JP2002060337A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation which potentiates melanin formation inhibitory effect synergistically, exerts effects on the prophylaxis and amelioration of pigmentation after sunburn, stain, freckle, chloasma or the like, ameliorates skin bleaching effect and shows high safety. SOLUTION: This skin care preparation is obtained by formulating an extract from a plant belonging to the genus Epigaea in combination with one or more than two kinds selected from the following components: L-ascorbic acid and its salts or derivatives other than ascorbate glycoside, 2-hyddroxycarboxylic acid and its salts or derivatives, hydroquinone and its derivatives, cysteine and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, an extract from placenta and an extract from a plant/alga showing melanin production inhibitory effect, to a skin care preparation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has a synergistically enhanced melanin production inhibitory effect, is effective in preventing and improving pigmentation, spots, freckles, spots, etc. after sunburn, and has a markedly improved skin whitening effect. And a highly safe external preparation for skin.

[0002]

2. Description of the Related Art Conventionally, darkening of skin by ultraviolet rays,
In order to prevent or improve pigmentation of the skin, such as spots and freckles, components having an action of inhibiting melanin production or reducing the produced melanin pigment have been screened and formulated into skin external preparations. For example, ascorbic acid, cysteine, hydroquinone, placenta extract, 2-
Hydroxy acids and their derivatives, extracts from plants and algae and the like are used.

[0003] However, ascorbic acid, cysteine and hydroquinone are susceptible to oxidation-reduction reaction and are unstable, and 2-hydroxy acid has a problem in skin safety when an effective amount is added, placental extracts, plants and algae However, when an effective amount is added to the extract, there is a problem that an unpleasant odor or color may be imparted to the external preparation for skin.

[0004] The genus Ipana is an evergreen shrub of the eruptiaceous plant, and has been eaten raw because of its sweetness, digestion and antipyretic nature. It is also known that leaves contain ursolic acid.

[0005]

DISCLOSURE OF THE INVENTION The present invention solves the above-mentioned problems, has an extremely strong melanin production inhibitory effect on the skin, and has a high safety in terms of skin irritation and skin sensitization. The purpose of the present invention was to obtain an external preparation for skin which does not have the above problems.

[0006]

In order to solve the above-mentioned problems, various studies have been made. As a result, the use of a component having a specific melanin production-inhibiting action and an extract of the genus Citrus spp. The present inventors have found that a skin external preparation which is synergistically enhanced and has no safety problems such as skin irritation and skin sensitization can be obtained, and the present invention has been completed.

[0007]

Embodiments of the present invention will be described.

[0008] Examples of L-ascorbic acid and salts or derivatives thereof other than ascorbic acid glycoside used in the present invention include L-ascorbic acid, sodium L-ascorbate, magnesium L-ascorbate and L-ascorbic acid. Potassium, L-ascorbate such as calcium L-ascorbate, L-ascorbate monostearate, L-ascorbate monopalmitate, L
L-ascorbic acid dialkyl or dialkenyl ester derivatives such as L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid dioleate, etc., L-ascorbic acid L-ascorbic acid trialkyl or trialkenyl ester derivatives such as tristearate, L-ascorbic acid tripalmitate and L-ascorbic acid trioleate; L-ascorbyl sulfate;
L-ascorbic acid sulfates such as sodium ascorbyl sulfate, potassium L-ascorbyl sulfate, magnesium L-ascorbyl sulfate, calcium L-ascorbyl sulfate and salts thereof, L-ascorbyl phosphate, sodium L-ascorbyl phosphate, L-ascorbyl Potassium phosphate, L-ascorbyl magnesium phosphate, L-
L-ascorbic acid phosphates such as calcium ascorbyl phosphate and salts thereof can be mentioned. Of these L-ascorbic acid and salts or derivatives thereof, particularly preferred are L-ascorbic acid, L-ascorbyl phosphate and magnesium salts thereof.

The hinokitiol and derivatives thereof used in the present invention are not particularly limited, and include hinokitiol glycosides such as hinokitiol, hinokitiol zinc complex, hinokitiol glucoside, and acetyl derivatives thereof.

The 2-hydroxycarboxylic acid and salts or derivatives thereof used in the present invention are not particularly limited, but 2-hydroxycarboxylic acids having 2 to 22 carbon atoms are preferable, and 2-hydroxycarboxylic acids having 2 to 6 carbon atoms are more preferable. -Hydroxycarboxylic acid is preferably used in view of the effects of the present invention. For example, 2-hydroxyacetic acid, lactic acid, malic acid, tartaric acid, citric acid and salts thereof, and alkyl esters of 2-hydroxycarboxylic acid, cholesterol esters, glycosides, which improve the skin affinity of 2-hydroxycarboxylic acid, Phosphatidyl esters, L-arginine salts and the like.

The hydroquinone and its derivatives used in the present invention are not particularly limited, but hydroquinone glycosides are preferably used.
α-D-glucoside, hydroquinone-β-D-glucoside, hydroquinone-α-L-glucoside, hydroquinone-β-L-glucoside, hydroquinone-α-D
-Hexasaccharide glycosides such as -galactoside, hydroquinone-β-D-galactoside, hydroquinone-α-L-galactoside, hydroquinone-β-L-galactoside, hydroquinone-α-D-ribose, hydroquinone-β-
D-ribose, hydroquinone-α-L-ribose, hydroquinone-β-L-ribose, hydroquinone-α
Pentacarbon sugar glycosides such as -D-arabinose, hydroquinone-β-D-arabinose, hydroquinone-α-L-arabinose, hydroquinone-β-L-arabinose;
Hydroquinone-α-D-glucosamine, hydroquinone-β-D-glucosamine, hydroquinone-α-L-
Glucosamine, hydroquinone-β-L-glucosamine, hydroquinone-α-D-galactosamine, hydroquinone-β-D-galactosamine, hydroquinone-
amino sugar glycosides such as α-L-galactosamine and hydroquinone-β-L-galactosamine; hydroquinone-α
-D-glucuronic acid, hydroquinone-β-D-glucuronic acid, hydroquinone-α-L-glucuronic acid, hydroquinone-β-L-glucuronic acid, hydroquinone-
Uronic acid glycosides such as α-D-galacturonic acid, hydroquinone-β-D-galacturonic acid, hydroquinone-α-L-galacturonic acid, and hydroquinone-β-L-galacturonic acid can be exemplified. Examples of the derivative include an ester such as an acetylated product and an ether such as a methylated product. Among them, hydroquinone-β-D-glucose is most preferable from the viewpoint of the effect of the present invention.

The cysteine and derivatives thereof used in the present invention are not particularly limited.
Or phospholipid esters of cysteine, sphingosine and its derivatives, glycolipid esters, sugar esters, sterol esters, and alkyl or alkenyl esters having 8 to 20 carbon atoms.

The glucosamine and its derivatives used in the present invention are not particularly limited, and include, for example, glucosamine, glucosamine esters such as acetylglucosamine, and glucosamine ethers such as glucosamine methyl ether.

The azelaic acid and derivatives thereof used in the present invention are not particularly limited, but include, for example, azelaic acid, azelaic acid monoesters such as azelaic acid monoalkyl ester, and azelaic acid diesters such as azelaic acid dialkyl ester. Is mentioned.

The placenta extract used in the present invention may be of any origin as long as it is used in a usual external preparation for skin.

[0016] Plants to obtain extracts for use in the present invention, the algae, especially the type is not limited as far as extracts from plants and algae melanin production inhibitory activity is known, witch hazel (Hamamelis japonica Sieb. Et Zucc.), Cinnamon Saku ( Hamamelis mollis Oliv.), Hamameris ( Hamame
lis virginiana L.) witch hazel plant of the genus, etc., Hoshitsudzuri (Saxifraga aizoon Jacq.), Shikotansou (Saxifrag
a cherlerioides D. Donvar. rebunshirensis (Engl . e
t Irmsch) Hara, Saxifraga bronchialalis L.), ginjisou ( Saxifraga cortusaefolia Sieb. et Zucc.),
Squirrel ( Saxifraga fortunei Hook. F. Var. I
ncisolobata (Engl. et Irmsch.) Nakai), Saxifraga nipponica Makino, Sendaisou ( Saxifraga sendaica Maxim.), Saxifra
ga stolonifera Meerb.), Saxifraga ( Saxifraga )
j aponica Boiss.), black moss ( Saxifraga fusca )
Maxim.), Spider Magsa ( Saxifraga merkii Fish. Var.
laciniata Nakai), Sakumai Sakura ( Saxifraga lac)
iniata Nakai et Takeda), Shikotanso ( Saxifraga )
bronchialalis L.), Mukagoyukinosita ( Saxifraga ce)
rnua L.) and other saxifrage plants, Jinko ( Aquilaria)
agallocha Roxb.), Camellia japonica L., its variants and tea ( Came)
Camellia plants, such as llia sinensis (L.) O. Kuntze) and its variants, safflower ( Aesculus carnea Hayn)
e), Aesculus chinensis Bunge, Aesculus chinensis Bunge, Aesculus hippocastanum L., Aesculus genus plants such as Aesculus turbinata Bl.
Knotweed ( Polygonum cuspidatum Sieb. Et Zucc.),
Honeybird ( Polygonum cuspidatum Sieb. Et
Hachidyoense Ohwi), Giant Knotweed ( Polyg )
onum sachalinense Fr. Schm.) Polygonum plants such, oilseed isodon plants typified by Melissa (Melissa officinalis L.), Ibuki thyme (Thymus serph
yllum L. subsp. quinquecostatus (Aelak. ) Kitamur
a), thyme ( Thymus vulgaris L.) and the like, plants of the genus Artemisia absinthium
L.), Artemisia annua (Artemisia annua L.), Kawara carrots (Artemisia apiacea Hance), Artemisia capillaris (A
rtemisia capillaris Thunb.), Artemisi
a cina Berg.), Tarragon ( Artemisia dracunculus )
L.), Artemisia japonica Thunb.,
Mibuyomogi (Artemisia maritima L.), wormwood (Artem
Artemisia plants such as isia princeps Pamp.), Yarrow ( Achillea alpina L.), Yarrow ( Ac )
hillea milleifolium L.), gypsophila ( Ac )
hillea moschata Jacq., etc., E. spp. ( Eupatorium japonicum Thunb.), Sawa's bulbul ( Eupatorium lindleyanum DC.), Bulbul ( Eupatorium chinense L. var. oppositifolium (Koid
z.) Murata et H. Koyama)
American linden ( Tilia americana L.), scallop ( Tiliacordata Mill.), Linden ( Tili )
a europaea L.), Tiliajaponica (Miq.) Si
Monk.), Tilia miqueliana Maxim., Tilia platyphyllos Scop., etc., linden plants, Hypericum ascyron L., Hypericum erectum Thunb., Hypericum japonicum Thunb. Hypericum plants such as St. John's wort ( Hypericum perforatum L.),
Iva saxifrage (Tanakaea radicans Fr. et Sav.) On a rock Saxifraga plant to be representative, Satsumafuji (Daphne
genkwa Sieb. etZucc.), camphor tree ( Daphne kius )
iana Miq.), Daphne mezereum
L.), Daphne odora Thunb., Onishibari ( Daphne pseudo-mezereum A. Gray), Naniwazu ( Daphne kamtchatica Maxim. Var. Yezoensis Ohwi),
Daphne miyabeana Makino and other Daphne genus plants, Diplomorpha phymatog
lossa (Koidz.) Nakai), Ganpi ( Diplomorpha sikoki )
ana (Fr. et Sav.) Honda), Kiganpi ( Diplomorpha )
trichotoma (Thunb.) Nakai), Ganpi plants such as mithota ( Edgeworthia chrysantha Lindl.), Paeonia lactiflora Pal
l.), Dutch Peony ( Paeonia officinalis)
L.), button ( Paeonia suffruticosa Andr.), And other button genus plants, Glycyrrhiza glabra
L.), Kikanzou (Glycyrrhiza kansuensis Chang et
peng), licorice ( Glycyrrhiza urarensis Fisch.), liquorice plants represented by mulberry ( Morus alba L.), Clara ( Sophora flavescens Ait.),
The plants of the genus Genus such as Japanese soybean ( Sophora japonica L.), Drosera angelica Hud
s.), Drosera peltata (Drosera peltata Smith), sundew (Drosera routundifolia L.), Komousengoke (Drosera spathulata Labill.) Drosera plants such as, Urashimatsutsuji (Arctostaphylos alpina (L.) S
preng.var. japonica (Nakai) Hulten) , bearberry (Arctostaphylos uva-ursi (L.) Spreng.) Urashimatsutsuji plant of the genus, etc., Kaimensou (Ceratodictyon spongi
osum ), sphagnum algae, artless coral ( Corallina sp.), coral ( Corallina officinali )
s ), Corallina pilurifera, etc., Coralum algae, Dictyopteris latiuscula , Dictyopteris undulata , Hericahaz ( Dic )
tyopteris prolifera ), Sujiyahazu ( Dictyopteris pl )
agiogramma ), Himeyahazu ( Dictyopteris repens ),
Ezoyahazu (Dictyopteris divaricata), Uraboshiyahazu (Dictyopteris polypodioides) Yahazugusa algae such as, Hariamiji Amijigusa algae typified by (Dictyota spinulosa), hijiki algae typified hijiki (Hizikia fusiformis), Sozo sp. (Laurencia sp. ), Kurosozo ( Laurencia intermedia ), Mitsodesozo ( Lauren
cia okamurai ), Sozonohana ( Laurencia grevillean )
a ), Osozo ( Laurencia glandulifera ), Hanesozo ( Laurencia pinnata ), Kobusozo ( Laurencia undulat )
a ) Sozoa algae, such as the fushitsunagi ( Lomentaria catenat)
a), Kosujifushitsunagi (Lomentaria hakodatensis) Fushitsunagi algae such as, cassiope lycopodioides (Myelophycus caespito
sus ), Darus alga ( Palmaria)
palmata ), Darus alga, Sargassum ( Sar)
gassum fulvellum ), pea ( Sargassum yendo )
i ), Mametawara ( Sargassum piluriferum ), Yam Tamok ( Sargassum patens ), Akamoku ( Sargassum horn )
eri), Nokogirimoku (Sargassum serratifolium), Oba sawtooth Mok (Sargassum giganteifolium), Yoremoku (Sargassum tortile), Yanagimoku (Oobamoku: Sargassum ringgoldianum), Nejimoku (Sargassum
sagamianum), Hahakimoku (Sargassum kjellmanianu
m ), sea lantern ( Sargassum thunbergii ), fushijimoku ( Sargassum confusum ), isomok ( Sargassum )
hemiphyllum ), sara ( Sargassum nigrifolium ),
Stalked mushroom ( Sargassum micracanthum ), Tamanashimoku ( Sargassum nipponicum ), Ginseng ( Sargassum vu )
lgare ), phloem (Hollyhock: Sargassum dupli)
catum), Ezononejimoku (Sargassum yezoense) Sargassum algae such as, Ishimozuku (Sphaerotrichia divar
Illustrative algae typified by icata ) are exemplified.

Among the above-mentioned plants and algae, Hamameli
Su (Hamamelis virginiana L.)Saxifra
ga stolonifera Meerb.), Jinko (Aquilaria agall
ocha Roxb.), Cha (Camellia sinensis (L.) O. Kunt
ze) and its variant, knotweed (Polygonum cuspidatum S
ieb. et Zucc.), Melissa (Melissa officinalis
L.), time (Thymus vulgaris L.), mugwort
(Artemisia capillarisThunb.), European saw
CAchillea milleifolium L.), Hypericum (Hype
ricum erectum Thunb.), Hypericum perforatum (Hypericu
m perforatum L.), peonies (Paeonia lactiflora 
Pall.), Button (Paeonia suffruticosaAndr.) 、 Spec
Incan elephant (Glycyrrhiza glabra L.), Licorice (G
lycyrrhiza urarensis Fisch.), Mulberry (Morus alba 
L.), Clara (Sophora flavescensAit.), Mosengo
Ke (Drosera routundifolia L.), Uwaurushi (Arctos
tap hylos uva-ursi (L.) Spreng.), Herayahaz (Dict
yopteris prolifera), Haramiji (Dictyota spinulo
sa), Hijiki (Hizikia fusiformis), Sozo sp. (Laure
ncia sp.)Lomentaria catenata),I
Wahige (Myelophycuscaespitosus), Darth (Palmaria
 palmata), Willow moku (Oobamoku:Sargassum ring
goldianum), Ezononejimoku (Sargassum yezoens
e), Fushijimoku (Sargassum confusum) 、 Ishimozu
(Sphaerotrichia divaricataOne selected from)
Alternatively, two or more kinds of plants and algae are preferably used.

Extracts from plants and algae having an inhibitory action on melanin production are obtained by drying or drying one or more parts of various kinds of whole plants or their leaves, bark, roots, flowers, branches and the like. To use. The extraction solvent is not particularly limited, and includes monohydric alcohols such as water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, and n-octyl alcohol, glycerin, ethylene glycol, and ethylene. Polyhydric alcohols such as glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol and derivatives thereof, acetone, methyl ethyl ketone, methyl isobutyl ketone,
Ketones such as methyl-n-propyl ketone, ethyl acetate,
Esters such as isopropyl acetate, ethers such as ethyl ether, isopropyl ether and n-butyl ether, hydrocarbons such as squalane, petrolatum, paraffin wax and paraffin oil, olive oil, wheat germ oil,
Rice oil, sesame oil, macadamian nut oil, almond oil,
Vegetable fats such as coconut oil, animal fats such as beef tallow, lard, whale oil and the like are exemplified. Further, a polar solvent to which an inorganic salt such as a phosphate buffered saline is added, and a solvent to which a surfactant is added can be used, and there is no particular limitation.

Further, as the extraction method, a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, a method of pressing a plant or algae to obtain an extract For example, these methods are used alone or in combination of two or more.

The ratio of the plant or algae to the solvent at the time of extraction is not particularly limited.
0.1 to 1000 times by weight, especially in terms of extraction operation and efficiency.
5 to 100 times by weight is preferred. It is convenient to set the extraction pressure and the extraction temperature in a range from 0 ° C. to the boiling point of the solvent at normal pressure, and the extraction time varies depending on the extraction temperature.
It is preferable to set the time in a range from time to two weeks.

The extract of the plant or algae thus obtained can be used as it is, but it may be subjected to purification operations such as deodorization, decolorization and concentration, as long as the effect is not lost. May be used as a fraction using column chromatography or the like. These extracts, purified products, and fractionated products can be dried by removing the solvent therefrom, and can be used in a form solubilized in a solvent such as alcohol or in an emulsion form. it can.

The components obtained by purification and fractionation from plant extracts include flavonoids contained in oil-soluble extract components of hamameli tannin, licorice and licorice abundantly contained in leaves of hamamelis, particularly glabridine and hispagrabridine. And (-)-epicatechin contained in an extract of the genus Polygonum.

The amount of the component having an effect of inhibiting melanin production in the external preparation for skin is considered to be 0.0001 to 10% by weight in consideration of its effect and odor and color tone when added. It is desirable to do.

The ericaceae ( Ericaceae ) used in the present invention
Examples of the plant of epigaea (Epigaea L.), Iwanashi (Epigaea asiatica Maxim.), The United States char sheet (Epi
gaea repens L.). Extracts from these plants of the genus Igarashi ( Epigaea L.) can be used as they are, or at least one or more of their leaves, bark, roots, flowers, branches, fruits, etc., either raw or dried. And extracts from leaves are the best in terms of effectiveness.

The extraction solvent, the extraction method, and the compounding method of the extract when obtaining the extract from the plants of the genus Sorbus are the same as those for obtaining the extract from the above-mentioned melanin production-inhibiting plant and algae. Further, the amount of the extract of the genus Charus in the external preparation for skin is not particularly limited, but is generally 0.0001 to 10% by weight, preferably 0.001 to 5% by weight.
% By weight.

The external preparation for skin of the present invention may contain, if necessary,
Oils and fats, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, thickeners usually used in pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics, and cleansers , Drugs, fragrances, resins, alcohols and the like can be appropriately compounded. Further, the dosage form of the external preparation for skin of the present invention is arbitrary, and for example, it can be provided as a solubilizing system such as a lotion, an emulsifying system such as a cream or an emulsion, or a dispersion system such as a calamine lotion. An aerosol dosage form filled together with the aerosol may be used.

[0027]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, preparation examples of an extract of a plant of the genus Genus, a placenta extract, and a plant and an algae extract having an inhibitory action on melanin production used in the present invention will be described.

[Iwanashi Extract 1] Iwanashi ( Epigaea)
asiatica Maxim.) 550 g of leaves are dried and ground, and
Extraction was carried out by stirring in 1,500 ml of a volume% aqueous ethanol solution at 25 ° C. for 5 days. Next, the extract was filtered, and the filtrate was collected to obtain a chard extract 1.

[Iwanashi extract 2] Iwanashi ( Epigaea)
asiatica Maxim.) 500 g of leaves are dried and crushed, and
The mixture was stirred and extracted in 1,000 ml of a 1,3-butylene glycol aqueous solution at 25 ° C for 5 days. Next, the extract was filtered, and the filtrate was collected to obtain a chard extract 2.

[American char pear extract] 350 g of leaves of American char pear ( Epigaea repens L.) were minced, and 1,3
-7 at 20 ° C in 1,000 ml of butylene glycol
Extracted by soaking for days. The extract was filtered, and the filtrate was collected to obtain a American chard extract.

[Placenta extract] A commercially available water-soluble placenta extract (manufactured by Nichirei) was used.

[Kitadori extract] Knotweed ( Polygonum
cuspidatum Sieb. et Zucc.)
It was pulverized and stirred and extracted in 1,500 ml of a 50% by volume aqueous ethanol solution at 25 ° C. for 5 days. Next, the extract was filtered, and the filtrate was collected to obtain a knotweed extract.

[ Kitadori Extract Fraction] Knotweed ( Polygo
dry powder 2 of rhizome of num cuspidatum Sieb. et Zucc.)
00 g was immersed in 2,000 ml of a 50% by volume aqueous ethanol solution and extracted at room temperature for 7 days. Next, the extract was filtered, the filtrate was concentrated under reduced pressure, dissolved in 800 ml of a 30% by volume aqueous ethanol solution, and the DIAION MCI Gel was dissolved.
Apply to an HP-20 column (manufactured by Mitsubishi Chemical Corporation) and apply
The fraction eluted with a 0% by volume aqueous ethanol solution was collected. Subsequently, the fraction was subjected to silica gel thin layer chromatography to obtain a chloroform / methanol mixture (volume ratio = 5:
Fractionation was performed using 1) as a developing solvent. Among the obtained fractions, the fraction containing (-)-epicatechin was scraped off and dissolved in 50 ml of 50% by volume ethanol to obtain a knotweed extract fraction.

[ Hamelis extract] Hamamelis ( Hameme
lis virginiana L.) 500 g of leaves are dried, crushed and
25 ° C in 1,000 ml of 0 volume% ethanol aqueous solution
For 5 days. Next, the extract was filtered, and the filtrate was collected to obtain a Hamamelis extract.

[Hamellis extract fraction] Hamamelis ( Ha
(mamelis virginiana L.), and a total of 500 g of leaves and bark were minced and extracted with stirring in 1,500 ml of hot water for 5 hours.
Then, the extract is filtered, and the filtrate is filtered by DIAION MCI.
It was applied to a Gel HP-20 column (manufactured by Mitsubishi Kasei Corporation) and eluted with a mixed solvent of ethanol and water. A fraction having a hamamelitannin content of 50% by weight or more was collected and used as a hamamelis extract fraction.

[ Hypericum perforatum extract] Whole plant 35 of flowering season of Hypericum perforatum L.
0 g, cut into olive oil in 1,000 ml at 20 ° C.
For 7 days. The extract was filtered and the filtrate was collected to obtain a Hypericum perforatum extract.

[Licorice extract] Spanish licorice ( Glycyr)
rhiza glabra L.) roots and rhizomes (500 g) are dried and pulverized, and are dried at 25 ° C. in 1,000 ml of anhydrous ethanol aqueous solution.
For 24 hours. The extract is filtered to collect the filtrate, concentrated under reduced pressure, and lyophilized to dryness. The dried product was stirred and extracted in 1,000 ml of ethyl acetate at 20 ° C. for 2 days. After extraction, it was dried under reduced pressure to obtain a licorice extract.

[ Goldfish extract] Ginkgo ( Aquillaria)
agallocha Roxb.) was dried and pulverized, and immersed in ethanol 1,000 at 20 ° C. for 10 days. Next, the extract was filtered, and the filtrate was concentrated to 1/10 volume to obtain a ginger extract.

[Oolong tea extract] Oolong tea ( Thea s
inensis L. var. viridis Szkzyl.) leaves were dried and pulverized, and dried at 50 ° C. in 1,000 ml of purified water for 24 hours.
The mixture was stirred and extracted for hours. The extract was filtered, and the filtrate was concentrated to 1/5 volume to obtain an oolong tea extract.

[Melissa extract] Melissa of
ficinalis L.) leaves were crushed and extracted with stirring in 1,000 ml of 1,3-butylene glycol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a Melissa extract.

[Thyme extract] Thyme ( Thymus vulgari
s L.) was dried and pulverized, and extracted with stirring in 1,500 ml of a 50% by volume aqueous glycerin solution at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a thyme extract.

[Button extract] button ( Paeonia suffru)
ticosa Andr.) is dried and pulverized, and is dried at 25 ° C. in 1,000 ml of a 95% by volume aqueous ethanol solution at 25 ° C.
Extracted with stirring for days. The extract was filtered, and the filtrate was collected to obtain a button extract.

[Mulberry Extract] 350 g of mulberry ( Morus alba L.) root bark is minced, and 1,3-butylene glycol 1,0
It was immersed in 00 ml at 20 ° C. for 7 days for extraction. The extract was filtered and the filtrate was collected to obtain a mulberry extract.

[ Achillea millefolium extract] Flowers 320 of Achillea milleifolium L.
g was homogenized in 2,000 ml of physiological saline at 10 ° C., and further extracted with stirring for 4 hours. The extract was filtered, and the filtrate was collected to obtain an Achillea millefolium extract.

[0045] [sundew extract] sundew (Dr
osera routundifolia L.) was crushed and extracted with stirring in 1,000 ml of absolute ethanol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain an A. moss extract.

[ Plecium lucidum extract]
taphylos uva-ursi (L.) Spreng.) leaves (350 g) were minced and dissolved in 1,000 ml of 1,3-butylene glycol for 20 minutes .
Extraction was performed by immersion at 7 ° C. for 7 days. The extract was filtered, and the filtrate was collected to obtain a mulberry extract.

[Herayahazu extract], [Hariamiji extract], [Sozo sp. Extract], [Darusu extract] Herayahazu ( Dictyopteris prolifer) collected from the sea
a ), Haramiji ( Dictyota spinulosa ), Sozo sp. ( La
urencia sp.) and all algae of Dulse ( Palmaria palmata ) are washed with water and then minced, and an equal volume of phosphate buffered saline (pH
After the dispersion in 7.4), the mixture was extracted with stirring in a blender mill for 3 hours. The extract was filtered, and the filtrate was collected to obtain each of the above extracts.

According to the formulations shown in Table 1, Examples 1 to 12 and Comparative Examples 1 to 12 were prepared as the cosmetics according to the present invention. These serums were prepared by mixing and homogenizing all components. In addition, all the items were shown by weight%.

[0049]

[Table 1]

[0050]

[Table 2]

[0051]

[Table 3]

Examples 1 to 3 of the present invention prepared according to the above formula
Example 12 and Comparative Examples 1 to 12 were evaluated for the effect of improving pigmentation symptoms. The effect of improving the pigmentation symptom was such that 20 female panelers having remarkable pigmentation symptoms such as spots and freckles were grouped into a group, and each group was blinded with Examples 1 to 12 and Comparative Examples 1 to 12 respectively. The skin was used twice a day for one month, and the state of pigmentation of the skin after one month was observed and compared with that before use. The state of pigmentation was evaluated according to the criteria shown in Table 4,
Tables 5 and 6 show the average values of the 20 subjects.

[0053]

[Table 4]

[0054]

[Table 5]

[0055]

[Table 6]

As is clear from Tables 5 and 6, all the groups using the examples according to the present invention showed remarkable improvement in the pigmentation symptom. The symptoms had been improved to the extent that pigmentation was only observed. In particular, Iwanashi extract 1 and L-
Example 1 using magnesium ascorbyl phosphate in combination
Good improvement was observed in Example 8 using the knotweed extract fraction and Example 9 using the Hamamelis extract fraction together. On the other hand, in the comparative example use group in which the substance having the melanin production inhibitory action was blended alone, although the improvement of the pigmentation symptom can be observed, the degree of the improvement is clearly compared to the corresponding example use group. It was small.

In Examples 1 to 12 of the present invention, no change in the state of the preparation such as precipitation, separation, agglomeration, discoloration, and discoloration of the components was observed during the use test period. In addition, in each group used in Examples, there was no paneler showing a skin irritating reaction or a skin sensitizing reaction.

Another embodiment of the present invention will be described.

Example 13 Serum (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 32.5 (5) Fatty Acid Glycerin 0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20EO) sorbitan monolaurate 2.0 (8) Propylene glycol 5.0 (9) Iwanashi extract 2 0.4 (10 ) Sodium lactate 0.3 (11) Purified water 34.8 Production method: The oily components (1) to (7) and the aqueous components (8) to (11) are mixed and homogenized, respectively, and heated to 75 ° C. The oily component is added to the aqueous component, emulsified, and cooled with stirring.

Example 14 Essence (1) Squalane 5.0 (% by weight) (2) White petrolatum 2.0 (3) Beeswax 0.5 (4) Sorbitan sesquioleate 0.8 (5) Poly Oxyethylene oleyl ether (20EO) 1.2 (6) Propylene glycol 5.0 (7) Purified water 58.2 (8) Carboxyvinyl polymer (1% by weight aqueous solution) 20.0 (9) American char pear extract 5 (10) Potassium hydroxide 0.1 (11) Ethanol 5.0 (12) Fragrance 0.2 (13) Ascorbic acid 0.5 Production method: The oil phase components of (1) to (5) are mixed and mixed. Dissolve and homogenize by heating to ° C. On the other hand, the aqueous phase components (6) to (9) were mixed and dissolved, heated to 75 ° C., added with the oil phase component, uniformly emulsified with a homomixer, and added with (10) to adjust the pH. To adjust. After cooling, add (11) to (13) at 40 ° C and mix.

Example 15 Skin Lotion (1) Ethanol 10.0 (wt%) (2) Hydroxyethylcellulose 1.0 (3) Iwanashi extract 1 1.0 (4) Glycerin 7.0 (5) Sodium guaiazulene sulfonate 0.5 (6) α-hydroxyacetic acid 0.5 (7) Purified water 80.0 Production method: Mix (1) to (7) to make uniform.

Example 16 Emulsion for Skin (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid paraffin 7.0 (5) Polyoxy Ethylene (10EO) monooleate 1.5 (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Iwanashi extract 2 1.0 (9) Purified water 79.0 (10) Lactic acid bacteria extraction Product 0.5 (11) Placental extract 0.3 Production method: Mix and heat the oil phase components of (1) to (5) to dissolve uniformly and keep at 70 ° C. On the other hand, the aqueous phase components (6) to (9) are mixed and heated to be uniform, and the temperature is set to 70 ° C. The oil phase component is gradually added to the aqueous phase component with stirring, emulsified, cooled, and the components (10) and (11) are added at 40 ° C.

Example 17 Skin Gel (1) Purified Water 90.9 (% by weight) (2) Carboxyvinyl Polymer 0.5 (3) American Pear Extract 0.3 (4) Dipropylene Glycol 8 0.0 (5) Potassium hydroxide 0.1 (6) Hinokitiol-β-D-glucoside 0.2 Production method: After (2) and (3) are uniformly dissolved in (1), (4) is added. Then, (5) is added to thicken, and (6) is added and mixed uniformly.

Example 18 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic Type Glyceryl monostearate 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (7) Propylene glycol 5.0 (8) Iwanashi extract 1 0.5 (9) Oolong tea extract 0.0 2 (10) Purified water 36.8 Production method: Mix and dissolve the oil phase components (1) to (6) and heat to 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 19 Oil-in-water emulsion ointment (1) White petrolatum 25.0 (% by weight) (2) Stearyl alcohol 25.0 (3) Sodium lauryl sulfate 10.0 (4) Glycerin 1.0 (5) Iwanashi extract 2 0.5 (6) Melissa extract 0.2 (7) Purified water 38.3 Production method: The oil phase components of (1) to (3) were mixed and dissolved to make uniform, and 75 Heat to ° C. On the other hand, (4) to (6) are dissolved in (7) and dissolved by heating at 75 ° C., and the oil phase component is added to this and emulsified.

Example 20 Lotion (1) Ethanol 10.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Hinokitiol-β-D-glucoside tetraacetate 0.5 (4 ) Dipotassium glycyrrhizinate 0.5 (5) American char pear extract 0.2 (6) Fragrance 0.1 (7) Purified water 78.7 Production method: (1) to (6) are sequentially added to (7) Mix and dissolve uniformly.

Example 21 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self Emulsified glyceryl monostearate 2.0 (5) Propylene glycol 10.0 (6) Potassium hydroxide 0.3 (7) Iwanashi extract 1 0.5 (8) Purified water 69.0 (9) Titanium oxide 1.0 (10) Bengala 0.1 (11) Yellow iron oxide 0.4 (12) Fragrance 0.1 (13) Button extract 0.1 Production method: Mix oil phase components (1) to (4) And heated to 75 ° C. to make it uniform. On the other hand, the components (5) to (8) were mixed and 75
The mixture was heated and dissolved at ℃ to make it uniform, and the pigments of (9) to (11) were added thereto and uniformly dispersed with a homomixer to obtain an aqueous phase component. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and the components (12) and (13) are added and mixed at 40 ° C.

Example 22 Emulsion Foundation (1) Stearic acid 2.0 (% by weight) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglyceryl monoisopalmitate 9.0 (6) 1,3-butylene glycol 8.0 (7) Potassium hydroxide 0.1 (8) Iwanashi extract 2 0.3 (9) Purified water 51.2 ( 10) Titanium oxide 9.0 (11) Talc 7.4 (12) Bengala 0.5 (13) Yellow iron oxide 1.1 (14) Black iron oxide 0.1 (15) Fragrance 0.1 (16) Thyme Extract 0.2 Production method: The oil phase components (1) to (5) are mixed and heated to 75 ° C. to make uniform. On the other hand, the aqueous phase components (6) to (9) are mixed,
The mixture is heated to 75 ° C. and dissolved to make the mixture uniform, and the pigments (10) to (14) are added thereto and uniformly dispersed by a homomixer. After adding the oil phase component and emulsifying, the mixture is cooled and cooled at 40 ° C. (15),
Add and mix component (16).

Example 23 Hand cream (1) Cetanol 4.0 (% by weight) (2) Vaseline 2.0 (3) Liquid paraffin 10.0 (4) Glyceryl monostearate 1.5 (5) Polyoxyethylene (60EO) Glyceryl isostearate 2.5 (6) Tocopherol acetate 0.5 (7) Glycerin 20.0 (8) Methyl parahydroxybenzoate 0.1 (9) American char extract 0.3 (10 ) Hydroquinone-β-D-glucoside 0.1 (11) Purified water 59.0 Production method: Mix and dissolve the oil phase components (1) to (6) and heat to 75 ° C. On the other hand, the aqueous phase components (7) to (11) are mixed and dissolved and heated to 75 ° C. Then, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 24 Jelly-like Peel-off Pack (1) Polyvinyl alcohol 15.0 (% by weight) (2) Carboxymethylcellulose 5.0 (3) 1,3-butylene glycol 3.0 (4) Ethanol 0 (5) Polyoxyethylene (20EO) oleyl ether 0.5 (6) Sardine extract 1 0.2 (7) Achillea millefolium extract 0.1 (8) Purified water 70.2 Preparation method: (8) Add 3) and heat to 75 ° C. to this
(1) and (2) are added for dissolution, and (4) to (7) are added for solubilization.

Example 25 Massage Gel (1) Dipropylene glycol 7.0 (% by weight) (2) Glycerin 8.0 (3) Polyoxyethylene (15EO) oleyl ether 1.0 (4) Carboxyvinyl polymer 0.4 (5) Methylcellulose 0.2 (6) Char pear extract 2 0.4 (7) Zinnia extract 0.2 (8) Potassium hydroxide 0.1 (9) Purified water 82.7 Production method: 75 ° C The components (1) to (8) are sequentially added, dissolved and homogenized to the heated (9).

[Example 26] Face wash (1) Stearic acid 2.0 (% by weight) (2) Cetanol 3.0 (3) Vaseline 10.0 (4) Liquid paraffin 33.0 (5) Isopropyl myristate 7.5 (6) Glyceryl monostearate 2.5 (7) Polyoxyethylene (20EO) sorbitan monostearate 2.5 (8) Glycerin 5.0 (9) American char extract 0.3 (10 ) Potassium hydroxide 0.1 (11) Purified water 33.9 (12) Herayahazu extract 0.2 Production method: The oil phase components of (1) to (7) are mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (8) to (11) are mixed and dissolved by heating to 70 ° C. The oil phase component is gradually added to the aqueous phase component for pre-emulsification, then uniformly emulsified by a homomixer, cooled, and the component (12) is added at 40 ° C.

Example 27 Skin Lotion (1) Ethanol 20.0 (% by weight) (2) Hydroxyethylcellulose 1.0 (3) Iwanashi extract 10.2 (4) Glycerin 7.0 (5) Sodium guaiazulene sulfonate 0.5 (6) Haramidi extract 0.2 (7) Purified water 71.1 Production method: Mix (1) to (7) to make uniform.

Example 28 Gel for Skin (1) Purified water 84.2 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Iwanashi extract 2 0.1 (4) 1,3- Butylene glycol 15.0 (5) Sozo sp. Extract 0.1 (6) Potassium hydroxide 0.1 Production method: (2) to (5) were added sequentially to (1), and the mixture was uniformly dissolved (6). ) To increase the viscosity.

[Example 29] Lotion (1) Ethanol 10.0 (wt%) (2) 1,3-butylene glycol 10.0 (3) American char pear extract 0.1 (4) Dipotassium glycyrrhizinate 0 5.5 (5) Dulce extract 0.2 (6) Fragrance 0.1 (7) Purified water 79.1 Production method: The components (1) to (6) are added to (7) in order, and mixed uniformly. Dissolve.

In Examples 13 to 29 of the present invention, the effects of improving skin irritation and pigmentation symptoms were examined.
For skin irritation, a 48-hour obstruction sticking test was performed by 20 male panelists, and the results were determined according to the criterion shown in Table 7, and indicated by the average value of the skin irritation index of 20 persons. The jelly-like peel-off pack of Example 24 was peeled off 20 minutes after application and then closed, and the face wash of Example 26 was evaluated with a 1% by weight aqueous solution. The improvement effect of the pigmentation symptoms was obtained by grouping 10 female panelers who had remarkable pigmentation symptoms such as spots and freckles, using each of the examples twice a day blindly for one month. The state of pigmentation of the skin after months was observed, and the improvement effect was shown by the number of panelists who were evaluated to have an improvement effect compared to before use. Table 8 shows the results of the effects of improving skin irritation and pigmentation symptoms.

[0077]

[Table 7]

[0078]

[Table 8]

As shown in Table 8, the examples of the present invention showed no skin irritation, good safety, and excellent pigmentation improving effect.

[0080]

Industrial Applicability As described in detail above, the present invention synergistically enhances the melanin production inhibitory effect, is effective in preventing and improving pigmentation, spots, freckles, spots, etc. after tanning. An external preparation for skin with significantly improved whitening effect was obtained.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 X MN RU 7/021 7/021 7/50 7/50 F term (Ref.) CC07 CC12 CC23 DD23 DD31 DD33 DD41 EE01 EE03 EE10 EE12 EE13 EE16

Claims (2)

[Claims] 1. L-ascorbic acid and its salts or derivatives thereof, hinokitiol and its derivatives, 2-hydroxycarboxylic acid and its salts or its derivatives, hydroquinone and its derivatives, cysteine and its derivatives, excluding ascorbic acid glycosides, An external preparation for skin containing one or more selected from glucosamine and its derivatives, azelaic acid and its derivatives, placental extracts, and plant and algal extracts having a melanin production inhibitory activity, and an extract of a plant belonging to the genus Sorbus. 2. A plant / algae extract having a melanin production inhibitory action, wherein said extract is of the genus Mansacea, Saxifraga, Zinko, Camellia, Aesculus, Polygonum, Acacia genus,
Genus genus, artemisia, yarrow, yarrow, linden genus, hypericum, sarcophaga, ginseng, ganpi, honeysuckle, genus genus, mulberry, genus, moss Plants and sponges,
Genus Coralum, Artemisia spp.
2. The external preparation for skin according to claim 1, wherein the external preparation is one or more selected from the group consisting of extracts from algae of the genus Sozo, Fushi-nagi, Genus Genus, Darus, Genus Hondawara, and Genus Genus.