JP2002020256A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation having effects of obviating ski flabbiness and increasing bust size- and causing no side effects due to continuous use. SOLUTION: This skin care preparation is such as to be formulated with, as active ingredients, an extract from a plant belonging to the genus Kigelia L. and a wheat flour protein hydrolyzate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a novel external preparation for skin. For more details, tighten the sagging skin,
Moreover, the present invention relates to an external preparation for skin having an effect of increasing the bust size.

[0002]

2. Description of the Related Art The sagging of the skin is caused by a decrease in the elasticity of the dermis, a decrease in the support of the skin adipose tissue, and a decrease in the muscle strength supporting the skin. Is known (Japanese Unexamined Patent Application Publication No.
-12453 publication).

[0003] Cosmetics containing an extract of a plant of the genus Sausage are known to exhibit a bust-up effect by tightening action (French Patent Publication No. 2759910), and a plant having an estrogen-like action. It is also disclosed that the combined use of the extract can increase the size and pharming effect of the bust (International Patent Application Publication 2000-002531).

[0004]

A cosmetic containing an extract of a plant of the genus Sausage has a tightening effect, but does not provide a significant effect of increasing the size of the bust. Requires the use of a compound exhibiting an action similar to that of estrogen which is a female hormone, and there is a possibility that undesired side effects may be caused by continuous use. In view of the above, an object of the present invention is to provide an external preparation for skin which has an effect of tightening the sagging of the skin and increasing the bust size, and which does not cause a side effect due to continuous use.

[0005]

As a result of various studies to solve the above problems, the genus Sausage ( Kigelia L.)
By using an extract from a plant and a wheat protein hydrolyzate in combination, it tightens the sagging skin and has the effect of increasing the bust size, and it has been found that there is no side effect even by continuous use. It was completed.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION First, an extract from a plant of the genus Sausage ( Kigelia L.) used in the present invention will be described.

[0007] The sausage tree ( Kigelia L.) plant is
It is a dicotyledonous plant of Bignoniaceae , an evergreen or deciduous tree. About 10 species are distributed and planted in Africa. In the present invention, the sausage tree is not particularly limited as long as it is a plant of the genus Sausage, but from the availability, sausage tree ( Kigelia africana (Lamk.) Bent
h.) is preferably used. Although various parts such as fruits, bark, seeds and leaves can be used, it is preferable to use fruits from the viewpoint of their effects.

In the present invention, the sausage plant is extracted as it is or after being subjected to processing such as shredding, drying, and pulverization. The extraction is performed by immersion in an extraction solvent. Stirring may be performed to increase the extraction efficiency, or homogenization may be performed in an extraction solvent. It is appropriate that the extraction temperature is set to a temperature of about 5 ° C. to the boiling point of the extraction solvent or lower. The extraction time varies depending on the type of extraction solvent and the extraction temperature,
It is appropriate that the time is about 4 hours to 2 weeks.

As an extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin; ethers such as ethyl ether and propyl ether; esters such as ethyl acetate and butyl acetate And polar organic solvents such as ketones such as acetone and ethyl methyl ketone, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used. The ratio of the plant to the solvent at the time of extraction is not particularly limited, but the solvent is preferably 0.1 to 1000 times by weight, particularly 0.5 to 100 times by weight, from the viewpoint of the extraction operation and efficiency with respect to the plant 1.

The extract of the plant of the genus Sausage with the above-mentioned solvent can be used as it is for the external preparation for skin according to the present invention, but the concentrated and dried extract is dissolved again in water or a polar solvent, or It may be used after purification treatment such as decolorization, deodorization, desalting, etc., or fractionation treatment by column chromatography, as long as the effects of the invention are not impaired. For preservation, it can be freeze-dried after the purification treatment and dissolved in a solvent before use. Further, it may be used by being encapsulated in vesicles such as liposomes or microcapsules.

The amount of the extract of the plant of the genus Sausage in the external preparation for skin is not particularly limited. However, even if it is incorporated in a large amount, the effect is not changed.
The content is preferably 0% by weight, more preferably 0.01 to 5% by weight.

Next, the wheat protein hydrolyzate used in the present invention will be described.

The protein contained in wheat is a known viscous protein called gluten, and can be obtained by separating and extracting from wheat by a conventional method. For example, when obtaining wheat protein, a small amount of water is added to flour and kneaded firmly, and then the starch is washed away with water to obtain a massive solid. This is wheat protein.

When the wheat protein is hydrolyzed in the present invention, the above-mentioned solid mass can be used as it is or after drying, and further, a purified product or a partially modified product may be used. Wheat protein may be used.

The hydrolyzate of wheat protein can be obtained by subjecting the above wheat protein to hydrolysis treatment using an alkali, acid, enzyme, oxidizing agent, reducing agent and the like.

The hydrolysis of the wheat protein with an alkali is performed by heating in a dilute aqueous alkaline solution. The aqueous solution or dispersion of the wheat protein is stirred in the presence of an alkaline agent such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate at about 60 to 180 ° C. for about 10 minutes to 10 hours. Here, the concentration of the aqueous solution or aqueous dispersion of wheat protein is preferably 2 to 40% by weight,
The amount of the alkaline agent used is preferably 0.5 to 30 parts by weight based on 100 parts by weight of wheat protein.

The wheat protein hydrolysis treatment with an acid is carried out by heating in a dilute aqueous acid solution. The aqueous solution or dispersion of wheat protein is stirred in the presence of an inorganic acid such as hydrochloric acid or sulfuric acid or an organic acid such as acetic acid at about 60 to 120 ° C. for about 10 minutes to 10 hours. Here, the concentration of the aqueous solution or aqueous dispersion of wheat protein is preferably 2 to 40% by weight, and the amount of acid used is 0.5 to 100 parts by weight of wheat protein.
It is preferable to set it to 30 parts by weight.

The enzymatic hydrolysis of wheat protein is preferably carried out in a dilute aqueous solution of an enzyme having protease activity. Usually, pepsin, alkaline protease, papain, or the like is added to an aqueous solution or aqueous dispersion of an object to be hydrolyzed. In the presence of the enzymes, the enzyme reaction is carried out for about 1 to 10 hours under conditions near the optimum pH and the optimum temperature of these enzymes. Here, the concentration of the aqueous solution or dispersion of wheat protein is
Preferably, the amount is 2 to 40% by weight, and the amount of the enzyme used is 0.1 to 25 parts by weight based on 100 parts by weight of the wheat protein.

Further, the wheat protein hydrolysis treatment with a reducing agent or an oxidizing agent is preferably carried out in a dilute aqueous solution of the reducing agent or the oxidizing agent. Compound, erythorbic acid,
In the presence of a reducing agent such as hydrazine or an oxidizing agent such as hydrogen peroxide or hypochlorite, a hydrolysis reaction is carried out at about 10 to 100 ° C. for 10 minutes to 10 hours. Here, the concentration of the aqueous solution or aqueous dispersion of wheat protein is preferably 2 to 40% by weight, and the amount of the reducing agent or oxidizing agent used is 0.5 to 100% by weight of wheat protein.
It is preferably 25 parts by weight.

In the above hydrolysis treatment, the obtained wheat protein hydrolyzate has a molecular weight of 2,000 to 200,000.
It is preferable from the viewpoint of the effect of the present invention that the hydrolysis treatment is terminated so that the molecular weight is 10,000.
It is preferable to adjust the treatment concentration and the treatment time of the hydrolysis so as to be 0 to 170,000.

Further, the wheat protein hydrolyzate obtained by the hydrolysis treatment may be soluble in water or an aqueous ethanol solution in order to be easily incorporated into an external preparation for skin and to sufficiently exert the effects of the present invention. preferable.

The above-mentioned hydrolysis treatment is performed not only alone but also
A combination of more than one species may be performed. The wheat protein hydrolyzate-containing solution thus obtained can be used as it is or as a powder after freeze-drying the solution. Furthermore, the above solution is desalted by ultrafiltration or the like.
It may be used as a deodorized purified product.

The amount of the wheat protein hydrolyzate in the external preparation for skin is not particularly limited, but is preferably 0.01 to 10% by weight based on the total amount of the external preparation for skin.
Furthermore, 0.01 to 5% by weight is most preferable from the viewpoint of usability.

The external preparation for skin of the present invention may contain, if necessary,
Oils, fats, moisturizers, powders, pigments, emulsifiers, solubilizers, detergents, ultraviolet absorbers, thickeners, drugs, fragrances, resins, alcohols, etc., which are usually compounded in skin external preparations Can be. In addition, the dosage form of the external preparation for skin of the present invention is arbitrary, for example, as a solubilizing system such as a lotion, an emulsifying system such as a cream or an emulsion, and a dispersion system such as a calamine lotion.
It can also be provided or in the form of an aerosol filled with a propellant.

The application site of the external preparation for skin according to the present invention is not particularly limited, and can be applied not only to the face but also to the whole body such as the neck, arm, upper body, lower body, buttocks.

[0026]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

First, a sausinoki plant extract and a wheat protein hydrolyzate used in the present invention were prepared in the following manner.

[Sausage Tree Extract] Sausage Tree ( Kigelia africana (Lamk.) Benth.) Fruit 50
0 g was pulverized, immersed in 5000 g of a 50% by weight aqueous ethanol solution, and subjected to stirring extraction at 25 ° C. for 24 hours. The extract was filtered to collect the filtrate, which was then sterilized with a Millipore filter to obtain an extract of a plant of the genus Sausage.

[Wheat protein hydrolyzate] 40 g of commercially available wheat gluten (reagent product; manufactured by Wako Pure Chemical Industries) was dispersed in 160 g of water, and the pH was adjusted to 8.0 with a small amount of sodium bicarbonate.
The liquid temperature was adjusted to 37.0 ° C. in a thermostat, 0.5 g of commercially available trypsin (reagent product) was added, and the mixture was hydrolyzed by an enzyme reaction for 3 hours while stirring with a stirrer. This was heated to 80 ° C. to inactivate the enzyme, neutralized with hydrochloric acid, and then filtered to remove insolubles, and the total amount was adjusted to 200 g with pure water to obtain a wheat protein hydrolyzate. The weight average molecular weight of the obtained wheat protein hydrolyzate was 75,000.

Example 1 of the present invention was prepared according to the formulation shown in Table 1.
An oil-in-water emulsified cosmetic solution was prepared. In addition, at the same time, an oil-in-water emulsified cosmetic solution containing no wheat protein hydrolyzate was prepared, and was set as Comparative Example 1. The production method is shown below.

Manufacturing method: The oil phase components a to e are mixed and heated to 75 ° C. to be dissolved and homogenized. On the other hand, f-h aqueous phase components are mixed,
Dissolve and heat to 75 ° C. and pre-emulsify by gradually adding the oil phase component. After adding i, the mixture is emulsified uniformly with a homomixer, and j is added to adjust the pH. 40 ° C after cooling
And add k to n to mix and homogenize.

[0032]

[Table 1]

In order to demonstrate the bust-up effect of the oil-in-water emulsified essence shown in Example 1, 20 female panelists in their 20s and 40s who are concerned about the slack and size of the bust are taken as a group, 2 times a day. The thoracic thorax was used continuously for two months, and the size of the bust and the state of sagging before and after use were observed. For reference, Comparative Example 1 was similarly evaluated.

Regarding the effect of increasing the size of the bust, the under bust and the top bust were measured before and after using the embodiment, and the average value of the difference was calculated. Regarding the sagging improvement effect, the image of the chest was taken into a computer, and the images before and after use were evaluated as “improved;
Evaluation was made by scoring in four stages of "slight improvement; 2", "no change; 1", and "deterioration;0", and calculating an average score. Table 2 shows the results.

[0035]

[Table 2]

As is clear from Table 2, in the group using Example 1 of the present invention, the difference between the top bust and the under bust was large, the bust size was increased, and the sag was improved. . However, in the group using Comparative Example 1, although the bust-up effect and the sag improving effect were recognized, the effect was lower than that of Example 1.

Furthermore, in order to show the effect of the oil-in-water emulsion type serum shown in Example 1 on the slack of the neck and cheeks, a group of 10 female panelists in their 20s and 40s who are concerned about the slack of the neck or cheeks Each part was used twice a day continuously for two months, and the state before the start of use and the state after the end of use were observed. For reference, Comparative Example 1 was similarly evaluated.

The results were as follows: images of the use site were taken by computer, and the images before and after use were compared, and the results of the sensory evaluation were "improved;3","slightlyimproved;2","nochange;1",
The evaluation was made by scoring in four stages of “worse; 0” and calculating the average score. Table 3 shows the results.

[0039]

[Table 3]

As shown in Table 3, the evaluation on the neck and cheeks also showed that the group using Example 1 of the present invention was excellent in the effect of improving the slack. However, in the use group of Comparative Example 1, although the sagging improvement effect was recognized, the effect was not as good as that of Example 1.

In Example 1 of the present invention, precipitation, separation, agglomeration, unpleasant odor,
No change in the state of the preparation such as discoloration was observed. Further, in the group used in Example 1, there were no panelists exhibiting a skin irritating reaction, a skin sensitizing reaction, or any other change in physical condition that could be caused by continuous use.

Another embodiment of the present invention will be described.

Example 2 Skin Lotion (1) Ethanol 10.0 (% by weight) (2) Hydroxyethylcellulose 1.0 (3) Glycerin 7.0 (4) Sausage Plant Extract 2.0 ( 5) Wheat protein hydrolyzate 4.0 (6) Purified water 76.0 Production method: Mix (1) to (6) to make uniform.

Example 3 Skin Gel (1) Purified Water 85.4 (% by weight) (2) Carboxyvinyl Polymer 0.5 (3) Sausage Plant Extract 2.0 (4) Wheat Protein Hydrolyzate 4.0 (5) Dipropylene glycol 8.0 (6) Potassium hydroxide 0.1 Production method: After (2) is uniformly dissolved in (1), (3), (4),
(5) is added and then (6) is added to thicken.

Example 4 Skin Cream (1) Beeswax 6.0 (% by weight) (2) Cetanol 5.0 (3) Reduced Lanolin 3.0 (4) Squalane 29.5 (5) Lipophilic Type Glyceryl monostearate 4.0 (6) Polyoxyethylene (20EO) sorbitan monolaurate 5.0 (7) Propylene glycol 5.0 (8) Sausinoki plant extract 1.0 (9) Wheat protein water Decomposed product 3.0 (10) Purified water 38.5 Production method: Mix and dissolve the oil phase components (1) to (6) and heat to 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer.

Example 5 Jelly-like peel-off pack (1) polyvinyl alcohol 15.0 (% by weight) (2) carboxymethyl cellulose 5.0 (3) 1,3-butylene glycol 3.0 (4) ethanol 6 0 (5) Polyoxyethylene (20EO) oleyl ether 0.5 (6) Sausage plant extract 1.0 (7) Wheat protein hydrolyzate 2.0 (8) Purified water 67.5 Production method: (8) ) Is added to (3) and heated to 75 ° C. to this
(1) and (2) are added and dissolved, and (4) to (7) are added and uniformly dissolved.

Example 6 Massage Gel (1) Dipropylene glycol 7.0 (% by weight) (2) Glycerin 8.0 (3) Polyoxyethylene (15EO) oleyl ether 1.0 (4) Carboxyvinyl polymer 0.4 (5) Methylcellulose 0.2 (6) Sausage extract plant extract 1.0 (7) Wheat protein hydrolyzate 3.0 (8) Potassium hydroxide 0.1 (9) Purified water 79.3 Manufacturing method: The components (1) to (8) are sequentially added to (9) heated to 75 ° C., dissolved and homogenized.

Example 7 Body Lotion (1) Octyl palmitate 7.0 (% by weight) (2) Methylphenylpolysiloxane 5.0 (3) Methylpolysiloxane 1.0 (4) Behenyl alcohol 1.0 ( 5) Sorbitan monostearate 1.5 (6) Polyoxyethylene monostearate (20EO) sorbitan 1.5 (7) Purified water 68.12 (8) 1,3-butylene glycol 3.0 (9) Glycerin 1 0.0 (10) Polyethylene glycol (average molecular weight 20,000) 2.0 (11) Carboxyvinyl polymer 0.06 (12) Xanthan gum 0.06 (13) Sodium alginate 0.06 (14) Potassium hydroxide (2.5% by weight aqueous solution) 0.5) (15) Sausinoki plant extract 1.0 (16) Wheat protein hydrolyzate 1.0 (17) 95% ethanol 6.0 (18) Methyl parahydroxybenzoate 0.1 (19) Flavor .1 Preparation: (1) mixing the oil phase component to (6), heated to dissolve to 75 ° C.. On the other hand, the aqueous phase components (7) to (13) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. After the addition of the component (14), the mixture was cooled while mixing.
Add the components (15) to (19) at ℃ and mix and homogenize.

Example 8 Gel lotion (1) Octyl palmitate 7.0 (% by weight) (2) Methylpolysiloxane 3.0 (3) 1,3-butylene glycol 3.0 (4) Glycerin 1 0.0 (5) Acrylic acid / alkyl methacrylate copolymer 0.3 (6) Carboxyvinyl polymer 0.3 (7) Purified water 76.8 (8) 2-Amino-2-methyl-1-propanol 3 (9) 95% ethanol 6.0 (10) Sausage extract plant extract 1.0 (11) Wheat protein hydrolyzate 1.0 (12) Methyl parahydroxybenzoate 0.2 (13) Fragrance 0.1 Production method: Mix and dissolve the oil phase components of (1) and (2) at 75 ° C
Heat to On the other hand, the aqueous phase components (3) to (7) are mixed and dissolved and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. After the addition of the component (8), the mixture is cooled while being mixed.
At 0 ° C, the components (9) to (13) are added, mixed and homogenized.

Example 9 Hand lotion (1) Liquid paraffin 15.5 (% by weight) (2) Microcrystalline wax 5.0 (3) Lipophilic glyceryl monostearate 3.0 (4) Behenyl alcohol 3. 0 (5) Hardened oil 2.5 (6) Polyoxyethylene monostearate (20EO) sorbitan 2.0 (7) Stearic acid 1.0 (8) Retinol palmitate 0.25 (9) Methylpolysiloxane 2 (10) dl-α-tocopherol acetate 0.05 (11) Purified water 44.87 (12) Glycerin 15.0 (13) 1,3-butylene glycol 5.0 (14) Sodium hydroxide 0.13 ( 15) Sausinoki plant extract 1.0 (16) Wheat protein hydrolyzate 1.0 (17) Propyl parahydroxybenzoate 0.2 (18) Dipotassium glycyrrhizinate 0.2 (19) γ-oryzanol 0.1 Production method: Oil phase (1) to (10) Mixing minute, heated to dissolve to 75 ° C.. On the other hand, the aqueous phase components (11) to (13) are mixed and dissolved, and heated to 75 ° C. Next, after the oil phase component is added to the water phase component and pre-emulsified, the mixture is uniformly emulsified by a homomixer. After the addition of the component (14), the mixture was cooled while being mixed.
Add the components (15) to (19) at ℃ and mix and homogenize.

[0051]

As described above in detail, according to the present invention, an external preparation for skin which has the effect of tightening the sagging skin and increasing the bust size, and which does not cause side effects due to continuous use, can be obtained.

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[Procedure amendment]

[Submission date] August 28, 2001 (2001.8.2
8)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claim 1

[Correction method] Change

[Correction contents]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] Claim 2

[Correction method] Change

[Correction contents]

[Procedure amendment 3]

[Document name to be amended] Statement

[Correction target item name] 0005

[Correction method] Change

[Correction contents]

[0005]

As a result of various studies to solve the above problems, the genus Sausage ( Kigelia D
C. ) By using the extract from the plant and the wheat protein hydrolyzate together, it has the effect of tightening the sagging skin and increasing the bust size, and it has been found that there is no side effect even with continuous use. The present invention has been completed.

[Procedure amendment 4]

[Document name to be amended] Statement

[Correction target item name] 0006

[Correction method] Change

[Correction contents]

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION First, an extract from a plant of the genus Sausinoki ( Kigelia DC .) Used in the present invention will be described.

[Procedure amendment 5]

[Document name to be amended] Statement

[Correction target item name] 0007

[Correction method] Change

[Correction contents]

The plant of the genus Sausinoki ( Kigelia DC .) Is a dicotyledonous plant belonging to the family Bignoniaceae .
It is an evergreen or deciduous tree, and about 10 species are distributed and planted in Africa. In the present invention, the sausage tree is not particularly limited as long as it is a plant of the genus Sausage, but from the availability, sausage tree ( Kigelia africana (Lamk.) Bent
h.) is preferably used. Although various parts such as fruits, bark, seeds and leaves can be used, it is preferable to use fruits from the viewpoint of their effects.

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Claims (2)

[Claims] 1. An extract from a plant of the genus Sausinoki ( Kigelia L.) in combination with a wheat protein hydrolyzate,
External preparation for skin. 2. The sausage tree ( Kigelia africana (Lamk.) Bent) is a sausage tree ( Kigelia L.) plant.
The external preparation for skin according to claim 1, which is h.).