JP2002128682A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation capable of improving its bleaching effect and also excellent in terms of safety including low skin irritancy and low skin sensitization. SOLUTION: This skin care preparation is obtained by formulating at least one ingredient selected from L-ascorbic acid and salts or derivatives thereof except ascorbic acid glycosides, hinokitiol and derivatives thereof, 2- hydroxycarboxylic acids and salts or derivatives thereof, hydroquinone and derivatives thereof, cysteine and derivatives thereof, glucosamine and derivatives thereof, azelaic acid and derivatives thereof, placenta extract, and plant/alga extracts having melanogenesis inhibitory activity and an extract obtained by putting molasses to extraction followed by removing coloring comonent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention has a synergistically enhanced melanin production inhibitory effect, is effective in preventing and improving skin pigmentation such as darkening of skin, spots and freckles due to ultraviolet rays, and has a remarkably effective skin whitening effect. The present invention relates to an improved external skin preparation having excellent safety.

[0002]

2. Description of the Related Art Conventionally, darkening of skin by ultraviolet rays,
In order to prevent or improve pigmentation of the skin, such as spots and freckles, components having an action of inhibiting melanin production or reducing the produced melanin pigment have been screened and formulated into skin external preparations. For example, ascorbic acid, 2-hydroxycarboxylic acid, hydroquinone, cysteine, placenta extract, extracts from plants, algae, and the like are used.

[0003]

However, ascorbic acid, hydroquinone, and cysteine are susceptible to oxidation-reduction reaction and are unstable, and 2-hydroxycarboxylic acid has a problem in safety to the skin when an effective amount is added. Placental extracts and extracts from plants and algae have a problem that when added in an effective amount, it may impart an unpleasant odor or color to the external preparation for skin.

[0004] The present invention solves the above problems,
An object of the present invention is to provide a skin external preparation having a very strong skin melanin production inhibitory action and having no safety problems such as skin irritation and skin sensitization.

[0005]

In order to solve the above-mentioned problems, various studies have been made. As a result, an extract obtained by removing a coloring component from molasses and a component having an action of inhibiting a specific melanin production are disclosed. By using together,
The present inventors have found that a skin external preparation having a whitening effect synergistically enhanced and having no safety problems such as skin irritation and skin sensitization can be obtained, thereby completing the present invention.

[0006]

Embodiments of the present invention will be described.

The extract used in the present invention, which is extracted from molasses and obtained by removing coloring components, will be described. The type of molasses used as a raw material is not particularly limited. For example, when sucrose contained in sugarcane or sugar beet is squeezed out and purified through clarification, concentration, crystallization, etc., sucrose is evaporated. The residual liquid obtained by separating the sucrose crystals can be used. Next, a method for preparing an extract obtained by extracting a coloring component from molasses is not particularly limited as long as the coloring component is removed and a whitening effect component is effectively extracted. Water, ethanol, methanol, n-butanol, isopropyl alcohol, 1,3-butylene glycol, propylene glycol,
Examples of the means for removing coloring components using glycerin, ethyl acetate or the like or a mixed solution thereof as an extraction solvent include activated carbon, activated clay treatment, or a method using silica gel, activated alumina, a synthetic resin adsorbent, a reverse osmosis membrane, or the like. . It is also possible to dry by spray drying, freeze drying or the like as needed. Extracts extracted from such molasses and obtained by removing coloring components are disclosed in JP-A-5-8592.
No. 7 is preferably used, and commercially available molashiz liquid manufactured by Taiyo Kagaku can also be used.

In the present invention, the amount of the extract extracted from the molasses and obtained by removing coloring components is not particularly limited, but is generally 0.0001 to 10% by weight, preferably 0.001 to 5% by weight. Mix. 0.0001% by weight
If less than 10% by weight, the effect is not exhibited.
The effect cannot be expected to increase.

In the present invention, examples of L-ascorbic acid and salts or derivatives thereof other than ascorbic acid glycoside used together with an extract obtained by removing a coloring component from molasses include L-ascorbic acid and L-ascorbic acid. -Sodium ascorbate, L-magnesium ascorbate,
L-ascorbate such as potassium L-ascorbate and calcium L-ascorbate, monoalkyl or mono-L-ascorbate such as L-ascorbate monostearate, L-ascorbate monopalmitate and L-ascorbate monooleate Alkenyl ester derivatives, ascorbic acid monoester derivatives such as L-ascorbic acid-2-sulfate, L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid dioleate and the like L-ascorbic acid dialkyl or dialkenyl ester derivatives L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, etc.
Trialkyl or trialkenyl ester derivatives of ascorbic acid, L-ascorbyl phosphate, sodium L-ascorbyl phosphate, potassium L-ascorbyl phosphate,
L-ascorbyl phosphates such as magnesium L-ascorbyl phosphate and calcium L-ascorbyl phosphate can be mentioned. Of these L-ascorbic acid and salts or derivatives thereof, particularly preferred are L-ascorbic acid, L-ascorbyl phosphate and magnesium salts thereof.

In the present invention, the hinokitiol and its derivatives used together with the extract obtained by removing the coloring components extracted from molasses are not particularly limited, and hinokitiol glycosides such as hinokitiol, hinokitiol zinc complex, hinokitiol glucoside and the like. And acetyl derivatives thereof.

In the present invention, the 2-hydroxycarboxylic acid and its salt or derivative used together with the extract obtained by extracting the molasses extracted from molasses are not particularly limited, but 2-hydroxycarboxylic acid having 2 to 22 carbon atoms is not particularly limited. Hydroxycarboxylic acids are preferred, and 2-hydroxycarboxylic acids having 2 to 6 carbon atoms are more preferably used from the viewpoint of the effects of the present invention. For example, 2-hydroxyacetic acid, lactic acid, malic acid,
Examples include tartaric acid, citric acid and salts thereof, and alkyl esters, cholesterol esters, glycosides, phosphatidyl esters, L-arginine salts of 2-hydroxycarboxylic acid, which have improved skin affinity of 2-hydroxycarboxylic acid.

In the present invention, hydroquinone and a derivative thereof used together with an extract obtained by removing a coloring component from molasses are not particularly limited, but hydroquinone glycosides are preferably used. For example, hydroquinone-α- D-glucoside, hydroquinone-β-D-
Glucoside, hydroquinone-α-L-glucoside, hydroquinone-β-L-glucoside, hydroquinone-
Hexasaccharide glycosides such as α-D-galactoside, hydroquinone-β-D-galactoside, hydroquinone-α-L-galactoside, hydroquinone-β-L-galactoside, hydroquinone-α-D-ribose, hydroquinone-β- D-ribose, hydroquinone-α-L-ribose, hydroquinone-β-L-ribose, hydroquinone-α-D-arabinose, hydroquinone-β-D
Pentacarbon sugar glycosides such as arabinose, hydroquinone-α-L-arabinose, hydroquinone-β-L-arabinose, hydroquinone-α-D-glucosamine, hydroquinone-β-D-glucosamine, hydroquinone-
α-L-glucosamine, hydroquinone-β-L-glucosamine, hydroquinone-α-D-galactosamine,
Hydroquinone-β-D-galactosamine, hydroquinone-α-L-galactosamine, hydroquinone-β-
Amino sugar glycosides such as L-galactosamine, hydroquinone-α-D-glucuronic acid, hydroquinone-β-D-
Glucuronic acid, hydroquinone-α-L-glucuronic acid, hydroquinone-β-L-glucuronic acid, hydroquinone-α-D-galacturonic acid, hydroquinone-β
And uronic acid glycosides such as -D-galacturonic acid, hydroquinone-α-L-galacturonic acid, and hydroquinone-β-L-galacturonic acid. Examples of the derivative include an ester such as an acetylated product and an ether such as a methylated product. Among them, hydroquinone-β-D-glucose is most preferable from the viewpoint of the effect of the present invention.

In the present invention, the cysteine and its derivative used together with the extract obtained by removing the coloring component from molasses are not particularly limited, but for example, cysteine or a phospholipid ester of cysteine, sphingosine and its derivative. Examples thereof include esters, glycolipid esters, sugar esters, sterol esters, and alkyl or alkenyl esters having 8 to 20 carbon atoms.

In the present invention, glucosamine and its derivatives used together with the extract obtained by removing the coloring component from molasses are not particularly limited, but for example, glucosamine or glucosamine esters such as acetylglucosamine, and glucosamine methyl ether. Glucosamine ethers and the like.

In the present invention, the azelaic acid and its derivative used together with the extract obtained by extracting the molasses from the molasses are not particularly limited. For example, azelaic acid or azelaic acid such as azelaic acid monoalkyl ester is used. Monoesters, azelaic acid diesters such as azelaic acid dialkyl ester and the like can be mentioned.

The placenta extract used in the present invention together with the extract obtained by extracting the molasses from the molasses and removing the coloring component is not particularly limited as long as it is used in a usual external preparation for skin.

In the present invention, any extract from plants and algae known to inhibit melanin production to be used together with the extract obtained by removing colored components from molasses is not particularly limited. Hamamelis japonica S
ieb. et Zucc.), Cinnamon Saku ( Hamamelis mollis Ol)
iv.), Hamelis ( Hamamelis virginiana L.), etc., and the hawksbill ( Saxifraga aizoon Jac)
q.), Gypsophila ( Saxifraga cherlerioides D. Don)
var. rebunshirensis (Engl. et Irmsch) Hara, Saxif
raga bronchialalis L.), gingival ( Saxifraga cor )
tusaefolia Sieb. et Zucc.), Daimonjisou (Saxif
raga fortunei Hook.f.var.incisolobata (Engl. et
Irmsch.) Nakai), Hull saxifrage (Saxifraga nippo
nica Makino), Sendai Saw ( Saxifraga sendaica Ma)
xim.), Saxifraga stolonifera Meer
b.), Fukiyukinosita ( Saxifraga j aponica Bois
s.), Spider Magnolia ( Saxifraga fusca Maxim.), Spider Magusa ( Saxifraga merkii Fish. var. laciniata Naka
i) 、 Kumamayukinosita ( Saxifraga laciniata Nakai e)
t Takeda) and Chicorysis ( Saxifraga bronchialalis )
L.), Saxifraga cernua L., and other plants of the genus Saxifraga, Zinko ( Aquilaria agallocha Ro)
xb.), Camellia, Camellia
japonica L.) and its variants, tea ( Camellia sinensis)
Camellia plants such as (L.) O. Kuntze) and its variants, safflower ( Aesculus carnea Hayne), Aesculus chinensis Bunge, horse chestnut ( Aesculus hippocastanum L.), horse chestnut ( Aesculus )
turbinata Bl.) and other horse chestnut plants, knotweed ( Polyg)
onum cuspidat um Sieb. et Zucc., Polygonum cuspidatum Sieb. et Zucc. var. hachi
dyoense Ohwi), Giant Knotweed ( Polygonum sachalinen )
se Fr.Schm.) Polygonum such as a plant of the genus, Melissa (Melissa off
icinalis L.) and Thymus serphyllum L. subs.
p. quinquecostatus (Aelak.) Kitamura), Thyme ( Thy
mus vulgaris L.), Artemisia absinthium L., Artemisia annua L., Artemisia
apiacea Hance), Artemisia capillari
s Thunb.), Artemisia cina Berg., Tarragon ( Artemisia dracunculus L.), Artemisia japonica Thunb., Artemis
ia maritima L.), Artemisiaprinceps Pam
p.), Artemisia plants such as Yarrow ( Achillea alpin)
a L.), Achillea milleifoliu
m L.), Achillea moschata Ja
cq.) and other Yarrow species such as Yarrow ( Eupatoriu)
mjaponicum Thunb.), Sawa's bulbul ( Eupatorium lind )
leyanum DC.), Bulbul ( Eupatorium chinense )
L. var. Oppositifolium (Koidz.) Murata et H. Koyam
a) and other plants of the genus Bulbul, Tilia
americana L.), Fuyubodaiju ( Tilia cordata Mil)
l.), European linden ( Tilia europaea L.), linden ( Tilia japonica (Miq.) Simonk.), bodaiju ( T
ilia miqueliana Maxim.), Natsubodaiju ( Tilia pl
atyphyllos Scop.), linden plants, Hypericum ascyron L., Hypericum
erectum Thunb.), Hypericum japonicu ( Hypericum japonicu )
m Thunb.), Hypericum perforatum ( Hypericum perforatum)
Hypericum plant of the genus L.), etc., rock saxifrage (Tanak
aea radicans Fr. et Sav.), a plant belonging to the genus Iwakashinota, Daphne genkwa Sieb. et Zuc
c.), camphor tree ( Daphne kiusiana Miq.), kougan daisetsu ( Daphne mezereum L.), Daphne magna ( Daphne odora Thunb.), bonsai ( Daphne pseudo )
-mezereum A. Gray), Naniwazu ( Daphne kamtchatica )
Var. Yezoensis Ohwi), crow shikimi ( Daphne )
miyabeana Makino) and other artichoke plants, Diplomorpha phymatoglossa (Koidz.) Naka
i), Ganpi ( Diplomorpha sikokiana (Fr. et Sav.) H
onda), Diplomorpha trichotoma (Thunb.)
Ganpi plants such as Nakai), Mitsumata ( Edgeworthia ch)
rysantha Lindl.) edgeworthia plant, Spain licorice represented by (Glycyrrhiza glabra L.), Kikanzou (Glycyrrhiza kansuensis Chang et peng), licorice (Glycyrrhiza urarensis Fisch.) Glycyrrhiza plants such as, Naga bus Roh sundew (Drosera angelica Hud
s.), Drosera peltata (Drosera peltata Smith), sundew (Drosera routundifolia L.), Komousengoke (Drosera spathulata Labill.) Drosera plants such as, Urashimatsutsuji (Arctostaphylos alpina (L.) S
prevar. var. japonica (Nakai) Hulten) and Uwaurushi ( Arctostaphylos uva-ursi (L.) Spreng.), and other species of the genus Rhododendron, Ceratodictyon spongi
osum ), sphagnum algae, innocence coral ( Corallina sp.), coral ( Corallina officinali )
s ), Corallina pilurifera, and other coral alga, Dictyopteris latiuscula , Dictyopteris undulata , and Hericahaz ( Dic )
tyopteris prolifera ), Sujiyahazu ( Dictyopteris pl )
agiogramma ), Himeyahazu ( Dictyopteris repens ),
Ezoyahazu (Dictyopteris divaricata), Uraboshiyahazu (Dictyopteris polypodioides) Yahazugusa algae such as, Hariamiji Amijigusa algae typified by (Dictyota spinulosa), hijiki algae typified hijiki (Hizikia fusiformis), Sozo sp. (Laurencia sp. ), Kurosozo ( Laurencia intermedia ), Mitsodesozo ( Lauren
cia okamurai ), Sozonohana ( Laurencia grevillean )
a ), Osozo ( Laurencia glandulifera ), Hanesozo ( Laurencia pinnata ), Kobusozo ( Laurencia undulat )
a ) Sozoa algae, such as the fushitsunagi ( Lomentaria catenat)
a), Kosujifushitsunagi (Lomentaria hakodatensis) Fushitsunagi algae such as, cassiope lycopodioides (Myelophycus caespito
sus ), Darus alga ( Palmaria)
palmata ), Darus alga, Sargassum ( Sar)
gassum fulvellum ), pea ( Sargassum yendo )
i ), Mametawara ( Sargassum piluriferum ), Yam Tamok ( Sargassum patens ), Akamoku ( Sargassum horn )
eri), Nokogirimoku (Sargassum serratifolium), Oba sawtooth Mok (Sargassum giganteifolium), Yoremoku (Sargassum tortile), Yanagimoku (Oobamoku: Sargassum ringgoldianum), Nejimoku (Sargassum
sagamianu m ), Hahakimoku ( Sargassum kjellmanianu )
m ), sea lantern ( Sargassum thunbergii ), fushijimoku ( Sargassum confusum ), isomok ( Sargassum )
hemiphyllum ), sara ( Sargassum nigrifolium ),
Stalked mushroom ( Sargassum micracanthum ), Tamanashimoku ( Sargassum nipponicum ), Ginseng ( Sargassum vu )
lgare ), phloem (Hollyhock: Sargassum dupli)
catum), Ezononejimoku (Sargassum yezoense) Sargassum algae such as, Ishimozuku (Sphaerotrichia divar
Illustrative algae typified by icata ) are exemplified.

Among the above-mentioned plants and algae, Hamameli
Su (Hamamelis virginiana L.)Saxifra
ga stolonifera Meerb.), Jinko (Aquilaria agall
ocha Roxb.), Cha (Camellia sinensis (L.) O. Kunt
ze) and its variant, knotweed (Polygonum cuspidatum S
ieb. et Zucc.), Melissa (Melissa officinalis
L.), time (Thymus vulgaris L.), mugwort
(Artemisia capillarisThunb.), European saw
CAchillea milleifolium L.), Hypericum (Hype
ricum erectum Thunb.), Hypericum perforatum (Hypericu
m perforatum L.), Spanish fern (Glycyrrhiza g
labra L.), Licorice (Glycyrrhiza urarensis Fisc
h.)Drosera routundifolia L.), c
Waurushi (Arctostaphylos uva-ursi (L.) Spreng.),
Herayahaz (Dictyopteris prolifera), Hariamiji
(Dictyota spinulosa), Hijiki (Hizikia fusiformi
s), Sozo sp. (Laurencia sp.)Lomenta
ria catenata), Mustache (Myelophycus caespitosu
s), Darth (Palmaria palmata), Willow moku
Bamoku:Sargassum ringgoldianum), Fushijimoku (S
argassum confusum), Ezononejimoku (Sargassum yez
oense) 、 Ishimozuku (Sphaerotrichia divaricata) Or
One or more plants or algae selected from
Used.

Plant / algal extracts having a melanin production inhibitory activity include various whole plants or their leaves, bark, roots, flowers, branches,
One or two or more sites such as stems and seeds are used as they are or are dried and pulverized. The extraction solvent is not particularly limited, but includes monohydric alcohols such as water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, and n-octyl alcohol, glycerin, ethylene glycol, and ethylene. Polyhydric alcohols such as glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol and derivatives thereof, acetone, methyl ethyl ketone, methyl isobutyl ketone,
Ketones such as methyl-n-propyl ketone, ethyl acetate,
Esters such as isopropyl acetate, ethers such as ethyl ether, isopropyl ether, n-butyl ether, hydrocarbons such as squalane, petrolatum, paraffin wax, paraffin oil, olive oil, wheat germ oil,
Rice oil, sesame oil, macadamian nut oil, almond oil,
Vegetable oils and fats such as coconut oil and animal fats and oils such as beef tallow, lard, whale oil and the like can be mentioned. Further, a polar solvent to which an inorganic salt such as a phosphate buffered saline solution is added, or a solvent to which a surfactant is added can also be used.

Further, the extraction method includes a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, and a method of pressing a plant or algae to obtain an extract. For example, these methods are used alone or in combination of two or more.

The ratio of the plant or algae to the solvent at the time of extraction is not particularly limited.
0.1 to 1000 times by weight, especially in terms of extraction operation and efficiency.
5 to 100 times by weight is preferred. It is convenient to set the extraction pressure and the extraction temperature in a range from 0 ° C. to the boiling point of the solvent at normal pressure, and the extraction time varies depending on the extraction temperature.
It is preferable to set the time in a range from time to two weeks.

The extract of the plant or algae thus obtained can be used as it is, but it may be subjected to purification operations such as deodorization, decolorization, concentration, etc. as long as the effect is not lost. May be used as a fraction using column chromatography or the like. These extracts, purified products, and fractionated products can be dried by removing the solvent therefrom, and can be used in a form solubilized in a solvent such as alcohol or in an emulsion form. it can.

The components obtained by purifying and fractionating from the plant extract include hamamelitannin, which is often contained in the leaves of hamamelis, and flavonoids, which are contained in the oil-soluble extract of licorice, in particular, glabridine, hispagrabridine, and the genus (-)-Epicatechin and the like contained in the plant extract are exemplified.

The amount of these components having an effect of inhibiting melanin production in the external preparation for skin is not particularly limited, but is considered from the viewpoint of its effect, odor when added, and color tone.
It is desirable to set the concentration range of 0.0001 to 10% by weight.

The external preparation for skin of the present invention may, if necessary,
Oils and fats, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, thickeners usually used in pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics, and cleansers , Drugs, fragrances, resins, alcohols and the like can be appropriately compounded. The dosage form of the external preparation for skin of the present invention is arbitrary. For example, it can be provided as a solubilizing system such as a lotion, an emulsifying system such as a cream or an emulsion, or a dispersion system such as a calamine lotion. You may take the form of a filled aerosol.

[0026]

Next, the present invention will be described in detail with reference to examples.

First, preparation examples of extracts, placenta extracts, and plant and algal extracts having an inhibitory action on melanin production, which are extracted from molasses and obtained by removing coloring components, used in the present invention will be described.

[Extract obtained by removing colored components from molasses] Commercially available molashiz liquid (manufactured by Taiyo Kagaku Co., Ltd.) was used.

[Placental extract] A commercially available water-soluble placenta extract (Nichirei) was used.

[Kitadori extract] Knotweed ( Polygonum
cuspidatum Sieb. et Zucc.)
It was pulverized and stirred and extracted in 1,500 ml of a 50% by volume aqueous ethanol solution at 25 ° C. for 5 days. Next, the extract was filtered, and the filtrate was used as a knotweed extract.

[ Kitadori Extract Fraction] Knotweed ( Polygo
dry powder 2 of rhizome of num cuspidatum Sieb. et Zucc.)
2,000 ml of a 50% by volume aqueous ethanol solution
And extracted at room temperature for 7 days. Next, the extract was filtered, the filtrate was concentrated under reduced pressure, dissolved in 800 ml of a 30% by volume aqueous solution of ethanol, and DIAION MCI Ge was dissolved.
l HP-20 column (manufactured by Mitsubishi Chemical Corporation)
The fraction eluted with a 40% by volume aqueous ethanol solution was collected. Then, the above fraction was subjected to silica gel thin layer chromatography to form a chloroform / methanol mixture (volume ratio =
5: 1) as a developing solvent. Among the obtained fractions, the fraction containing (-)-epicatechin was scraped off, and 5
It was dissolved in 50 ml of 0% by volume ethanol to obtain a knotweed extract fraction.

[ Hamelis extract] Hamamelis ( Hameme
lis virginiana L.) 500 g of leaves are dried, crushed and
25 ° C in 1,000 ml of 0 volume% ethanol aqueous solution
For 5 days. Next, the extract was filtered, and the filtrate was collected to obtain a Hamamelis extract.

[Hamellis extract fraction] Hamamelis ( Ha
(mamelis virginiana L.), and a total of 500 g of leaves and bark were minced and extracted with stirring in 1,500 ml of hot water for 5 hours.
Then, the extract is filtered, and the filtrate is filtered by DIAION MCI.
It was applied to a Gel HP-20 column (manufactured by Mitsubishi Kasei Corporation) and eluted with a mixed solvent of ethanol and water. A fraction having a hamamelitannin content of 50% by weight or more was collected and used as a hamamelis extract fraction.

[Phaseolus vulgaris extract] Whole plant 35 of flowering season of Hypericum vulgaris ( Hypericum perforatum L.)
0 g, cut into olive oil in 1,000 ml at 20 ° C.
For 7 days. The extract was filtered and the filtrate was collected to obtain a Hypericum perforatum extract.

[ Glycyrrhiz ] [ Glycyrrhiz ]
a urarensis Fisch.), dried and pulverized, and dried in 1,000 ml of anhydrous ethanol aqueous solution.
Stirring was performed at 24 ° C for 24 hours. The extract is filtered to collect the filtrate, concentrated under reduced pressure, and lyophilized to dryness. The dried product was stirred and extracted in 1,000 ml of ethyl acetate at 20 ° C. for 2 days. After extraction, it was dried under reduced pressure to obtain a licorice extract.

[ Zinko Extract] Zinko ( Aquillaria)
agallocha Roxb.), dried and pulverized, and immersed in 1,000 ml of ethanol at 20 ° C for 10 days. Next, the extract was filtered, and the filtrate was 1/10
It was concentrated to a volume to give a ginger extract.

[Oolong tea extract] Oolong tea ( Thea s
inensis L. var. viridis Szkzyl.) leaves were dried and pulverized, and dried at 50 ° C. in 1,000 ml of purified water for 24 hours.
The mixture was stirred and extracted for hours. The extract was filtered, and the filtrate was concentrated to 1/5 volume to obtain an oolong tea extract.

[0038] [Melissa extract] Melissa (Melissa of
ficinalis L.) leaves were crushed and extracted with stirring in 1,000 ml of 1,3-butylene glycol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a Melissa extract.

[Thyme extract] Thyme ( Thymus vulgari
s L.) was dried and pulverized, and extracted with stirring in 1,500 ml of a 50% by volume aqueous glycerin solution at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a thyme extract.

[ Achillea millefolium L.] Flower 320
g was homogenized in 2,000 ml of physiological saline at 10 ° C., and further extracted with stirring for 4 hours. The extract was filtered, and the filtrate was collected to obtain an Achillea millefolium extract.

[0041] [sundew extract] sundew (Dr
osera routundifolia L.) was crushed and extracted with stirring in 1,000 ml of absolute ethanol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain an A. moss extract.

[ Plecium lucidum extract]
taphylos uva-ursi (L.) Spreng.) leaves (350 g) were minced and dissolved in 1,000 ml of 1,3-butylene glycol for 20 minutes .
Extraction was performed by immersion at 7 ° C. for 7 days. The extract was filtered, and the filtrate was collected to obtain a mulberry extract.

[Hellayahaz extract], [Hariamiji extract], [Sozo sp. Extract], [Darusu extract] Hariyahazu ( Dictyopteris prolifera ), Hariaamiji ( Dictyota spinulosa ), Soso sp. ( Laurencia ) collected from the sea s
p.) and dulse ( Palmaria palmata ) were washed with water, cut into 500 g pieces each, dispersed in an equal volume of phosphate buffered saline (pH 7.4), and then extracted with stirring in a blender mill for 3 hours. . The extract was filtered, and the filtrate was collected to obtain each of the above extracts.

According to the formulations shown in Table 1, Examples 1 to 12 and Comparative Examples 1 to 12 were prepared as the cosmetics of the present invention. These serums were prepared by mixing and homogenizing all components. In addition, all the items were shown by weight%.

[0045]

[Table 1]

[0046]

[Table 2]

[0047]

[Table 3]

Examples 1 to 3 of the present invention prepared according to the above formula
Example 12 and Comparative Examples 1 to 12 were evaluated for the effect of improving pigmentation symptoms. The effect of improving the pigmentation symptom was such that 20 female panelers having remarkable pigmentation symptoms such as spots and freckles were grouped into a group, and each group was blinded with Examples 1 to 12 and Comparative Examples 1 to 12 respectively. The skin was used twice a day for one month, and the state of pigmentation of the skin after one month was observed and compared with that before use. The state of pigmentation was evaluated according to the criteria shown in Table 4,
Tables 5 and 6 show the average values of the 20 subjects.

[0049]

[Table 4]

[0050]

[Table 5]

[0051]

[Table 6]

As is evident from Tables 5 and 6, in the group using the examples according to the present invention, remarkable improvement in the pigmentation symptom was observed in all the groups. The symptoms had been improved to the extent that pigmentation was only observed. In particular, an extract extracted from molasses and obtained by removing a coloring component, Example 1 using L-ascorbyl magnesium phosphate in combination, Example 8 using a knotweed extract fraction, and a joint extract of Hamamelis extract In the group using Example 9, good improvement was observed. On the other hand, in the comparative example use group in which the substance having the melanin production inhibitory action was blended alone, although the improvement of the pigmentation symptom can be observed, the degree of the improvement is clearly compared to the corresponding example use group. It was small.

In Examples 1 to 12 of the present invention, during the above-mentioned use test period, precipitation, separation,
No change in the state of the preparation such as aggregation, discoloration or discoloration was observed. In addition, in each group used in Examples, there was no paneler showing a skin irritating reaction or a skin sensitizing reaction.

Another embodiment of the present invention will be described.

Example 13 Serum (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 32.5 (5) Fatty Acid Glycerin 0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20E.O.) sorbitan monolaurate 2.0 (8) Propylene glycol 5.0 (9) Colored components extracted from molasses 0.4 (10) Sodium lactate 0.3 (11) Purified water 34.8 Production method: Oil component of (1) to (7) and aqueous component of (8) to (11) Are mixed and homogenized, and heated to 75 ° C. The oily component is added to the aqueous component, emulsified, and cooled with stirring.

Example 14 Essence (1) Squalane 5.0 (% by weight) (2) White petrolatum 2.0 (3) Beeswax 0.5 (4) Sorbitan sesquioleate 0.8 (5) Poly Oxyethylene oleyl ether (20E.O.) 1.2 (6) Propylene glycol 5.0 (7) Purified water 58.2 (8) Carboxyvinyl polymer (1% by weight aqueous solution) 20.0 (9) Extracted from molasses Extract obtained by removing colored components 1.5 (10) Potassium hydroxide 0.1 (11) Ethanol 5.0 (12) Fragrance 0.2 (13) L-ascorbic acid 0.5 Production method: (1) ) To (5) are mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the aqueous phase components (6) to (9) were mixed and dissolved, heated to 75 ° C., added with the oil phase component, uniformly emulsified with a homomixer, and added with (10) to adjust the pH. To adjust. After cooling, add (11) to (13) at 40 ° C and mix.

Example 15 Skin Lotion (1) Ethanol 10.0 (% by weight) (2) Hydroxyethylcellulose 1.0 (3) Extract 1.0 (extracted from molasses and obtained by removing coloring components) 4) Glycerin 7.0 (5) Sodium guaiazulene sulfonate 0.5 (6) 2-Hydroxyacetic acid 0.5 (7) Purified water 80.0 Production method: Mix (1) to (7) to make uniform .

Example 16 Emulsion for Skin (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid paraffin 7.0 (5) Polyoxy Ethylene (10E.O.) monooleate 1.5 (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Extract 1.0 extracted from molasses and obtained by removing coloring components 1.0 ( 9) Purified water 79.0 (10) Lactic acid bacterium extract 0.5 (11) Placenta extract 0.3 Production method: The oil phase components of (1) to (5) are mixed, heated and uniformly dissolved, Keep at ° C. On the other hand, the aqueous phase components (6) to (9) are mixed and heated to be uniform, and the temperature is set to 70 ° C. The oil phase component is gradually added to the aqueous phase component with stirring, emulsified, cooled, and the components (10) and (11) are added at 40 ° C.

[Example 17] Gel for skin (1) Purified water 90.9 (wt%) (2) Carboxyvinyl polymer 0.5 (3) Extract 0 extracted from molasses and obtained by removing coloring components 0 0.3 (4) Dipropylene glycol 8.0 (5) Potassium hydroxide 0.1 (6) Hinokitiol 0.2 Production method: After (2) and (3) are uniformly dissolved in (1), (4) Is added, then (5) is added to thicken, (6) is added and mixed uniformly.

Example 18 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic Type Glyceryl monostearate 4.0 (6) Polyoxyethylene (20E.O.) sorbitan monolaurate 5.0 (7) Propylene glycol 5.0 (8) Extracted from molasses to obtain coloring components Extract 0.5 (9) Oolong tea extract 0.2 (10) Purified water 36.8 Production method: Mix and dissolve the oil phase components (1) to (6) and heat to 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 19 Oil-in-water emulsion ointment (1) White petrolatum 25.0 (% by weight) (2) Stearyl alcohol 25.0 (3) Glycerin 10.0 (4) Sodium lauryl sulfate 1.0 (5) Extract extracted from molasses and obtained by removing coloring components 0.5 (6) Ginkgo extract 0.2 (7) Purified water 38.3 Production method: The oil phase components of (1) to (4) Mix and dissolve to make uniform and heat to 75 ° C. On the other hand, (5) and (6) are dissolved in (7) and dissolved by heating at 75 ° C., and the oil phase component is added to this and emulsified.

Example 20 Lotion (1) Ethanol 10.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Hinokitiol 0.5 (4) Dipotassium glycyrrhizinate 0.5 ( 5) Extract extracted from molasses and obtained by removing coloring components 0.2 (6) Fragrance 0.1 (7) Purified water 78.7 Production method: (1) to (6) are sequentially added to (7) Mix and dissolve uniformly.

Example 21 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self Emulsified glyceryl monostearate 2.0 (5) Propylene glycol 10.0 (6) Potassium hydroxide 0.3 (7) Extract extracted from molasses and obtained by removing coloring components 0.5 (8) Purification Water 69.0 (9) Titanium oxide 1.0 (10) Bengala 0.1 (11) Yellow iron oxide 0.4 (12) Fragrance 0.1 (13) Thyme extract 0.1 Production method: (1)- The oil phase component of (4) is mixed and heated to 75 ° C. to make it uniform. On the other hand, the components (5) to (8) were mixed and 75
The mixture was heated and dissolved at ℃ to make it uniform, and the pigments of (9) to (11) were added thereto and uniformly dispersed with a homomixer to obtain an aqueous phase component. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and the components (12) and (13) are added and mixed at 40 ° C.

Example 22 Emulsion Foundation (1) Stearic acid 2.0 (% by weight) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglyceryl monoisopalmitate 9.0 (6) 1,3-butylene glycol 8.0 (7) Potassium hydroxide 0.1 (8) Extract extracted from molasses and obtained by removing coloring components 0.3 (9) Purified water 51.2 (10) Titanium oxide 9.0 (11) Talc 7.4 (12) Bengala 0.5 (13) Yellow iron oxide 1.1 (14) Black iron oxide 0.1 (15 ) Fragrance 0.1 (16) Melissa extract 0.2 Production method: Mix the oil phase components (1) to (5) and heat to 75 ° C to make it uniform. On the other hand, the aqueous phase components (6) to (9) are mixed,
The mixture is heated to 75 ° C. and dissolved to make the mixture uniform. The pigments (10) to (14) are added to the mixture, and the mixture is uniformly dispersed with a homomixer. After adding the oil phase component and emulsifying, the mixture is cooled and cooled at 40 ° C. (15),
Add and mix component (16).

Example 23 Hand Cream (1) Cetanol 4.0 (% by weight) (2) Vaseline 2.0 (3) Liquid paraffin 10.0 (4) Glyceryl monostearate 1.5 (5) Polyoxyethylene (60E.O.) glyceryl isostearate 2.5 (6) Tocopherol acetate 0.5 (7) Glycerin 20.0 (8) Methyl parahydroxybenzoate 0.1 (9) Color components extracted from molasses Extract obtained by removing water 0.3 (10) Hydroquinone-β-D-glucoside 0.1 (11) Purified water 59.0 Production method: Mix and dissolve oil phase components (1) to (6) Heat to 75 ° C. On the other hand, the aqueous phase components (7) to (11) are mixed and dissolved and heated to 75 ° C. Then, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 24 Jelly-like peel-off pack (1) Polyvinyl alcohol 15.0 (% by weight) (2) Carboxymethyl cellulose 5.0 (3) 1,3-butylene glycol 3.0 (4) Ethanol 0 (5) Polyoxyethylene (20EO) oleyl ether 0.5 (6) Extract extracted from molasses and obtained by removing coloring components 0.2 (7) Achillea millefolium extract 0.1 (8) Purified water 70 2 Production method: Add (3) to (8) and heat to 75 ° C. to this
(1) and (2) are added to dissolve, and (4) to (7) are added to solubilize.

Example 25 Massage Gel (1) Dipropylene glycol 7.0 (% by weight) (2) Glycerin 8.0 (3) Polyoxyethylene (15EO) oleyl ether 1.0 (4) Carboxyvinyl polymer 0.4 (5) Methylcellulose 0.2 (6) Extract extracted from molasses and obtained by removing coloring components 0.4 (7) Hypericum perforatum extract 0.2 (8) Potassium hydroxide 0.1 (9) ) Purified water 82.7 Production method: Components (1) to (8) are sequentially added to (9) heated to 75 ° C, dissolved and homogenized.

[Example 26] Face wash (1) Stearic acid 2.0 (% by weight) (2) Cetanol 3.0 (3) Vaseline 10.0 (4) Liquid paraffin 33.0 (5) Isopropyl myristate 7.5 (6) Glyceryl monostearate 2.5 (7) Polyoxyethylene (20E.O.) sorbitan monostearate 2.5 (8) Glycerin 5.0 (9) Color components extracted from molasses The extract obtained by removing the water 0.3 (10) Potassium hydroxide 0.1 (11) Purified water 33.9 (12) Herayahazu extract 0.2 Production method: The oil phase components of (1) to (7) Mix and dissolve by heating, 70
° C. On the other hand, the aqueous phase components (8) to (11) are mixed and dissolved by heating to 70 ° C. The oil phase component is gradually added to the aqueous phase component for pre-emulsification, then uniformly emulsified by a homomixer, cooled, and the component (12) is added at 40 ° C.

Example 27 Skin Lotion (1) Ethanol 20.0 (% by weight) (2) Hydroxyethylcellulose 1.0 (3) Extract 0.2 extracted from molasses and obtained by removing coloring components 0.2 ( 4) Glycerin 7.0 (5) Sodium guaiazulene sulfonate 0.5 (6) Haramidi extract 0.2 (7) Purified water 71.1 Production method: (1) to (7) are mixed and made uniform.

Example 28 Gel for Skin (1) Purified water 84.2 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Extract extracted from molasses and obtained by removing coloring components 0 1 (4) 1,3-butylene glycol 15.0 (5) Sozo sp. Extract 0.1 (6) Potassium hydroxide 0.1 Production method: (2) to (5) are sequentially added to (1). After uniform dissolution, (6) is added to increase the viscosity.

Example 29 Lotion (1) Ethanol 10.0 (% by weight) (2) 1,3-butylene glycol 10.0 (3) Extract 0 extracted from molasses and obtained by removing coloring components 0 1 (4) Dipotassium glycyrrhizinate 0.5 (5) Dulce extract 0.2 (6) Fragrance 0.1 (7) Purified water 79.1 Production method: The components of (1) to (6) are replaced with (7) And then uniformly mix and dissolve.

In Examples 13 to 29 of the present invention, the effects of improving skin irritation and pigmentation symptoms were examined.
For skin irritation, a 48-hour obstruction sticking test was performed by 20 male panelists, and the results were determined according to the criterion shown in Table 7, and indicated by the average value of the skin irritation index of 20 persons. The jelly-like peel-off pack of Example 24 was closed 20 minutes after the coating was peeled off, and the face wash of Example 26 was evaluated with a 1% by weight aqueous solution. The improvement effect of the pigmentation symptoms was obtained by grouping 10 female panelers who had remarkable pigmentation symptoms such as spots and freckles, using each of the examples twice a day blindly for one month. The state of pigmentation of the skin after months was observed, and the improvement effect was shown by the number of panelists who were evaluated to have an improvement effect compared to before use. Table 8 shows the results of the effects of improving skin irritation and pigmentation symptoms.

[0073]

[Table 7]

[0074]

[Table 8]

As shown in Table 8, the examples of the present invention showed no skin irritation, good safety, and an excellent effect of improving pigmentation.

[0076]

Industrial Applicability As described in detail above, the present invention synergistically enhances the melanin production inhibitory effect, is effective in preventing and improving pigmentation, spots, freckles, spots, etc. after tanning. An external preparation for skin with significantly improved whitening effect was obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 R 7/021 7/021 7/48 7/48 7/50 7/50 31/05 31/05 31/122 31/122 31/19 31/19 31/194 31/194 31/198 31/198 31/375 31/375 31/7008 31/7008 35/50 35/50 35 / 78 35/78 CE QT JZ 35/80 35/80 Z A61P 17/00 A61P 17/00 43/00 105 43/00 105 F term (reference) 4C083 AA032 AA071 AA072 AA081 AA082 AA111 AA112 AB032 AB232 AB242 AB442 AC012 AC022 AC072 AC102 AC122 AC182 AC242 AC302 AC352 AC422 AC442 AC482 AC542 AC782 AC792 AD092 AD112 AD202 AD262 AD272 AD282 AD512 AD532 AD552 AD641 AD642 AD662 CC04 CC05 CC07 CC11 CC12 CC23 DD22 DD23 DD27 DD33 DD41 EE06 EE10 EE12 A04 MA02 MA MA09 MA63 NA05 NA06 ZA89 ZB21 ZC75 4C087 AA01 AA02 BB22 BB58 MA63 NA0 5 NA06 ZA89 ZB21 ZC75 4C088 AA13 AB12 AB26 AB29 AB38 AB43 AB44 AB45 AB60 AB66 MA63 NA05 NA06 ZA89 ZB21 ZC75 4C206 AA01 AA02 CA19 CB21 DA07 FA53 MA02 MA04 MA83 NA05 NA06 ZA89 ZB21 ZC75

Claims (2)

[Claims] 1. L-ascorbic acid and its salts or derivatives thereof, hinokitiol and its derivatives, 2-hydroxycarboxylic acid and its salts or its derivatives, hydroquinone and its derivatives, cysteine and its derivatives, excluding ascorbic acid glycosides, 1 selected from glucosamine and its derivatives, azelaic acid and its derivatives, placental extracts, plant and algal extracts having a melanin production inhibitory action
An external preparation for skin, comprising a seed or two or more kinds thereof and an extract extracted from molasses and obtained by removing a coloring component. 2. A plant or algal extract having a melanin production inhibitory action, wherein said extract is selected from the group consisting of witch hazel, saxifrage genus, giant genus, camellia genus, cinnamon genus, genus genus, genus serrata, genus genus genus, artemisia genus, yarrow genus, Plants of the genus Bulbulina, linden genus, hypericum, genus Genus genus, ginkgo genus, gampi, mitsumata, licorice genus, genus genus, genus genus moss, and genus spp.
It is one or more species selected from the group consisting of extracts from algae of the genus Artemisia, Aphididae, Hijiki, Sozo, Fusunipa, Ichihige, Darus, Hondawara, Ishimozuku. 2. The external preparation for skin according to 1.