JP2002121127A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation having remarkably improved bleaching effects and further even excellent aspects of safety such as skin irritation or skin sensitizing potential. SOLUTION: This skin care preparation is obtained by formulating the following ingredient (A) with an extract from Coptis japonica Makino. (A) one or more kinds selected from L-ascorbic acid and its derivative and a salt thereof except ascorbic acid glycosides, hinokitiol and its derivative, a 2- hydroxycarboxylic acid and its derivative and a salt thereof, hydroquinone and its derivative, cysteine and its derivative, glucosamine and its derivative, azelaic acid and its derivative, a placenta extract, a plant extract having inhibitory actions on melanin formation and an extract from algae having inhibitory actions on the melanin formation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a highly safe skin external preparation which has a significantly improved skin whitening effect and is highly safe.
INDUSTRIAL APPLICABILITY The skin external preparation of the present invention synergistically enhances the melanin production inhibitory effect and is effective for preventing and improving pigmentation, spots, freckles, etc. after sunburn.

[0002]

2. Description of the Related Art Conventionally, darkening of skin by ultraviolet rays,
In order to prevent or improve pigmentation of the skin, such as spots and freckles, components having an action of inhibiting the production of melanin pigment or reducing the produced melanin pigment have been incorporated into skin external preparations. For example, ascorbic acid, cysteine, hydroquinone, placenta extract, 2-hydroxycarboxylic acid and derivatives thereof, and extracts from plants and algae are used.

[0003] However, the improvement effect when these components are independently incorporated into an external preparation for skin or the like has not always been sufficient. Furthermore, ascorbic acid, cysteine, and hydroquinone are susceptible to oxidation-reduction reaction and have a problem in stability, and 2-hydroxycarboxylic acid has a problem in safety to skin. In addition, placental extracts and extracts from plants and algae have a problem that an undesired odor or color may be imparted to the external preparation for skin depending on the blending amount.

[0004]

SUMMARY OF THE INVENTION In view of the above-mentioned problems of the prior art, the present invention significantly improves the whitening effect,
Another object of the present invention is to provide a skin external preparation excellent in safety such as skin irritation and skin sensitization.

[0005]

Means for Solving the Problems The present inventors have made various studies to solve the above problems, the component having an effect of inhibiting the specific melanogenesis, Coptis (Co
ptis japonica Makino) extract has been found to provide a synergistically enhanced whitening effect and to provide a safe external preparation for skin irritation and skin sensitization. The invention has been completed.

That is, the present invention relates to (A) L-ascorbic acid excluding ascorbic acid glycoside and its derivatives and their salts, hinokitiol and its derivatives, 2-hydroxycarboxylic acid and its derivatives and their salts,
1 selected from hydroquinone and its derivatives, cysteine and its derivatives, glucosamine and its derivatives, azelaic acid and its derivatives, placenta extract, plant extract with melanin production inhibitory activity, and algal extract with melanin production inhibitory activity It is intended to provide a skin external preparation characterized by containing a seed or two or more kinds and an extract of spinach ( Coptis japonica Makino).

[0007]

Embodiments of the present invention will be described.

The spinach ( Coptis jap) used in the present invention
onica Makino) is a plant belonging to the Ranunculaceae family ( Coptis Salisb.). Although various parts of a plant can be used for the spinach extract used in the present invention, a rhizome is particularly preferably used.

The amount of the extract obtained from spinach in the external preparation for skin is not particularly limited, but it is generally 0.0001 to 10% by weight, especially 0.001% by weight, based on the total amount of the external preparation for skin.
The content of 1 to 5% by weight is preferable because the effect and the storage stability of the product are excellent.

[0010] The L-ascorbic acid and its derivatives other than ascorbic acid glycoside used in the present invention and their salts are not particularly restricted but include, for example, L-ascorbic acid, sodium L-ascorbate and L-ascorbic acid. Magnesium acid, potassium L-ascorbate,
L-ascorbates such as calcium L-ascorbate, L-ascorbic acid monostearate, L-ascorbic acid monopalmitate, L-ascorbic acid monooleate and the like, and L-ascorbic acid monoalkyl or monoalkenyl esters; Ascorbic acid sulfates such as ascorbic acid-2-sulfate; dialkyl or dialkenyl L-ascorbate such as L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L-ascorbic acid dioleate;
L-ascorbic acid trialkyl or trialkenyl esters such as L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbyl phosphate, sodium L-ascorbyl phosphate, L-ascorbyl phosphate L-ascorbyl phosphates such as potassium ascorbyl phosphate, magnesium L-ascorbyl phosphate, and L-ascorbyl calcium phosphate are exemplified. In particular, L-ascorbic acid, L-ascorbyl phosphate, and L-ascorbyl magnesium phosphate are most preferred from the viewpoint of the effects of the present invention.

The hinokitiol and derivatives thereof used in the present invention are not particularly limited, and include, for example, hinokitiol glycosides such as hinokitiol, hinokitiol zinc complex, hinokitiol glucoside and acetyl derivatives thereof.

The 2-hydroxycarboxylic acid and its derivatives and salts thereof used in the present invention are not particularly limited, but are preferably 2-hydroxycarboxylic acids having 2 to 22 carbon atoms, for example, 2-hydroxycarboxylic acid or 2-hydroxycarboxylic acid. Derivatives such as 2-hydroxycarboxylic acid alkyl esters, 2-hydroxycarboxylic acid cholesterol esters, 2-hydroxycarboxylic acid glycosides, 2-hydroxycarboxylic acid phosphatidyl esters, and salts thereof. Further, 2-hydroxycarboxylic acids having 2 to 6 carbon atoms are preferably used from the viewpoint of the effect of the present invention,
Examples include 2-hydroxyacetic acid, lactic acid, malic acid, tartaric acid, citric acid and salts thereof. Examples of such salts include metal salts such as sodium salt, potassium salt, magnesium salt, and aluminum salt; L-arginine salt;
Any organic salt such as -amino-2-methyl-1,3-propanediol salt may be used.

The hydroquinone and derivatives thereof used in the present invention are not particularly limited, but hydroquinone glycosides are preferably used. Examples thereof include hydroquinone-α-D-glucoside, hydroquinone-β-D-glucoside, and hydroquinone-glycoside. α-L-glucoside, hydroquinone-β-L-glucoside, hydroquinone-α-
Hexasaccharide glycosides such as D-galactoside, hydroquinone-β-D-galactoside, hydroquinone-α-L-galactoside, hydroquinone-β-L-galactoside, hydroquinone-α-D-ribose, hydroquinone-β
-D-ribose, hydroquinone-α-L-ribose,
Hydroquinone-β-L-ribose, hydroquinone-
Pentose sugar glycosides such as α-D-arabinose, hydroquinone-β-D-arabinose, hydroquinone-α-L-arabinose, hydroquinone-β-L-arabinose, hydroquinone-α-D-glucosamine, hydroquinone-β- D-glucosamine, hydroquinone-α-
L-glucosamine, hydroquinone-β-L-glucosamine, hydroquinone-α-D-galactosamine, hydroquinone-β-D-galactosamine, hydroquinone-α-L-galactosamine, hydroquinone-β-L-
Amino sugar glycosides such as galactosamine, hydroquinone-
α-D-glucuronic acid, hydroquinone-β-D-glucuronic acid, hydroquinone-α-L-glucuronic acid, hydroquinone-β-L-glucuronic acid, hydroquinone-α-D-galacturonic acid, hydroquinone-β-D-
And uronic acid glycosides such as galacturonic acid, hydroquinone-α-L-galacturonic acid, and hydroquinone-β-L-galacturonic acid. Examples of the derivatives thereof include esters such as acetylated products and ethers such as methylated products, and hydroquinone-β-D-glucoside is most preferred from the viewpoint of the effects of the present invention.

The cysteine and its derivative used in the present invention are not particularly limited, but include, for example, cysteine or phospholipid ester of cysteine, ester with sphingosine and its derivative, glycolipid ester, sugar ester, sterol ester and carbon. Examples include alkyl or alkenyl esters of the formulas 8 to 20.

[0015] Glucosamine and its derivatives used in the present invention are not particularly limited, and include, for example, glucosamine esters such as glucosamine and acetylglucosamine, and glucosamine ethers such as glucosamine methyl ether.

The azelaic acid and its derivatives used in the present invention are not particularly limited, but, for example, azelaic acid monoesters such as azelaic acid and azelaic acid monoalkyl ester, and azelaic acid diesters such as azelaic acid dialkyl ester. Is mentioned.

The placenta extract used in the present invention includes:
Examples include those obtained by subjecting the placenta of mammals such as cows and pigs to blood removal, crushing, freezing, and the like, extracting water-soluble components, and further removing impurities. Generally, it is commercially available as a water-soluble placenta extract.

Inhibition of melanin production used in the present invention
The type of plant from which a plant extract having
For example, Mansaku (Hamamelis japonica Sieb. Et
Zucc.), Cinnaman Saku (Hamamelis mollis Oliv.),
Hamamelis (Hamamelis virginiana L.) etc.
Genus plant, Hossuri (Saxifraga aizoon Jacq.), Chico
Tanso (Saxifraga cherlerioides D. Don var.rebu
nshirensis (Engl. Et Irmsch) Hara,Saxifraga bronc
hialalis L.), ginjisou (Saxifraga cortusaefolia
 Sieb. Et Zucc.), Daimonjisou (Saxifraga fortu
nei Hook.f.var.incisolobata (Engl. Et Irmsch.)
Nakai), Haruyukinoshita (Saxifraga nipponica Makin
o), Sendaisou (Saxifraga sendaica Maxim.) 、 Yu
Kinoshita (Saxifraga stolonifera Meerb.) 、 Fukiyuki
Noshita (Saxifraga japonica Boiss.) 、 Black spider
(Saxifraga fusca Maxim.), Spider Magsa (Saxifraga 
merkii Fish.var.laciniata Nakai) 、 Kumoma Yukino
Sita (Saxifraga laciniata Nakai et Takeda), Chico
Tanso (Saxifraga bronchialalis L.) 、 Mukagoyuki
Noshita (Saxifraga cernua L.) etc.
Things, Jinko (Aquilaria agallocha Roxb.)
Camellia spp.Camellia japonica L.)
And its variants, Cha (Camellia sinensis (L.) O. Kunt
ze) and its variants such as camellia plants, safflower
(Aesculus carnea Hayne)Aesculus 
chinensis Bunge), Horse chestnut (Aesculus hipp
ocastanum L.), horse chestnut (Aesculus turbinata Bl.)
Such as horse chestnut plants, knotweed (Polygonum cuspidatum
 Sieb. Et Zucc.), Honeybeebird (Polygonum c
uspidatu m Sieb. Et Zucc.var.hachidyoense Ohw
i), Giant knotweed (Polygonum sachalinense Fr. Sch
m.) and other genus plants such as Melissa (Melissa officinalis 
L.), Ibuki-ji
Gypsophila (Thymus serphyllum L. subsp.quinquecos
tatus (Aelak.) Kitamura), Time (Thymus vulgaris
L.) and the like,Arte
misia absinthium L.), ginseng (Artemisia ann
ua L.), River carrot (Artemisia apiaceaHanc
e), mugwort (Artemisia capillaris Thunb.),
Chinese mugwort (Artemisia cina Berg.), Tarragon (Arte
misia dracunculus L.), Artemisia mugwort (Artemisia ja
ponica Thunb.), Mibu-Mugomi (Artemisia maritima 
L.), mugwort (Artemisia princeps Artemisia such as Pamp.)
Genus plant, Yarrow (Achillea alpina L.), Seyo
Yarrow (Achillea milleifolium L.), Jaco
Yarrow (Achillea moschata Jacq.) And other saws
Gypsophila spp.Eupatorium japonicum T
hunb.), Sawa's bulbul (Eupatorium lindleyanum D
C.), Bulbul (Eupatorium chinense L. var.op
positifolium (Koidz.) Murataet H. Koyama)
Safflower plant, American linden (Tilia americana
L.), Fuyubodaiju (Tilia cordata Mill.), Say
Linden (Tilia europaea L.), linden (Tilia
 japonica (Miq.) Simonk.), Bodaiju (Tilia miqu
eliana Maxim.), Natsubodaiju (Tilia platyphyllo
s Linden plants such as Scop.Hypericum
 ascyron L.), Hypericum (Hypericum erectum Thu
nb.), Himeotogiri (Hypericum japonicum Thun
b.), Hypericum perforatum (Hypericum perforatum L.)
Hypericum plants such as St. John's wort,Tanakaea r
adicans Fr. et Sav.)
Plant, Satsuma Fuji (Daphne genkwa Sieb. Et Zucc.),
Pepper (Daphne kiusianaMiq.) 、 Koshjin
Butterfly (Daphne mezereum L.), Daphnia (Daph
neodora Thunb.), Onishibari (Daphne pseudo-mezere
um A. Gray), Naniwazu (Daphne kamtchatica Maxim.
var.yezoensis Ohwi), crow shikimi (Daphnemiyabea
na Daphnia spp., Makino)
(Diplomorpha phymatoglossa (Koidz.) Nakai), cancer
Pi (Diplomorpha sikokiana (Fr. et Sav.) Honda),
Kiganpi (Diplomorpha trichotoma (Thunb.) Nakai)
Gampi plants such asEdgeworthia chrysantha
 Lindl.), Representative of the genus Mitsumata, Spanish persimmon
elephant(Glycyrrhiza glabra L.)Glycyrr
hizakansuensis Chang et peng), Licorice (Glycyrrh
iza urarensis Fisch.) Etc., licorice plants, Nagabano
MossDrosera angelica Huds.) 、 Ishimochiso
CDrosera peltata Smith)Drosera
 routundifolia L.)Drosera spath
ulata Labill.) And other genus plants, Urashimatsu
Azalea (Arctostaphylos alpina (L.) Spreng.var.japo
nica (Nakai) Hulten)Arctostaphylos u
va-ursi (L.) Spreng.)
No.

The algae obtained from the algae extract having an inhibitory effect on melanin production used in the present invention are not particularly limited, and include , for example, sponge ( Ceratodictyon spongiosu).
m ), sphagnum algae and innocence coral ( C
orallina sp.), coral ( Corallina officinali )
s ), Corallina pilurifera, and other coral alga, Dictyopteris latiuscula , Dictyopteris undulata , and Hericahaz ( Dic )
tyopteris prolifera ), Sujiyahazu ( Dictyopteris pl )
agiogramma ), Himeyahazu ( Dictyopteris repens ),
Ezoyahazu (Dictyopteris divaricata), Uraboshiyahazu (Dictyopteris polypodioides) Yahazugusa algae such as, Hariamiji Amijigusa algae typified by (Dictyota spinulosa), hijiki algae typified hijiki (Hizikia fusiformis), Sozo sp. (Laurencia sp. ), Kurosozo ( Laurencia intermedia ), Mitsodesozo ( Lauren
cia okamurai ), Sozonohana ( Laurencia grevillean )
a ), Osozo ( Laurencia glandulifera ), Hanesozo ( Laurencia pinnata ), Kobusozo ( Laurencia undulat )
a ) Sozoa algae, such as the fushitsunagi ( Lomentaria catenat)
a), Kosujifushitsunagi (Lomentaria hakodatensis) Fushitsunagi algae such as, cassiope lycopodioides (Myelophycus caespito
sus ), Darus alga ( Palmaria)
palmata ), Darus alga, Sargassum ( Sar)
gassum fulvellum ), pea ( Sargassumyendo )
i ), Mametawara ( Sargassum piluriferum ), Yam Tamok ( Sargassum patens ), Akamoku ( Sargassum horn )
eri), Nokogirimoku (Sargassum serratifo lium), Oba sawtooth Mok (Sargassum giganteifolium), Yoremoku (Sargassum tortile), Yanagimoku (Oobamoku: Sargassum ringgoldianum), Nejimoku (Sargassum
sagamianum), Hahakimoku (Sargassum kjellmanianu
m ), sea lantern ( Sargassum thunbergii ), fushijimoku ( Sargassum confusum ), isomok ( Sargassum )
hemiphyllum ), sara ( Sargassum nigrifolium ),
Stalked mushroom ( Sargassum micracanthum ), Tamanashimoku ( Sargassum nipponicum ), Ginseng ( Sargassum vu )
lgare ), phloem (Hollyhock: Sargassum dupli)
catum), Ezononejimoku (Sargassum yezoense) Sargassum algae such as, Ishimozuku (Sphaerotrichia divar
Illustrative algae typified by icata ) are exemplified.

Among the above-mentioned plant extracts and algal extracts having an inhibitory effect on melanin production, Hamamelis
virginiana L.), Saxifraga ( Saxifraga stolonifera )
Meerb.), Jinko ( Aquilaria agallocha Roxb.),
Tea ( Camellia sinensis (L.) O. Kuntze) and its variants, knotweed ( Polygonum cuspidatum Sieb. Et Zuc
c.), Melissa ( Melissa officinalis L.), Thyme ( Thymus vulgaris L.), Artemisia ca.
pillaris Thunb.), Achillea ( Achillea )
milleifolium L.), Hypericum erectum
Thunb.), Hypericum perforatum ( Hypericum perforatum)
L.), Spanish liquorice ( Glycyrrhiza glabra L.),
Licorice ( Glycyrrhiza urarensis Fisch.), Datura moss ( Drosera routundifolia L.), Pleurotus ( Arct )
ostaphylos uva-ursi (L.) Spreng.), Herayahaz ( Di
ctyopteris prolifera ), Haramiji ( Dictyota spinu )
losa ), Hizikia ( Hizikia fusiformis ), Soso sp. ( Lau)
rencia sp.), fushigumi ( Lomentaria catenata ),
Sardines ( Myelophycus caespitosus ), Daruss ( Palma )
ria palmata ), willow moku (Obamoku: Sargassum r)
inggoldianum), Ezononejimoku (Sargassum yezoens
e ), an extract from one or more plants and algae selected from Sargassum confusum , and Sphaerotrichia divaricata are preferably used.

Extraction from spinach or plants and algae having melanin production inhibitory activity may be carried out by extracting one or more parts of the whole plant or algae or its leaves, bark, roots, flowers, branches, stems, seeds and the like. Is used as it is or after being dried and pulverized. The extraction solvent is not particularly limited, but may be water, ethanol,
Monohydric alcohols such as methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol, n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene Polyhydric alcohols such as glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, and hexylene glycol or derivatives thereof; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, and methyl-n-propyl ketone; ethyl acetate; Esters such as isopropyl acetate, ethyl ether, isopropyl ether, n-
Ethers such as butyl ether, hydrocarbons such as squalane, petrolatum, paraffin wax, paraffin oil, olive oil, wheat germ oil, rice oil, sesame oil, macadamian nut oil, almond oil, coconut oil, and other vegetable oils, tallow, pork Fats and animal fats such as whale oil are exemplified. Also,
Polar solvents to which inorganic salts such as phosphate buffered saline have been added, and solvents to which surfactants have been added can also be used, and there is no particular limitation.

Further, as the extraction method, a method of extracting by impregnation at room temperature, in a cooled or heated state, a method of extraction using a distillation method such as steam distillation, a method of pressing a plant or algae to obtain an extract For example, these methods are used alone or in combination of two or more.

The ratio of the plant or algae to the solvent at the time of extraction is not particularly limited.
0.1 to 1000 times by weight, especially in terms of extraction operation and efficiency.
5 to 100 times by weight is preferred. It is convenient to set the extraction pressure and the extraction temperature in a range from 0 ° C. to the boiling point of the solvent at normal pressure, and the extraction time varies depending on the extraction temperature.
It is preferable to set the time in a range from time to two weeks.

The extract of the plant or algae thus obtained can be used as it is, but it may be subjected to purification operations such as deodorization, decolorization, concentration, etc. as long as the effect is not lost. May be used as a fraction using column chromatography or the like. These extracts, purified products, and fractionated products can be dried by removing the solvent therefrom, and can be used in a form solubilized in a solvent such as alcohol or in an emulsion form. it can.

[0025] Components obtained by purification and fractionation from plant extracts include hamamelitannin, which is often contained in leaves of hamamelis, and flavonoids, which are contained in oil-soluble extract components of licorice, especially glabridine, hispagrabridine, and the genus (-)-Epicatechin and the like contained in the plant extract.

The amount of the component (A), which has the effect of inhibiting melanin production, in the external preparation for skin is not particularly limited, but from the viewpoint of its effect, odor and color tone when added, 0.0001-10 based on the total amount of the external preparation
% By weight is desirable.

The external preparation for skin of the present invention may contain, if necessary,
Oils and fats, humectants, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, preservatives, which are usually blended in pharmaceuticals, quasi-drugs, skin cosmetics, hair cosmetics and cleansers Antioxidants, thickeners, drugs, fragrances, resins, alcohols and the like can be appropriately compounded. Further, the dosage form of the external preparation for skin of the present invention is arbitrary, and for example, it can be provided as a solubilizing system such as a lotion, an emulsifying system such as a cream or an emulsion, or a dispersion system such as a calamine lotion. An aerosol dosage form filled together with the aerosol may be used.

[0028]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, preparation examples of a spinach extract, a placenta extract, and a plant extract and an algal extract having an inhibitory action on melanin production used in the present invention will be described.

[Our water extract] [Our water ( Coptis jap)
550 g of Rhizome of C. onica Makino) was dried and pulverized, and extracted by stirring in 1,500 g of a 50% by weight aqueous ethanol solution at 25 ° C. for 5 days. Next, the extract was filtered, and the filtrate was used as a spinach extract.

[Placenta extract] A commercially available water-soluble placenta extract (manufactured by Nichirei) was used.

[Kitadori extract] Knotweed ( Polygonum
cuspidatum Sieb. et Zucc.)
It was pulverized and stirred and extracted in 1,500 g of a 50% by weight aqueous ethanol solution at 25 ° C. for 5 days. Next, the extract was filtered, and the filtrate was used as a knotweed extract.

[ Kitadori Extract Fraction] Knotweed ( Polygo
dry powder 2 of rhizome of num cuspidatum Sieb. et Zucc.)
00 g was immersed in 2,000 g of a 50% by weight aqueous ethanol solution and extracted at room temperature for 7 days. Next, the extract was filtered, the filtrate was concentrated under reduced pressure, and a 30% by weight aqueous ethanol solution 8 was added.
00g, DIAION MCI Gel H
The mixture was applied to a P-20 column (manufactured by Mitsubishi Kasei Corporation), and the fraction eluted with a 40% by weight aqueous ethanol solution was collected.
Subsequently, the above fraction was subjected to silica gel thin layer chromatography to form a chloroform / methanol mixture (weight ratio = 5: 1).
Was used as a developing solvent for fractionation. Among the obtained fractions, the fraction containing (-)-epicatechin was scraped off and dissolved in 50 g of 50% by weight ethanol to obtain a knotweed extract fraction.

[ Hamelis extract] Hamamelis extract
lis virginiana L.) 500 g of leaves are dried, crushed and
The mixture was extracted with stirring in 1,000 g of a 0% by weight aqueous ethanol solution at 25 ° C. for 5 days. Next, the extract was filtered, and the filtrate was collected to obtain a Hamamelis extract.

[Hamelis extract fraction] Hamamelis ( Ha
(mamelis virginiana L.) was cut into a total of 500 g, and extracted with stirring in 1,500 g of hot water for 5 hours. Then, the extract is filtered, and the filtrate is filtered by DIAION MCIG.
The resultant was applied to an el HP-20 column (manufactured by Mitsubishi Kasei Corporation) and eluted with a mixed solvent of ethanol and water. A fraction having a hamamelitannin content of 50% by weight or more was collected to obtain a hamamelis extract fraction.

[ Phaseolum perforatum extract] Whole plant of flowering season of Hypericum perforatum L. 35
0 g was minced and immersed in 1,000 g of olive oil at 20 ° C. for 7 days for extraction. The extract was filtered and the filtrate was collected to obtain a Hypericum perforatum extract.

[Licorice extract] Licorice ( Glycyrrhiza ur)
arensis Fisch.) was dried, pulverized, and extracted with stirring in 1,000 g of absolute ethanol at 25 ° C. for 24 hours. The extract is filtered to collect the filtrate, concentrated under reduced pressure, and lyophilized to dryness. The dried product was stirred and extracted in 1,000 g of ethyl acetate at 20 ° C. for 2 days. After extraction, it was dried under reduced pressure to obtain a licorice extract.

[ Zinko Extract] Zinko ( Aquillaria)
agallocha Roxb.), a total of 300 g, dried and pulverized, and dried at 20 ° C. in 1,000 g of absolute ethanol at 10 ° C.
Dipped for days. Next, the extract was filtered, and the filtrate was diluted 1/1.
It was concentrated to 0 volume to obtain a ginger extract.

[Oolong tea extract] Oolong tea ( Thea s
Inensis L. var. viridis Szkzyl.) leaves (440 g) were dried, pulverized and extracted with stirring in 1,000 g of purified water at 50 ° C. for 24 hours. The extract was filtered, and the filtrate was concentrated to 1/5 volume to obtain an oolong tea extract.

[0039] [Melissa extract] Melissa (Melissa of
ficinalis L.) was crushed and extracted with stirring in 1,000 g of 1,3-butylene glycol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain a Melissa extract.

[Thyme extract] Thyme ( Thymus vulgari
s L.) was dried and pulverized, and extracted by stirring at 25 ° C. for 5 days in 1,500 g of a 50% by weight aqueous glycerin solution. The extract was filtered, and the filtrate was collected to obtain a thyme extract.

[ Achillea millefolium L.) Flower 320
g was homogenized in 2,000 g of physiological saline at 10 ° C., and further extracted with stirring for 4 hours. Filter the extract,
The filtrate was collected to obtain an Achillea millefolium extract.

[0042] [sundew extract] sundew (Dr
osera routundifolia L.) was crushed and extracted with stirring in 1,000 g of absolute ethanol at 25 ° C. for 5 days. The extract was filtered, and the filtrate was collected to obtain an A. moss extract.

[ Erythrophilus Extract] Erythrophila ( Arctos
taphylos uva-ursi (L.) Spreng.) leaves (350 g) were minced and placed in 1,000 g of 1,3-butylene glycol at 20 ° C.
For 7 days. The extract was filtered, and the filtrate was collected to obtain a mulberry extract.

[Hellayas extract], [Hariamiji extract], [Sozo sp. Extract], [Darus extract] Hellayaz ( Dictyopteris prolifera ), Hariaamiji ( Dictyota spinulosa ), Soso sp. ( Laurencia ssp.) Collected from the sea
p.) and all the algae of Dulse ( Palmaria palmata ) were washed with water, minced, dispersed in an equal volume of phosphate buffered saline (pH 7.4), and then extracted with stirring in a blender mill for 3 hours. The extract was filtered, and the filtrate was collected to obtain each of the above extracts.

Using the formulations shown in Table 1, Examples 1 to 12 and Comparative Examples 1 to 12 were prepared as the cosmetics of the present invention. These serums were prepared by mixing and homogenizing all components. In addition, all the items were shown by weight%.

[0046]

[Table 1]

[0047]

[Table 2]

[0048]

[Table 3]

Examples 1 to 3 of the present invention prepared according to the above formulation
Example 12 and Comparative Examples 1 to 12 were evaluated for the effect of improving pigmentation symptoms. Twenty female panelers having remarkable spots, freckles, and other pigmentation symptoms were grouped into one group, and Examples 1 to 12 and Comparative Examples 1 to 12 were each applied twice a day for one month for one month. Used. One month after each panel, the state of pigmentation of the skin was observed and evaluated in comparison with the state before use. The state of pigmentation was evaluated according to the criteria shown in Table 4, and the average value of 20 persons was calculated. The results are shown in Tables 5 and 6.

[0050]

[Table 4]

[0051]

[Table 5]

[0052]

[Table 6]

As is evident from Tables 5 and 6, in the group using the examples according to the present invention, remarkable improvement in the pigmentation symptom was observed in all the groups, and after the end of the use test, it was mild or slight. The symptoms had been improved to the extent that pigmentation was only observed. In particular, Example 1 using a combination of a spinach extract and L-ascorbyl magnesium phosphate,
Good improvement was observed in the use groups of Example 8 in combination with the knotweed extract fraction and Example 9 in combination with the Hamamelis extract fraction. On the other hand, in the comparative example use group in which the substance having the melanin production inhibitory action was blended alone, although the improvement of the pigmentation symptom can be observed, the degree of the improvement is clearly compared to the corresponding example use group. It was small.

In Examples 1 to 12 of the present invention, no change in the state of the preparation such as precipitation, separation, agglomeration, discoloration and discoloration of the components was found during the above use test period. In addition, in each group used in Examples, there was no paneler showing a skin irritating reaction or a skin sensitizing reaction.

Another embodiment of the present invention will be described.

Example 13 Serum (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 37.5 (5) Fatty acid glycerin 4. 0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20EO) sorbitan monolaurate 2.0 (8) 1,3-butylene glycol 5.0 (9) Urethane extract 4 (10) Sodium lactate 0.3 (11) Purified water 39.8 Production method: The oily components (1) to (7) and the aqueous components (8) to (11) were mixed and homogenized, respectively, to 75 ° C. Heat. The oily component is added to the aqueous component to emulsify and then cooled to 30 ° C. with stirring.

Example 14 Essence (1) Squalane 5.0 (% by weight) (2) Vaseline 2.0 (3) Beeswax 0.5 (4) Sorbitan sesquioleate 0.8 (5) Polyoxy Ethylene oleyl ether (20EO) 1.2 (6) Glycerin 5.0 (7) Purified water 58.2 (8) Carboxyvinyl polymer (1% by weight aqueous solution) 20.0 (9) Urethane extract 1.5 (10 ) Potassium hydroxide 0.1 (11) Ethanol 5.0 (12) Fragrance 0.2 (13) L-ascorbic acid 0.5 Production method: The oil phase components of (1) to (5) are mixed, and 75 ° C. To dissolve and homogenize. On the other hand, the aqueous phase components (6) to (9) were mixed and dissolved, heated to 75 ° C., added with the oil phase component, uniformly emulsified with a homomixer, and added with (10) to adjust the pH. To adjust. After cooling, (11) to (13) are added at 40 ° C. to mix and homogenize.

Example 15 Lotion (1) Ethanol 10.0 (% by weight) (2) Hydroxyethylcellulose 1.0 (3) Ouren extract 1.0 (4) Glycerin 7.0 (5) Guaiazulene sulfone Sodium acid 0.5 (6) 2-hydroxyacetic acid 0.5 (7) Purified water 80.0 Production method: (1) to (7) are mixed and made uniform.

Example 16 Emulsion (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Squalane 7.0 (5) Polyoxyethylene (10EO) ) Monooleate 1.5 (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Ouren extract 1.0 (9) Purified water 79.0 (10) Lactic acid bacteria extract 0.5 (11) Placenta extract 0.3 Production method: Mix and heat the oil phase components of (1) to (5) to dissolve uniformly and keep at 70 ° C. On the other hand, the aqueous phase components (6) to (9) are mixed and heated to homogenize, and the temperature is raised to 70 ° C. The oil phase component is gradually added to the aqueous phase component with stirring, emulsified, and then cooled. The components (10) and (11) are added at 40 ° C., and the mixture is homogenized.

[Example 17] Moisturizing gel (1) Purified water 90.9 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Urethane extract 0.3 (4) Sorbitol 8.0 (5) Potassium hydroxide 0.1 (6) Hinokitiol 0.2 Production method: After (2) and (3) are uniformly dissolved in (1), (4) is added, and then (5) is added to increase the viscosity. , (6) are added and mixed uniformly.

Example 18 Protective Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic Glyceryl Monostearic acid ester 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate ester 5.0 (7) 1,3-butylene glycol 5.0 (8) Urethane extract 0.5 (9) Oolong tea extract 0.2 (10) Purified water 36.8 Production method: Mix and dissolve the oil phase components (1) to (6) and heat to 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 19 Oil-in-water emulsion ointment (1) White petrolatum 25.0 (% by weight) (2) Stearyl alcohol 25.0 (3) Glycerin 10.0 (4) Sodium lauryl sulfate 1.0 (5) Spinach extract 0.5 (6) Zinko extract 0.2 (7) Purified water 38.3 Production method: Mix and dissolve the oil phase components of (1) to (4) to make uniform, 75 ° C Heat to On the other hand, (5) and (6) are dissolved in (7) and dissolved by heating at 75 ° C., and the oil phase component is added to this and emulsified. After emulsification, the mixture is cooled to 30 ° C. with stirring.

[Example 20] Lotion (1) Ethanol 10.0 (wt%) (2) 1,3-butylene glycol 10.0 (3) Hinokitiol 0.5 (4) Dipotassium glycyrrhizinate 0.5 ( 5) Spinach extract 0.2 (6) Purified water 78.7 Production method: (1) to (5) are sequentially added to (6), and uniformly mixed and dissolved.

Example 21 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Behenyl alcohol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self Emulsified glyceryl monostearate 2.0 (5) 1,3-butylene glycol 10.0 (6) Potassium hydroxide 0.3 (7) Ouren extract 0.5 (8) Purified water 69.0 (9) ) Titanium oxide 1.0 (10) Bengala 0.1 (11) Yellow iron oxide 0.4 (12) Fragrance 0.1 (13) Thyme extract 0.1 Production method: oil phase of (1) to (4) The ingredients are mixed and heated to 75 ° C. to homogeneity. On the other hand, the components (5) to (8) were mixed and 75
The mixture was heated and dissolved at ℃ to make it uniform, and the pigments of (9) to (11) were added thereto and uniformly dispersed with a homomixer to obtain an aqueous phase component. The oil phase component is added to the aqueous phase component, emulsified by a homomixer, cooled, and the components (12) and (13) are added at 40 ° C. to mix and homogenize.

Example 22 Liquid Foundation (1) Stearic acid 2.0 (% by weight) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Deca Glyceryl monoisopalmitate 9.0 (6) 1,3-butylene glycol 8.0 (7) Potassium hydroxide 0.1 (8) Ouren extract 0.3 (9) Purified water 51.2 (10) Titanium oxide 9.0 (11) Talc 7.4 (12) Bengala 0.5 (13) Yellow iron oxide 1.1 (14) Black iron oxide 0.1 (15) Fragrance 0.1 (16) Melissa extract 0.2 Production method: The oil phase components (1) to (5) are mixed and heated to 75 ° C. to make uniform. On the other hand, the aqueous phase components (6) to (9) are mixed,
The mixture is heated to 75 ° C. and dissolved to make the mixture uniform. The pigments (10) to (14) are added to the mixture, and the mixture is uniformly dispersed with a homomixer. After adding the oil phase component and emulsifying, the mixture is cooled and cooled at 40 ° C. (15),
Add and mix component (16).

Example 23 Hand Cream (1) Cetanol 4.0 (% by weight) (2) Vaseline 2.0 (3) Squalane 10.0 (4) Glyceryl monostearate 1.5 (5) Poly Oxyethylene (60EO) Glyceryl isostearate 2.5 (6) Tocopherol acetate 0.5 (7) Glycerin 20.0 (8) Methyl parahydroxybenzoate 0.1 (9) Ouren extract 0.3 (10) Hydroquinone -β-D-glucoside 0.1 (11) Purified water 59.0 Production method: Mix and dissolve the oil phase components (1) to (6) and heat to 75 ° C. On the other hand, the aqueous phase components (7) to (11) are mixed and dissolved and heated to 75 ° C. Then, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 24 Jelly-like peel-off pack (1) Polyvinyl alcohol 15.0 (% by weight) (2) Carboxymethyl cellulose 5.0 (3) 1,3-butylene glycol 3.0 (4) Ethanol 0 (5) Polyoxyethylene (20EO) oleyl ether 0.5 (6) Ouren extract 0.2 (7) Achillea millefolium extract 0.1 (8) Purified water 70.2 Production method: (8) ) And heat to 75 ° C. to this
(1) and (2) are added and dissolved, and (4) to (7) are added and dissolved.

Example 25 Massage Gel (1) Dipropylene glycol 7.0 (% by weight) (2) Glycerin 8.0 (3) Polyoxyethylene (15EO) oleyl ether 1.0 (4) Carboxyvinyl polymer 0.4 (5) Hydroxyethylcellulose 0.2 (6) Orange extract 0.4 (7) Hypericum extract 0.2 (8) Potassium hydroxide 0.1 (9) Purified water 82.7 Production method: 75 The components (1) to (8) are sequentially added to (9) heated to ° C., dissolved and homogenized.

[Example 26] Face wash (1) Stearic acid 10.0 (wt%) (2) Cetanol 3.0 (3) Palmitic acid 10.0 (4) Isopropyl myristate 7.5 (5) Glyceryl Monostearate 2.5 (6) Polyoxyethylene (20EO) sorbitan Monostearate 2.5 (7) Glycerin 12.0 (8) Ouren extract 0.3 (9) Potassium hydroxide 6.0 ( 10) Purified water 46.0 (11) Herayahazu extract 0.2 Production method: The oil phase components of (1) to (6) are mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved by heating to 70 ° C. The oil phase component is gradually added to the aqueous phase component for pre-emulsification, then uniformly emulsified by a homomixer, cooled, and the component (11) is added at 40 ° C.

Example 27 Lotion (1) Ethanol 20.0 (% by weight) (2) Hydroxyethylcellulose 1.0 (3) Urethane extract 0.2 (4) Glycerin 7.0 (5) Guaiazulene sulfone Sodium acid 0.5 (6) Haramiji extract 0.2 (7) Dulse extract 0.2 (8) Purified water 70.9 Production method: (1) to (8) are mixed and made uniform.

[Example 28] Moisturizing gel (1) Purified water 84.2 (% by weight) (2) Carboxyvinyl polymer 0.5 (3) Urethane extract 0.1 (4) 1,3-butylene glycol 15 0.0 (5) Sozo sp. Extract 0.1 (6) Potassium hydroxide 0.1 Production method: (2) to (5) are sequentially added to (1), and after uniform dissolution, (6) is added. Thicken.

In Examples 13 to 28 of the present invention, the effects of improving skin irritation and pigmentation symptoms were examined.
For skin irritation, a 48-hour obstruction sticking test was performed by 20 male panelists. The results were determined according to the criteria shown in Table 7, and represented by the average value of the skin irritation index of 20 persons. The gel-like peel-off pack of Example 24 was closed 20 minutes after the coating was peeled off and then closed, and the face wash of Example 26 was evaluated with a 1% by weight aqueous solution. The effect of improving the pigmentation symptom was determined by grouping 10 female panelists having remarkable pigmentation symptoms such as spots and freckles twice a day and twice a day in each group.
Used for months. The effect of improvement was indicated by the number of panelists who observed the pigmentation state of the skin after one month and evaluated that the effect of the improvement was higher than before use. Table 8 shows the results of the effects of improving skin irritation and pigmentation symptoms.

[0073]

[Table 7]

[0074]

[Table 8]

As shown in Table 8, the Examples of the present invention showed no irritation to the skin, good safety, and an excellent effect of improving pigmentation.

[0076]

Industrial Applicability As described in detail above, the present invention synergistically enhances the melanin production inhibitory effect, is effective in preventing and improving pigmentation, spots, freckles, spots, etc. after tanning. An external preparation for skin with significantly improved whitening effect was obtained.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 MNR 31/05 31/05 31/122 31/122 31/19 31 / 19 31/194 31/194 31/198 31/198 31/375 31/375 31/7008 31/7008 35/50 35/50 35/78 35/78 FW 35/80 35/80 Z A61P 17 / 16 A61P 17/16 43/00 111 43/00 111 F term (reference) 4C083 AA072 AA082 AA111 AA112 AB032 AB232 AB242 AB432 AC012 AC022 AC072 AC102 AC122 AC132 AC182 AC242 AC291 AC301 AC302 AC352 AC402 AC422 AC442 AC471 AC472 AC482 AC542 AC581 AC782 AC79209 AD112 AD191 AD282 AD472 AD512 AD532 AD551 AD552 AD641 AD642 AD662 BB51 CC04 CC05 CC07 DD22 DD23 DD27 DD31 DD41 EE01 EE13 EE16 4C086 AA01 AA02 BA18 EA02 MA02 MA03 MA04 MA63 NA14 ZA89 ZC02 4C087 AA01 AA02 ZA18 AB88 MAA AB3 2 AB38 AB43 AB44 AB45 AB48 AB60 AB66 AC01 AC03 AC04 AC05 AC06 AC11 BA07 BA08 BA09 BA10 CA02 CA03 CA05 CA06 CA14 MA02 MA03 MA04 MA07 MA08 MA63 NA14 ZA89 ZC02 4C206 AA01 AA02 CA19 CB21 DA36 JA58 MA02 MA03 MA04 MA83 NA14 ZAC Z

Claims (3)

[Claims] 1. An external preparation for skin, comprising the following component (A) and an extract of urethane. (A) L-ascorbic acid excluding ascorbic acid glycoside and derivatives thereof and salts thereof, hinokitiol and derivatives thereof, 2-hydroxycarboxylic acid and derivatives thereof and salts thereof, hydroquinone and derivatives thereof, cysteine and derivatives thereof, One or two selected from glucosamine and its derivatives, azelaic acid and its derivatives, placenta extract, plant extract having melanin production inhibitory activity, and algal extract having melanin production inhibitory activity
More than species. 2. A plant extract having a melanin production-inhibiting action, wherein the extract is selected from the group consisting of genus Mansacea, Saxifraga, Zinko, Camellia, Aesculus genus, Polygonum genus, Acacia genus, Ibukija genus, Artemisia genus, Yarrow genus, and Acacia genus. At least one plant extract selected from plants belonging to the genus, linden genus, hypericum genus, genus genus genus, artichoke genus, gampi genus, honey beetle genus, licorice genus, iwanashi genus, gourd genus genus, uramatsu azalea. The external preparation for skin according to claim 1. 3. The algal extract having a melanin production-inhibiting activity belongs to the genus Sponge, Coral genus, Sphagnum, Amidriga, Hijiki, Sozo, Fushitsunagi, Ichihige, Darusu, Hondawara and Ishimozuku. The external preparation for skin according to claim 1 or 2, which is one or more algal extracts selected from algae.