JP2002161043A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a safe skin care preparation having normalizing effects on skin immunity and further having ameliorating effects on skin roughening, ameliorating effects on firmness and wrinkles of the skin and ameliorating effects on adhesion of makeup. SOLUTION: This skin care preparation comprises one or more kinds of extracts from a tuber of Harpagophytum procumbens and a thickened root of Lepidium meyenii W used therein.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin such as pharmaceuticals, quasi-drugs and cosmetics. More specifically, the present invention relates to a safe and effective external skin preparation containing one or more extracts of devil's claw and maca.

[0002]

2. Description of the Related Art Devil's Claw has a scientific name of Harpagop.
Hytum procumbens refers to a tuber of a plant. This plant is a sesame plant distributed in the African desert and is called Devil's Claw because it has hard thorns. It is used as a medicinal plant.

[0003] Maka is the scientific name Lepidium meyen
ii W refers to an enlarged root of a plant. This plant is an alpine plant in the Northern Peruvian Mountains and is cultivated as food for Indio. It is used as a medicinal product for the purpose of promoting libido and recovering from fatigue.

[0004]

[0003] Skin external preparations such as cosmetics are often used for a long period of time, and are applied to organs having a large area such as the skin. In addition, there are various effects required for external preparations for skin, and effects such as prevention of skin aging and rough skin are required. In addition, the skin's functions include keeping the body from losing water so that it can live even in a dry atmosphere, and of course there are external physical defensive functions. Are also playing an important role. The skin is composed of epidermal keratinocytes, Langerhans cells, dermal dendritic cells, vascular endothelial cells, macrophages, etc.
It is believed that it is processed immediately upon contact, migrates to the lymph nodes and presents it to T cells, and a series of subsequent immune response reactions begins. It is also known that exposure to ultraviolet light and stress can reduce this immune function, and may cause various skin diseases (including those that do not lead to diseases) even if they do not lead to carcinogenesis. Normalization of skin immunity is an item that should be fully considered.
Further, there is a demand for cosmetics having not only the effect of skin immunity but also an effect of improving skin roughness, an effect of improving skin sticking, wrinkling, and an effect of improving makeup paste.

[0005]

Means for Solving the Problems As a result of intensive studies in consideration of safety and effectiveness with the skin, it has been found that an external preparation for skin using an extract of devil's claw and maca is most suitable for the purpose of the present invention. . It was found that the extracts of Devil's Claw and Maca have the effect of normalizing skin immunity, the effect of improving rough skin, the effect of improving skin sticking, wrinkles, and the effect of applying makeup. Since these effects are not solely due to the skin immunity normalizing effect, it is conceivable that various effects work in a complex and useful manner.

The method of using the devil's claw and maca extracts is not particularly limited, but when used as an extract, it is cut with a mixer or the like as necessary to facilitate the extraction.
Smash. This is extracted with water or a hydrophilic organic solvent.
The hydrophilic organic solvent used is extracted with methanol, ethanol, acetone, glycerin, 1,3 butylene glycol, propylene glycol, etc., or a mixture thereof, or a mixture of at least one hydrophilic organic solvent and water. However, since it is a preparation applied to the skin, a solvent which does not cause any problem even when used in an external preparation for skin such as water, ethanol, and glycerin has a wider range of use because there is no need to distill off the solvent. In our experiments, hot water extraction or a low concentration aqueous solution of a hydrophilic organic solvent is preferred. The extraction conditions vary depending on the degree of cutting, the purpose, and the type of the solvent, but when only water is used, considerable heating is possible, and even when the temperature is increased to 100 ° C., the effectiveness does not decrease significantly. One part or all of the solvent is distilled off depending on the type of the solvent and the dosage form of the external preparation for skin. This is mixed with a skin external preparation.

[0007] Devil's claw and maca extracts are blended into an external preparation for the skin. The amount varies depending on the extraction method and blending purpose, but the amount is 0.0001 to 10.0 as a solid content.
% Is preferred. In addition, since the other ingredients to be blended are not limited, they may be freely selected, but it is natural to select ingredients that do not contradict the purpose of the safe and effective external preparation for skin of the present invention. It is. For this reason, the use of various agents effective for whitening, antioxidation, cell activation (prevention of cell aging), moisturization, prevention of rough skin, and improvement thereof makes the object of the present invention more effective. In addition, there is no problem in selecting an arbitrary dosage form such as cream, milky lotion, lotion, pack, spray, gel and the like depending on the use and the like.

[0008] Hereinafter, a production example as an example of an actual extraction method and an example in which the production example is blended will be described. However, the present invention is not limited to these examples.

Production Example-1 Devil's Claw (Harpagophytum pro)
After cutting 100 g of dried tubers of C.cumbs, 2 kg of purified water was added, heated to 80 ° C., cooled after 5 hours, filtered with filter paper, and the filtrate was concentrated under reduced pressure.

Production Example-2 Devil's Claw (Harpagophytum pro)
After cutting 100 g of dried tubers of Cubens, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was concentrated under reduced pressure.

Production Example 3 After cutting 100 g of maca (dried radish of Lepidium meyenii W) into 100 g, 2 kg of purified water was added, heated to 80 ° C., and after 5 hours, allowed to cool and then filtered with filter paper. After filtration, the filtrate was concentrated under reduced pressure.

Production Example-4 100 g of maca (dried radish of Lepidium meyenii W) was shredded, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand with stirring for 10 days. The filtrate was concentrated under reduced pressure.

In the examples, the formulations shown in Table 1 are used. Both A and B are heated and dissolved at 80 ° C., and B is gradually added to A while stirring to emulsify. The mixture was cooled with stirring, stopped stirring at 35 ° C., and left to prepare a cream.

[0014]

The following experiment was conducted to confirm the effect. Test 1 Skin Immune Function Recovery Test Eight-week-old C3H / HeN male mice were divided into six groups, and 10 mJ / cm ² was applied to the shaved abdomen of the mice of the first to fifth groups.
/ Day of UV irradiation for 4 consecutive days. Day 1, Day 2,
Immediately after the irradiation on the third day and the fourth day, 50 μl / day of a 2% solution (the solvent was an extraction solvent) of Production Examples 1 to 4 was applied to the irradiation sites of the mice in the first to fourth groups, respectively. Nothing was applied to the irradiated sites of the mice in the fifth group. The sixth group was not irradiated with ultraviolet rays. One day after the end of the irradiation, the irradiation site (No. 6)
In the mice of the group, contact allergy sensitization with dinitrofluorobenzene (DNFB) was performed on the abdomen (substantially the same as the irradiation site of the mice of the first to fifth groups). Further, 5 days after the sensitization, it was induced in both ears, and one day later, the swelling value of the both ears (the thickness of the pinna before the induction was subtracted from the thickness of the pinna one day after the induction) Was measured, and the recovery rate (%) of the contact allergic reaction was calculated by the following equation.

Recovery rate = (ab) × 100 / (c−b)

Here, a represents the value of pinna swelling in the first to fourth groups, b represents the value of pinna swelling in the fifth group, and c represents the value of pinna swelling in the sixth group. Table 2 shows the results.

[0018]

[Table 2]

Test for Evaluating the Usefulness of Two Tests Fifty female volunteers aged 18 to 49 were randomly divided into five groups. One example on the right face and one comparative example on the left face
The same amount was used three times a day. After 3 months (the amount was not specified), the following evaluation was performed on the condition of the skin. 2-1 Peeling stratum corneum cell test A cellophane tape was stuck on the skin, and after 10 seconds, it was slowly peeled off, stained with hematoxin / eosin, evaluated according to the following criteria, and the average value of each group was calculated. Table 3
Shown in 1. Uniformity evaluation 1 The stratum corneum has peeled off considerably unevenly. Evaluation 2 The stratum corneum was peeled off somewhat unevenly. Evaluation 3 The stratum corneum was peeled non-uniformly on an extremely small part. Evaluation 4 The stratum corneum was uniformly peeled. 2. Degree of multilayer peeling evaluation 1 A considerable degree of multilayer peeling is observed. Evaluation 2 Slightly delamination is observed. Evaluation 3 Almost no delamination was observed. 3. Nuclear survivability evaluation 1 Nuclear remains considerably. Evaluation 2 Some nuclear remains. Evaluation 3 No nuclear remains

[0020]

[Table 3]

2-2 Subjective evaluation The following criteria were used to hear about the effect of improving skin roughness, the effect of reducing skin swelling and wrinkles, and the effect of applying makeup. Table 4 shows the results. (There was no person who complained of abnormal skin during the test period) Very improved compared to before use 3 Improved compared to before use 2 Improved slightly compared to before use 1 Use No change compared to before 0 Deteriorated compared to before use -1 Degraded compared to before use -2 Very deteriorated compared to before use -3

[0022]

[Table 4]

[0023]

The present invention has the function of restoring and normalizing the function of skin immunity from the above test, and the skin preparation for external use using one or more extracts of devil's claw and maca is actually rough. The improvement effect, skin swelling, wrinkle amelioration effect, and cosmetic sizing were improved, and it was found that the skin external preparation was highly effective. Needless to say, it has been considered edible since ancient times and has no problem with safety.

Claims (1)

[Claims] An external preparation for skin using at least one extract of devil's claw and maca.