JP3502826B2 - Skin preparation - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [0001] The present invention relates to inhibition of melanin production.
The action is synergistically enhanced, and the skin is darkened by UV rays.
For prevention and improvement of skin pigmentation such as mi, buckwheat
Effective, with significantly improved skin whitening effect, excellent safety
The present invention relates to a topical skin preparation. [0002] Conventionally, blackening of the skin by ultraviolet rays,
Prevent or improve skin pigmentation such as spots and freckles
In order to inhibit melanin production or
Ingredients that have the effect of reducing dyes are screened
And has been blended into skin external preparations. For example, Ascorbi
Acid, 2-hydroxycarboxylic acid, hydroquinone,
Stains, placenta extracts, plants, algae extracts, etc.
It's being used. [0003] However, the Asco
Rubinic acid, hydroquinone, and cysteine are redox reactions.
2-hydroxycarboxylic acid
If you add an effective amount, there is a problem with skin safety.
Placental extracts and extracts from plants and algae
When combined, it gives only an unpleasant odor or color to the external preparation for skin.
There was a problem such as not. The present invention solves the above problems,
It has a very strong skin melanin production inhibitory effect, and the skin
Skin with no safety issues such as skin irritation and skin sensitization
The purpose is to obtain an external preparation for skin. [0005] [Means for Solving the Problems] To solve the above problems
After various investigations, lavender extract
And a component having an action of inhibiting specific melanin production
When used together, the whitening effect is synergistically enhanced.
Moreover, there are safety issues such as skin irritation and skin sensitization.
And found that an external skin preparation can be obtained.
It came to be completed. [0006] DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention will be described. Raw material for lavender extract used in the present invention
As a lavender, it doesn't matter what kind, for example
lavender(Lavandula vera DC.) Whole grass, flowers, head flowers,
Leave one or more parts of the flower spikes raw or dry
Use. Extraction method is not particularly limited, but room temperature, cooling
Or a method of extraction by impregnation in a heated state, steam steaming
Extraction using distillation methods such as distillation, pressing and extraction
The compression method etc. which obtain are illustrated. Obtained from the above method
Steamed steam using raw flower spikes among lavender extracts
The extract obtained by distillation is called lavender oil,
Most preferably used in view of the effect. In the present invention, the lavender extract
The blending amount is not particularly limited, but generally 0.0001 to 1
0% by weight, preferably 0.001 to 5% by weight is blended.
If it is less than 0.0001% by weight, the effect is not exhibited.
If it is 0% by weight or more, an increase in the effect cannot be expected. Use with lavender extract in the present invention
L-ascorbic acid excluding ascorbic acid glycoside and
Examples of the salt or derivative thereof include L-ascorbi.
Acid, sodium L-ascorbate, L-ascorbi
Magnesium phosphate, potassium L-ascorbate, L-
L-ascorbate such as calcium ascorbate,
L-ascorbic acid monostearate, L-ascorbi
Acid monopalmitate, L-ascorbic acid monoolee
L-ascorbate monoalkyl or monoal
Kenyl ester derivative, L-ascorbic acid-2-sulfate
Ascorbic acid monoester derivatives such as steal, L-a
Scorbic acid distearate, L-ascorbic acid dipa
Lumitate, L-ascorbate dioleate, etc.
Dialkyl or dialkenyl ester derivatives of ascorbate
Conductor, L-ascorbic acid tristearate, L-as
Corbic acid tripalmitate, L-ascorbic acid tri
Trialkyl L-ascorbate such as oleate
Realkenyl ester derivative, L-ascorbylline
Acid, sodium L-ascorbyl phosphate, L-ascorb
Potassium bilphosphate, L-ascorbyl phosphate magnesi
L-as such as um, L-ascorbyl calcium phosphate
Mention may be made of colvir phosphate. These L-
Of ascorbic acid and its salts or derivatives thereof,
Preferred examples include L-ascorbic acid and L-as
Examples include colvir phosphate and its magnesium salt. Used with lavender extract in the present invention
Hinokitiol and its derivatives are not particularly limited
Hinokitiol, hinokitiol zinc complex, hinoki
Hinokitiol glycosides such as chithiol glucoside and
And the like. Used with lavender extract in the present invention
2-Hydroxycarboxylic acid and salts or derivatives thereof
Although it does not specifically limit as, it is C2-C22 2-
Hydroxycarboxylic acids are preferred, and more
~ 6 2-hydroxycarboxylic acids are the points of the effect of the present invention
Are preferably used. For example, 2-hydroxy vinegar
Acid, lactic acid, malic acid, tartaric acid, citric acid and its salts,
Improved the skin affinity of 2-hydroxycarboxylic acid,
Alkyl ester of 2-hydroxycarboxylic acid, choles
Terol ester, glycoside, phosphatidyl ester,
Examples include L-arginine salts. In the present invention, used with lavender extract
Hydroquinone and its derivatives are particularly limited
However, hydroquinone glycosides are preferably used,
For example, hydroquinone-α-D-glucoside, hydride
Rhoquinone-β-D-glucoside, hydroquinone-α-
L-glucoside, hydroquinone-β-L-glucosi
Hydroquinone-α-D-galactoside, hydro
Quinone-β-D-galactoside, hydroquinone-α-
L-galactoside, hydroquinone-β-L-galacto
Hexose sugar glycosides such as sid, hydroquinone-α-D-ribo
, Hydroquinone-β-D-ribose, hydroxy
Non-α-L-ribose, hydroquinone-β-L-li
Bose, hydroquinone-α-D-arabinose, high
Droquinone-β-D-arabinose, hydroquinone-
α-L-arabinose, hydroquinone-β-L-ara
Five carbon sugar glycosides such as vinose, hydroquinone-α-D-
Glucosamine, hydroquinone-β-D-glucosami
, Hydroquinone-α-L-glucosamine, hydro
Quinone-β-L-glucosamine, hydroquinone-α-
D-galactosamine, hydroquinone-β-D-galac
Tosamine, hydroquinone-α-L-galactosamine,
Amino sugars such as hydroquinone-β-L-galactosamine
Glycoside, hydroquinone-α-D-glucuronic acid, high
Droquinone-β-D-glucuronic acid, hydroquinone-
α-L-glucuronic acid, hydroquinone-β-L-glu
Cronic acid, hydroquinone-α-D-galacturonic acid,
Hydroquinone-β-D-galacturonic acid, hydroxy
Non-α-L-galacturonic acid, hydroquinone-β-
List uronic acid glycosides such as L-galacturonic acid
Can do. In addition, as derivatives thereof, acetylated compounds, etc.
List ethers such as esters and methylated compounds.
Among these, hydroquinone-β-D-G
Leucose is most preferable from the viewpoint of the effect of the present invention. In the present invention, used with lavender extract
Cysteine and its derivatives are not particularly limited.
For example, cysteine or a phospholipid ester of cysteine
Esters and sugars of stealth, sphingosine and its derivatives
Lipid esters, sugar esters, sterol esters and charcoal
8 to 20 prime alkyl or alkenyl esters
Etc. For use with lavender extract in the present invention
Glucosamine and its derivatives are particularly limited
There is no such as glucosamine or acetylglucosami
Glucosamine esters such as
And glucosamine ethers such as ether. In the present invention, used with lavender extract
Azelaic acid and its derivatives are particularly limited
For example, azelaic acid or azelaic acid monoa
Azelaic acid monoesters such as alkyl esters, aze
Azelaic acid diesters such as dialkyl esters of rhine acid
And the like. In the present invention, used with lavender extract
As a placenta extract, it is used for normal topical skin preparations
If it is a thing, the basis in particular will not ask | require. [0017] Hamelis (Hamamelis virginiana
L.), Yukinoshita (Saxifraga stolonifera Meerb.),
Zincou (Aquilaria agallocha Roxb.), Cha (Camel
lia sinensis (L.) O. Kuntze) and its variants, Itado
Li (Polygonum cuspidatum Sieb. Et Zucc.), Merri
S (Melissa officinalis L.), time (Thymus vulga
ris L.), SEAchillea millefolium (Achillea milleifol
ium L.), Hypericum (Hypericum erectum Thun
b.), Sunflower (Hypericum perforatum
L.), Spanish daylily (Glycyrrhiza glabra L.),
Daylily (Glycyrrhiza urarensis Fisch.), Moussen
Joke (Drosera routundifolia L.)Arct
ostaphylos uva-ursi (L.) Spreng.), Herayahaz (Di
ctyopteris prolifera), Harajimi (Dictyota spinu
losa), Hijiki (Hizikia fusiformis), Sozo sp.Lau
rencia sp.), Fushitsunagi (Lomentaria catenata),
Siwahige (Myelophycus caespitosus), Dulse (Palma
ria palmata), Willow Moku (Obermoku:Sargassum r
inggoldianum)Sargassum confusu
m), Esononezmok (Sargassum yezoense), Ishimo
Zuku (Sphaerotrichia divaricata1) selected from
Species or two or more plants, algaeForI can. Plants and algae having inhibitory action on melanin production
Extracts are all kinds of whole grass or its leaves, bark, roots, flowers, branches,
Leave one or more parts of stems, seeds, etc. raw or dry
Dry and pulverize before use. The extraction solvent is particularly limited
There is no water, ethanol, methanol, isopropanol
, Isobutanol, n-hexanol, methylamyl
Lucol, 2-ethylbutanol, n-octyl alcohol
Monohydric alcohols such as glycerin, ethylene glycol
, Ethylene glycol monomethyl ether, propylene
Glycol, propylene glycol monomethyl ether
, Propylene glycol monoethyl ether, trie
Tylene glycol, 1,3-butylene glycol, hexile
Polyhydric alcohols such as glycols or derivatives thereof,
T, methyl ethyl ketone, methyl isobutyl ketone,
Ketones such as methyl-n-propyl ketone, ethyl acetate,
Esters such as isopropyl acetate, ethyl ether,
Ethers such as propyl ether and n-butyl ether
, Squalane, petrolatum, paraffin wax, para
Hydrocarbons such as fin oil, olive oil, wheat germ oil,
Rice oil, sesame oil, macadamian nut oil, almond oil,
Vegetable oils such as coconut oil, animal oils such as beef tallow, pork tallow and whale oil
I can give it. Inorganic such as phosphate buffered saline
Polar solvent with added salt, solvent with added surfactant
It can also be used. Further extraction methods include room temperature, cooling or
Extraction by impregnation in a heated state, such as steam distillation
Which distillation method to extract, squeezing plants or algae
Squeezing methods and the like to obtain the extract, and these methods
Are extracted alone or in combination of two or more. The ratio of plant or algae to solvent during extraction is
Although it does not specifically limit, solvent 0.
1 to 1000 times by weight, especially in terms of extraction operation and efficiency, 0.
5-100 weight times is preferable. Also extraction pressure and extraction temperature
The degree should be in the range from 0 ° C. to the boiling point of the solvent under normal pressure.
Convenient, the extraction time varies depending on the extraction temperature etc. 2
The time is preferably in the range of 2 weeks. Extraction of the plant or algae thus obtained
As for the extract, the extract can be used as it is.
As long as the effect is not lost, purification operations such as deodorization, decolorization, concentration, etc.
Add work or even column chromatography
May be used as a fraction. These extracts and
Purified products and fractions can be obtained by removing the solvent from them.
Can also be dried, and alcohol
It can be used in the form of solubilized in a solvent or in the form of an emulsion.
You can. Obtained by purification and fractionation from the above extract.
As a component, hamameli, which is abundant in the leaves of the hamamelis
Flavonoi in oil-soluble extractives of tannin and licorice
Moss, especially glabridin, hispagrabridin, genus
(-)-Epicatechin etc. contained in plant extracts are exemplified
The Has the effect of inhibiting the production of these melanins.
The amount of ingredients to be added to the external preparation for skin is not particularly limited
However, from the point of the effect, smell when added, color tone,
Desirably, the concentration range is 0.0001 to 10% by weight.
That's right. In the external preparation for skin of the present invention, if necessary,
Conventional pharmaceuticals, quasi drugs, skin cosmetics, hair cosmetics and
Oils, moisturizers, powders, pigments, milk
Agent, solubilizer, cleaning agent, UV absorber, thickener, medicine
Mixing agents, fragrances, resins, alcohols, etc. as appropriate
it can. Moreover, the dosage form of the external preparation for skin of the present invention is arbitrary.
For example, solubilizing system such as lotion, cream, emulsion, etc.
Provided as a dispersion system such as emulsification system and calamine lotion
Of aerosol filled with propellant
You may take a dosage form. [0026] EXAMPLES Next, the present invention will be described in detail with reference to examples.
explain. First, a lavender extract used in the present invention,
Plants and algae with placental extract and melanin production inhibitory activity
An example of the preparation of a kind extract [Lavender extract 1] Commercially available.
Falco Rex Lavender (Ichimaru Falcos)
Was used. [Lavender extract 2] Commercially available
A lavender extract (manufactured by Koei Kogyo Co., Ltd.) was used. [Lavender oil] Lavend available on the market
er Oil (manufactured by Charabo) was used. [Placenta extract] Commercially available water-soluble plastic
Center extract (manufactured by Nichirei) was used. [Itadori Extract] Itadori (Polygonum
cuspidatum Sieb. Et Zucc.)
Crushed in 1,500 ml of 50 vol% ethanol aqueous solution
And stirred at 25 ° C. for 5 days. Then extract the extract
The filtrate was used as the itadori extract. [Itadori Extract Fraction]Polygo
num cuspidatum Sieb. Et Zucc.) Rhizome dry powder 2
00 g of 2,000 ml of 50% ethanol aqueous solution
It was immersed in and extracted at room temperature for 7 days. Then extract the extract
Filter, concentrate the filtrate under reduced pressure, 30% ethanol in water
Dissolve in 800 ml of liquid, DIAION MCI Ge
l Apply to HP-20 column (Mitsubishi Kasei Co., Ltd.)
Collects fractions eluted with 40% ethanol aqueous solution
did. The fraction was then purified on a silica gel thin layer chromatograph.
The chloroform / methanol mixture (volume ratio =
Fractionation was performed using 5: 1) as the developing solvent. Obtained picture
Scrape the fraction containing (-)-epicatechin
Extracted by itadori in 50 ml of 0% ethanol by volume
It was a painting. [Hammamelis extract] Hammamelis (Hamame
lis virginiana L.) Leaves 500g of dried and ground 5
25 ° C in 1,000 ml of 0 vol% ethanol aqueous solution
And stirred for 5 days. The filtrate is then filtered and the filtrate is
It recovered and used as a Hamelis extract. [Hammamelis extract fraction] Hamelis (Ha
mamelis virginiana L.) A total of 500g of leaves and bark
It was cut and extracted with stirring in 1,500 ml of hot water for 5 hours.
The extract is then filtered and the filtrate is DIAION MCI.
To Gel HP-20 column (Mitsubishi Kasei)
And elute with ethanol / water mixed solvent.
Fractions with a water content of 50%
A fraction was taken out. [Circus extract]
Giri (Hypericum perforatum L.) Whole plant 35
Cut 0g into 20ml of 1,000ml olive oil
And extracted for 7 days. Filter the extract and recycle the filtrate.
This was used as an extract of a seahorse. [Liquorice Extract] Licorice (Glycyrrhiz
a urarensis Fisch.) Roots and rhizomes 500g dried, flour
Crushed, 25 in 1,000 ml of absolute ethanol aqueous solution
The mixture was extracted at 24 ° C. for 24 hours. Filter the extract and recycle the filtrate.
After concentrating and concentrating under reduced pressure, it is freeze-dried. Dry
Solid material in 1,000 ml of ethyl acetate at 20 ° C. for 2 days
Extracted with stirring. After extraction, dry under reduced pressure and extract licorice
did. [Zinkou extract] Zincou (Aquillaria
agallocha Roxb.) Branches and trunks, total 300g dried, flour
Crushed and in ethanol 1000ml at 20 ° C for 10 days
Soaked for a while. The extract is then filtered and the filtrate is 1/10.
Concentrate to volume to make a ginkgo extract. [Oolong tea extract] Oolong tea (Thea s
inensis L. var.viridis 440g of Szkzyl.) Leaves
Dried, ground and dried in 1,000 ml of purified water at 50 ° C.
Extracted with stirring for hours. The extract is filtered and the filtrate is 1/5 volume.
To obtain a oolong tea extract. [Melissa extract] Melissa (Melissa of
ficinalis L.) Crush 300g of leaves and 1,3-butylene
Extraction by stirring in 1,000 ml of recall at 25 ° C for 5 days
did. Filter the extract, collect the filtrate and extract Melissa
It was. [Time extract] Time (Thymus vulgari
s L.) 450g
Stir for 5 days at 1500C in 1,500 ml serine aqueous solution
Extracted. Filter the extract, collect the filtrate and extract the time
It was a thing. [Achillea millefolium extract]
YarrowAchillea milleifolium L.) Flower 320
g at 10 ° C. in 2,000 ml of physiological saline
Then, the mixture was extracted with stirring for another 4 hours. Filter the extract
And collect the filtrate to obtain the extract of Achillea millefolium.
It was. [Mouse moss extract]Dr
osera routundifolia L.) 300g of whole plant
Stir in 1,000 ml of water ethanol at 25 ° C for 5 days
Extracted. Filter the extract, collect the filtrate,
The extract was taken out. [Rust extract] Raspberry (Arctos
taphylos uva-ursi (L.) Spreng.
20 in 1,000 ml of 1,3-butylene glycol
Extraction was performed by dipping at 7 ° C. for 7 days. Filter the extract and remove the filtrate.
It was recovered and used as a rumbling extract. [Hellaya hazu extract], [Hariamiji extraction
Product], [Sozo sp. Extract], [Dulse extract] from the sea
Taken, Herayahaz (Dictyopteris prolifera),needle
Amiji (Dictyota spinulosa), Sozo sp.Laurencia s
p.), Darus (Palmaria palmata) Washed all algae
After that, chop each 500g, equal amount of phosphate buffered saline
(Dispersed in pH 7.4) and stirred for 3 hours with a blender mill
Extracted. Filter the extract, collect the filtrate and extract each of the above
It was a thing. The beauty according to the present invention with the prescription shown in Table 1.
Examples 1 to 12 and Comparative Examples 1 to 1 as a solution
12 was prepared. These serums mix all ingredients and are uniform
Was prepared. In addition, all the quantities are weight%
Displayed. [0047] [Table 1] [0048] [Table 2][0049] [Table 3] Examples 1 to 3 of the present invention prepared by the above formulation
For Example 12 and Comparative Examples 1 to 12, pigmentation
The effect of improving wearing symptoms was evaluated. Improvement of pigmentation symptoms
Is a woman with significant pigmentation symptoms such as spots and freckles
A group of 20 sex panelists.
12 and Comparative Examples 1 to 12 are blinded respectively.
Use twice a day for 1 month, and skin color after 1 month
The state of elementary deposition was observed and evaluated in comparison with before use. color
The state of elementary deposition is evaluated according to the criteria shown in Table 4,
The average values of 20 people were calculated and shown in Tables 5 and 6. [0051] [Table 4] [0052] [Table 5] [0053] [Table 6] As apparent from Tables 5 and 6, the present invention
In the example use group according to the
Improvement has been observed, and after the use test is completed,
Or to the extent that only slight pigmentation is observed
Symptoms improved. In particular, lavender oil and L-asp
Example 1, Ita, combined with magnesium corbyl phosphate
Example 8, combined with Dori extract fraction, extract of Hamelis
In the use group of Example 9 combined with the painting, good improvement
It was seen. In contrast, it has an inhibitory effect on melanin production.
In the use group of the comparative example in which the substances to be blended alone are used, the color
Although improvement of elementary deposition symptoms can be recognized, each response
The degree of improvement is clearly small compared to the working group
It was a thing. Incidentally, the first to twelfth embodiments of the present invention are described.
During the use test period, the precipitation, separation,
No changes in the state of the formulation such as agglomeration, odor change or discoloration
There wasn't. In each example use group, skin irritation
There are no panelists that showed any reaction or skin sensitization reaction
It was. Another embodiment of the present invention will be described. [0057] [Example 13] Cosmetic liquid (1) Beeswaw 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 32.5 (5) Fatty acid glycerin 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene (20E.O.) sorbitan monolaurate 2.0 (8) Lavender oil 0.4 (9) Propylene glycol 5.0 (10) Sodium lactate 0.3 (11) Purified water 34.8 Production method: (1) to (8) oily component and (9) to (11) aqueous
Each component is mixed and homogenized and heated to 75 ° C. aqueous
Add oily ingredients to emulsify and cool with stirring
The [0058] [Example 14] Cosmetic liquid (1) Squalane 5.0 (% by weight) (2) White petrolatum 2.0 (3) Beeswax 0.5 (4) Sorbitan sesquioleate 0.8 (5) Polyoxyethylene oleyl ether (20E.O.) 1.2 (6) Lavender oil 1.5 (7) Propylene glycol 5.0 (8) Purified water 58.2 (9) Carboxyvinyl polymer (1% by weight aqueous solution) 20.0 (10) Potassium hydroxide 0.1 (11) Ethanol 5.0 (12) Fragrance 0.2 (13) L-ascorbic acid 0.5 Manufacturing method: Mix the oil phase components (1) to (6) and heat to 75 ° C.
To dissolve and homogenize. On the other hand, the water phase components (7) to (9) are mixed.
Combine, dissolve and heat to 75 ° C, add the oil phase ingredients
Emulsify uniformly with a homomixer and add (10) to adjust the pH.
adjust. Add and mix (11)-(13) at 40 ° C after cooling
The [0059] [Example 15] Skin lotion (1) Ethanol 10.0 (wt%) (2) Hydroxyethyl cellulose 1.0 (3) Lavender extract 1 1.0 (4) Glycerin 7.0 (5) Guaiazulene sodium sulfonate 0.5 (6) 2-hydroxyacetic acid 0.5 (7) Purified water 80.0 Production method: (1) to (7) are mixed and made uniform. [0060] [Example 16] Emulsion for skin (1) Stearic acid 0.2 (% by weight) (2) Cetanol 1.5 (3) Vaseline 3.0 (4) Liquid paraffin 7.0 (5) Polyoxyethylene (10E.O.) monooleate 1.5 (6) Lavender oil 1.0 (7) Glycerin 5.0 (8) Triethanolamine 1.0 (9) Purified water 79.0 (10) Lactic acid bacteria extract 0.5 (11) Placenta extract 0.3 Manufacturing method: Mix the oil phase components (1) to (6) and heat to dissolve evenly.
Melt and keep at 70 ° C. On the other hand, the water phase components (7) to (9) are mixed.
In this case, the mixture is heated to a uniform temperature of 70 ° C. In this water phase component
Oil phase components are gradually added with stirring and emulsified, then cooled.
Then, the components (10) and (11) are added at 40 ° C. [0061] [Example 17] Gel for skin (1) Purified water 90.9 (wt%) (2) Carboxyvinyl polymer 0.5 (3) Lavender extract 1 0.3 (4) Dipropylene glycol 8.0 (5) Potassium hydroxide 0.1 (6) Hinokitiol 0.2 Manufacturing method: (2) and (3) are uniformly dissolved in (1), then (4)
Add, then add (5) to thicken, add (6)
Mix evenly. [0062] [Example 18] Cream for skin (1) Beeswaw 6.0 (wt%) (2) Cetanol 5.0 (3) Reduced lanolin 8.0 (4) Squalane 29.5 (5) Lipophilic glyceryl monostearate 4.0 (6) Polyoxyethylene (20E.O.) sorbitan monolaurate 5.0 (7) Lavender oil 0.5 (8) Propylene glycol 5.0 (9) Oolong tea extract 0.2 (10) Purified water 36.8 Manufacturing method: Mix and dissolve the oil phase components (1) to (7) to 75 ° C.
Heat. On the other hand, the water phase components (8) to (10) are mixed and dissolved.
Heat to 75 ° C. Next, the oil phase component is added to the water phase component.
And pre-emulsified, and then homogenized with a homomixer
Turn into. [0063] [Example 19] Oil-in-water emulsion ointment (1) White petrolatum 25.0 (wt%) (2) Stearyl alcohol 25.0 (3) Glycerin 10.0 (4) Sodium lauryl sulfate 1.0 (5) Lavender oil 0.5 (6) Ginkgo extract 0.2 (7) Purified water 38.3 Production method: Mix and dissolve oil phase components (1) to (5)
And heat to 75 ° C. On the other hand, (6) is dissolved in (7) and 7
Dissolve by heating at 5 ° C., add the oil phase component to this and add milk
Turn into. [0064] [Example 20] Lotion (1) Ethanol 10.0 (wt%) (2) 1,3-butylene glycol 10.0 (3) Hinokitiol 0.5 (4) Dipotassium glycyrrhizinate 0.5 (5) Lavender extract 2 0.2 (6) Fragrance 0.1 (7) Purified water 78.7 Manufacturing method: Add (1) to (6) to (7) sequentially and mix and dissolve uniformly.
To understand. [0065] [Example 21] Makeup base cream (1) Stearic acid 12.0 (wt%) (2) Cetanol 2.0 (3) Glyceryl tri-2-ethylhexanoate 2.5 (4) Self-emulsifying glyceryl monostearate 2.0 (5) Lavender oil 0.5 (6) Propylene glycol 10.0 (7) Potassium hydroxide 0.3 (8) Purified water 69.0 (9) Titanium oxide 1.0 (10) Bengala 0.1 (11) Yellow iron oxide 0.4 (12) Fragrance 0.1 (13) Thyme extract 0.1 Manufacturing method: Mix the oil phase components (1) to (5) and heat to 75 ° C.
And uniform. On the other hand, the components (6) to (8) are mixed, and 75
Heat to 0 ° C and dissolve to make uniform, and then add pigments (9) to (11)
And uniformly disperse with a homomixer and the water phase component
To do. The oil phase component is added to the water phase component and homomixed.
After emulsification with a sir, cool and form (12) and (13) at 40 ° C.
Add minutes and mix. [0066] [Example 22] Emulsion foundation (1) Stearic acid 2.0 (wt%) (2) Squalane 5.0 (3) Octyldodecyl myristate 5.0 (4) Cetanol 1.0 (5) Decaglyceryl monoisopalmitate 9.0 (6) Lavender oil 0.3 (7) 1,3-butylene glycol 8.0 (8) Potassium hydroxide 0.1 (9) Purified water 51.2 (10) Titanium oxide 9.0 (11) Talc 7.4 (12) Bengala 0.5 (13) Yellow iron oxide 1.1 (14) Black iron oxide 0.1 (15) Fragrance 0.1 (16) Melissa extract 0.2 Manufacturing method: Mix the oil phase components (1) to (6) and heat to 75 ° C.
And uniform. On the other hand, the aqueous phase components (7) to (9) are mixed,
Heat and melt at 75 ° C to make it uniform, and add (10) to (14)
Add pigment and disperse uniformly with homomixer. oil
Add the phase ingredients to emulsify and cool, then at 40 ° C (15),
Add and mix component (16). [0067] [Example 23] Hand cream (1) Cetanol 4.0 (wt%) (2) Vaseline 2.0 (3) Liquid paraffin 10.0 (4) Glyceryl monostearate ester 1.5 (5) Polyoxyethylene (60E.O.) glyceryl isostearate 2.5 (6) Tocopherol acetate 0.5 (7) Lavender oil 0.3 (8) Glycerin 20.0 (9) Methyl paraoxybenzoate 0.1 (10) Hydroquinone-β-D-glucoside 0.1 (11) Purified water 59.0 Manufacturing method: Mix and dissolve the oil phase components (1) to (7) to 75 ° C.
Heat. On the other hand, the water phase components (8) to (11) are mixed and dissolved.
Heat to 75 ° C. Next, add the oil phase component to the water phase component.
And pre-emulsified, and then uniformly emulsified with a homomixer
The [0068] [Example 24] Jelly peel-off pack (1) Polyvinyl alcohol 15.0 (% by weight) (2) Carboxymethylcellulose 5.0 (3) 1,3-butylene glycol 3.0 (4) Ethanol 6.0 (5) Polyoxyethylene (20E.O.) oleyl ether 0.5 (6) Lavender extract 1 0.2 (7) Achillea millefolium extract 0.1 (8) Purified water 70.2 Production method: Add (3) to (8) and heat to 75 ° C. to this
(1), (2) can be added and dissolved, and (4)-(7) can be added.
Solubilize. [0069] [Example 25] Massage gel (1) Dipropylene glycol 7.0 (% by weight) (2) Glycerin 8.0 (3) Polyoxyethylene (15E.O.) oleyl ether 1.0 (4) Carboxyvinyl polymer 0.4 (5) Methylcellulose 0.2 (6) Lavender extract 2 0.4 (7) Sunflower extract 0.2 (8) Potassium hydroxide 0.1 (9) Purified water 82.7 Production method: (9) heated to 75 ° C, components (1) to (8) in order
Next addition, dissolution, homogenization. [0070] [Example 26] Face wash (1) Stearic acid 2.0 (wt%) (2) Cetanol 3.0 (3) Vaseline 10.0 (4) Liquid paraffin 33.0 (5) Isopropyl myristate 7.5 (6) Glyceryl monostearate 2.5 (7) Polyoxyethylene (20E.O.) sorbitan monostearate 2.5 (8) Lavender oil 0.3 (9) Glycerin 5.0 (10) Potassium hydroxide 0.1 (11) Purified water 33.9 (12) Herayahaz extract 0.2 Production method: Mix (1) to (8) oil phase components, dissolve by heating, 70
℃. On the other hand, the water phase components (9) to (11) are mixed and heated.
Dissolve to 70 ° C. Gradually add oil phase component to this water phase component
And then pre-emulsified, and then homogenously with a homomixer
After emulsification, the mixture is cooled, and the component (12) is added at 40 ° C. [0071] [Example 27] Lotion for skin (1) Ethanol 20.0 (wt%) (2) Hydroxyethyl cellulose 1.0 (3) Lavender extract 1 0.2 (4) Glycerin 7.0 (5) Guaiazulene sodium sulfonate 0.5 (6) Harajiri extract 0.2 (7) Purified water 71.1 Production method: (1) to (7) are mixed and made uniform. [0072] [Example 28] Gel for skin (1) Purified water 84.2 (wt%) (2) Carboxyvinyl polymer 0.5 (3) Lavender extract 2 0.1 (4) 1,3-butylene glycol 15.0 (5) Sozo extract 0.1 (6) Potassium hydroxide 0.1 Manufacturing method: (2) to (5) were sequentially added to (1) and dissolved uniformly.
Add (6) later to increase viscosity. [0073] [Example 29] Lotion (1) Ethanol 10.0 (wt%) (2) 1,3-butylene glycol 10.0 (3) Lavender extract 1 0.1 (4) Dipotassium glycyrrhizinate 0.5 (5) Dulse extract 0.2 (6) Fragrance 0.1 (7) Purified water 79.1 Manufacturing method: Components (1) to (6) are added to (7) sequentially and mixed uniformly.
Dissolve. Examples 13 to 29 of the present invention
The effects of improving skin irritation and pigmentation were investigated.
Skin irritation is 48 hours closed by 20 male panelists
An embolization test was conducted, and the results were in accordance with the criteria shown in Table 7.
The average value of the skin irritation index of 20 people
It was. The jelly peel-off pack of Example 24 was coated
After the film was peeled off 20 minutes after the cloth, the film was closed.
The face wash was evaluated with a 1% by weight aqueous solution. Pigmentation
The effect of improving wearing symptoms is remarkable pigmentation such as spots and freckles.
A group of 10 female panelists with wearing symptoms.
Each example with blinds twice a day for one month
Use and observe the state of skin pigmentation after one month
Panelists evaluated as having an improvement effect compared to before use
The improvement effect was shown by the number of people. Skin irritation and pigmentation symptoms
Table 8 shows the result of the improvement effect. [0075] [Table 7] [0076] [Table 8]As shown in Table 8, the examples of the present invention are skin irritation.
Safety, good safety, and improved pigmentation
It was shown to be excellent in good effect. [0078] As described above in detail, according to the present invention, the
Ranin production inhibitory action is synergistically enhanced,
It is useful for prevention and improvement of pigmentation, blotches, buckwheat, melasma, etc.
An external skin preparation that is effective and has a significantly improved skin whitening effect.
I was able to get it.

──────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI A61K 31/05 A61K 31/05 31/122 31/122 31/19 31/19 31/194 31/194 31/198 31/198 31/375 31/375 31/7008 31/7008 35/50 35/50 35/78 35/78 C E J Q R T 35/80 35/80 Z A61P 17/16 A61P 17/16 (56) References JP-A-9-1336827 (JP, A) JP-A-10-182402 (JP, A) JP-A-11-60467 (JP, A) JP-A-11-335233 (JP, A) JP-A 2000-53559 ( JP, A) JP 2000-86494 (JP, A) JP 2000-119156 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (1)

(57) Patent Claims 1. A heat Nokichioru and derivatives thereof, c id <br/> hydroquinone and derivatives thereof, cysteine and derivatives thereof,
Glucosamine and its derivatives, azelaic acid and its derivatives, hamamelis (Hamamelis virginiana L.), Yuki
Noshita ( Saxifraga stolonifera Meerb. ), Jinkou
( Aquilaria agallocha Roxb. ), Cha ( Camellia sine
nsis (L.) O. Kuntze) and its variants, Japanese knotweed (Polyg
onum cuspidatum Sieb. et Zucc.) , Melissa (Meliss
a officinalis L. ), Thymus ( Thymus vulgaris L. ),
Yarrow (Achilleamilleifolium L.),
St. John's wort (Hypericum erectum Thunb.), Western
Otogiri (Hypericum perforatum L.), Spain Kang
Elephant ( Glycyrrhiza glabra L. ), Daylily ( Glycyrrhi )
za urarensis Fisch. ), Drosera routu
ndifolia L. ), Arctostaphylos uva-ursi
(L.) Spreng. ), Herayahazu ( Dictyopteris prolifer
a ), Harajiri ( Dictyota spinulosa ), Hijiki ( Hiz
ikia fusiformis ), Sozo sp. ( Laurencia sp. ), Fushi
Jumpsuit (Lomentaria catenata), cassiope lycopodioides (Myelophyc
us caespitosus ), Dulse ( Palmaria palmata ), Yana
Gimmoku ( Sargassum ringgoldianum ), Fu
Sisjimoku ( Sargassum confusum )
( Sargassum yezoense ), Sphaerotrichia
1 or 2 or more types selected from plants having a melanin production inhibitory action selected from divaricata ) and algal extracts, and a lavender extract The skin whitening effect is significantly improved,
Skin external preparation.