 2.5 (7) Trimethylglycine 3.0 (8) Xanthan gum (1% by weight aqueous solution) 20.0 (9) Carboxyvinyl polymer (1% by weight aqueous solution) 10.0 (10) Purified water 5.0 (11) Ethanol 5.0 (12) Methyl parahydroxybenzoate 0.1 (13) Diethylenetriaminepentaacetic acid pentasodium solution 0.2 ( 14) Collagen-like peptide 0.1 (EXTENSIN BG manufactured by Koken) (15) Yokuinin extract 0.1 (Yokuinin extract Maruzen Pharmaceutical) (16) Peony extract 0.1 (Peonyaku extract Maruzen Pharmaceutical) (17) B Extract 0.1 (button extract, manufactured by Maruzen Pharmaceutical) (18) Lemon extract 0.1 (lemon extra liquid, manufactured by Ichimaru Falcos) (19) Gentian extract 0.1 (manufactured by Infran-ATF Technoble) (20) ) Ascorbic acid phosphate magnesium salt 30.0 (10 wt% aqueous solution) (21) Sodium citrate (10 wt% aqueous solution) suitable amount (22) Sodium hydroxide (10 wt% aqueous solution) proper amount (23) Purified water Production method: Mix and dissolve the oil phase components (1) to (4) and heat to 75 ° C. On the other hand, the aqueous phase components (5) to (10) are mixed and dissolved, and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. After cooling with stirring, (11) to (20) were added at 40 ° C. to mix and homogenize, and the pH was adjusted to 8.0 using the components (21) and (22). ) With purified water
00.

Example 13 Whitening Lotion (1) Purified Water 40.0 (% by weight) (2) Dipotassium glycyrrhizinate 0.1 (3) Sodium lactate (10% by weight aqueous solution) 2.0 (4) Glycerin 2.0 (5) Ethanol 10.0 (6) Diethylenetriaminepentaacetic acid pentasodium solution 0.2 (7) Collagen-like peptide 0.1 (EXTENSIN BG manufactured by Koken Co., Ltd.) (8) Yokuinin extract 0.1 (Yokuinin extraction Liquid Maruzen Pharmaceutical) (9) Peony extract 0.1 (Peony extract Maruzen Pharmaceutical) (10) Button extract 0.1 (Button extract Maruzen Pharmaceutical) (11) Lemon extract 0.1 (Lemon (12) Gentian extract 0.1 (Infran-ATF Technoble) (13) Magnesium ascorbic acid phosphate 30.0 (10% by weight aqueous solution) (14) Trimethylglycine 5.0 (15) Suitable amount of sodium hydroxide (10% by weight aqueous solution) (16) Purified water Amount based on the total amount of 100 Production method: (1) Ingredients of (2) to (14) are sequentially added After adding, mixing, dissolving and homogenizing, the pH is adjusted to 8.0 with the component (15) and the total amount is adjusted to 100 with purified water of (16).

Example 14 Whitening Essence (1) Decamethylcyclopentasiloxane 10.5 (% by weight) (2) 2-Ethylhexyl paramethoxycinnamate 10.0 (3) Methylpolysiloxane 7.0 ( 4) stearic acid 1.0 (5) decaglyceryl distearate 2.0 (6) lipophilic glyceryl monostearate 1.0 (7) stearyl glycyrrhetinate 0.1 (8) cetanol 1.0 (9) dibutyl Hydroxytoluene 0.1 (10) dl-α-tocopherol acetate 0.1 (11) 1,3-butylene glycol 5.0 (12) Methyl paraoxybenzoate 0.2 (13) Carboxyvinyl polymer (1% by weight aqueous solution) 33.0 (14) pentasodium diethylenetriaminepentaacetic acid solution 0.2 (15) sodium N-stearoyl-L-glutamate 1.0 (16) purified water 25.7 (17) sodium hydroxide (10% by weight aqueous solution) 1.5 (18) Collagen-like peptide 0.1 (EXTENSIN BG manufactured by Koken) (19) Yokuinin extract 0.1 (Yokuinin extract Maruzen Pharmaceutical) (20) Peony extract 0.1 (Peony extract Maruzen) (21) Button Extract 0.1 (Button Extract Maruzen Pharmaceutical) (22) Lemon Extract 0.1 (Lemon Extra Liquid Ichimaru Falcos) (23) Gentian Extract 0.1 (Infran- (ATF Technoble Co., Ltd.) Production method: Mix and dissolve the oil phase components (1) to (9) and heat to 75 ° C. On the other hand, the aqueous phase components (10) to (16) are mixed and dissolved, and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. Cool with stirring, add (17) to (23) at 40 ° C, mix and homogenize.

Example 15 Face Wash (1) Myristic acid 26.0 (% by weight) (2) Stearic acid 10.2 (3) Palmitic acid 1.8 (4) Lipophilic glyceryl monostearate 0 (5) Lauric acid diethanolamide 1.5 (6) Glycerin 15.0 (7) Potassium hydroxide 7.8 (8) Methyl parahydroxybenzoate 0.1 (9) Dipotassium glycyrrhizinate 0.1 (10) Purification Water 34.4 (11) Trimethylglycine 0.1 (12) Ethanol 0.5 (13) Licorice extract 0.1 (oil-soluble licorice extract powder, manufactured by Maruzen Pharmaceutical Co., Ltd.) (14) Yokuinin extract 0.1 (Yokuinin extract (15) Peony extract 0.1 (Peony extract, Maruzen Pharmaceutical) (16) Button extract 0.1 (Button extract, Maruzen Pharmaceutical) (17) Gentian extract 0.1 (Infran -ATF Technoble Co.) Manufacturing method: (1)-( The oil phase component of 5) is mixed and dissolved and heated to 75 ° C. On the other hand, the aqueous phase components (6) to (10) are mixed and dissolved and heated to 75 ° C. Next, after adding the oil phase component to the aqueous phase component and saponifying, the mixture was cooled with stirring, and cooled to 40 ° C.
Add (11) to (17), mix and homogenize.

[0058]

As described in detail above, according to the present invention, an external preparation for skin that is effective in preventing and improving pigmentation, spots, freckles and the like after sunburn and has a high skin whitening effect can be obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification code FI Theme coat ゛ (Reference) A61K 7/50 A61K 7/50 F-term (Reference) 4C083 AA082 AA111 AA112 AA122 AB032 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC302 AC422 AC442 AC472 AC482 AC532 AC542 AC582 AC642 AD092 AD162 AD172 AD352 AD411 AD431 AD432 AD472 AD512 AD532 AD572 AD642 AD662 CC04 CC05 CC23 DD23 DD31 EE12 EE16

Claims (2)

[Claims] 1. One or two selected from collagen and its hydrolyzate, and salts and derivatives thereof, and plant-derived peptides having an amino acid composition similar to collagen.
An external preparation for skin containing at least one species and an extract obtained from a Citrus plant. 2. The external preparation for skin according to claim 1, further comprising one or more selected from an anti-inflammatory agent, an antioxidant, and a whitening agent.