JP2006213610A - Trypsin inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a new trypsin inhibitor regarding to the trypsin inhibitor containing specific plant extracts. <P>SOLUTION: This trypsin inhibitor contains 1 kind or ≥2 kinds of extracts of plants selected from Magnolia obovata Thunb, Scutellaria baicalensis Georgi, Artemisia montana Pamp, Aloe arboresens Mill, Perilla frutescens L., Lavendula angustifolia Mill, Potentilla tormentilla Schrank, Filipendula ulmaria L., Maxim, Rosa carina L., Epipactis papillosa Franch et. al., or Cephalanthera longibracteata Blume, Althaea officialis L. Batsch, Prunus persica L. Batsch, Swertia japonica (Schult) Makino and Astragalus sinicus L. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a trypsin inhibitor containing a specific plant extract.

Trypsin, a kind of serine protease that is a proteolytic enzyme, causes acute or chronic pancreatic inflammation and thrombus formation (Patent Document 1). Furthermore, since this enzyme is also contained in the excrement of animals including humans, it is known that it may cause rashes, skin irritation, or diaper rashes in the area around the anus and colostomy. (Non-Patent Documents 1 and 2). Therefore, it is conceivable to use a trypsin inhibitor as one method for effectively preventing or ameliorating pancreatic inflammation, thrombus formation, skin inflammation, diaper rash, etc. in the region around the excretory organ.
Japanese Patent Laid-Open No. 5-85934 Meyer Hoffert Ulf et al., Trypsin induces epidermal proliferation and inflammation in murine skin, Experimental Dermatology, 13, 234-241 (2004) Toru Takahashi, Jun Sugiura, Inhibitory effect on enzymes involved in diaper rash of eucalyptus extract, Abstracts of the 122nd Annual Meeting of the Pharmaceutical Society of Japan, 111

  The problem to be solved is to provide a novel trypsin inhibitor.

  The inventor of the present invention has an excellent trypsin inhibitory action on a plant extract selected from honoki, koganebana, mugwort, aloe, perilla, lavender, tormentilla, psyllium, rose, orchid, belude mallow, peach, symbion and genge As a result, the present inventors have completed the trypsin inhibitor useful for the prevention or improvement of pancreatic inflammation, thrombus formation, skin inflammation and diaper rash in the region around the excretory organ according to the present invention.

  That is, the present invention provides an extract of one or two or more kinds of plants selected from honoki, koganebana, mugwort, aloe, perilla, lavender, tormentilla, psyllium, wild rose, orchid, bellow duck, peach, assembly and genge. Containing trypsin inhibitors are provided.

  The trypsin inhibitor containing a specific plant extract according to the present invention has an excellent trypsin inhibitory action and is effective for pancreatic inflammation, thrombus formation, skin inflammation and diaper rash in the surrounding area of excretory organs, etc. It is a drug that can be prevented or improved.

  The honoki extract used in the present invention is a leaf, rhizome, bark, seed or flower, preferably bark (herbal medicine name: Koboku), extracted from a magnoliaceae, Magnolia obovata Thunb. It is obtained. Leaves, rhizomes, bark, seeds or florets are preferably cut or crushed appropriately.

  The extract of Scutellaria used in the present invention is obtained by extracting a root (herbal medicine name: Ogon), leaves, seeds, flower buds or bark, preferably a root of a scorpionaceae genus Scutellaria baicalensis Georgi using a solvent. It is what was done. Roots, leaves, seeds, flower buds or bark are preferably appropriately cut or crushed.

  Artemisia extract used in the present invention refers to leaves, stems, roots, seeds or florets, preferably leaves, extracted using a solvent, Artemisia princeps Pamp. Or Artemisia montana Pamp. It was obtained. Leaves, stems, roots, seeds or florets are preferably cut or crushed appropriately.

  The aloe extract used in the present invention is a leaf, flower, seed or root of a lily family Aloe genus Cape Aloe (Aloe ferox Mill. Or Aloe africana Mill., Aloe spicata Baker. The leaves are obtained by extracting with a solvent. It is preferable to use leaves, flowers, seeds or roots that have been appropriately cut or ground.

  The perilla extract used in the present invention is a leaf, flower, stem, seed or perilla frutescens (L.) Britton var. Acuta Kudo or P. frutescens (L.) Britton var. Crispa Decne. Roots, preferably leaves, are obtained by extraction with a solvent. It is preferable to use leaves, flowers, stems, seeds or roots that have been appropriately cut or ground.

  The lavender extract used in the present invention is obtained by extracting leaves, flowers, stems, seeds or roots, preferably flowers, using a solvent, with a lavender family lavender (Lavandula angustifolia Mill. Or L. latifolia Mill.). It is a thing. It is preferable to use leaves, flowers, stems, seeds or roots that have been appropriately cut or ground.

  The tormentilla extract used in the present invention is obtained by extracting a flower, leaf, stem, seed or root, preferably a rhizome, of a rose family Potentilla tormentilla Schrank using a solvent. Flowers, leaves, stems, seeds or roots are preferably cut or pulverized appropriately.

  The extract of the sunflower primrose used in the present invention is an extract of flowers, leaves, stems, seeds or roots, preferably inflorescences of Filipendula ulmaria (L.) Maxim. Using a solvent. It was obtained. Flowers, leaves, stems, seeds or roots are preferably cut or pulverized appropriately.

  The rose extract used in the present invention is a flower, leaf, stem, root, seed or fruit, preferably a fruit, preferably a fruit, extracted using a solvent. It is obtained. Flowers, leaves, stems, roots, seeds or fruits are preferably cut or crushed appropriately.

  The orchid extract used in the present invention includes Aozu orchid (Epipactis papillosa Franch et Savat.), Sakaneran (Neottia nidusavis (L.) LCRich. Var. Manshurica Komar. (L.) Soo) is obtained by extracting flowers, seeds, leaves, stems or roots, preferably roots, with a solvent. The flowers, seeds, leaves, stems or roots are preferably cut or pulverized appropriately.

  The bellows oyster extract used in the present invention is obtained by extracting a flower, leaf, stem, root, or seed, preferably a root, using a solvent in a mallow family, Althaea officinalis L. It is. Flowers, leaves, stems, roots or seeds are preferably cut or crushed appropriately.

  The peach extract used in the present invention is an extract of flowers, leaves, seeds, fruits, bark or roots, preferably leaves or seeds, of a rose family Prunus persica (L.) Batsch using a solvent. It was obtained. Flowers, leaves, seeds, fruits, bark or roots are preferably cut or crushed appropriately.

  The assembly extract used in the present invention is obtained by extracting flowers, leaves, stems, seeds or roots, preferably whole plants, using a solvent, in the genus Genus Genus (Swertia japonica (Schult.) Makino). It is a thing. Flowers, leaves, stems, seeds or roots are preferably cut or pulverized appropriately.

  The genus extract used in the present invention is obtained by extracting flowers, leaves, stems, seeds or roots, preferably whole grasses and seeds, of a leguminous genera (Astragalus sinicus L.) using a solvent. Is. Flowers, leaves, stems, seeds or roots are preferably cut or pulverized appropriately.

  Solvents used in the production of the specific plant extract used in the present invention include water, lower alcohols such as ethanol, propyl alcohol, isopropyl alcohol, butanol and isobutanol, propylene glycol, 1,3-butylene glycol, 1,2 -Butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, Low polarities such as polyhydric alcohols such as polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc. Solvent, acid (hydrochloric acid, sulfur , Nitric acid, phosphoric acid, formic acid, an alkali (sodium hydroxide) and acetic acid, potassium hydroxide, calcium hydroxide, one or two or more single solvents or mixed solvents thereof selected from ammonia, etc.) or the like.

In producing a specific plant extract used in the present invention, the extraction condition can be arbitrarily set as long as the extraction temperature is not less than the freezing point and not more than the boiling point of the solvent to be used, specifically −4 ° C. To 150 ° C. Further, the pressure applied for extraction is appropriately set within the range of 1.0 to 2.5 kg / cm ² . In addition, the weight ratio of the solvent to the raw material plant can be arbitrarily set within the range of 4: 1 to 1: 100 of the raw material: solvent, but the weight ratio of 1: 5 to 1:20 is particularly preferable. Is preferred. The extraction time is not particularly limited except for an extremely short time such as within one hour, and is in the range of several days to several weeks.

  As the specific plant extract used in the present invention, it is possible to use a further purified extract obtained from the above-mentioned solvent and extraction conditions. Specific purification methods include filtration methods using filter paper, filter aids, membrane filters, etc., liquid separation operation methods, distillation methods, sublimation methods, precipitation methods, recrystallization methods, centrifugal separation methods, and vacuum concentration methods. , PH adjustment, salting out and the like, and one or more of these methods are selected.

  As the trypsin inhibitor of the present invention, the above-mentioned specific plant extract can be used as it is, water, alcohols, polyhydric alcohols, surfactants, acids, alkalis, thickeners, excipients. A trypsin inhibitor can be prepared by appropriately adding a preservative or the like to the plant extract. As content of the specific plant extract in the said trypsin inhibitor, it is at least 0.0001 mass% or more, Preferably it is 0.01-80.0 mass%, Most preferably, it is the range of 1.0-50.0 mass%. Examples of the dosage form of the trypsin inhibitor include liquid, solid, powder, granule, pellet, gel, mucous, mousse, etc., and further impregnated with a suitable carrier such as a wet tissue. Are used in the same way.

  The trypsin inhibitor of the present invention is used for pharmaceuticals for oral administration or parenteral administration, as well as external medicines such as ointments, lotions, creams, emulsions, quasi-drugs, cleaning cosmetics, wet tissue for baby wipes, and baby It can be blended and used as an active ingredient in foods represented by powders, sanitary sheets, care sheets, and health foods. The amount of the trypsin inhibitor may be at least 0.001% by mass or more, preferably 0.1 to 75.0% by mass.

  In addition to the aforementioned trypsin inhibitor, which is an essential component, it is exemplified in the following for orally administered or parenterally administered pharmaceuticals, topical pharmaceuticals, quasi drugs, cleaning cosmetics and foods containing the trypsin inhibitor of the present invention. A variety of functionalities can be obtained by optionally using formulation-adjusting ingredients such as film-forming agents, physiologically active ingredients, colorants, surfactants, fragrances, excipients, preservatives, and antibacterial agents as additives. An excellent formulation can be constructed. The content of the components and additives in various preparations is generally used in a concentration range of 0.0001 to 50% by mass. The following components or additives may be added in advance during the production process of the preparation or may be added during the production, and may be appropriately selected in consideration of workability.

  The film-forming agent used in the present invention can be arbitrarily selected as long as it is a compound having a property of forming a normal film. For example, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange Rafah oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, kukui nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor Oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (cured oil, etc. ) Etc., beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, can Waxes such as lira wax, montan wax, shellac wax, rice wax, mineral oils such as liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid , Linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin fatty acid and other natural fatty acids, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methyl Fatty acids such as synthetic fatty acids such as pentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

  Polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivative, Dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified polymer silicone, organopolysiloxane, methylphenylpolysiloxane, polysiloxane , Poly (N-acylalkylenimine) modified silicone, dimethylpolysiloxane, methylphenylpolysiloxane, nitrogen-containing Kuryl-silicone graft copolymer, decamethylcyclopentasiloxane, fluorine-substituted alkyl-modified silicone, organopolysiloxanylsilylalkyl-modified silicone, tricyclic diterpenecarboxylic acid-modified silicone, trifluoroalkyl-modified silicone, divinylpolydimethyl Siloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, Octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, tetramethyltetraphenylteto Cyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy-modified polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethyl Examples thereof include silicone compounds such as aminopropylsiloxane / dimethylsiloxane copolymer and eugenol-modified silicone.

  The physiologically active ingredient used in the present invention can be arbitrarily selected as long as it is a compound or extract having any useful physiological activity for a living body. For example, p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfone Amide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acid derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazole- 4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl -2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] potassium aminobutanoate Salt), benzo Riazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, ascorbic acid or salts thereof and derivatives thereof (phosphate-L-ascorbine) Magnesium sulfate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyproline phosphate ascorbate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, sodium salt of L-ascorbic acid phosphate, phosphorus L-ascorbate Acid ester potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium Umum salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid Potassium salt, magnesium L-ascorbate, calcium L-ascorbate, aluminum L-ascorbate, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D- Galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt Salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbyl phosphate Acid ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid Phosphoric acid ester barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbic acid phosphate diethanolamine salt, 6-o -Alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphorus Acid ester triisopropanolamine salt , 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate cholesterol ester, palmitic acid-L-ascorbyl, isopalmitic acid-L- Ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid- L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl , Oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-mal Triosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L -Ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbic acid tetra-2-ethylhexanoate, L-ascorbic acid tetraoleate, 5,6-isopropyl Reden-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmi Tate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbi Caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphate diester, ascorbic acid inositol binding derivative Ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.).

  Tocopherol or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate ester , Tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-toco Ferryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α- Tocopheryl maltoside, D- β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L -α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6-yloxy) propan-2-ol, 1- (carboxypropylamino) ) -3- (α-Tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] cysteine, S- [ 3- (α-Tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamyl system Nilglycine, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid Etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.) Acid or its derivatives (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoyloxymethyl-5-hydroxy-4H- Pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5- Roxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate , Kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.).

  Oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or a salt thereof and derivatives thereof, baicalein or a salt thereof and derivatives thereof, berberine or a salt thereof and derivatives thereof, chrysin or a salt thereof and derivatives thereof, apigenin or a salt thereof and them Derivatives, luteolin or salts thereof and derivatives thereof, acacetin or salts thereof and derivatives thereof, diosmethine or salts thereof and derivatives thereof, kaempferol or salts thereof and derivatives thereof, trifolin or salts thereof and derivatives thereof, astra Galine or a salt thereof and derivatives thereof, quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof , Rutin or a salt thereof and derivatives thereof, morin or a salt thereof and derivatives thereof, myricetin or a salt thereof and derivatives thereof, myristitrin or a salt thereof and derivatives thereof, datiscetin or a salt thereof and derivatives thereof, quercetagetin or a derivative thereof Salts and derivatives thereof, isorhamnetin or salts thereof and derivatives thereof, pinocembrin or salts thereof and derivatives thereof, naringenin or salts thereof and derivatives thereof, hesperetin or salts thereof and derivatives thereof, eriodictyol or salts thereof and the like Derivatives, pinobankin or salts thereof and derivatives thereof, aromadendrine or salts thereof and derivatives thereof, engelitin or salts thereof and derivatives thereof, taxofolin or salts thereof and derivatives thereof , Astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and derivatives thereof, glutathione or a salt thereof and derivatives thereof, isoflavone glycoside (6-o-apiosylpuerarin-4′-o-glucoside, 6- o-glucosyl puerarin, 3'-hydroxypuerarin-4'-o-glucoside, 6-o-apiocil-3'-hydroxypuerarin), γ-pyrone glycosides (maltol-3-o- (6'-o -Apiosyl) -glucoside, maltol-3-o- (6'-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or a salt thereof and derivatives thereof (5,4-dimethylellagic acid, 3, 3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid , Amritoside, etc.), Lucinol, Ondisaponi , Bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy-N- (2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) Benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl- 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (2-hydroxyphenyl) benzamide, etc.), diphenylpyrine, cyproheptadine, triprolidine, dimethindene, Ozagrel, isothipentyl, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury Sakurorofen, mercuric oxide, mercurous chloride, hydrogen peroxide, zinc peroxide, placenta (bovine, porcine, equine, ovine, etc.) extract.

  Hydroquinone or its salts and derivatives thereof (hydroquinone α-D-glucose, hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose , Hexose sugar glycosides such as hydroquinone α-L-galactose, hydroquinone β-L-galactose, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose , 5-quinone glycosides such as hydroquinone α-D-arabinose, hydroquinone β-D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine , Hydroquinone α-L-glucosamine, Hydroquinone β-L- Amino sugar glycosides such as lucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D- Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturonic acid Hydroquinone glycosides such as uronic acid glycosides, hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyl Oxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) ) Hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 2-β -Hydroquinone hydroxyalkyl ether glycosides such as -D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol).

  Isonitrile antibiotics such as isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitric acid F, dermadein, tricobilidein, etc. Acid, p-geranylorceric acid ethyl ester geranylorcinol, p-farnesylorceric acid, p-farnesylorceric acid ethylester farnesylorcinol, p-dodecanylorceric acid, p-dodecanylorceric acid ethylester Dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethyl ester tetradecanylorcinol, p-hexadecanylorceric acid, p-hexadecanylorceric acid ethyl ester hexa De Nylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tridecanylorceric acid ethyl ester undecanylo Lucinol, p-pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorserine Acid, p-cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, blef Erdin, oxydesveratrol, resorcinol derivative (4-cyclohexylresorcinol), 3-hydroxyketone compound (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o , P-dihydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compounds (1,5-bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxy) Phenyl-m-methoxyphenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ -Aminobutyric acid oleyl ester, etc.), lucinol.

  Lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2-heptylchromone, 2-nonylchromone, 2- Hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone, 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone, 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy-2-pentadecylchromone, 7-hydroxy-2- (1-ethylpentyl) Chromone), azelaic acid derivatives (azelaic acid monoalkyl ester, azelaic acid dialkyl ester, etc.), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D-malto Pyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3- (1-naphthyl) alanine, DL-N-propionyl-3- (1- Naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL -N-Isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (3-methylvaleryl) -3- (1-naphthyl) Alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1- (Futyl) alanine, DL-N-pivaloyl-3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1 -Naphthyl) alanine, DL-N- (2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- ( 1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N-undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) Alanine, DL-N-tetradecanoyl-3- (1-naphthyl) alanine, DL-N-pentadecanoyl-3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-Heptadecanoyl-3- (1-naphthyl) alanine, DL -N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) alanine, DL- N-Acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N-vinylacetyl- 3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL-N- ( 4-Pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- (1-naphthyl) Alanine, DL-N- (2-Methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10 -Undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydride Xylacetyl-3- (1-naphthyl) alanine, DL-N- (6-hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) ) Alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- ( 11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) ) Alanine, DL-N- (2-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4- Hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) -3- (1-naphthyl) alanine, DL-N- (m-toluyl) -3- (1-naphthyl) alanine DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL-N- (1-naphthyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl)- 3- (1-Naphtyl) alanine, DL-N- (4-Carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (2-Picolyloyl) -3- (1-naphthyl) alanine, DL- N- (3-Picoliloyl) -3- (1-naphthyl) alanine, DL-N- (4-Picolyloyl) -3- (1-naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) Alanine, DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4 -Methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanineamide, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ester Tyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N -(4-Methylvaleryl) -3- (1-naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3 -(1-naphthyl) alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.).

  Benzolactam derivatives, indolactam derivatives, cedrol, guaiool, 1- (4-hydroxyphenthio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5 -N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxyphenol, 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2 -Methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol, 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxy Phenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy-5- (1-methylhexyl) phenol, 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methyl Xylphenol, malvelin, feruginol, sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4 -Pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1, 4-pentadien-3-one, haginin, agrimofor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, caramenenes (caramenene, 7-hydroxycaramenene) , 5-hydroxycaramenene, 7-methoxycaramenene, etc.), trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L- Al Guinine ethyl ester, 5-methyl-2 (3H) -furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formyl Furan, 3-formylfuran, methyl α-furyl ketone, furfuryl acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-imino Dibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride, chlorimipramine, trimipramine, etc.), dibenzocycloheptadienes (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxipetitin, etc.), Torahydrocoparol glycoside (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydromanur, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocopalol maltoside , Tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiroether compound, piochelin, phenothiazine compound, promethazine, alimemazine, alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate.

  4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy ) Benzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl- 1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4 -(10-carboxydecane-1-oxy) -2-hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid Acid, 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetic acid) Xylbutyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2- Hydroxybenzoic acid, 4- (4-methoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy- 2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxy Propyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid 4- (4-hydroxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid Hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -1-butene 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3-hydroxy- 5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl- 5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3-pentene, 3 -Methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1- Yl-cyclohexane) -2-pe Nthene, 2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane etc. monosaccharide, disaccharide or trisaccharide glycoside), escinol, parahydroxycinnamic acid-4- ( 2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin.

  4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto- 3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxyphenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp -Hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p- Hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydride) Xylbenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenyl Glycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp-methoxyphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenyl Glycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenylglycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert- Butoxycarbonyl-Lp-hydroxyl Nilglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxy Carbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine benzyl ester hydrochloride, N-9- Fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycine amide, Lp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine Allyl ester p-to Ensulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp -Hydroxyphenyl glycine ethyl ester hydrochloride, Dp-hydroxyphenyl glycine ethyl ester hydrochloride, Lp-hydroxyphenyl glycine methyl ester, Dp-hydroxyphenyl glycine methyl ester, 1,3-diallyl indan-2-carboxylic acids, stachybosine Pheophorbide derivatives.

  Eleucerin, isoeleucerine or 4-β-hydroxyisoeleucerin, eleucerinol, spiroketal derivative (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2 -Hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene ) -6,6-Dioxaspiro [4.5] dec-3-ene, 2- (2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] Nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4] nonane, 2- (2-hexynyl) -1,6-dioxaspiro [4.4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] Nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1, 6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-hexyl-1,6-dioxaspiro [4.4] nonane, 3, 4-Benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] nonane, 2- (2,4-hexadiynylidene)- 1,6-dioxaspiro [4.4] non-3-ene etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmine, aminophosphonic acid derivative or salt thereof, diphenhydramine or salt thereof, pregnenolone or derivative thereof, lutein , Farnesyl isopropanol derivative, hexahydrofarnesyl acetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2 -Hydroxy Benzoic acid, 5- (1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid 4- (1-naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl 2-hydroxybenzoic acid, 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid 4- (2-naphthylaminocarbonyl) benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative , Borneol-p- Droxycinnamate glucoside, Borneol-p-hydroxycinnamate maltoside, Borneol-p-hydroxycinnamate maltotrioside, Cinnamic acid-4- (2,2,6-Trimethyl-yl-cyclohexane)- 2-Butyl ester derivative.

  2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2', 4 ' -Dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- (2,4-dihydroxyphenyl) -1- Hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxyphenyl) -1-nonanone, 1- ( 2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1-dodecanone, 1- (2,4-dihydroxy Phenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-oct Tadecanone, 1- (2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy -4'-methoxypropiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4-methoxyphenyl) -1-pentanone, 1- (2-hydroxy -4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octanone, 1- (2- Hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy-4-methoxyphenyl) -1-undecanone, 1- (2 -Hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2-hydroxy-4-methoxy) Phenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2′-methoxyacetophenone) 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4′-hydroxy-2′-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ′, 4 ′ -Dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropiophenone), lactone derivative (1,6-dioxaspiro [4.4] nonane-2,7-dione 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5 -Undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide , 2-undecen-4-olide, 2-decene-4-olide, 2-nonen-4-olide, 2-hepten-4-olide, 2-undecen-5-olide, 2-decene-5-olide, 2 -Nonene-5-olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-decanolide, 4-methyl-4-nonanolide, 4-methyl -4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl- 4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5-undecanolide, 2 -Methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-metho Cycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl -4-undecanolide, 2-methyl-4-nonanolide, 2- (4-hydroxybutyl) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5- Decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6 -Allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide, 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7- Methyl aloesol coumaroyl ester, 2'-8-C -Glucosyl-7-methyl aloesol cinnamoyl ester, chloropyramine.

  Salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, amentoflavone, ethylene oxide, ethylene glycol, diethylene glycol, Triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, propylene oxide, propylene glycol, 1,3-butylene glycol, pentyl glycol, glycerin, erythritol, pentaerythritol, dipentaerythritol , Threitol, arabitol, xylitol, ribitol Polyhydric alcohols such as galactitol, sorbitol, mannitol, lactitol, maltitol, cytilitol, laminitol, valienamine, valididamine, and validatol, glucose, galactose, mannose, xylose, fructose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, cordobiose Laminaribiose, nigerose, cellobiose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythronolactone, micalose, cladinose, Axenose, Alkanose, Olivomai Course, Chromose, Ebami Course, Vinerose, Noga Saccharides such as glucose, bilenose, nobiose, moenuronic acid, galosamine, cibirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacarcinose, aldogalose, blastminosin , Trehalose or derivatives thereof, D-mannosamine and derivatives thereof, primeverose or derivatives thereof.

  Sodium lactate, hydantoin and its derivatives, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyl Oxyethyl methacrylate, galactosyloxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl- β-D-glucuronopyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D- Glucopyranosyl-β-D-glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dip Sogenic acid, 3-o- [α-L-rhamnopyranosyl-β-D-glucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β- D-glucuronopyranosyl] -29-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol and the like.

  Retinol or a salt thereof and a derivative thereof (retinyl unsaturated fatty acid ester such as retinyl linoleate, retinyl linolenate, retinyl oleate, and retinyl arachidonic acid), retinal or a salt thereof and a derivative thereof, dehydroretinal or a salt thereof and the like Derivatives thereof, retinoic acid or salts thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[ 8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[ 8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[[8- (3,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4- [ [[8- (2,4-dimethylphenol L) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethyl) Phenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxy Phenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-) Naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogue (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino ] Carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5 -Zimechi -8-phenyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4- [[(5,6-dihydro-5,5,8-trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl -8-phenyl-2-naphthalenyl) -1-propenyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4 -[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl-2- (naphthalenyl) carbonyl] oxy] benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluorophenyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4 -[[(5,6-Dihydro-5,5,6-trimethyl] -8-phenyl-2- (naphth Talenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-( 5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2 -Naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[(5 6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl ] Thiocarbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] methyl] benzoic acid, 4-[[[((5 , 6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] an Benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro- 5,5-Dimethyl-8- (2,4-dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5-6-dihydro-5,5-dimethyl-8- ( 4-methylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4 -[[[((5,6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl- 8-Phenyl) -2-naphthalenyl] methyl] amino] benzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thiocarbonyl] benzoic acid 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-hydroxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] Amino] -2-nitrobenzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4- [ [[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[((5,6-dihydro-5,5- Dimethyl-8- (2-naphthalene)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-8-phenyl-2-naphthalenyl) carbonyl] aminobenzoic acid, 4- [ [(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3- Luobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[((5,8,10 , 10a-Tetrahydro-10,10-dimethyl-9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino ] Carbonyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-) 1H-Inden-5-yl) vinyl] benzoic acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid).

  Carotene or a salt thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, capsanthin, crocetin and other carotenoids), lycopene or a salt thereof and the like Derivatives, thiamine or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbenchamine, bisbutiamine, thiamine monophosphate disulfide, benfotiamine, chicotiamine, octothiamine, dicetiamine, fursultiamine, prosulfuramine Thiamine, astaxanthin thiamine phosphate diester, etc.), thiamine sulfate, riboflavin or its salts and derivatives thereof (flavin adenine dinucleotide, flavin mononucleotide, ribophine) Vinphosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1-β-D-ribofuranosylnicotinic acid, etc.), pyridoxine or its salts and derivatives thereof (pyridoxine 3,4-dipalmitate) , 3,4-dicaprylic acid pyridoxine, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, cyanocobalamin or a salt thereof and derivatives thereof, cobalamines (methylcobalamin, adenosyl) Cobalamin, hydroxocobalamin, aquacobalamin etc.), folic acid or its salts and derivatives thereof, nicotinic acid or its salts and derivatives thereof, pantothenic acid or its salts and derivatives thereof, biotin or its salts and their derivatives, choline or Its salt and These derivatives, inositol, or salts thereof and derivatives thereof.

  Ergocalciferol or salts thereof and derivatives thereof, cholecalciferol and salts thereof and derivatives thereof (1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1-methyl) -2-cyclopenten-4-yl-oxy]- 23, 24, 25, 26 27-pentanorcholecalciferol etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, menadiol or Salts thereof and derivatives thereof, carnitine or salts thereof and derivatives thereof, ferulic acid or salts thereof and derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orotic acid or salts thereof and derivatives thereof, rutin or salts thereof Salts and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salts thereof and derivatives thereof, adenylthiomethylpentose or salts thereof Their derivatives, methyl methionine sulfonium chloride or a derivative thereof.

  Valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine Or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino-1-oxododecyl) -L-histidine, N -2-Ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β-alanyl-L-histidine, N-dodecylamino Carbonyl-β-alanyl-L-histidine N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) and their sulfates, phosphates, nitrates, citrates, or pyrrolidones Amino acids such as amino acid derivatives such as carboxylic acids, glycolic acid, citric acid, malic acid, tartaric acid, α-hydroxy acids such as lactic acid and succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2- Hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristine Acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-hydroxyarachidonic acid, cerebronic acid, α-hydroxyne Boronic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) -2-hydroxyethanoic acid, 2- (3 '-Hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-methoxyphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2- Hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'-dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid , Xylonic acid, lyxonic acid, aronic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, taronic acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic Or hydroxypolycarboxylic acids (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone, pantoyl lactone, glucoheptonolactone, mannonolactone, galactoheptonolactone, etc.) 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformate, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid, 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate, etc.), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid, cerebronic acid, citramalic acid , Agaricic acid, alloy Acid, pantoic acid, lactobionic acid, hexrosonic acid, photosensitizer 301, allantoin, pentadecanoic acid glyceride, estradiol, etenyl estradiol, antialol or its glycoside, rioniresinol or its glycoside, rhododendrol or its coordination Glycosides, platifironol or glycosides thereof.

  Lactone compounds (D-glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone , Γ-D-galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic Lactone, γ-octanoic lactone, nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lactone, stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or derivatives thereof, 6-benzylaminopurine or derivatives thereof, 1,4-diazadicyclo Kutan, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril, aracepril, lisinopril, enalapril, delapril, benazepril , Cilazapril, Imidapril, Quinapril, Trendapril, Perindopril, Temocapril, Losartan, Endothelin, Galactomannan saccharide polymer, Mucin, Trimethylglycine, Proteoglycan, Lactic acid bacteria extract, Lactic acid bacteria culture extract, Lactic acid bacteria fermented milk extract, Bifidobacteria extract, Bifidobacteria Culture fluid extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture fluid extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus Nutrient solution extract, Basidiomycetes extract, basidiomycetes culture extract, bacterial cell disruption extract, bacterial culture extract, cultured human dermal cell rupture extract.

  Benzochroman derivative, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, propyl gallate, sesamol, sesamolin, gossypol, maritimaine, sulfretin, xanthene-2, 7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, astaxanthin, etc.), phlorotannins, superoxide dismutase Catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof and derivatives thereof, Curcumin or a salt thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′- o-β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, sphingosine chlorogenic acid Esters and derivatives thereof, chlorogenic acid glycolipid esters, chlorogenic acid sugar esters, chlorogenic acid sterol esters, thiazole derivatives or salts thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) ) Thiazole, 2- (3,4-diethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxy Phenyl) thiazole,), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives.

  Phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxyethylamino) Phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxyphylline, oxtriphyrin, etc.), benzophenone Derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sulfonic acid Sodium, 2,4-dihydroxybenzo Phenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivative (1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl -3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxy) Cinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxy Benzene, 1- (2- (6- (4-hydroxy-3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxy Cybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3, 4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3-xylosyl) glucosyl) Ethyl-3,4-dihydroxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydro Cybenzene, 1- (2- (3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3- (4-dihydroxycinnamoyl) glucosyl) Ethyl) -3,4-dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, etc.).

  Paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, Octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (Urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, Camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocarbine, triazine derivatives (4,4'4 "-(1 , 3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidyl chromanol derivatives (1,2-dilaurylglycero-3-phospho-2'-hydroxy Methyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxy Chroman, 1,2-distearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-diarachidonylglycero- 3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl- 2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8 '-Tetramethyl-6'-hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman 1-palmitoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetra Til-6′-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2′-hydroxymethyl-2 ′, 5 ′, 7 ′, 8′-tetramethyl-6′-hydroxychroman, 1- Stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman), L-carnosine zinc complex, umbelliferone, Esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, thorisobenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin .

  Zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hamamelitannin, acertannin, tetragalloyl glucose, pentagalloyl glucose, hexa Gallotannins such as galloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, Elazitannins such as peduncragin, geraniin, isotarkevin, granatin A, granatin B, ketulinic acid, quebragic acid, casuarinin, nuphalin, procyanidin B-2, thiacinensin A, thiacinensin B ), Quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropylpiperazine derivatives, carxin compounds, chromanol glycosides (2- (α- D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d-camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid , Hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives.

  Glycyrrhizic acid or a salt thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α-glycyrrhizinate trisodium, α-glycyrrhizinate monopotassium Dipotassium glycyrrhizinate, α-glycyrrhizinate monoammonium, β-glycyrrhizinate trisodium, β-glycyrrhizinate monopotassium, β-glycyrrhizinate dipotassium, β-glycyrrhizinate monoammonium, etc.), glycyrrhetinic acid or salts thereof and derivatives thereof ( α-glycyrrhetinic acid, β-glycyrrhetinic acid, α-glycyrrhetinic acid stearyl, β-glycyrrhetinic acid stearyl, α-glycyrrhetinic acid pyridoxine, β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycylretinoic acid Glyceryl tyrrhetate, disodium 3-succinyloxyglycyrrhetinate, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, pantothenic acid calcium, pantothenyl ethyl ether and the like, and their derivatives, and derivatives thereof, Aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxy Carbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethyl Chlohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate ammonium, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate potassium, trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Gnesium, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) Cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p- Methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate sodium, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexane Potassium tetracarboxylate, calcium trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, magnesium trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- ( p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolamine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylic acid Acid, sodium trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate Trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2 -Trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate potassium, trans-4- (pyridine-4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) ) Potassium cyclohexanecarboxylate, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate calcium, etc.), sulfatide.

  Astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin dipalmitate, astaxanthin dipalmitoleate, astaxanthin diheptadecanoate, astaxanthin dielaidate, astaxanthin Diricinoleic acid ester, astaxanthin petrothelinic acid ester, astaxanthin vaccenic acid ester, astaxanthin eleostearic acid ester, astaxanthin punicic acid ester, astaxanthin licanoic acid ester, astaxanthin parinaric acid ester, astaxanthin gadoric acid ester, astaxanthin 5-eicosene Acid ester Taxanthin 5-docosenoic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin desenic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid ester, astaxanthin Dioleic acid ester, astaxanthin distearic acid ester, astaxanthin dieicosapentaenoic acid ester, astaxanthin didocosahexaenoic acid ester, astaxanthin dilinolenic acid ester, astaxanthin dilinolenic acid ester, astaxanthin diarachidonic acid ester, etc.), astaxanthin diglycerophosphate (astaxanthin) Diglycerophosphate Ter, astaxanthing lyserophosphate palmitic acid, astaxanthing lyserophosphatidylcholine palmitic acid, astaxanthing lyserophosphatidylcholine DHA, astaxanthing lyserophosphatidylinositol palmitic acid, astaxanthing lyserophosphatidylinositol DHA, astaxanthing lysinophosphatidyl oleositol , Astaxanthing lyserophosphatidylcholine linoleic acid, etc.), steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl -2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- (2-ethoxyethyl) ) Benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2- Methyl propanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoate, 1 -(2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl-2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- ( 2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl]- 1H-benzimidazole, 2- [4- (2- (4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, etc.) , An alanine derivative or a salt thereof (N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -L-alanine, N- {3-Isopentyl-4-methyl-2- [4- (3-trifluoromethyl Rubenzamido) benzoylimino] -3H-thiazoline-5-carbonyl} -2-methylalanine, N- {3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H -Thiazoline-5-carbonyl} -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H -Thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid), chlorpheniramine maleate, Diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acid mucopolysaccharide or salt thereof, sulfated dextran or salt thereof.

  Chroman derivatives, pyridoxine or a salt thereof and derivatives thereof, pyridoxal or a salt thereof and derivatives thereof, pyridoxamine or a salt thereof and derivatives thereof, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or a hydrolyzate thereof , Alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salicin powder, iodine compound, iodoform, 1-alkylcarbapenem compound, N-substituted azepane derivative or salt thereof, sorbic acid or salt thereof, propion Acids or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2-keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (quercitol, etc.) ), Inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol methyl ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p -Chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol , Ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylpheno , Elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), amphoteric surfactant, anionic surfactant (lauryl sulfate) Sodium, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride, methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitizer 101 Photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivatives and acid addition salts thereof.

  Cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl isoeugenol, ethyl isoeugenol, salicylic acid eugenol, etc.), minoxidil, capsicum tincture, nonyl acid vanillamide, cantalis tincture, pepper tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ictamol, α-borneol, cyclandelate, nonyl acid valenylamide, capsaicin, gingerone, follicular hormone (estrone, estradiol, ethinyl estradiol, etc.), isoflavone, Oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8-preni Flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenylflavone, nicorandil, cyclosporic acid, carbostyril derivative or salt thereof, dicarboxylic acid (glutaric acid, adipic acid, pimelic acid, suberic acid , Azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative.

  Anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor-5 alpha-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plataquinone, yuglone, shikonin, quinizarin , Alizarin, abietin, levopimar, betulin, α-amylin, catechin compounds (catechin, epigallocaequine, epigallocatechin gallate, epicatechin, epicatechin gallate, catechin rhamnopyranoside catechin, etc.), diisopropyl fluorophosphate, (2R, 6R) -2,6-Dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis [(1S, 2R) -2-hydroxy Indan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R) -2,6-dihydroxy-4- (tert -Butyl dimethyl (Tylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R , 6R) -2,6-Dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1 -Yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2- Hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- Droxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylic acid dimethyl, ( 2S, 6S) -2,6-Dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert- Butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7 -Dicarboxylic acid diamide, N, N'-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7 -Dicarboxylic acid diamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenesulfonylamino] -tetrahydropyran-4-carboxylate hydroxy Amido, 4- [4- (4-Chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxy Carbamoylcyclobutyl) -amino] -propionic acid, 4- (4′-chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1,3-dihydroisoindol-2-yl)- Ethyl] -4-oxobutyric acid, {1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -carbamic acid isopropyl ester, 2- [4- (4- Fluorophenoxy) -benzenesulfonyl Mino] -N-hydroxy-2-methylfuropionamide, 3- [4- (4-fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxyfuropionamide, 3- (4-phenoxybenzenesulfonyl) -7 -Oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methylcarbamoylpropylcarbamoyl) -4- (4'-fluorobiphenyl) -4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropionamide, and N-hydroxy-2- (4-phenylpiperidine -1-sulfonyl) -acetamide.

  Ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3,5,5-trimethylhexyloxy) benzoic acid Methyl, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoate Acid methyl, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5- (3,5,5-trimethylhexyl Methyl oxy) benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, methyl 4-N-hexyloxy-2-hydroxybenzoate, 2-hydroxy-4-N-octyloxybenzoic acid Chill, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4- (3,7-dimethyl-6 -Octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) 2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexylethoxy) -2-hydroxybenzoic acid, 4-N-hexyloxy-2 -Hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-H Roxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2-hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl- 4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, sodium 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 4-{(2E) -3, Methyl 7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, ethyl 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate , 5-{(2E) -3,7dimethyl-2,6-octadienyloxy} -2-hydroxybenzoate, 3-{(2E) -3,7-dimethyl-2,6-octadienyl Ethyl oxy} -2-hydroxybenzoate, ethyl 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoate, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxybenzoate, 4-{(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy} -2-hydroxybenzoic acid methyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid (2E) -3, 7-dimethyl-2,6-octadienyl, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 5-{(2E) -3,7- Dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzoic acid, 3- { (2E) -3,7-dimethyl-2,6-octadienyloxy} -5-hydroxybenzoic acid, 2-hydroxy-4-{(2E, 6E) -3,7,11-trimethyl-2,6 , 10-dodecatrienyloxy} benzoic acid, 4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -3-methoxy Benzoic acid, 2-acetoxy-4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3, 7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4-{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, dimethyl- 2,6-octadienyloxy} benzoic acid, N- (2-hydroxyethyl) -4-{(2E) -3,7-dimethyl-2,6-octadienyloxy} -2-hydroxybenzamide, 4 -{(2E) -3,7-dimethyl-2,6-octadienylamino} -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyl Oxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadecyloxy) benzoic acid, 3- (11-hydroxy Cyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 4-[(2E ) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7-dimethyl-9- (2,6,6- Trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5,7,8-tetramethyl-2- ( 4,8,12-Trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyl Oxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-butenyloxy) benz Amides, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyloxy) Benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6, 10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N-di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6-octa Dienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-octadienyl]] aminobenz Mido, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N, N-diethyl -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide.

  Anacardic acid or its derivatives (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadecatrienylsalicylic acid propyl ether, 6-pentadecatrienylsalicylic acid butyl ether, 6-pentadecatrienylsalicylic acid butyl ether, Enil salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6-pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6 -Pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicylaldehyde propyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2- Tyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6-pentadecatrienyl cinnamic acid, 2-butyl ether-6-pentadeca Trienylcinnamic acid, 2-methyl ether-6-pentadecatrienyl cinnamic alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamic alcohol, 2-propyl ether-6-pentadecatrienyl cinnamic alcohol , 2-butyl ether-6-pentadecatrienyl] cinnamic alcohol, etc.), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xanthothymol, isoxanthothymol, gucciferon, etc.), stilbene derivatives or salts thereof Morgine or a salt thereof and derivatives thereof, N-acetylglucosamine.

  Phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerol, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanolamine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid 2-cysteinyl phosphatidic acid, 1-glutathionyl phosphatidic acid, 2-glutathionyl phosphatidic acid, 1-azelaoyl phosphatidic acid, 2-azelaoyl phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidine Acid, ceramide, glucosylceramide, galactosylceramide, cerebroside, phosphati Luglucosyl acylglycerol, N-oleoyl sphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, sphingomyelin, soy lecithin, egg yolk Lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydroergosterol, phytosterol, 25- Hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ketocholesterol oxime, 6-ketocholesterol and 7-ketocholes Rolls or derivatives thereof), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (galaose, ganglytriose, gangliotetraose, globotetraose, neolactotetraose, neo Lactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyferrin, 3-deazaadenosine, carboxysamide derivatives, inositol polyamines, sialic acid, triterpenic acid Derivatives, lactose, lactosamine derivatives, sulfated chitin derivatives, albumin.

  Tropolone and its derivatives, guanidine, ethanolamine, aminoguanidine, flavanones (naringin, naringenin, naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic acid Acid tannin, tannic acid, geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloylglucose, heptagalloylglucose, tetragalloylglucose, triggerroylglucose, pentagalloylglucose, digalloylquinic acid, triggerroylquinic acid) 2-hydroxyphenylalkylamine derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) Henyl-2,4,6-trienoic acid, 3- (3,5-dimethoxy-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.) Γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β-hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β -Hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester Γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β-hydroxybutyric acid phenyl ester, Roh -β- hydroxybutyrate glycol ester, .gamma.-amino -β- hydroxybutyric acid sorbitol ester, .gamma.-amino -β- hydroxybutyric acid polyoxyethylene glycol ester, .gamma.-amino -β- hydroxybutyric acid glycerin ester, etc.).

  Amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide, myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.) , Alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethylaminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium Betaine), pyrimidine N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidini) L) pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine- 3-oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino -4-allylamino-6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3 -Oxide, 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxide, 2,5-diamino- 4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrodinyl) pyrimidine-3-oxide, 2-amino-4-methyl-5-piperidino -6- (1- Loridinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5-bromo-6- (1-pyrodinyl) pyrimidine-3- Oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6-piperidinopyrimidine-3-oxide, 2-methyl- 4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3-oxide monohydrochloride, 2-acetylamino-4-methyl -6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2 , 4-Diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide 2,4-Diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4-dichlorophenoxy) pyrimidine- 3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2,4-dichlorophenoxy) pyrimidine- 3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, monopentadecanoic acid glyceride sulfate, etc. Glyceride sulfate.

  Monopentadecyl glyceryl ether sulfate, 1-o-hexadecyl-2-o-methyl glycerol, 1-o-octadecyl-2-o-methyl glycerol, 1-o-oleyl-2-o -Methylglycerol, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt, gingerone glycoside, benzeneoxyacetic acid derivative ([5- [2- [1-phenyl-1- (3-pyridyl) Methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid), isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived Proanthocyanidins, purified procyanidin oligomers, procyanidins B-1, procyanidins B-2, procyanidins B-3, procyanidins C-1 ), Phthalazinones, benzoxazinone compounds, phosphonic acid derivatives, cyproterone, 5.alpha.-androstene-3.alpha, 17.beta.-diol, medroxyprogesterone, norethisterone, Mesutanoron.

  Chicken crown extract, bovine, porcine or human placenta extract, porcine or bovine stomach, duodenum, intestine, spleen extract or degradation product thereof, bovine or porcine brain tissue extract, collagen derivatives such as water-soluble collagen, acylated collagen Collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, porcine or bovine blood cell protein degradation product (globin peptide) ), Cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof or derivatives thereof, skim milk powder and degradation products thereof or derivatives thereof, lactoferrin or degradation thereof , Egg component, fish decomposition product, yeast metabolite, yeast extract, bacterial metabolite, bacterial extract, mold Or metabolites such as mushrooms, actinomycete metabolites, extracts such as fungi or mushrooms, actinomycetes extract, natto metabolites, natto extract, rice fermented extract, rice bran (red potato, white birch) fermented extract, euglena extract Or a decomposition product thereof or a water-soluble derivative thereof, a lactic acid fermentation product of raw milk or skim milk powder, trehalose or a derivative thereof, and the like.

  Seawater such as deep sea water, for example, sea salt, dried sea water, dead sea or Atlantic or Pacific sea water (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or mud (fango), for example , Italian fungo, German fungo, Eifelfango, Freiburgfango, etc. Strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), natural products such as marine components such as saintoku stone.

Almond extract, Ammarok extract, Oyster extract, Ovana okera extract, Okera extract, Konfuyo extract, Uncaria extract, Geigicha extract, Gypsophila extract, Licorice extract, Kranigean extract, Wheat (wheat) extract , Rice (rice) extract, Koreaia extract, Sidwaya extract, Sankyu extract, Sanvitro extract, Sunpens extract, Silane (river cucumber) extract, Senkyu (river cucumber) extract, Senna extract, Sempukuka extract, Sentsutsusai extract, Suriga Tin extract, Nodake (former cucumber) extract, pearl barley (yokuinin) extract, hamago extract, honey beetle extract (palm bud) extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry bark) extract, malvano jar (Bitter) Extract, Murasa Kiirisu extract, white-bellied extract, mugwort extract, yashajitsu extract, hongkong extract, bituminous extract, crayfish extract, citrus extract, millipede extract, acacia extract, acerola extract, ichibi (winter position) extract, fern birch extract , Quers extract, chestnut extract, tortoise extract, tomato extract (extended life grass) extract, seri extract, buckwheat extract, dabilia extract, nazuna extract, fujibaka (orchid) extract, chamomile extract, mulberry extract, bitumen extract, watermelon extract Matsuhodo extract, pearl barley extract, cinnamon extract, mango extract, yamaguwa extract, bellflower extract, toshishi extract, splint extract, spray dried extract, maize extract, senkyu extract, dokkatsu extract , Psycho extract, Bowfu extract, Hamaboufu extract, Ogon extract, Peony skin extract, Gennoshoco extract, Kuzune root extract, Licorice extract, Pyrup extract, Shouma extract, Safflower extract, Green tea extract, Black tea extract, Asen drug extract, Anise extract, Itadori ( Tiger cane extract, seaweed extract, shrimp extract, katsume extract (komiko) extract, ogi (yellow cocoon) extract, yellow eagle extract, giant crow (calocon) extract, onamomi (crow's ear) extract, onyogara (natural hemp) extract, oyster Extract, Ginseng Extract, Ginger Extract, Gama (Amber Yellow) Extract, Kansui Extract, Ginseng (Sengakurasaku) Extract, Chromoji Extract, Chrysanthemum Extract, Sisal (Sisal) Extract, Saximar Button Kale Extract, Cinnamon Peel Extract, Cinacenni Saw extract ) Extract, Daimonjisou extract, toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, hakusen extract, dill extract, honeybird extract, sea bream extract, human camellia extract, castor extract Pea extract, floral blanca extract, hamula extract, sagebrush extract, convolvulus extract, sandalwood extract, ganoderma biloba extract, reef moth extract, kawayanagi extract, akameyana Ginkgo extract, Pussy willow extract, Inco lye willow extract, Kinu willow extract, Koryu willow extract, Unryu willow extract, Miyama willow extract, Willow willow extract, Oba willow extract, Tairikinu willow extract, Fox willow extract, Doronoki extract, bayberry (Plum) extract Agave Mid-Autumn, Aonu Agave Extract, Fukurin Agave Extract, Mitsumata Extract, Aonori Extract, Usba Aonori Extract, Suea Aonori Extract, Hira Aonori Extract, Bow Aonori Extract, Hosoeda Aonori Extract, Comb Extract, Macombu Extract, Recomb Extract Honeycomb extract, wakame extract, hirome extract, awakame extract, hijiki extract, hibamata extract, sea urchin extract, usbau Prickly pear extract, Kirebano miuchiwa extract, Akaba miuchiwa extract, Kona miuchiwa extract, Okinawa pear extract, Usukiuchiwa extract, Etsuki miuchiwa extract, Shiroki rhinoceros extract, Amakusa Rhinoceros extract, Giraffe rhinoceros extract, Juniper ginkgo biloba extract, Tsunomatsuta Extract, Marubatsu no Mata Extract, Hirakotoji Extract, Sugi Nori Extract, Shikinori Extract, Kainori Extract, Yakuzusa Extract, Uraboshiyahaz Extract, Sea Urchin Extract, Ishimozuku Extract, Misjikonbu Extract, Atsuba Misujikonbu Extract, Isomok Extract, Nagashima Moku Extract, Shimomoku Extract , Narasamo extract, Mametawara extract, Japanese chestnut extract, Yatsuma Tamoku extract, Umitorano extract, Oba mokuki , Fusiform moku extract, haha moku extract, yoremoku extract, sawtooth moku extract, plantain extract, centipede extract, nuraxa extract, cronouraxa extract, bark peanut extract, pine tree extract, giant tiger beetle extract, silkworm extract, beetle extract Fushitsunagi extract, Hirohafushitsugi extract, Kurosozo extract, Kobosozo extract, Hanesozo extract, Sozonohana extract, Hazela mushroom extract, Thira extract, Camote deazafuran extract, Hamica extract, Pole verde extract, Nabonegro extract, Udo extract, Shishido extract, Gashout extract, oak extract, bovine taxis extract, cuckoo thistle extract, scallop (sheep hooves) extract, Gymnema sylvestre extract, karooo extract, gyokuyo Nuka extract, Konronka extract, Sabunryo extract, Jasmine (Matsurika) extract, hollyhock extract, Shoulite extract, Arabidopsis extract, lily of the valley extract, Souzu extract, Deco extract, Tochu (Butchu) extract, Nagii Kada (Bucher bloom) extract, Teppo cucumber extract , Tokiwa Mansaku Extract, Nankin Gouze Extract, Niwarushi Extract, Nadeshiko Extract, Michiyanagi Extract, Elderflower Extract, Morohaya Extract, Bamboo Willow Extract, Weeping Willow Extract, Magnolia Extract, Yakuzou Extract, Tamaki Fujime Extract, Amami Gauco Extract Extract, shellfish extract (cockle extract, green mussel extract, European oyster extract, scallop extract, clam extract, clam extract, bonito extract, (Sword mussel extract, red mussel extract, abalone extract, turban shell extract, bi-extract, etc.) ) Extract, Maruba morning glory extract, morning glory extract, Athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, Ayuyu extract, Hagateto extract, Hyugaiteu extract, Senninoku extract, Sugimori Gateto Extract, Hosoa Ototou Extract, Aogatetou Extract, Haribiyu Extract, Amaranthus Hypochondriax Extract, Aristolomeria (Yurizuisen) Extract, Arcana (Arkanna) Extract, Algarrobo (Cabbage) Extract, A Sasa (shinshin grass) extract, yew (first place) extract, strawberry extract, locust bean extract, Inazuna (teilexi) extract, rice extract, dog mint extract, sardine tobacco (Iwatsuki) extract, sardine hiba extract, sardine pine extract, wheat (chibsanoki) ) Extract, Duckweed (Float) Extract, Usbenitachaoi Extract, Unyadegato (Unkalia) Extract, Enokitake (Spider) Extract, Elingi Extract, Pre-Lotus Elinji Extract, Ogata Hakken Extract, Oguruma (Civil Scent) Extract, Steller's beetle (cereals) extract, oka extract, okazeli (serpentine) extract, okra extract, onidokoroko extract, tokoro extract, nagadokoroko (hikai) extract, onionis extract, yuuko extract, oyster extract, ginkgo biloba extract, gaku hydrangea Extract, Cascara Sagradae , Gypsophila extract, Ginseng extract, Kaniwa extract, Carnation extract, Gerbera extract, Camcum (camo duck) extract, Color extract, Oat extract, Karin extract (Stone bamboo) extract, Ezokawaranadeshiko (buckwheat, buckwheat) extract, Kantara Asa extract, Kikutanigiku extract, quinoa (quinoa) extract, cabbage extract, kiwi extract, gyory (Nishikawa willow, taro willow) extract, Kiranso (golden grass) Extracts , Kourien (Hu (Yellow) extract, coconut extract, cosmos extract, coconut krill extract, rice oil extract, konjac extract, saffron (banban flower, west red flower) extract, sapodilla extract, sangre de grad (croton) extract, sanchinin carrot (37 ginseng) ) Extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji mushroom extract, hinoki shimeji mushroom extract, scallop shimeji mushroom extract, scallop shimeji mushroom extract, buna shimeji mushroom extract, honji messi extract, shirotamogitake extract, shimokurene (hot pepper) extract, saishin Extract, cactus extract, jade beard (barley winter) extract, shrimp congeraceae extract, Zhao hydrangea (Tsunayama) extract, white roe butterfly extract, white clover (chicken bone) extract, ginkgo biloba (Ryuka, Ryuka, Shenchobana) extract, Tin Psycho (Xu Longエ キ ス) extract, purslane (horse tooth soap, horse tooth soap) extract, boiled extract, cherry blossom extract, koki kekoku extract, papaver extract, okinawa kekoku extract, hon kek koku extract, koji kokukoku extract, deer kinkokukoku extract, kiba nano Seccok extract, cedron extract, celery extract, senshinren (bentling ream) extract, takasaburo (bamboo lotus) extract, tachidokoro (hikai) extract, dahlia (tenjiku button) extract, tarwi extract, senkinshi extract, sardine extract , Chancapiedra extract, tulip extract, chorogi extract, tsukuritake mushroom extract, camellia extract, camellia extract, cornflower extract, corn extract, corn hair (nanban) Hair) extract, toxa (wood band) extract, ash (crust) extract, turkey extract, jujube extract, sword bean extract, jujube extract, nabena extract, sea cucumber extract (Hemp) extract, scented violet extract, nutmeg extract, nem extract, neb extract, nem extract, Nemuri extract, Digokubana extract , Agaric extract, White-faced agaric extract, Usukimorinokasa extract, Haran extract, Parrurus (Prunus japonicus) extract, Balsamina (Villus serrata, Prunus) extract, Harlin Dou extract, Handaikai (Taikai sea) extract, Brown bear Rear extract, Beet extract, Hiba extract, Sunflower extract, Pepper extract, Himezu (Tenpo) extract, Himematsutake (Kawariharatake, Hiromatsutake) extract, Fuyushinatsutake mushroom (Coleoptera) extract, Brazilian licorice extract, Hazelnut extract, Loofah extract, Bencaiso extract , Nettle extract, scallop extract, narcissus extract, nendo extract, scallop extract, ground scallop extract, spinach extract, scallop, acute pupa, peony grass extract ) Extract, jojoba extract, Borage extract, Bordeaux extract, Hononiku (meat jujube, Daiki) extract, Honsecek (iron crust stone, sparrow mountain stone extract) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract, Tamanouse Haren'ekisu, the old con Kin Lenka extract, Actinidia (catmint) extract, pine cone extract, Wolfiporia Extensa (茯苓) extract, Matiko (Cordon Hermosillo) extract, quince extract, Ma
Rain (Billow Mulled Squid) Extract, Manzanya (Andesca Mitsuru) Extract, Mizusobako Extract, Mizuasagao (Dragongrass) Extract, Green Squid Extract, Wheat Strawberry Extract, Munya Extract, Murasakikikibu Extract, Omurasakikibu Extract, Murasaki Kinafuji ( Kunming chicken blood wisteria extract, moge extract, cinnamon extract, cornflower extract, yacon extract, coconut extract, yabu tobacco (crane gourd, tennasei) extract, mokka extract, lily extract, ligan (Thunder circle) extract, lime extract , Rye extract, rakkyo extract, shallot (apple white) extract, apple extract, gentian extract, litchi (toothpick, toothpick nucleus) extract, yokuinin extract, mini sasanishiki extract, chlorella bulgaris extract, chlorella pyrenoid extract, chlore・ Ellipsoidia extract, Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cypress extract, Amakusanori extract, Aomidro extract, Kawanoori extract, Marimo extract, Motsukihitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Aname extract, Sugime extract, Troll comb extract, Antokume extract, Tsuruarame extract, Kuroshiome extract, Nekoshikonbu extract, Ainu wakame extract, Chigaiso extract, Ezoi Shige extract, Yabanemoku extract, Trumpet extract, Uganomok extract, Joromoku extract, Hyamoku extract, Tamanashimok extract Honda Walla Extract, Sugi Moku Extract, Bovine Kenori Extract, Susabi Nori Extract, Akebono Mozuku Extract, Cyprinus , Fusanori extract, Hosobana minohana extract, Hanafnori extract, Itohonori extract, Kaginori extract, Mirin extract, Hosobamyrin extract, Kikutosaka extract, Ezonameshi extract, Ibaranori extract, Kagyi baranori extract, Saidaibara extract, Tatyibara extract, Ogonori Extract, Vulgaris extract, Honey beetle extract, Otsunori extract, Red ginseng extract, Loofah water, Birch (white birch) or red pine sap, Barley (barley) extract, Okuri higotai (Yeju leakage, Indigo head) extract , Bacillus cicada extract, Dutch honey bee extract, Garcinia extract, Kawaran ginseng (blue cocoon) extract, oyster extract, quilla extract, quince extract, ginkgo biloba extract, calendula extract, Sawagurumi (wild walnuts) extract, Shimotsuke Wu extract, Shajin extract, plum extract, pineapple extract, Chinese cabbage extract, Japanese cypress extract, beech extract, physalis (Torone) extract, maitake (maiko) extract, Misohagi extract (Kiso) extract, Mukuroji (prolonged skin) extract, bean sprout extract, Eucalyptus extract, Suabisimus extract, Lettuce (Chisha) extract, Ogon extract, Tonka bean extract, Burdock extract, Yakuinin extract, Achacha extract, Hypericum extract, Sanadagusa extract, fukurimamiji extract, raspberry comb extract, oyster comb extract, onikonbu extract, gohei kumbu extract, nagacombu extract, pea comb extract, prunus kumbu extract, rattle extract, lala extract, benimozuku extract, hosobenimokusu , Kagekinori Extract, Ezotosaka Extract, Silamo Extract, Birch Extract, Akebi (Kitsutsu) Extract, Achacha (Amacha) Extract, Dutch Bile Extract, Kanran Extract, Kumquat Extract, Gobaishi Extract, Gentian Shoko (Old Grass) Extract, Sesame Extract, Sesame Seed Cultured cell extract, sesame seed extract, rice bran extract, pomegranate extract, pear extract, Daio extract, tomato extract, Nanten extract, Noamiami extract, Neubara extract, paprika Extract, pistachio extract, betel wax (big garment, coconut) extract, Japanese bursa extract, bokeh (wooden) extract, Hosobao gulma extract, mao (mao) extract, mimosa extract, sagebrush extract, himema willow extract, willow deer extract, cotton wisteria Mongolia extract, Chlamydomona Extract, red clover extract, red clover extract, red clover extract, hypericum extract, enamel extract, birch extract, southern berry extract, clove extract, red clover (logwood) extract, red clover (red bud) extract, red clover extract Akane extract, Akane (Hakusai) extract, Hydrangea (hydrangea) extract, Abemaki extract, Fig extract, Asparagus extract, Ume (Plum) extract, Vulgari extract, Estragon extract, Enju (Apricot flower, Camellia rice) extract, Kashiwa (Bamboo tree, bamboo leaf) extract, decoction extract, hippopotamus extract, birch extract, knugi (bamboo shoots) extract, oleander extract, citrus orange (Koji, Tachibana, Obenimikan, Fukurican, Sagamikouji, Ponkan) extract, Santara extract, Comfrey extract, horseradish extract, green foxtail extract, catfish extract, Japanese oak extract, Japanese oak extract, crape myrtle extract, dicoppi extract, white birch extract, white clover (clover) extract, horseradish extract, black tea extract, Green tea extract, Tsuwabuki extract, Tencha (bamboo tea) extract, Tendai-yaku extract, Nani Waibara (gold cherry tree) extract, peanut (peanut) extract, Kay extract, Nikkei extract, Ceylon nicky extract, Yabunikei (cinnamon) extract, Keishi (Keishi) extract, Nozenkazura (Linxia) extract, Lotus (Lotus) extract, Chinese cabbage extract, Hadakagi extract, Hanasuge (Mystic) extract, Hermanus (Mykai flower) extract, Rose (Rose) extract, Barbasco extract, Beech extract, American beech extract, Dog beech extract ,Europe Extract (Incense) extract, Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, pear thistle extract, paddy thistle extract, noel thistle extract, large thistle extract, cacao extract, elcampuri extract, otsu-rafuji (anti-self) extract, gadget (莪 朮) Extract, Chrysanthemum salmon extract, Kyodo (Kikyo, Kikyo Root) extract, Kizuta extract, Pepper (Pepper) extract, Cola acuminata extract, Sagiomodaka (Sawamata) extract, Pomelo extract, Sanshuyu (Yamamuro) extract, Tsuji Fuji extract, Ootsuki-rafuji extract, Choreimaitake (bamboo shoots) extract, Japanese camellia extract, Amanita extract, Ginseng extract, Korean ginseng extract (Ryu gall) extract, Naginata Kouju extract, Banana extract, Pu'er tea (normal tea) extract, plum Extract, Bow Fu (Windproof) Extract, Ansokkou (Benzo) Extract, Hub Extract, Oshiogusa Extract, Assamirisiogususa Extract, Kawashimagususa Extract, Kawatake Extract, Ishijelly Extract, Hassai Extract, Spirulina Extract, Aiaciocio Extract, Funolinouske Extract, Himetengusa Extract , Hyperus extract, Oobusa extract, Chino Limo extract, red grape grape extract, azuki bean (red bean) extract, nettle extract, cascarilla extract, kapok extract, guarana extract, Ezo strawberry extract, o Nada strawberry extract, shrimp strawberry extract, nava white strawberry extract, maple strawberry extract, couse mint extract, cowberry (Etsutachibana) extract, cola vera extract, sugar cane extract, cinnamon onyx extract, honeysuckle (gold and silver flower, endurance winter) extract, larch extract, Dandelion extract, Centarium extract, Shirobana dandelion extract, Mouko dandelion extract, Tsuzuki azuki bean extract, Tsurutsuchiakebi extract, Teuchigurumi extract, Tokiwakuryu extract, Chestnut extract, Castor extract, Prune extract, Veronica extract, Bisna extract , Mitsuwashi extract, myrrh extract, witch hazel extract, black willow extract, latania (chlamelia) extract, lemon extract, dairy extract, agetsu extract, propoly , Eye (Aiba) extract, Asenyaku (Asen Yaku) extract, Avocado extract, Amadokoroko (Tamatake) extract, Amigasayuri extract, Baimo (shellfish) extract, Igakozorina (Gallhead) extract, Ibukitorano extract, Echinashi (Villus serrata) extract, Oren (yellow ream) extract, Oguruma (turned over) extract, Hypericum pertussis (Little cut grass) extract, Oniguri extract, Orange extract, Cassia extract, Kamiyatsu (weed) extract, Kawamidori extract, Kawamomogi , Watercress extract, Kenashi Sartorii rose (Tsumago, mountain return) extract, Koki Sekkokoku extract, Kouhon (Kakimoto, Karamotomoto) extract, Koryokyo (Kora Kashiwa) extract, gosho strawberry (covered bonsai) extract, Psycholan orchid extract, cherry extract, diquitaris extract , Linden extract, salamander extract Indian sea bream extract, shukushamitsu (sand seed, shredded sand) extract, juzudama extract, shirominanten (southern tense) extract, hirohasenega extract, takasago rurihigotai (southeast indigo sashimi) extract, takaharabi extract Tsurugafuji extract, Chigaya extract, Toga (winter coconut) extract, Hanabishi (Shitsuri, Shishitsuri) extract, Hamasuge (Katsukiko) extract, Hishi (Rishimi) extract, Fuyukazura (South rattan) extract, Bundou (mung bean) extract, Sandalwood extract, Butcher bloom extract, Hosoba Abragiku extract, Myrtle Tennansho (Tennan star) extract, Miracle fruit extract, Mukunoki extract, cornflower extract, Yachiyanagi extract, mistletoe (willow parasite) extract, Yabukouji (purple gold beef) extract, Itohimehagi extract , Jujusmo extract, Tamajusmo Kiss, Mizojuzumo extract, Urushigusa extract, Keushigurusa extract, Loquat extract, Akamok extract, Togemoku extract, Akaba extract, Maruba akaba extract, Harigane extract, Durs extract, Yuna extract, Belladonna extract, Hoonoki extract, Harunire Peel, maple leaf) extract, Asa (aspen) extract, Dutch mustard (cresson) extract, valerian (valerian) extract, clematis extract, columse basques, rosewood extract, soybean (soybean) extract, Chinese yam extract, yam extract, nozen Hallen extract, Capsicum extract, Giant kelp extract, Hijirimen extract, Proboscis extract, Hyus banori extract, Agi (Ayu) extract, Asunaro extract, Alpinia extract, Katsudai (Suzukuku) extract, Inubiyu (Honagainubiyu) Ex , Aogateto extract, Haribuyu extract, Ayuyu extract, Hagateou extract, Hosonagabuyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominaeshi extract (Tatsufuji Aoi) Extract, Kahoku Salamander (Amber) Extract, Chamomile Extract, Kinonaki Extract, Red Adenaki Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chicken Crown, Chicken Crown) Extract, Bay bay extract, Koushinbara (monthly flower) extract, Copaiba balsam extract, Yamazakura extract, Edhigashi extract, Miyaza cherry extract, Yoshino cherry extract, Kasami cherry extract, Kanza cherry extract, sugar beet Kiss, Sarasinashouma (Hemp) Extract, Shikunshi (Miseko) Extract, Birch Extract, Cinnamon Extract, Sorrel (Acid Model) Extract, Dandelion Extract, Sowca (Grass) Extract, Chicory Extract, Chosen Elm (Camellia) Extract , Tsuruna extract, Tokon extract, leek extract, leek extract, peach extract, patchouli extract, Japanese amber extract, cypress extract, pimenta extract, jade extract, Hiroha Okinagus (Bald eagle) extract, Blackberry extract, Makuri (Marine herb) extract, Magnolia sprengue extract, Mizokakushi (half-sided lotus) extract, Honey beet extract, Moso prickly extract, Pyramid (commercial land) extract, Yucca extract, Yolo Rush extract, forsythia extract, syringen extract, cypress extract, tocha Mosquito (Yahazutsu nomata) extract, Japanese redwood extract, Anaaaosa extract, Human rush extract, Hirohanohito rush extract, Usuhito rush extract, Iroro extract, Ishi
Jelly extract, arame extract, tamamitaki extract, tambanori extract, katanori extract, cherry blossom extract, Fujimatsumo extract, kawamozuku extract, aokawa mozuku extract, himeka mozuku extract, yakchi (Michichi) extract, ashitaba (tomorrow) extract, ukiyagira (three ridges) ) Extract, tiger weevil extract, Satsuma mandarin (Chen) extract, toucan beetle (coconut) extract, kina extract, goldfish extract, horseshoe moth (horse whip grass) extract, kubijinsou extract, kohone (river bone) extract, burdock (beef bowl, cow lion) ) Extract, ragweed (bamboo rape) extract, syringen extract, hawthorn extract, tanjin (dansang) extract, chikutsujinjin (bamboo ginseng) extract, tsurudukudami (what-necked potato) extract, tsurunjinjin (four leaf ginseng) extract, chili pepper (banban) ) Extract (Sadako) extract, Natsumikan extract, elderberry (bone graft) extract, hazelnut (coconut) extract, ashidokoro (roth root) extract, mint (light load, light load leaf) extract, Hamabou Fu (hama windbreak) extract, Higotai extract, Fujimodoki (Chojizakura) , Spikelet extract, black currant extract, yuzu extract, waxy bean extract, porcupine extract, yellow weevil extract, weevil (summer hay) extract, large crape myrtle (banaba) extract, large hawthorn extract, calahoo (sparkle) extract, Guava extract, Goshishi (Gomico) extract, Shazenso extract, Rose rose extract, Hinata daikozu (cow knee) extract, American grape extract, European grape extract, Yama grape extract, Mandarin extract, Mishima psycho (Shibako) extract, Pea extract, Tosaka Modoki extract , Ikanoashi Extract, Hosobonori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigigi Extract, Hanagigi Extract, Usuba Watanagi Extract, Moroitogusa Extract, Fumoitusa Extract, Hanayagi Extract, Willow Tree Extract, Moyuyurena Extract Kori extract, Mosas willow extract, Sasabayanagori extract, Wasabi extract, Ikarisou extract, Yachimata Kariso (Inyokaku) extract, Narco lily extract, Kagikaruma Narukoli (yellow spirit) extract, Oregano extract, Oshida extract, Onji extract, Spruce extract, Crow biscuit ( (Half-summer) extract, pheasant (fruit berry) extract, wolfberry (bamboo shoots, coconut, coconut leaves, ground bark) extract, goshuyu (kure potato) extract, senega extract, sendan extract, tamarind extract, tarragon extract, cho Sendaiou (Dahi) extract, bee extract (Bamboo bud) extract, daisies (Daisy) extract, Milobaran extract, himekuma willow extract, mockin extract, laurel extract, Yabu scotch extract, Anaaasa extract, Macrocystis integrafolia extract, Neocities Ruetkeana extract, nettle extract, duckweed extract, caterpillar extract, japonica extract, striped primrose extract, Ezotsunomata extract, tsugetsunamata extract, fusaikawa mushroom extract, anemone extract, mill extract, chromyl extract, sakibuchimiru extract, nagamil extract, hiramil extract, matsumo extract Okinawa Mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Mafunori extract, flax extract, casino ki (fruit) extract, Kozo extract , Hana mint extract, breadfruit extract, hirakototoji extract, Kotojitsu no Mata extract, Yareus banori extract, Kagious banori extract, Susius banori extract, Amiaosa extract, Nagaaosa extract, Hosobanosakamodoki extract, Hirohatosakamodoki extract, Scorpion extract, black-spotted beetle extract, nematode squirrel extract, yusora extract, tsutsu-no-sakamodoki extract, nankaito-sakamodoki extract, Himetosakamodoki extract, tochibanjin extract, tiger lily extract, beetle extract, beetle extract , Kikarasuuri (Gurone) extract, fenugreek extract, wisteria bean extract, Japanese lentil extract, chickpea extract, mungbean extract, rabbit garlic extract, canamgra extract, Karahanasoueki , Raspberry extract, buffalo extract, beak cucumber extract, arakashi extract, anse extract, honan extract, Ichiyakusu (one herb) extract, licorice extract, psyllium (car forerunner, car forerunner) extract, plantain Yachabushi extract, olive extract, giant black-bellied extract, seisei extract, calla cucumber extract, cinnamon cucumber extract, chrysanthemum extract, striped peony extract, ginseng extract, scallop extract, kukui nut extract, camphor extract, kubeba extract, buckthorn extract, shellfish Ear) extract, snapdragon extract, snapdragon extract, kisspi extract, beetle extract, cilantro extract, kobushi extract, magnolia extract, sage extract, binankazura extract, pine bush sae , Colombo extract, Conslango extract, Sasanka extract, Sweet potato extract, Sanebuto jujube (acid soy sauce) extract, Sandscon (Yamazune) extract, Shishiga shirasu extract, Coriander extract, Stevia extract, Takatodai extract, Tairayou , Leaf leaf tea, bitter tea, bitter tea) extract, taranoki extract, bitter gourd extract, nullde (penta) extract, hakamura laboshi (bone crushing extract) extract, clove magnolia extract, sugar beet extract, clover (weed) ) Extract, mushroom carrot (participant) extract, mangosteen extract, myoga extract, melaroika extract, yachabushi (yasha) extract, himeya shabushi extract, obaya chabushi extract, yaksoso extract, yamahanokiki (yama yam) extract, longan (longan) meat extract, Locon (Yoshi, Sone) extract, logwood Extract, Lantana extract, Ichihatsu (primary) extract, Kashuu extract, Kantou extract, Sanjiko extract, Shiramo extract, Prunus extract, Hitosuba licorice extract, Fritillary extract, Motsuyaku extract, Vulture extract, Yoremok extract, Blueberry , Mango extract, Inondo extract, Elemi extract, Danmar extract, Vanilla bins extract, Pine extract, Aokazura extract , Yellow sapote extract, ylang ylang extract, phalaenopsis extract, uba tea extract, ezuzuran extract, unboku extract, elderberry extract, sasayukiyuki, sasano Yuki Extract, Toucan Cactus Extract, Omiya Catez Extract, Onoelan Extract, Crab Extract Ginsekai Extract, Kimbusen Extract, Guapeba Vermelha Extract, Kugenuma Maran Extract, Cooze Berry Extract, Cutty River Extract, Curkurigo Latifolia Extract, Kuroganemochi (rescue) Extract, Cucumber Extract, Sapotea Marillo Extract, Salmon Berry Extract , Salamander extract, Sancaku cactus extract, Salamander extract, Shunlan extract, Shozuk extract, Shirobanatsu extract, Cinconaxill La extract, swim berry extract, star apple extract, sulgaran (oran) extract, pearl butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, cinnamon extract, dark mono cherry extract, dark sweet cherry extract , Prickly pear extract, Choco nostay extract, Korean mugwort extract, Azalea extract, Azalea extract, Azalea extract, Duberry extract, Papaver extract, Tragacanth extract, Triacanthus extract, Neiseria berry Extract, Rapeseed Extract, Flying Plover Extract, Pau Doce Extract, Hakukayumatou Extract, Hakuru Berry Extract, Batata Extract, Hamakakiran Extract, Balata Extract, Harcanlan Extract Pecan nut extract, chickweed extract, hime-myoran extract, brazil carrot extract, braneen extract, fullceraria extract, blond psyllium extract, hetsukaran extract, henken extract, berry extract, persea extract, pervianburg extract, pereschia grandifolia extract, Boysenberry Extract, Hosairan Extract, Pouteria Sapota Extract, Pouteria Rukuma Extract, Hosobabaren Giku Extract, Whataberry Berry Extract, Masalan Baba Extract, Masalan Zuba Do Cearer Extract, Masheira de Boyi Extract, Matta Auryo Extract, Mulberry Extract, green potato extract, purple corn extract, megakansa opuntica extract, mokukirin extract, Japanese maple Kiss, Morero cherry extract, Yakawamura potato extract, cornflower mint extract, Ruritama thistle (Villus chinosa, Xinjiang indigo head) extract, Red currant extract, Red pitaya extract, wax palm extract, Loganberry extract, Dunaliella genus Dunaliella extract, Chlorococcus genus Chlorococcus extract, Kuwanomimo genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Jupiter extract, Aomydra genus extract, Thurguimidro extract, Himidomi genus extract, Flichera extract, Valonia Extract, Baronia tamabaronia extract, Magama genus Magamata extract, Magama genus Sericho moth extract, Magama genus Heraiwa potato extract Green algae extracts such as Prunus serrata, Cassano serrata, Mika squirrel extract, Collecaete extract, tsutsumimo extract, Scutella serrata extract, Sayamidro extract, Kungshomo extract, Sumiremo violet extract, Hoshimidro extract, Fushinashimidro extract, etc. Cyanobacteria genus extract, blue-green algae extract, blue-green algae extract, Piraella genus Pilaella extract, Shiomidomo genus Nagamisiomidro extract, Isovine genus Isovine extract, Isogawala genus Isogawara extract, Black moth genus Blacksen extract, Kashirazaki genus Kashirazaki extract , Muchimo genus extract, Muchimo genus extract, Muchimo vegetative extract, Ajigusa Sakibiro aji extract, Common genus Common gussa Kisses, Jigmiga genus Jigmusa extract, Namima genus Hirami Makukura extract, Someraceae genus Someraceae extract, Navaimo genus Navaimo extract, Chasomen genus Matsukichasomen extract, Nagamatsumo genus Nagamatsumo extract, Niseftmozum genus Necta Genus Chromo extract, Nisemo genus Nisemo Zuku extract, Ichimegasa Ichimegasa extract, Quercus zelkova extract, Cyprinus genus Umbosu extract, Urushigusa tobacco guasa extract, Crested genus Compositae extract, Dermatophyllum spp. Bukuro extract, Chishima fukuronori Chishima fukuronori extract, Kagomenori Kagomenori extract, Muraridori Murachidori extract, Shark Thrush genus Shazugusa extract, Yokojimanori Yokojimanori extract, Crayfish genus Cyprus extract, Fritillaria genus biloba extract, Crane genus Culmo extract, Cactus genus Chlome extract, Chrysanthemum genus Chrysanthemum genus, Spirella genus Extract Brown algae extracts such as Burukimo spp. Kona hada extract, Kona hada genus yogore kona hada extract, Kona hada genus Ao kona hada extract, Cyprinus genus Tsukmonori extract, Cyprinus spp. Vinegar, Kasamatsu genus Kasamatsu extract, Nisefusanori genus false Husa seaweed extract, Sodegarami genus Sodegaramiekisu, Hiro Ha Tama top genus Hiro Ha Tama top extract, Gelidium genus southern Gusa extract, Gelidium genus Kohiraekisu, te
Ngusa genus yohira extract, Tengusa genus extract, Hibiro hibishirodo extract, Hibiro genus hibishirodo extract, Rhizoma genus Rhizoma genus extract, Rhizome genus Ryumonsou extract, Ryumonso genus Ryumon sera Genus Nigella cricket extract, Okibara genus Giant rose extract, Coral spruce genus Ragalamado extract, Shiogusagoromo genus Shiogusagoromo extract, Iwanokawa genus Ikiiwakawa extract, Kainokawa genus Kinokawa extract, Canninote genus Cinote extract, Sangomo Genus scum cadaver extract, centipede spruce extract, centipede spruce extract, centipede spruce extract, centipede spur Extract, centipedeus genus extract, centipede genus marbahudara extract, cypress genus extract Kintoki Fushikintoki extract, Kintoki tsunomukade extract, Kintoki nagakintoki extract, Kintoki Sumimukade extract, Kakateto Obakintoki extract, Nagaobane spp. , Tsukasanoori Otsukasanori Extract, Tsukasanori Hanagakarimenia Extract, Hounoho Honoo Extract, Hikagenoi Hikagenoi Extract, Chrysalis spp. Atsubanori extract, Ogonori genus Ozonokonori extract, Ogonori genus Beniogonori extract, Ogonori genus Fukureshinori extract, Ogonori genus Murasaki birch extract, Ogonori genus Shinkabanori extract, Ogonori genus Tokabanori extract, Ogonori genus Kataogonori extract Ogonori genus Ryukyu Ogonori extract, Ogonori genus Ogonori extract, Ogonori genus tsutsuginu extract, Ogonori genus Utagata gonori extract, Ogonori genus Kubireogonori Kiss, Ogonori genus Mosaogonori extract, Ogonori genus Funabori extract, Fushikenori Fushikenori extract, Namiiwatake genus Namiitake extract, Saimi genus extract, Saimi genus extract, Lotus japonica genus extract Genus hemlock extract, staghorn genus extract, staghorn genus extract, scorpion scorpion sage Flatfish goat extract, Dulse sprout extract, Duls anadalus extract, Weavusa spruce extract, Benifcronori spp. , Villus spp., Ventura spp. , Usbeni genus Usbuni extract, Hasujiginu genus Hasujiginu extract, Nagakonohanori genus Nagakonohanori extract, Sugiginus genus Sugiginu extract, Sugiginus genus Abasus dignu extract, Heius banori genus Cagius banori extract, Haius banori genus Yeuus banori extract Genus Hyus banori extract, Usubanorimodoki genus Usubanorimodoki extract, Ayanishiki genus Ayanishiki extract, Ayaginu genus Ayaginu extract, Dadia genus Enasidia Kisses, Shimadadia Isohagi Extract, Shimadadia Shimadadia Extract, Dajimodaki Dajimodoki Extract, Makuri Makuri Extract, Hanegusa Hanegusa Extract, Hanegusa Hanamigusa Extract, Kozanemo Kozanemo Extract, Kozanemo Genus Isomurasoki Himegoke Extract, Himegoke Black Himegoke Extract, Hyodosigki Chrysanthemum Extract, Hyodosighiu Hyodosigusa Extract, Hyodosigus Usuba Hyodoschia Extract, Isomegusa Isomegusa Extract, Suzynagusa Genus Extract, Isobachous Red algae extracts such as Ideukogome extract, Ochimomoku genus Ochimomoku extract, Chisujinori genus Chisujinori extract, Shajikumo extract, Shiratamamo extract, Various compounds, plants and animals, such as plant algae extracts such as yellow alga extract such as citrus genus extract, lycnotum extract, flask genus extract, chaboflask extract, tripella extract, etc. -Microbial extracts, natural product-derived substances, etc.

  The animal / plant / microbe extract used as a physiologically active ingredient in the present invention is selected from various plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials, depending on the product type and form to be added. Processing routinely performed (e.g. grinding, milling, washing, extraction, degradation, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, powdering, granulation, dissolution, sterilization, pH adjustment , Deodorization, decolorization, etc., optionally selected and combined).

  Among the animal / plant / microbe extracts used as physiologically active ingredients in the present invention, for plant extracts, various parts of the plant used for production can be arbitrarily selected, for example, flowers, ears, pericarps, fruits, stems, leaves, Branches, branches and leaves, trunks, bark, rhizomes, root barks, roots, seeds or whole plants can be used. In addition, for animal and microbial extracts, the object used in the production can be selected arbitrarily. For example, various cells, subcellular organelles, tissues, organs, etc. Other sites, cells, tissues, organs, metabolites and the like can also be used. Furthermore, it can be obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (embryonic stem cells, fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes) Etc.), undifferentiated cell groups, cell groups in the middle of differentiation, metabolites thereof, and the like can also be used.

  The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, Polyhydric alcohol or hydrous polyhydric alcohol such as 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, polyethylene glycol (molecular weight: 100,000 to 100,000), acetone, ethyl acetate, diethyl ether , Dimethyl ether, ethyl methyl ether, dioxane, acetonitrile Various organic solvents such as xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, It is desirable to use one or a mixture of two or more selected from potassium oxide, calcium hydroxide, ammonia and the like. However, if it is not preferable to contain an organic solvent depending on the purpose of use, use only water, or perform extraction using a highly volatile solvent that is easy to remove the solvent after extraction. It is also possible to use a method such as dissolving in a solution.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1:10, and a weight ratio of 1: 1 to 1: 5 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, promeline, thermolysin, pronase, pepsin, rennin, Proteolytic enzymes (proteases) such as pancreatin, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular , Pectinase, polygalacturonase, dextranase, pralanase and other polysaccharide-degrading enzymes, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase Examples thereof include cell wall lytic enzymes such as oxidase, chitinase, and kilosanase. In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be arbitrarily set, but it is particularly preferable to set the optimum value for the enzyme used.

Fermentation or metabolic conversion by microorganisms can be performed by inoculating at least one or more types of microorganisms on plant-based raw materials, animal-based raw materials, or processed products thereof, and growing them. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Amphierna, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ascotrichosporon, Ashbia, Ashbya Genus, Asporomyces, Atelosaccharomyces, Azymocandida, Azymohansenula, Azymomyces, Azymoprocandida, Babjevia, Ballistosporomyces, Basidiotrichosporon, Bensingtonia, Blastobotrysbota, Blastodlastrzo Brettanomyces (Brettanomyces bruxellensis, Brettanomyces anomalus etc.), Bullera, Bulleromyces, Candida (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsment, Candida etchellsii, Candida etchellsment Candida intermedia, Candida krusei, Candida lactosa, Candida lipolytica, Candida mogii ), Candida parapsilosis, Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc. , Debaryomyces hansenii, etc.), Debaryozyma, Dekkera, Dekkeromyces, Dematium, Dipodascus, Eeniella, Enantiothamnus, Endoblastoderma, Endoblastomyces, Endomyces, Endomycopsis, Endyllium, Entelexis, Emas , Eutorula, Eutorulopsis, Fabospora, Fellomyces, Fermentotrichon, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliermondella, Hanseniaspora, HansenulaHanula, HansenulaHanula, Hansenula wickerhamii), Hypomyces genus, Issatchenkia genus, Kloeckera genus (Kloeckera brevis, Kloeckera fluorescens) , Kloeckera japonica, etc.), Kloeckeraspora, Kluyveromyces (Kluyveromyces bulgaricus, Kluyveromyces marxianus, Kluyveromyces thermotolerans, etc.), Kockovaella genus, Kurtzmanomyces, Leucosporidium, , Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycokluyveria, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora, Octosporomyces, Ogataea, O, Genus, Pachysolen genus, Parasaccharomyces genus, Paratorulopsis genus, Parendomyces sp Genus, Pseudohansenula, Pseudomonilia, Pseudomycoderma, Pseudosaccharomyces, Pseudozyma, Rhodomy Genus ces, Rhodosporidium, Genus Rhodotorula, Saccharomyces (genus Saccharomyces aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Saccharomyces exiguus, Saccharomyces unisporus, Saccharomyces fibuligera, etc.), Saccharomyces Selenotila genus, Selenozyma genus, Smithiozyma genus, Sporidiobolus genus, Sporobolomyces genus, Sporothrix genus, Stephanoascus genus, Sterigmatomyces genus, Sympodiomyces genus, Symringospora genus, Tetrapisispora genus, Torulaspora genus, Tordenpsiron genus, Torulopsiron genus, Torulopsis genus Genus Waltomyces, Willia, Willopsis, Wingea, Xanthophyllomyces, Yamadazyma, Zendera, Zygofabospora, Zygopichia, Zygohansenula, Zygorenospora, Zygosaccharomyces, Zymodebaryces, etc. The microorganisms classified as bacteria include the genus Acetobacter (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadospura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacteroides genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellatospora, Cellulomonas sp Enterobacter sp Genus, Halobacterium genus, Halococcus genus, Herbidospora genus, Hydrogenophilus genus, Hyphomicrobium genus, Hyphomonas genus, Intrasporangium genus, Janibacter genus, Kinesia spp. Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus divergens, Lactob acillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri , Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus bunchneri, Lactobacillus fermentatae, Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillus caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum, etc. ), Listonella, Lucibacterium, Luteococcus, Magnetospirillum, Marinilabilia, Marinospirillum, Mesorhizobium, Metallosphaera, Methylobacterium, Microbispora, Micrococcus, Microellobosporia, Micromonospora, Mycobacterium, Nocoides, Nocoides, Genus, Nonomuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus halophilis, Pediococcus acidilactis, Pediococcus cerevisiae, Pediocoedus pensacedos , Peptococcus genus, Peptostreptococcus genus, Pilimelia genus, Pimelobacter genus, Planobispora genus, Planococcus genus, Planomonospora genus, Prevotella genus, Propionibacterium genus, Proteus genus, Protomonas genus, Pseudomoncardia genus, Rahnella genus, Rathella genus, Rarobacter Genus, Rhizomonas, Rhodobacter, Rhodococcus, Rhodopseudomonas, Rhodospirillum, Rothia, Rubrobacter, Ruegeria, Saccharomonospora, Saccharothrix, Serratia, Sinorhizobium Streptoalloteichus spp., Streptococcus spp. (Streptococcus durans, Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis, Streptococcus dysgalactiae, Streptococc (us sanguis, Streptococcus acidominimus, Streptococcus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.) Examples include Thiobacillus genus, Thiomonas genus, Thiosphaera genus, Weissella genus, Xanthobacter genus, Xanthomonas genus, Zymomonas genus and the like. Microorganisms classified as ascomycetes, basidiomycetes or incomplete fungi other than yeast include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria , Botryotinia, Brachybasidium, Byssochlamys, Capnodium, Ceratocystis, Ceratomyces, Chaetomium, Chrysella, Chrysocelia, Chytridium, Claviceps, Cochliobolus, Coemansia, Genus Genus, Cyttaria, Dasyspora, Derchslera, Dirchmyces, Dichomyces, Dothidea, Endogone, Entomophthora, Emericella, Eupenicillium, Eurotium, Exobasidium, Gibberella, Glomus, Graphiola, Gymnoascus, Harpella Helicomyces, Hellvella, Hemicarpenteles, Hyphochytrium, Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium , Microascus, Microstroma, Medeolaria, Melampsora, Melampsporella, Morchella, Monascus, Monilinia, Monoblephalis, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olizadium, Genus, Penicillium, Perenospora, Pestalotiopsis, Phomopsi
Genus s, Phragmidiella, Pneumocystis, Preussia, Pleospora, Puccinia, Pythium, Ravenelia, Rickia, Rhinocladiella, Rhizidiomyces, Rhizoctonia, Sclerocnista, Saprolegnia, Scleella, Sclerotin Septobasidium genus, Sordaria genus, Sporidiobolus genus, Stibella genus, Stigmatomyces genus, Sydowiella genus, Talaromayces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus, etc.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, a sugar or ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerol, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salt, urea, uric acid, amino acids, etc. Vitamins and compounds that contain potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon Further, a compound containing arsenic, vanadium, chromium, fluorine or the like in the composition can be further added. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.), dialysis with semipermeable membrane, crystallization and recrystallization of components, filter paper, membrane filter, ultra filter, Examples thereof include filtration using activated carbon and filter aid, centrifugation, and density gradient separation methods such as fractional precipitation and density gradient sedimentation equilibrium, which are applications thereof.

  As preparation preparation ingredients such as colorants, surfactants, fragrances, excipients, etc., silicic anhydride, magnesium silicate, bentonite, titanium mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, carbonate Inorganic pigments such as calcium, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, hydrogen peroxide, sodium persulfate, ammonium persulfate, sodium perborate , Urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium peroxide orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide addition Body, sodium chloride hydrogen peroxide adduct, β-Chi Sinase enzyme solution, mushroom extract, inorganic reducing agents such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, thioglycol Redox agents such as magnesium acid and strontium thioglycolate), 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3, 3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride , Metaphenylenedia hydrochloride , Orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine , Nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N, N'-bis (4-aminophenyl) -2,5-diamino- 1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-sulfate Nitrophenol, ortho aminophenol sulfate, orthochloroparafe sulfate Range amine, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometasulfate Phenylenediamine, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'- Dye agents such as sodium diaminoazobenzene-5'-sulfonate and hematein.

  Natural animal fragrances such as musk, civet, castrium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil, cumin essential oil, black letter Essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil, dairy perfume essential oil, Tuberose essential oil, dichroic essential oil, orange flower essential oil, winter green essential oil, trubalsum essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, cocoon essential oil, hiba essential oil, sandalwood essential oil, petit gren essential oil, bay essential oil, vetiva essential oil, bergamot essential oil, pel Plant flavors such as balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary essential oil, Japanese mint essential oil, and other synthetic flavors Perfume, natural alcohols such as ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, synthetic alcohols such as 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol, etc. Alcohols, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, oleic acid Sil, octyldodecyl myristate, hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptyl undecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, diethyl Ethylene glycol hexanoate, neopentyl glycol diethyl hexanoate, cetyl 2-ethyl hexanoate, trimethylol propane triethyl hexanoate, pentaerythritol tetraethyl hexanoate, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, Dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, dioleic acid Esters such as Russia propylene glycol, aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, metal soaps such as zinc undecylenate.

  5-amino-o-cresol, o-aminophenol, m-aminophenol, p-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N-bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, resorcin, hydroquinone, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene / sodium sulfate, toluene-2,5-diamine, 2- (2'-hydroxyethylamino ) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-bis (2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol・ Sulfate, p-aminophenol Sulfate, o-chloro-p-phenylenediamine, sulfate, 2- (2'-hydroxyethylamino) -5-aminotoluene, sulfate, 4,4'-diaminodiphenylamine, sulfate, p-methylaminophenol・ Sulfate, p-phenylenediamine / sulfate, m-phenylenediamine / sulfate, toluene-2,5-diamine / sulfate, 2,4-diaminophenoxyethanol / hydrochloride, toluene-2,5-diamine / hydrochloric acid Salt, m-phenylenediamine, hydrochloride, 2,4-diaminophenol, hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine, hydrochloride, N-phenyl-p-phenylenediamine, hydrochloride, N -Phenyl-p-phenylenediamine / acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'-bis (4-aminophenyl) -2,5-diamino -1,4-quinonediimine o-Aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4- Methylaminoanthraquinone, nitro-p-phenylenediamine / hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate, 2-amino-5-nitrophenol / sulfate, resorcinol, nitro -p-Phenylenediamine / sulfate, p-nitro-o-phenylenediamine / sulfate, p-nitro-m-phenylenediamine / sulfate, red No. 2, red No. 3, red No. 102, red No. 104 ( 1) Red 105 (1), Red 106, Red 201, Red 227, Red 230 (1), Red 230 (2), Red 231, Red 232, Red 401 Red 502, Red 503, Red 504, Red 506, Yellow 4, Yellow No. 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1), Yellow 406, Yellow 407, Orange 205, Orange 207 , Orange No. 402, Green No. 3, Green No. 204, Green No. 205, Green No. 401, Green No. 402, Brown No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red cabbage dye, Red rice dye, Akane dye, Anato dye, Ikasumi dye, Turmeric dye, Enju dye, Krill dye, Amber dye, Caramel, Gold, Silver, Gardenia dye, Corn dye, Onion dye , Tamarind pigment, spirulina pigment, buckwheat whole plant pigment, cherry pigment, laver pigment, hibiscus pigment, grape juice pigment, marigold pigment, purple potato pigment, purple yam pigment, lac pigment, rutin and other pigments and colorants.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clustering, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Production of honoki bark extract 1 kg of honoki bark was chopped, and the whole amount was added to 10 kg of 30% 1,3-butylene glycol aqueous solution and extracted at room temperature for 1 week. Next, the obtained extract is filtered using filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2), and 1,3-butylene glycol is added so that the concentration of 1,3-butylene glycol in the solvent is 50%. The mixture was added and allowed to stand at −20 ° C. for 1 week. The obtained extract was filtered using a 0.45 φm membrane filter (manufactured by Toyo Roshi Kaisha, Ltd.) to obtain a honoki bark extract as the title component.

Manufacture of Koganebana Root Extract 1 kg of roots from which the pericardium of Koganebana was removed was chopped, and the total amount was added to 10 kg of purified water, followed by heat extraction at 60 ° C. for 2 hours. Next, after filtering the obtained extract using filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2), ethanol was added so that the ethanol concentration in the solvent would be 60%, and then at -20 ° C for 1 week. Left to stand. Next, the solution is diluted by adding purified water so that the ethanol concentration in the solvent is 60%, and the resulting extract is filtered using a 0.45φm membrane filter (Toyo Roshi Kaisha, Ltd.). As a result, the root extract, the root component, was obtained.

Production of Artemisia Leaf Extract 1 kg of dried leaves of Koganebana was chopped, and the whole amount was added to 10 kg of 50% ethanol aqueous solution and extracted at room temperature for 1 week. Next, the resulting extract was filtered using filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2), and the ethanol concentration in the solvent was 30% and the 1,3-butylene glycol concentration in the solvent was 20%. And was allowed to stand at −20 ° C. for 1 week. The obtained extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to obtain the mugwort leaf extract as the title component. Obtained.

Production of Aloe leaf extract 1 kg of dried leaf powder of Cape Aloe was added to 10 kg of purified water and extracted with stirring at room temperature for 1 day. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 65, manufactured by Toyo Roshi Kaisha, Ltd.), and allowed to stand at 4 ° C. Next, ethanol was added so that the ethanol concentration in the solvent was 50%, and the mixture was allowed to stand at −20 ° C. for 1 week. The resulting extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2 and 65) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to extract the title component, aloe leaves. I got a thing.

Production of Perilla Leaf Extract After steam-distilling 500 g of dried perilla leaves, the residue was added to 6 kg of 50% 1,3-butylene glycol aqueous solution and extracted at room temperature for one week. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 65, manufactured by Toyo Roshi Kaisha, Ltd.), and allowed to stand at −20 ° C. for 1 week. Then, the obtained extract is filtered using filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2 and 65) and 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to extract the perilla leaf as the title component. I got a thing.

Manufacture of Lavender Flower Extract 1 kg of dried lavender flowers was added to 10 kg of 50% 1,3-butylene glycol aqueous solution and extracted at room temperature for 1 week. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 65, manufactured by Toyo Roshi Kaisha, Ltd.), and allowed to stand at −20 ° C. for 1 week. The obtained extract was filtered using a 0.45φm membrane filter (manufactured by Toyo Roshi Kaisha, Ltd.) to obtain a lavender flower extract as the title component.

Production of tormentilla root extract 1 kg of tormentilla root was chopped, and the whole amount was added to 10 kg of purified water, followed by heating at 80 ° C. for 2 hours. Next, the obtained extract is filtered using a filter paper (ADVANTEC No. 2 manufactured by Toyo Roshi Kaisha, Ltd.), and then 1,3-butylene glycol is adjusted so that the concentration of 1,3-butylene glycol in the solvent is 30%. Was added and allowed to stand at −20 ° C. for 1 week. The obtained extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to obtain the tormentilla root extract as the title component. Obtained.

Manufacture of flowering extract of Licoris japonica 1 kg of Inflorescence of Licophorus japonica was shredded and the whole amount was added to 30 kg of 80% 1,3-butylene glycol aqueous solution and extracted at room temperature for 1 week. Next, the obtained extract was filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2), and then diluted and adjusted so that the concentration of 1,3-butylene glycol in the solvent was 50%. It was allowed to stand at -20 ° C for 1 week. The resulting extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.), so that the title component, N. japonica flowers, is extracted. I got a thing.

Production of Novara fruit extract 1 kg of Novara fruit was chopped and added to 20 kg of 50% 1,3-butylene glycol aqueous solution and extracted at room temperature for 1 week. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 2 manufactured by Toyo Roshi Kaisha, Ltd.), and then allowed to stand at −20 ° C. for 1 week. The resulting extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.), so that the novara fruit extract as the title component is obtained. Obtained.

Manufacture of orchid root extract 1 kg of dried roots of Aozuzuran was shredded, and the whole amount was added to 20 kg of 45% 1,3-butylene glycol aqueous solution and extracted with stirring at room temperature for 10 days. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 2 manufactured by Toyo Roshi Kaisha, Ltd.), and then allowed to stand at −20 ° C. for 1 week. The obtained extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to obtain the orchid root extract as the title component. Obtained.

Production of belode oyster root extract 1 kg of belude oyster root was chopped, and the total amount was added to 3 kg of 50% 1,3-butylene glycol aqueous solution, followed by extraction by heating at 60 ° C. for 3 hours. Next, the obtained extract was filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No. 2), and the filtrate was heat-treated at 80 ° C. for 3 hours and then allowed to stand at −20 ° C. for 1 week. . The obtained extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to extract the bellows oyster root extract as the title component. Got.

Production of peach leaf extract 1 kg of dried peach leaves were chopped, and the whole amount was added to 18 kg of purified water, followed by heat extraction at 70 ° C. for 2 hours. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 2 manufactured by Toyo Roshi Kaisha, Ltd.), and 1,3-butylene glycol concentration in the solvent was adjusted to 1,3-butylene glycol in the solvent. Butylene glycol was added and adjusted, and allowed to stand at −20 ° C. for 1 week. The resulting extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.) to obtain the peach leaf extract as the title component. Obtained.

Production of whole plant extract 1 kg of dried whole plant was cut into small pieces, and the whole amount was added to 12 kg of 40% ethanol aqueous solution and extracted at room temperature for one week. Next, the obtained extract was filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.2), and the filtrate was adjusted by adding ethanol so that the ethanol concentration in the solvent was 70%. The mixture was allowed to stand at 20 ° C for 1 week. The resulting extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.), so that the whole assembly extract is the title component. Got.

Manufacture of genge whole grass and seed extract 1 kg of dried genge whole grass and dried seed are chopped, and the whole amount is added to 10 kg of 20% 1,3-butylene glycol 30% ethanol mixed solution and extracted at room temperature for one week. did. Next, the obtained extract was filtered using a filter paper (ADVANTEC No. 2 manufactured by Toyo Roshi Kaisha, Ltd.) and allowed to stand at −20 ° C. for 1 week. The obtained extract is filtered using a filter paper (Toyo Filter Paper Co., Ltd., ADVANTEC No.131) and a 0.45φm membrane filter (Toyo Filter Paper Co., Ltd.), and the title ingredient, Genge whole plant and seeds An extract was obtained.

Trypsin inhibitory action test
A solution obtained by dissolving 250 μmol of the synthetic substrate Boc-Phe-Ser-Arg-MCA (Peptide institute INC) in 15 mL of 50 mM Tris-HCl buffer containing 20 mM calcium chloride and 1.0 w / v% dimethyl sulfoxide. 150 μL was added to a 96-well microplate. Next, 25 μL of each plant extract obtained in Example 1 to Example 14 was individually added to the same microplate, and then 4 μg / mL trypsin (Sigma) aqueous solution was added in an amount of 25 μL to each well. The reaction was carried out at 15 ° C. for 15 minutes. Next, the fluorescence intensity (Labsystems Multiskan MS-UV) at an excitation wavelength of 360 nm and a fluorescence wavelength of 450 nm was measured. Control was a system in which a 10 v / v% aqueous ethanol solution was added instead of the plant extract. The blank was a system in which a plant extract or a 10 v / v% ethanol aqueous solution was added, and no trypsin was added. And the trypsin activity inhibition rate (%) was computed from the value shown below from the value of each obtained fluorescence intensity. The results are shown in Table 1.
[formula]
Trypsin activity inhibition rate (%) = 100 × [(C−C _B ) − (S−S _B )] ÷ (C−C _B )
C: Fluorescence intensity in control addition system C _B : Fluorescence intensity in control addition system blank S: Fluorescence intensity in plant extract addition system S _B : Fluorescence intensity in plant extract addition system blank

Results of Trypsin Inhibitory Action Test As a result of testing the trypsin inhibitory action of each plant extract, as shown in Table 1, the trypsin activity inhibitory action was confirmed in all plant extracts. Accordingly, it has been found that the plant extract used in the present invention can be an effective trypsin inhibitor.

(Prescription example)
Examples of production of various pharmaceuticals, quasi drugs, cleaning cosmetics and foods using the trypsin inhibitor of the present invention are shown below, but the present invention is not limited thereto.

(Prescription Example 1) Capsule
Honoki extract 10.0g
Koganebana extract 10.0g
Magnesium ascorbate 0.5g
DL-α-tocopherol acetate 0.5g
Silicone oil 30.0g
Tween 80 0.05g
Corn starch 48.95g
The above ingredients were mixed uniformly and 200 mg was filled into a gelatin capsule to produce a capsule.

(Prescription Example 2) Capsule
Artemisia extract 10.0g
Aloe extract 5.0g
Starch 60.0g
Mannitol 10.0g
Calcium bicarbonate 5.0g
Polyvinylpyrrolidone 20.0g
The above ingredients were mixed uniformly and 200 mg was filled into a gelatin capsule to produce a capsule.

(Prescription Example 3) Tablet
Perilla extract 20.0mg
Lavender extract 80.0mg
Cornstarch 50.0mg
Hydroxypropyl methylcellulose 150.0mg
Carboxymethylchitin 30.0mg
The above ingredients were uniformly mixed and tableted to produce a tablet.

(Prescription Example 4) Tablet
Tormentilla extract 50.0mg
Iris genus extract 50.0mg
Corn starch 80.0mg
Methylcellulose 40.0mg
Magnesium stearate 20.0mg
Talc 10.0mg
The above ingredients were uniformly mixed and tableted to produce a tablet.

(Prescription Example 5) Granule
Novara extract 50.0mg
Carboxymethylcellulose 180.0mg
Propylene glycol 20.0mg
Sodium alginate 30.0mg
Sucrose 10.0mg
The above ingredients were uniformly mixed and granulated to produce granules.

(Prescription Example 6) Granule
Belode oyster extract 20.0mg
Peach extract 40.0mg
Carboxymethylcellulose 180.0mg
Sodium alginate 30.0mg
Erythritol 10.0mg
Citric acid 5.0mg
The above ingredients were uniformly mixed and granulated to produce granules.

(Formulation Example 7) Milk Mass%
Assembly extract 2.5
Astragalus extract 1.5
Squalane 5.0
Olive oil 5.0
Jojoba oil 5.0
Cetyl alcohol 1.5
Glycerol monostearate 2.0
Polyoxyethylene (20) cetyl ether 3.0
Polyoxyethylene (20) soorbitan monooleate 2.0
1,3-butylene glycol 1.0
Glycerin 2.0
P-Hydroxybenzoate ester
Residue with 100 purified water

(Formulation Example 8) Lotion Mass%
Aloe extract 3.0
Lavender extract 1.5
Glycerin 3.0
1,3-butylene glycol 5.0
Ethanol 15.0
Iron oxide 0.2
Zinc oxide 0.5
Kaolin 2.0
Trehalose 2.0
Dextrin 0.5
Photosensitive element 201 Appropriate amount Photosensitive element 401 Appropriate amount Perfume
Residue with 100 purified water

(Prescription Example 9) Ointment Mass%
Koganebana extract 4.0
Tormentilla extract 4.0
l-Menthol 3.0
DL-Camphor 0.5
Propylene glycol 15.0
Carboxyvinyl polymer 1.0
Hydroxyethyl cellulose 0.1
Triethanolamine 0.7
Purified water 25.0
Ethanol 100 residue

(Formulation Example 10) Body cleaner Mass%
Perilla extract 0.5
Bellows oyster extract 0.3
Sodium citrate 2.0
Potassium laurate 15.0
Potassium myristate 5.0
Propylene glycol 5.0
Sorbitol 3.0
Polyethylene powder 0.5
Hydroxypropyl chitosan solution 0.5
Preservative appropriate amount
pH adjuster appropriate amount perfume appropriate amount
Residue with 100 purified water

(Prescription Example 11) Baby powder mass%
Powdered mugwort extract 2.5
Powdered aloe extract 2.0
Zinc oxide 35.0
Betaine 2.0
Eucalyptus leaf oil 1.5
Menthol 3.2
Polyethylene powder 15.5
Perfume
Remaining as talc 100

(Formulation example 12) Impregnating liquid for wet tissue
Orchid extract 0.5
Oleander extract 0.3
Ethanol 2.0
Propylene glycol 5.0
Preservative appropriate amount
The remaining impregnation liquid in which purified water 100 was mixed was uniformly sprayed in an amount of 0.8% by mass on a tissue paper substrate having a basis weight of 45 g / m ² to produce a wet tissue.

(Prescription Example 13) Wet wiping sheet
Honoki extract 0.4
Assembly extract 0.8
Ethanol 8.0
Propylene glycol 12.0
Preservative appropriate amount
The liquid mixture obtained by mixing the remaining components as purified water 100 was sprayed uniformly in an amount of 1.2% by mass on 60 g / mm ² gauze to produce a wipe sheet.

Claims (1)

It contains an extract of one or more kinds of plants selected from honoki, koganebana, mugwort, aloe, perilla, lavender, tormentilla, psyllium, wild rose, orchid, bearded oyster, peach, senburi and genge Trypsin inhibitor