JP2002187816A - Bleaching cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly safe bleaching cosmetic synergistically enhanced in melanogenesis inhibitory action, thus effective for preventing and ameliorating pigmentation, fleckles, chloasma and the like after sunburn and markedly improved in skin bleaching effect. SOLUTION: This bleaching cosmetic contains the A-ingredient and the B- ingredient each mentioned below, and also contains at least one ingredient selected from anti-inflammatory agent, antioxidant and bleaching agent; A- ingredient: at least one kind of extract from plant (s) selected from those belonging to the genera Moraceae, Paeoniaceae, Leguminosae and Glycyrrhiza, and B-ingredient: at least one kind of ingredient selected from Gramineae plant extract, Gentianaceae plant extract, Scutellaria indica plant extract, lavender extract, Coptis japonica plant extract, perilla extract, and an extract obtained from molasses and freed from any colored component (s).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has a synergistically enhanced melanin production inhibitory effect, is effective in preventing and improving pigmentation, spots, freckles, spots, etc. after sunburn, and has a markedly improved skin whitening effect. Related to highly safe whitening cosmetics.

[0002]

2. Description of the Related Art Conventionally, darkening of skin by ultraviolet rays,
In order to prevent or improve pigmentation of the skin, such as spots and freckles, components having an action of inhibiting melanin production or reducing the produced melanin pigment have been screened and formulated into whitening cosmetics. For example, ascorbic acid, cysteine, hydroquinone, 2-hydroxy acids and derivatives thereof, placenta extracts, extracts from plants and algae, and the like are used.

[0003] However, ascorbic acid, cysteine and hydroquinone are susceptible to oxidation-reduction reactions and unstable, and 2-hydroxy acids have a problem in terms of skin safety when an effective amount is added, and placental extracts, plants and algae When the effective amount of the extract is mixed, the whitening cosmetic may have an undesirable odor or color.

[0004]

DISCLOSURE OF THE INVENTION The present invention solves the above-mentioned problems, has an extremely strong melanin production inhibitory effect on the skin, and has a high safety in terms of skin irritation and skin sensitization. The aim was to obtain a whitening cosmetic that had no problems.

[0005]

In order to solve the above-mentioned problems, various studies were conducted. By using the following components A and B together, and selecting from an anti-inflammatory agent, an antioxidant and a whitening agent. It has been found that by further using one or more of the above-mentioned combinations, a whitening effect is synergistically enhanced, and a whitening cosmetic free of safety problems such as skin irritation and skin sensitization can be obtained. Thus, the present invention has been completed. Here, the A component is one or more plant extracts selected from a mulberry plant extract, a button plant extract, a genus plant extract, and a licorice plant extract, and the B component is 1 selected from extracts obtained from Judasama plant extract, Gentian plant extract, Scutellaria plant extract, Lavender extract, Spinach plant extract, Perilla extract, molasses extracted and obtained by removing coloring components A species or two or more components.

[0006]

Embodiments of the present invention will be described.

The mulberry plant, one of the A components used in the present invention, is a dicotyledonous plant belonging to the mulberry family ( Moraceae ),
There is no particular limitation on the type, but Magua ( Morus alba L .; M
orusatropurpure Roxb.), Shimaguwa ( Morus australis P
oir.; Morus acidosa Griff.), Yamaguwa ( Morus bomby )
cis Koidz .; Morus alba L. var.stylosa Bur .; Moru
s japonica Bailey non Sieb.), Hachijowa ( Morus
lagayamae Koidz.), Logwa ( Morus latifolia (Bur.)
Poir.; Morus alba L. var. Latifolia Bur .; Morus
multicaulis Perr.; Morus alba L. var. multicaulis
Loud.), Morus mongolica (Bur.) Schnei
d.; Morus alba var. mongolica Bur.), Kromigwa ( M
orus nigra L.) and red migua ( Morus rubra L.). Among these mulberry plants, from the aspect of raw material supply, magwa ( Morus alba L .; Morus atropurpure Rox
b.) or Yamaguwa ( Morus bombycis Koidz .; Morus
alba L. var.stylosa Bur .; Morus japonica Bailey
non Sieb.), and cultivars thereof. The site to be used for obtaining the extract from the mulberry plant is not particularly limited, but root bark, bark, and leaves are preferable, and root bark is particularly preferable in view of its effects.

[0008] peony is a type of component A used in the present invention is a dicotyledonous plant belonging to the peony (Paeoniaceae), although not any type thereof peony (Pa
eonia lactiflora Pall.), Dutch peonies ( Paeo )
nia officinalis L.), button ( Paeonia suffruticosa )
Andr.), And cultivars thereof are preferably used. The site to be used for obtaining the extract from the botanical plant is not particularly limited, but it is preferable to use roots or root bark from the viewpoint of its effect.

[0009] Sophora genus plant is a type of component A used in the present invention is a dicotyledonous plant belonging to Leguminosae (Leguminosae), particularly no limitation on the type, the Clara (Sophor
a flavescens Ait.), Enju ( Sophora japonica )
L.) is preferably used. The site to be used for obtaining the extract from the plant of the genus Genus is not particularly limited, but from the viewpoint of its effect, it is preferable to use the roots of Clara and the buds of Enju.

The licorice genus plant, which is one of the A components used in the present invention, is a dicotyledonous plant belonging to the leguminous family ( Leguminosae ), and is not particularly limited in its kind, but includes Spanish liquorice ( Glycyrrhiza glabra L.) and citrus elephant. ( Glycyrrhi
za kansuensis Chang et peng, licorice ( Glycyrrhi )
za urarensis Fisch.) is preferred. The site to be used for obtaining the extract from the licorice plant is not particularly limited, but it is preferable to use a root from the viewpoint of its effect. In addition, licorice flavonoids such as glabridine and hispagrabridine purified from the extract can also be used.

The amount of the component A to be added to the whitening cosmetic is determined in view of its effect, odor and color tone when added.
It is desirable to set the concentration range of 0.0001 to 5% by weight.

[0012] Job's tears genus plant is one of the B component used in the present invention is a monocotyledonous plant belonging to Gramineae (Gramineae), although not any type thereof Coix (Coix
lachryma-jobi L. var.ma- yuen (Roman.) Stapf; Coi
x lachryma-jobi var.frumentacea Makino; Coix ma-
yuen Roman.) is preferably used. The site to be used for obtaining the extract from the plant of the genus Jujuda is not particularly limited, but it is preferable to refine the seeds and use them in view of their effects.

The genus Gentian plant, one of the B components used in the present invention, is a dicotyledonous plant belonging to the Gentianaceae family, and its type is not particularly limited , but Gentiana algida Pall., Indian gentian ( Gentiana kurroo Royle), gentian ( Genti
ana lutea L.), Gentian ( Gentiana scabra Bunge va)
r. buergeri (Miq.) Maxim . subvar. orientalis (Har
a) Toyokuni), Ezo Lindow ( Gentiana triflora Pal)
las. var. japonica (Kusn. ) Hara), three flower gentian (Gentia
na triflora Pallas. var. triflora) or the like is used,
Gentian ( Gentiana lutea L.) is particularly preferred from the viewpoint of its effect. Further, the site to be used for obtaining the extract from the Gentian plant is not particularly limited, but it is preferable to use a root or rhizome from the viewpoint of its effect.

[0014] Scutellaria plant that is one of the B component used in the present invention is a dicotyledonous plant belonging to the Labiatae family, although not any type thereof Scutellaria baicalensis Georgi (Scutellaria b
aicalensis Georgi), Scutellaria b
rachyspica Nakai et Hara), Scutellaria ( Scutellari )
a indica L.), Japanese persian beetle ( Scutellaria laeteviol
acea Koidz.), Tsunanami ( Scutellaria maekawae )
Hara), Scutellaria pekinensis Max
im. var. transitra (Makino) Hara), Ezotatsunami ( Sc
utellaria pekinensis Maxim.var.transitra (Makin
o) Hara Var. ussuriensis (Regel) Hara)
( Scutellaria strigillosa Hemel.) And the like, and especially Japanese willow is used preferably. As an extraction site for obtaining a plant extract, a root is preferable.

Lavandula angustifolia (L.) Mill .; Lavandul , one of the B components used in the present invention.
a spica L., pp; Lavandula officinalis Chaix; La
vandula spica var. angustifolia L. f.) is a plant belonging to the Labiatae genus Lavender. The site of use and the method of extraction when obtaining the extract from lavender are not particularly limited, but it is preferable to use an essential oil obtained by steam distillation of raw spikelets from the viewpoint of its effect. This essential oil is called lavender oil and is known to have a sedative effect.

The plant of the genus Ouren which is a kind of the component B used in the present invention includes, for example, spinach ( Coptis japonica (Thun)
b.) Makino), Coptis japonica (Thun
b.) Makino var. japonica ), Ceribaouren ( Coptis j
aponica (Thunb.) Makino var.dissecta (Yatabe) Naka
i), Coptis japonica (Thunb.) Maki
no var. major (Miq.) Satake), baika spinach ( Copti
s quinquefolia Miq.), Honey beetle ( Coptis trifol
ia (L.) Salisb.) and the like are not particularly limited. The rhizome is preferably used as an extraction site for obtaining a plant extract.

Perilla frutescens Britt. Var. Crispa (Thunb.) D, one of the B components used in the present invention.
ecne;. (. Thunb) Perilla crispa Nakai) is a dicotyledonous plant belonging to the Labiatae (Labiatae) Perilla genera, its leaves and fruit have been widely used as food. The site to be used for obtaining the perilla extract is not particularly limited, but it is preferable to use leaves or fruits from the viewpoint of its effect.

As an extract obtained by extracting a molasses and removing coloring components, which is one of the B components used in the present invention, for example, molashiz liquid manufactured by Taiyo Kagaku Co., Ltd. can be used. .

The amount of the B component to be added to the whitening cosmetic is determined in view of its effect, odor and color tone when added.
It is desirable to set the concentration range of 0.0001 to 5% by weight.

The above-mentioned plant extracts of the component A and the component B are used intact or dried at one or two or more sites of various whole plants or leaves, bark, roots, flowers, branches and the like. The extraction solvent is not particularly restricted but includes water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol,
Monohydric alcohols such as n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol, etc. Polyhydric alcohols or derivatives thereof, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; esters such as ethyl acetate and isopropyl acetate; ethers such as ethyl ether, isopropyl ether and n-butyl ether , Squalane, petrolatum, paraffin wax, paraffin oil and other hydrocarbons, olive oil, wheat germ oil, rice oil, sesame oil, macadamian nut oil, almond oil, yam Vegetable oils such as oil, beef tallow, lard, animal oils and fats, such as whale oil and the like. Further, a polar solvent to which an inorganic salt such as a phosphate buffered saline is added, and a solvent to which a surfactant is added can be used, and there is no particular limitation.

Examples of the extraction method include a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extracting using a distillation method such as steam distillation, and a method of pressing a plant to obtain an extract. For example, these methods may be used alone or in combination of two or more.

The ratio of the plant to the solvent at the time of extraction is not particularly limited, but the solvent is 0.1 to 1000 times by weight of the plant 1, especially 0.5 to 100 times by weight in terms of extraction operation and efficiency. preferable. The extraction pressure and temperature are 0 ° C under normal pressure.
To the boiling point of the solvent or lower, and the extraction time varies depending on the extraction temperature and the like, but is preferably in the range of 2 hours to 2 weeks.

The plant extract thus obtained is
The extract may be used as it is, but it may be subjected to purification operations such as deodorization, decolorization, concentration, etc., as far as the effect is not lost, or may be used as a fraction by using column chromatography or the like. These extracts and purified products,
The fractions can be dried by removing the solvent therefrom, and further, can be used in the form of a solution solubilized in a solvent such as alcohol or in the form of an emulsion.

The whitening cosmetic composition of the present invention can provide a high whitening effect by using the above-mentioned components A and B in combination, but is also one of an anti-inflammatory agent, an antioxidant and a whitening agent. Alternatively, by using two or more components in combination, a higher whitening effect can be obtained.

As the anti-inflammatory agent, any type and base can be used as long as it is usually used in an external preparation for skin. Cortisone, hydrocortisone, prednisolone,
Methylprednisolone, dexamethasone, betamethasone, triamcinolone, triamcinolone acetonide,
Steroidal anti-inflammatory agents such as fluocinolone acetonide, fluocinonide, beclomethasone and their phosphates, propionates, acetates, and succinates; salicylic acid derivatives such as salicylic acid and aspirin, salicylamide, ethenzamide, methyl salicylate; Indomethacin,
Indoleacetic acid derivatives such as sulindac, pyrazolidinedione derivatives such as phenylbutazone and oxyphenbutazone, anthranilic acid derivatives such as mefenamic acid and flufenamic acid, propionic acid derivatives such as ibuprofen, ketoprofen and naproxen, diclofenac and fenbufen Non-steroidal anti-inflammatory agents such as phenylacetic acid derivatives, benzothiazine derivatives such as piroxicam,
Salts and derivatives of glycyrrhizic acid such as glycyrrhizic acid and dipotassium glycyrrhizinate, and monoammonium glycyrrhizinate, salts and derivatives of glycyrrhetic acid such as glycyrrhetinic acid and stearyl glycyrrhetinate, glycyrrhetinyl stearate, disodium 3-succinyloxyglycyrrhetinate, guaiazulene, guaiazulene ethyl sulfonate, sodium guaiazulene sulfonate, azulene derivatives, allantoin, aloin, aloe-emodin, shikonin and isobutyl shikonin, acetyl shikonin, shikonin derivatives such isovaleryloxy shikonin such chamazulene, ginsenoside R _a1, ginsenoside R _a2, ginsenoside R _b1 ginsenoside etc., 20-ginsenoside derivatives such as glucosides Gin Seno glucoside R _f, paeoniflorin, Peono And Peonoshido, like paeonol derivatives such Peonorido.

[0026] as anti-inflammatory agents in the present invention, lithospermum (Lithospermi Radix), carrots (Ginseng Radi
x ) and the like can be used herbal extracts used as anti-inflammatory agents.

The antioxidant used in the present invention may be of any type and origin as long as it is generally used in external preparations for skin. Examples thereof include carotenoids, flavonoids, tannins, gallic acid and salts thereof. In addition, esters, tocopherol and derivatives thereof, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like are used.

The carotenoids used in the present invention include:
Α-carotene, β-carotene,
Examples include γ-carotene, lycopene, cryptoxanthin, lutein (xanthophyll), zeaxanthin, rhodoxanthin, crocetin and the like. In addition, these carotenoids may be used as they are, or derivatives such as glycosides and esters may be used.

The flavonoids used in the present invention, irrespective of their type and origin, are flavones and flavone glycosides such as flavone, chrysin, primetine, apigenin and luteolin, galangin, kaempferol, fisetin, quercetin, myricetin, Flavonols and flavonol glycosides such as rutin, isoflavones and isoflavone glycosides such as daidzein and genistein, flavanones,
Flavanones and flavanone glycosides such as pinocembrin, naringenin, sachranetin, hesperetin, eriodictyol, matisinol, etc .; Chalcone and chalcone glycosides such as butein, carconocartamidine, pedisin and pedicinin; benzalcumalananes and benzalkumaranone glycosides such as benzalcumalanone, sulfretin, leptosidine, and aurodin; pelargonidin, cyanidin, delphinidin and the like And anthocyan glycosides.

The tannins used in the present invention are broadly defined tannic acids present in many plants, especially bark of beech family plants such as oak and oak, leaves of gourd plants such as goby, nulde and urushi, and fruits of kariloku. , Gallotannin, gallotannic acid and the like. Tannins are a generic term for these complex aromatic compounds having a large number of phenolic hydroxyl groups widely distributed in the plant kingdom. Phenols and phenol carboxylic acids are obtained by alkali decomposition. In the present invention, these plant-derived tannins can be used as they are or purified, and artificially synthesized tannins can also be used. Further, gallic acid and its salts, which are constituents of tannin, and esters thereof can also be used. Among these tannins,
It is most preferable to use the hamameli tannin contained in the hamamelis extract.

The tocopherol and its derivatives used in the present invention are not particularly limited, and α-tocopherol,
Examples thereof include β-tocopherol, γ-tocopherol, d-δ-tocopherol, tocopherol acetate, DL-α-tocopherol nicotinate, and DL-α-tocopherol succinate.

In the present invention, as other antioxidant components, superoxide dismutase, thioredoxin, thioredoxin reductase, butylhydroxytoluene, butylhydroxyanisole and the like can be blended.

In the present invention, one selected from the above antioxidant components can be used alone or in combination of two or more. The amount of these antioxidants to be added to the skin external preparation depends on the antioxidant activity of each antioxidant, but is generally 0.0001 to 5% by weight, preferably 0.1% by weight.
001 to 5% by weight is suitable.

The whitening agents used in the present invention include:
If it is usually used for skin external preparations,
Regardless of the base, for example, L-ascorbic acid and its salts or derivatives thereof, hinokitiol and its derivatives,
2-hydroxycarboxylic acid and salts or derivatives thereof,
Hydroquinone and its derivatives, cysteine and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, placenta extract, plants having skin whitening action
One or more selected from algal extracts are exemplified.

Examples of L-ascorbic acid and salts and derivatives thereof used as whitening agents include L-ascorbic acid, sodium L-ascorbate, magnesium L-ascorbate, potassium L-ascorbate,
Calcium L-ascorbate, L-ascorbic acid monostearate, L-ascorbic acid monopalmitate, L-ascorbic acid monooleate, L-ascorbic acid-2-sulfate, L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid dioleate, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-
Ascorbic acid trioleate, L-ascorbic acid phosphate, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid calcium phosphate Salts and the like can be mentioned. Among these L-ascorbic acid and salts or derivatives thereof, particularly preferred are L-ascorbic acid, L-ascorbic acid phosphate and magnesium salts thereof.

The hinokitiol and its derivatives used as whitening agents are not particularly limited.
A hinokitiol zinc complex is exemplified.

The 2-hydroxycarboxylic acid and salts or derivatives thereof used as whitening agents are not particularly limited, but are preferably 2-hydroxycarboxylic acids having 2 to 22 carbon atoms, and more preferably 2-hydroxycarboxylic acids having 2 to 6 carbon atoms. Hydroxycarboxylic acid is preferably used in view of the effects of the present invention. For example, 2-hydroxyacetic acid, lactic acid, malic acid, tartaric acid,
Pyruvic acid, citric acid and salts thereof, and alkyl esters, cholesterol esters, glycosides, phosphatidyl esters, L-arginine salts of 2-hydroxycarboxylic acids, which have improved skin affinity of 2-hydroxycarboxylic acids, and the like. Can be

Hydroquinone and its derivatives used as whitening agents are not particularly limited, but hydroquinone glycosides are preferably used. For example, hydroquinone-α-D-glucose, hydroquinone-β-D-glucose, hydroquinone-α- L-glucose, hydroquinone-β-L-glucose, hydroquinone-α-
Hexasaccharide glycosides such as D-galactose, hydroquinone-β-D-galactose, hydroquinone-α-L-galactose, hydroquinone-β-L-galactose, hydroquinone-α-D-ribose, hydroquinone-β
-D-ribose, hydroquinone-α-L-ribose,
Hydroquinone-β-L-ribose, hydroquinone-
Pentose sugar glycosides such as α-D-arabinose, hydroquinone-β-D-arabinose, hydroquinone-α-L-arabinose, hydroquinone-β-L-arabinose, hydroquinone-α-D-glucosamine, hydroquinone-β- D-glucosamine, hydroquinone-α-
L-glucosamine, hydroquinone-β-L-glucosamine, hydroquinone-α-D-galactosamine, hydroquinone-β-D-galactosamine, hydroquinone-α-L-galactosamine, hydroquinone-β-L-
Amino sugar glycosides such as galactosamine, hydroquinone-
α-D-glucuronic acid, hydroquinone-β-D-glucuronic acid, hydroquinone-α-L-glucuronic acid, hydroquinone-β-L-glucuronic acid, hydroquinone-α-D-galacturonic acid, hydroquinone-β-D-
Examples thereof include uronic acid glycosides such as galacturonic acid, hydroquinone-α-L-galacturonic acid, and hydroquinone-β-L-galacturonic acid. Examples of the derivative include an ester such as an acetylated product and an ether such as a methylated product. Among them, hydroquinone-β-D-glucose is most preferable from the viewpoint of the effect of the present invention.

The cysteine and its derivatives used as whitening agents are not particularly restricted but include, for example, cysteine or phospholipid esters of cysteine, esters with sphingosine and its derivatives, glycolipid esters, sugar esters, sterol esters and C 8 carbon atoms. To 20 alkyl or alkenyl esters.

Glucosamine and its derivatives used as whitening agents are not particularly limited, and include, for example, glucosamine, glucosamine esters such as acetylglucosamine, and glucosamine ethers such as glucosamine methyl ether.

Azelaic acid and its derivatives used as whitening agents are not particularly restricted but include, for example, azelaic acid, azelaic acid monoesters such as azelaic acid monoalkyl ester, and azelaic acid diesters such as azelaic acid dialkyl ester. No.

Placenta extracts used as whitening agents include:
Any base can be used as long as it is used for a normal skin external preparation.

In the present invention, extracts from plants and algae known to have a whitening effect can also be used as whitening agents. Such plants and algae include Saxifraga ( Saxi
frag a stolonifera Meerb.), Jinko ( Aquilaria ag )
allocha Roxb.), tea ( Camellia sinensis (L.) O. K.
untze) and its variant, knotweed ( Polygonum cuspidatu)
m Sieb. et Zucc.), Melissa ( Melissa officinalis )
L.), thyme ( Thymusvulgaris L.), and mugwort ( A )
rtemisia capillaris Thunb.), Yarrow ( Achillea milleifolium L.), Hypericum ( Hyperi )
cum erectum Thunb.), Hypericum p ( Hypericum p
erforatum L.), Datura ( Drosera routundifoli )
a L.), Arctostaphylos uva-ursi (L.) S
preng.), Herayahazu (Dictyopteris prolifera), Hariamiji (Dictyota spinulosa), hijiki (Hizikia f u
siformis), Sozo sp. (Laurencia sp.), Fushitsunagi (Lomentaria catenata), cassiope lycopodioides (Myelophycus cae
spitosus ), Daruss ( Palmaria palmata ), Willow moku (Sabermoku: Sargassum ringgoldianum ), Ezononemoku ( Sargassum yezoense ), Fushijimoku ( Sargas )
sum confusum ), Ishimozuku ( Sphaerotrichia divaric )
One or more plants and algae selected from ata ) are preferably used.

Further, components obtained by purifying and fractionating these plant extracts can also be blended. Examples of such a component include (-)-epicatechin contained in a knotweed extract.

The amount of one or more components selected from these anti-inflammatory agents, antioxidants and whitening agents in a whitening cosmetic is determined in view of its effect, odor and color tone when added. Considering this, the concentration is desirably in the range of 0.0001 to 10% by weight.

In the whitening cosmetic of the present invention, if necessary,
Oils and fats, humectants, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, thickeners, drugs, and fragrances that are usually incorporated into pharmaceuticals, quasi-drugs, skin cosmetics, and cleansers , Resin, alcohols and the like can be appropriately compounded. Further, the dosage form of the whitening cosmetic of the present invention is arbitrary, and for example, it can be provided as a solubilizing system such as a lotion, an emulsifying system such as a cream or an emulsion, or a dispersion system such as a calamine lotion. An aerosol dosage form filled together with the aerosol may be used.

[0047]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, preparation examples of the plant extract and the like used in the present invention will be described.

[Mulberry Extract 1] Mulberry ( Morus alba L.)
350 g of the root bark was cut into small pieces, immersed in 1,000 ml of a 50% by volume aqueous 1,3-butylene glycol solution at 20 ° C. for 7 days, and extracted. The extract was filtered and the filtrate was collected to obtain mulberry extract 1.

[Mulberry Extract 2] Mulberry ( Morus alba L.)
350 g of the root bark was cut into small pieces, immersed in 1,000 ml of a 50% by volume aqueous ethanol solution at 20 ° C. for 10 days, and extracted. The extract was filtered and the filtrate was collected to obtain mulberry extract 2.

[Peony extract] Peony ( Paeoni)
a lactiflora Pall.) was pulverized and extracted with stirring in 1,000 ml of a 50% by volume aqueous solution of 1,3-butylene glycol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a peony extract.

[Button extract] button ( Paeonia suffru)
ticosa Andr.) is dried and pulverized, and is dried at 25 ° C. in 1,000 ml of a 95% by volume aqueous ethanol solution at 25 ° C.
Extracted with stirring for days. The extract was filtered, and the filtrate was collected to obtain a button extract.

[Clara extract] Clara ( Sophora flaves)
cens Ait.) was stirred for 5 days and extracted with 25 ° C. at the dry root 405g 50 volume% 1,3-butylene glycol solution 2,500ml in. The extract was filtered, and the filtrate was collected to obtain a Clara extract.

Licorice extract Spanish liquorice ( Gl
ycyrrhiza glabra L.) root and rhizome 500g,
Pulverized and dried in 1,000 ml of anhydrous ethanol
The mixture was stirred and extracted at 5 ° C. for 24 hours. The extract is filtered to collect the filtrate, concentrated under reduced pressure, and lyophilized to dryness.
The dried product was stirred and extracted in 1,000 ml of ethyl acetate at 20 ° C. for 2 days. After extraction and drying under reduced pressure, 5 g of the obtained extract was dissolved in 500 ml of a 95% by volume aqueous ethanol solution to obtain a licorice extract.

[Gentian Extract] Gentian ( Gentia)
It was stirred for 5 days and extracted with 25 ° C. at the root 422g of na lutea L.) 50 volume% 1,3-butylene glycol solution 2,500ml in. The extract was filtered, and the filtrate was collected to obtain a gentian extract.

[Ougon extract 1] Koganane willow ( Scute
llaria baicalensis Georgi), 215 g of herbal medicine Scutellariae Radix , which is a dry matter of root
25 in 2,500 ml of 3-butylene glycol aqueous solution
Stirring was performed at 5 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a pentagon extract.

[Ogon Extract 2] Scarlet willow ( Scute
150 g of a herbal medicine, Scutellariae Radix , which is a dried root of llaria baicalensis Georgi), was stirred and extracted in 2500 ml of a 50% by volume aqueous ethanol solution at 25 ° C for 10 days. The extract was filtered, and the filtrate was collected to obtain a pentagon extract 2.

[ Adlay extract] Adlay ( Coix lachry)
Ma- yuen (Roman. Stapf) 409 g of the white seeds of ma-jobi L. var. ma-yuen (Roman.) Stapf) was stirred and extracted at 25 ° C. for 5 days in 2,500 ml of a 50% by volume aqueous solution of 1,3-butylene glycol. The extract was filtered, and the filtrate was collected to obtain a barley extract.

[Lavender oil] Lavender ( Lavandula)
angustifolia (L.) Mill.) was steam-distilled to obtain lavender oil.

[Our Extract 1] [Our Extract ( Coptis ja)
255 g of the dried rhizome of Ponica (Thunb.) Makino was extracted by stirring at 2500C for 5 days in 2,500 ml of a 50% by volume aqueous solution of 1,3-butylene glycol. The extract was filtered, and the filtrate was collected to obtain a spinach extract 1.

[Our Extract 2] [Our Extract ( Coptis ja)
300 g of dried rhizome of Ponica (Thunb.) Makino) in 25 ml of a 50% by volume aqueous ethanol solution at 25 ° C.
Extracted with stirring for days. The extract was filtered, and the filtrate was collected to obtain a spinach extract 2.

[0061] [lavender extract] lavender (Lavand
ula angustifolia (L.) Mill.)
5% at 25 ° C in 3000 ml of 0% by volume ethanol aqueous solution.
Extracted with stirring for days. The extract was filtered, and the filtrate was collected to obtain a lavender extract.

[ Perilla frutescens ] Perilla ( Perilla frutescens)
.. Britt var crispa Decne (Thunb .);. Perillacrisp
a (Thunb.) Nakai）
The mixture was stirred and extracted in 2,500 ml of butylene glycol at 25 ° C. for 3 days. The extract was filtered, and the filtrate was collected to obtain a perilla extract.

[Honey extract] Morashizu liquid manufactured by Taiyo Kagaku Co., Ltd. was used.

[Placenta extract] A placenta extract manufactured by Nichirei Co. was used.

Next, a formulation example according to the present invention using the above extract is shown.

According to the formulation shown in Table 1, Example 1 of the present invention
-A whitening lotion according to Example 4 was prepared. At the same time, the A component (mulberry extract 1), B component (barley extract), and whitening agent (ascorbic acid phosphate magnesium salt), anti-inflammatory agent (dipotassium glycyrrhizinate), and antioxidant (hamamellitannin) Comparative Examples 1 to 5 in which only each component was blended were simultaneously prepared with the formulations shown in Table 2. The whitening lotion was prepared by sequentially adding all components to purified water, mixing and homogenizing.

[0067]

[Table 1]

[0068]

[Table 2]

The whitening lotions shown in Tables 1 and 2 were evaluated for the effect of improving pigmentation symptoms. The effect of improving the pigmentation symptoms was such that 20 female panelers having remarkable pigmentation symptoms such as spots and freckles were grouped into one group, and each group was blinded with Examples 1 to 4 and Comparative Examples 1 to 5 respectively. It was used twice a day for 2 weeks, and the state of pigmentation of the skin after 2 weeks was observed and compared with that before use. The state of pigmentation was evaluated according to the criterion shown in Table 3, and the average value of 20 persons was calculated and shown in Table 4.

[0070]

[Table 3]

[0071]

[Table 4]

As is clear from Table 4, in the use groups of Examples 1 to 4 according to the present invention, remarkable improvement of the pigmentation symptom was observed, and after the use test, mild or slight pigmentation was observed. Symptoms had improved to the extent that only deposition was noted. On the other hand, in the comparative group using the A component, the B component or the whitening agent, the anti-inflammatory agent and the antioxidant alone, the pigmentation symptom was improved, but compared with the group using the examples. The degree of improvement was clearly small.

Another embodiment of the present invention will be described.

Example 5 Oil-in-water emulsified cream (1) Squalane 10.00 (% by weight) (2) Octyldodecyl myristate 5.00 (3) Hydrogenated soybean phospholipid 0.20 (4) Bacyl alcohol 3.00 (5) Hardened oil 2.00 (6) Stearic acid 1.50 (7) Lipophilic glyceryl monostearate 1.50 (8) Polyglyceryl monostearate 0.70 (9) Behenyl alcohol 0.80 ( 10) Polyglyceryl monomyristate 0.70 (11) Beeswax 0.30 (12) Mixed fatty acid triglyceride 0.10 (13) d-δ-tocopherol 0.05 (14) Glyceryl glycyrrhetinate 0.05 (15) Purification Water 45.80 (16) Xanthan gum 0.20 (17) Sodium hydroxide 0.20 (18) 1,3-butylene glycol 15.00 (19) Paraoxybenzoate 0.05 (20) Purification 7.60 (21) Sodium hydroxide 0.20 (22) Sodium diethylenetriamine pentaacetate 0.20 (23) Magnesium L-ascorbic acid phosphate ester 2.00 (24) Barley extract 0.10 (25) Peony Extract 0.10 (26) Button extract 0.10 (27) Honey extract 0.10 (28) Gentian extract 0.30 (29) Succinyl atelocollagen solution 0.10 (30) Citric acid 0.05 ( 31) Purified water 2.00 Production method: Each of the oil phase components (1) to (14) and the water phase components (15) to (19) is heated to 80 ° C. and mixed and homogenized. Add the phases and emulsify with a homomixer. The mixture was cooled with stirring, and was previously mixed and dissolved at 40 ° C. (20) to (23) and
Add the components (24) to (31), stir and homogenize.

Example 6 Oil-in-water Emulsifying Whitening Essence (1) dl-α Tocopherol Acetate 0.10 (wt%) (2) 2-Ethylhexyl paramethoxycinnamate 10.00 (3) Methylpolysiloxane 7 0.000 (4) Decamethylcyclopentasiloxane 10.50 (5) 1,3-butylene glycol 5.00 (6) Stearyl glycyrrhetinate 0.10 (7) Dibutylhydroxytoluene 0.10 (8) Polyglycerin distearate 2.00 (9) Lipophilic glyceryl monostearate 1.00 (10) Stearic acid 1.00 (11) Cetanol 1.00 (12) Carboxyvinyl polymer 0.30 (13) Methyl paraoxybenzoate 0.20 (14) Purified water 43.00 (15) Sodium N-stearoyl-L-glutamate 1.00 (16) Sodium hydroxide 0.13 (17) Sodium diethylenetriaminepentaacetate Liquid 0.40 (18) Purified water 14.67 (19) Placenta extract 0.10 (20) Barley extract 1.00 (21) Gentian extract 1.00 (22) Peony extract 0.10 (23 ) Button extract 0.10 (24) Honey extract 0.10 (25) Succinyl atelocollagen solution 0.10 Production method: (1)-(5), (6)-(11), (12)-(15) , (16) ~ (1
After heating and uniformly dissolving the components of 8) at 80 ° C., they are sequentially mixed, emulsified by a homomixer, cooled while mixing, and the components (19) to (25) are sequentially added at 40 ° C. and mixed. , Make uniform.

Example 7 Whitening Lotion (1) Squalane 0.40 (% by weight) (2) Polyglyceryl monolaurate 0.10 (3) Long-chain α-hydroxy fatty acid 0.01 (4) Licorice extract 0 0.01 (5) Glycerin 0.50 (6) Glycerin 1.50 (7) Purified water 7.50 (8) Phenoxyethanol 0.20 (9) 1,3-butylene glycol 10.00 (10) Allantoin 0.10 (11) Placenta extract 0.10 (12) Peony extract 0.10 (13) Pearl barley extract 0.10 (14) Button extract 0.10 (15) Honey extract 0.10 (16) Citric acid 0.01 (17) sodium diethylenetriaminepentaacetate solution 0.05 (18) gentian extract 0.05 (19) succinyl collagen solution 0.01 (20) purified water 79.06 Production methods: (1) to (5) and Each of the components (6) and (7) is 80
After heating to ℃ to make the mixture uniform, both are mixed, made uniform and cooled. The components (8) to (20) are sequentially added at 35 ° C., and mixed and homogenized.

Example 8 Whitening Essence (1) Polyglyceryl Distearate 2.5 (wt%) (2) Glyceryl Tri-2-ethylhexanoate 8.0 (3) Dextrin Palmitate 1.0 (4) Lipophilic glyceryl monostearate 0.5 (5) Behenyl alcohol 0.5 (6) Glycerin 7.5 (7) Purified water 39.6 (8) Xanthan gum 0.4 (9) Ethanol 8.0 (10) Licorice Extract 0.1 (11) Barley extract 0.1 (12) Gentian extract 0.1 (13) Peony extract 0.1 (14) Purified water 27.6 (15) L-ascorbic acid phosphate Magnesium salt 3.0 (16) Sodium citrate 1.0 Production method: 70% each of the components (1) to (6) and (7) to (8)
After heating to ℃ to mix and dissolve, both components are mixed and emulsified with a homomixer. The mixture is cooled while stirring, and the components (14) to (16) and the components (9) to (13) previously mixed and dissolved at 40 ° C. are sequentially added, mixed and homogenized.

Example 9 Whitening Essence (1) Polyglyceryl Distearate 2.5 (wt%) (2) Glyceryl Tri-2-ethylhexanoate 8.0 (3) Hydrogenated Soybean Phospholipid 0.5 (4) Lipophilic glyceryl monostearate 0.5 (5) Behenyl alcohol 0.5 (6) Glycerin 7.5 (7) Purified water 39.6 (8) Xanthan gum 0.4 (9) Phosphorus L-ascorbate Acid ester magnesium salt 3.0 (10) Sodium hydroxide 0.2 (11) Sodium citrate 0.5 (12) Purified water 27.8 (13) Ethanol 8.0 (14) Licorice extract 0.1 ( 15) Orange extract 1 0.1 (16) Orange extract 1 0.1 (17) Perilla extract 0.1 (18) Gentian extract 0.5 (19) Lavender oil 0.1 Production method: (1) To (6) and (7) to (8)
After heating to 0 ° C. to mix and dissolve, both components are mixed and emulsified with a homomixer. The mixture is cooled while stirring, and the components (9) to (12) and the components (13) to (19) previously mixed and dissolved at 40 ° C. are sequentially added, mixed and homogenized.

Example 10 Whitening Emulsion (1) Squalane 3.00 (wt%) (2) Sodium N-stearoyl-L-glutamate 0.40 (3) Behenyl alcohol 0.80 (4) Lipophilic mono Glycerin stearate 0.80 (5) Stearic acid 0.40 (6) Stearyl glycyrrhetinate 0.05 (7) Purified water 71.40 (8) L-arginine 0.15 (9) Glycerin 1.00 (10) Silicic anhydride 1.00 (11) Microcrystalline cellulose 0.10 (12) 1,3-butylene glycol 5.00 (13) Xanthan gum 0.05 (14) Carboxyvinyl polymer 0.05 (15) Purified water 9.90 (16) Octaacetylated sucrose-denatured ethanol 4.00 (17) Methyl parahydroxybenzoate 0.10 (18) Placental extract 0.10 (19) Succinylated soluble collagen solution 0.10 (20) Purified water 0.90 (21) Adlay extract 0. 0 (22) Peony extract 0.10 (23) Button extract 0.10 (24) Honey extract 0.10 (25) Gentian extract 0.30 Production method: (1) to (6) and (7) To (12) each 70
After heating to ℃ to mix and dissolve, both components are mixed and emulsified with a homomixer. The mixture is cooled while stirring, and the components (13) to (17) and the components (18) to (25) previously mixed and dissolved at 40 ° C. are sequentially added, mixed and homogenized.

Example 11 Whitening lotion (1) Purified water 80.83 (% by weight) (2) L-ascorbic acid phosphate magnesium salt 2.00 (3) Glycerin 7.00 (4) Ethanol 8.00 (5) Sodium citrate 0.20 (6) Sodium hydroxide 0.24 (7) Sodium alginate 0.03 (8) Lavender extract 0.70 (9) Gentian extract 0.50 (10) Perilla extract 0.10 (11) Licorice extract 0.10 (12) Mulberry extract 1 0.10 (13) Japanese gourd extract 1 0.10 (14) Ouren extract 1 0.10 Production method: (1) The components (2) to (14) are sequentially added to
Dissolve and homogenize.

Example 12 Whitening Gel (1) Purified Water 90.9 (% by weight) (2) Carboxyvinyl Polymer 0.5 (3) Dipropylene Glycol 8.0 (4) Potassium Hydroxide 1 (5) Hinokitiol 0.2 (6) Clara extract 0.1 (7) Perilla extract 0.1 (8) Honey extract 0.1 Production method: (2) and (3) are homogenized in (1) Then, (5) is added, and then (4) is added to increase the viscosity, and (6) to (8) are added and uniformly mixed.

Example 13 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self Emulsified glyceryl monostearate 2.0 (5) Propylene glycol 10.0 (6) Potassium hydroxide 0.3 (7) Purified water 68.9 (8) Titanium oxide 1.0 (9) Bengala 0.1 (10) Yellow iron oxide 0.4 (11) Fragrance 0.1 (12) Button extract 0.1 (13) Ogon extract 1 0.1 (14) Placenta extract 0.5 Production method: (1)- The oil phase component of (4) is mixed and heated to 75 ° C. to make it uniform. On the other hand, the components (5) to (7) were mixed and 75
The mixture was heated and melted at ℃ to make it uniform, and the pigments (8) to (10) were added thereto and uniformly dispersed with a homomixer to obtain an aqueous phase component. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and the components (11) to (14) are added and mixed at 40 ° C.

Example 14 Emulsion Foundation (1) Stearic acid 2.0 (% by weight) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglycerin monoisopalmitate 9.0 (6) 1,3-butylene glycol 8.0 (7) Potassium hydroxide 0.1 (8) Purified water 51.1 (9) Titanium oxide 9.0 (10) Talc 7.4 (11) Bengala 0.5 (12) Yellow iron oxide 1.1 (13) Black iron oxide 0.1 (14) Fragrance 0.1 (15) Placenta extract 0.2 (16) Clara extract Product 0.1 (17) Mulberry extract 1 0.1 (18) Japanese gourd extract 1 0.1 (19) Ouren extract 1 0.1 Production method: Mix the oil phase components of (1) to (5) , 75 ° C to make uniform. On the other hand, the aqueous phase components (6) to (8) are mixed,
The mixture is heated to 75 ° C. and dissolved to make the mixture uniform. The pigments (9) to (13) are added to the mixture, and the mixture is uniformly dispersed with a homomixer. After adding and emulsifying the oil phase component, the mixture is cooled and then cooled at 40 ° C.
Add and mix the components of (19).

Example 15 Hand cream (1) Cetanol 4.0 (% by weight) (2) Vaseline 2.0 (3) Liquid paraffin 10.0 (4) Glyceryl monostearate 1.5 (5) Polyoxyethylene (60EO) Glyceryl isostearate 2.5 (6) Tocopherol acetate 0.5 (7) Glycerin 20.0 (8) Methyl parahydroxybenzoate 0.1 (9) Purified water 58.9 (10) Hydroquinone -β-D-glucoside 0.1 (11) Peony extract 0.1 (12) Licorice extract 0.1 (13) Perilla extract 0.1 (14) Spinach extract 1 0.1 Production method: (1 ) To (6) are mixed and dissolved and heated to 75 ° C. On the other hand, the aqueous phase components (7) to (9) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component for pre-emulsification, then uniformly emulsified by a homomixer, cooled, and the components (10) to (14) are added and mixed at 40 ° C.

Example 16 Jelly-like peel-off pack (1) Purified water 68.8 (% by weight) (2) 1,3-butylene glycol 3.0 (3) Polyvinyl alcohol 15.0 (4) Carboxymethyl cellulose 5 0.0 (5) Ethanol 6.0 (6) Polyoxyethylene (20EO) oleyl ether 0.5 (7) L-ascorbic acid phosphate magnesium salt 1.0 (8) Sodium citrate 0.5 (9) Mulberry extract 1 0.1 (10) Adlay extract 0.1 Production method: (2) is added to (1) and heated to 75 ° C. to this
(3) and (4) are added for dissolution, and (5) to (10) are added for solubilization.

Example 17 Massage Gel (1) Dipropylene glycol 7.0 (% by weight) (2) Glycerin 8.0 (3) Polyoxyethylene (15EO) oleyl ether 1.0 (4) Carboxyvinyl polymer 0.4 (5) Methylcellulose 0.2 (6) Potassium hydroxide 0.1 (7) Button extract 1.0 (8) Gentian extract 1.0 (9) Purified water 81.3 Production method: 75 ° C The components (1) to (8) are sequentially added to the heated (9), dissolved and homogenized.

Example 18 Face Wash (1) Stearic acid 2.0 (% by weight) (2) Cetanol 3.0 (3) Vaseline 10.0 (4) Liquid paraffin 33.0 (5) Isopropyl myristate 7.5 (6) Glyceryl monostearate 2.5 (7) Polyoxyethylene (20EO) sorbitan monostearate 2.5 (8) Glycerin 5.0 (9) Potassium hydroxide 0.1 (10) Purified water 33.2 (11) 2-hydroxyacetic acid 0.5 (12) Clara extract 0.1 (13) Placenta extract 0.5 (14) Lavender extract 0.1 Production method: (1) to (7) ) The oil phase components are mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (8) to (10) are mixed and dissolved by heating to 70 ° C. The oil phase component is gradually added to the aqueous phase component for pre-emulsification, then uniformly emulsified by a homomixer, cooled, and the components (11) to (14) are added at 40 ° C.

[Example 19] Whitening lotion (1) Purified water 85.4 (% by weight) (2) Ethanol 5.5 (3) 1,3-butylene glycol 3.0 (4) Phosphorus L-ascorbate Acid ester magnesium salt 3.0 (5) Sodium citrate 1.0 (6) Polyoxyethylene (50 EO) hydrogenated castor oil 0.3 (7) Methyl paraoxybenzoate 0.1 (8) Fragrance 0.1 (9 ) Mulberry extract 2 0.5 (10) Orange extract 2 0.5 (11) Orange extract 2 0.5 (12) Silicone resin 0.1 (Silicone SH5500, manufactured by Dow Corning Toray) Production method: (1) Mix and homogenize the components of (12).

Example 20 Face Wash (1) Myristic acid 26.0 (% by weight) (2) Stearic acid 10.2 (3) Palmitic acid 1.8 (4) Lauric acid diethanolamide 1.5 (5) ) Lipophilic glyceryl monostearate 0.5 (6) Purified water 36.0 (7) Glycerin 15.0 (8) Potassium hydroxide 7.8 (9) Dipotassium glycyrrhizinate 0.2 (10) Fragrance 0. 1 (11) Mulberry extract 2 0.3 (12) Orange extract 2 0.3 (13) Orange extract 2 0.3 Production method: Production method: mixing and dissolving the oil phase components of (1) to (5) 7
Heat to 5 ° C. On the other hand, the aqueous phase components of (6) to (9) are mixed,
Dissolve and heat to 75 ° C. Next, after adding the oil phase component to the aqueous phase component and saponifying, cooling with stirring,
Add (10) to (13) at 40 ° C, mix and homogenize.

[Example 21] Whitening cream (1) Purified water 54.0 (% by weight) (2) 1,3-butylene glycol 9.0 (3) Hydroxyethyl cellulose 0.1 (4) Sodium citrate 5 (5) Liquid paraffin 7.0 (6) Palm hardened fat 5.0 (7) Bacyl alcohol 3.0 (8) Cetyl palmitate 1.5 (9) Lipophilic glyceryl monostearate 1.3 (10 ) Polyoxyethylene glyceryl isostearate 0.7 (11) Methyl polysiloxane 0.1 (12) Diethylenetriaminepentaacetic acid pentasodium solution 0.2 (13) L-ascorbic acid phosphate magnesium salt (20% by weight aqueous solution) 15 0.0 (14) Fragrance 0.1 (15) Mulberry extract 2 0.5 (16) Orange extract 2 0.5 (17) Orange extract 2 0.5 Production method: water of (1) to (4) Mix phase components and heat to 75 ° C to dissolve and homogenize I do. On the other hand, the oil phase components of (5) to (11) are mixed,
Dissolve and heat to 75 ° C., gradually add to the aqueous phase component and emulsify. Cool while stirring, add (12) to (17) at 40 ° C, mix and homogenize.

Example 22 Daytime Cream (1) Dimethyl distearyl ammonium hectorite 0.6 (% by weight) (2) Methylphenyl polysiloxane 5.3 (3) Polyoxyethylene / methyl polysiloxane copolymer Combined 3.0 (4) Octamethylcyclotetrasiloxane 2.5 (5) Decamethylcyclopentasiloxane 23.0 (6) Liquid paraffin 0.5 (7) Stearic acid 0.5 (8) d-δ-tocopherol 0.1 (9) Fine particle titanium oxide 6.0 (10) Fine particle zinc oxide 1.0 (11) Calcined product of talc / potassium silicofluoride 2.5 (12) Silicic anhydride 2.5 (13) Phenoxyethanol 0.3 (14) 1,3-butylene glycol 6.0 (15) Purified water 44.145 (16) Sodium citrate 0.05 (17) Citric acid 0.005 (18) Sodium chloride 1.0 (19) Mulberry extraction Thing 2 0.3 (20) Oh Extract 2 0.3 (21) Urethane extract 2 0.3 (22) Fragrance 0.1 Production method: After dissolving and homogenizing (1) to (8), add (9) to (12) Then, the mixture is processed in a colloid mill and sufficiently dispersed. Next, the dissolved and homogenized components (13) to (21) are added to emulsify, and (22) is added and mixed.

Example 23 Whitening Milk (1) Tri-2-ethylhexanesanglyceryl 7.8 (% by weight) (2) Polyglyceryl distearate 2.4 (3) Hydrogenated soybean phospholipid 0.4 (4) Bacyl alcohol 0.1 (5) Purified water 69.5 (6) Glycerin 7.5 (7) L-ascorbic acid phosphate magnesium salt 3.0 (8) Sodium citrate 0.5 (9) Xanthan gum 0. 4 (10) Pentasodium diethylenetriaminepentaacetate 0.2 (11) 1,3-butylene glycol 2.5 (12) Methyl paraoxybenzoate 0.1 (13) Ethanol 4.0 (14) Fragrance 0.1 (15 ) Mulberry extract 20.5 (16) Orange extract 20.5 (17) Orange extract 20.5 Production method: Mix and dissolve oil phase components (1) to (4) to 75 ° C. Heat. On the other hand, the aqueous phase components (5) to (12) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. Cool while stirring, add (13) to (17) at 40 ° C, mix and homogenize.

With respect to Examples 5 to 23 of the present invention,
The effect of improving the pigmentation symptom was evaluated in the same manner as in Examples 1 to 4, and the results are shown in Table 5.

[0094]

[Table 5]

As is evident from Table 5, in all the groups using the examples according to the present invention, remarkable improvement of the pigmentation symptoms was observed, and after the use test, mild or slight pigmentation was observed. Symptoms had improved to the extent that they were only noticeable.

With respect to Examples 1 to 23 of the present invention,
Skin irritation was examined. Skin irritation, male panelists 20
A 48-hour obstruction sticking test was performed by each person, and the results were determined according to the criterion shown in Table 6, and indicated by the average value of the skin irritation index of 20 persons. The jelly-like peel-off pack of Example 13 was peeled off 20 minutes after application and then closed, and the face wash shown in Examples 15 and 20 was evaluated using a 1% by weight aqueous solution. Table 7 shows the results of the obstruction sticking test.

[0097]

[Table 6]

[0098]

[Table 7]

As shown in Table 7, Examples 1 to 3 of the present invention
Example 23 showed good safety without showing skin irritation.

In Examples 1 to 23 of the present invention, the precipitation, separation, and
No change in the state of the preparation such as aggregation, discoloration or discoloration was observed.

[0101]

Industrial Applicability As described in detail above, the present invention synergistically enhances the melanin production inhibitory effect, is effective in preventing and improving pigmentation, spots, freckles, spots, etc. after tanning. A highly safe whitening cosmetic having a significantly improved whitening effect was obtained.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor, Noriko Masuzaki 112-1, Okada-cho, Yokaichi, Shiga Prefecture Inside Noevir Product Research Institute, Inc. (72) Inventor Hiromi Yamashita 112-1, Okada-cho, Yokaichi, Shiga Prefecture Noevir, Inc. Inside the product research laboratory (72) Inventor Shoichi Ueno 112-1, Okada-cho, Yokaichi, Shiga Prefecture Within Noevir Product Research Institute, Inc. (72) Inventor Susumu Matsuda 112-1, Okada-cho, Yokaichi, Shiga Prefecture, Japan Noevir Product Research Institute, Inc. (72 ) Inventor Akira Yamaguchi 112-1 Okada-cho, Yokaichi-shi, Shiga Prefecture Noevir Shiga Research Institute, Inc. (72) Inventor Kazutoshi Tanda 112-1, Okada-cho, Yokaichi-shi, Shiga Prefecture F-term in Shiga Research Institute, No.4C083 AA022 AA082 AA111 AA112 AA122 AB032 AB052 AB172 AB212 AB232 AB242 AB372 AB432 AB472 AC012 AC022 AC072 AC122 AC172 AC182 AC242 AC292 AC302 AC342 AC352 AC422 AC442 AC482 AC522 AC582 AC682 AC912 AD092 AD112 AD132 AD152 AD222 AD242 AD262 AD282 AD352 AD392 AD532 AD552 AD572 AD642 AD662 CC04 CC05 CC12 CC23 DD22 DD27 DD31 DD33 DD41 EE16

Claims (2)

[Claims] 1. A whitening cosmetic comprising the following components A and B in combination; component A; selected from a mulberry plant extract, a button plant extract, a genus plant extract, and a licorice plant extract. One or more plant extracts, a B component; a Juzudama plant extract, a Gentian plant extract,
One or two selected from extracts of Scutellaria genus plant extract, lavender extract, spinach extract, perilla extract, and molasses and obtained by removing coloring components
More than species ingredients. 2. The whitening cosmetic according to claim 1, further comprising one or more selected from an anti-inflammatory agent, an antioxidant, and a whitening agent.