JP2002012550A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation excellent in skin-moisturizing effect, skin-beautifying effect, rough skinameliorating effect and compatibility with the skin owing to the skin's physiological function improvement resulting from its application, and also high in stability and safety. SOLUTION: This skin care preparation is obtained by formulating a base of agent for external use with a combination of either one of specific plant extract mixtures including extract mixtures derived from Matricaria chamomilla L., Foeniculum vulgare Miller, Humulus lupulus L., Achillea millefolium L., Melissa officinalis L. and Viscum coloratum Nakai var. lutescens Miyabe et Kudo (or Viscum album L. var. lutescens Makino), at least one extract selected from those derived from a specific plant group and at least one anti- inflammatory agent. The skin is cared for by the use of a combination of at least two selected from the above skin care preparations.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to the use of a plurality of plant extracts in combination and one or more anti-inflammatory agents in combination, so that it is easily applied to the skin, and has a high skin moisturizing effect and a beautiful skin effect. A skin external preparation capable of exhibiting an effect of improving skin roughness, and a method for caring for the skin, comprising using the skin external preparation in combination.

[0002]

2. Description of the Related Art Conventionally, extracts of various kinds of plants including medicinal plants have been used for external preparations for skin (Fragrance Journal, Extra Issue No. 1, 1979,
The magazine, extra edition No. 6, 1986, etc.). In recent years, with an increase in plant orientation due to nature and animal welfare, there is an increasing tendency to seek active ingredients in plant extracts.

[0003] However, although plant extracts have various actions, the actions are often not so strong as a whole, and if an external preparation for skin contains an amount of the plant extract that produces the expected action and effect, In some cases, undesired coloring or odor was observed, or the stability of the preparation was sometimes reduced. Attempts have been made to enhance the effect by combining a plurality of plant extracts, but since various factors are involved in the physiological function of the skin in a complex manner, combining only a small number of plant extracts requires It is difficult to improve the condition of the skin sufficiently.

[0004]

Accordingly, in the present invention, by sufficiently improving the physiological function of the skin, a high skin moisturizing effect, a beautiful skin effect, and a rough skin improving effect can be exhibited, and the skin is compatible with the skin. The purpose was to obtain an external preparation for skin excellent in formulation stability and safety.

[0005]

As a result of various studies to solve the above-mentioned problems, a mixture of an extracted mixture of a specific plant and one or more selected from a specific plant group is combined,
Further, it was found that good results can be obtained by incorporating one or more of the anti-inflammatory agents in combination.
The present invention has been completed.

That is, in the present invention, (A) chamomile ( Matricaria chamomilla L.), fennel ( Foenic )
ulum vulgare Miller), hops ( Humulus lupulus )
L.), Achillea millefolium
L.), Melissa ( Melissa officinalis L.) and Mistletoe ( Viscum coloratum Nakai var. Lutescens Miyabe e.)
extract mixture of tKudo or Viscum album L. var. lutescens Makino) and (B) horse chestnut ( Aesculus turbinata )
Blume), Horse chestnut ( Aesculus hippocastanum)
L.), carrot ( Daucus carota L.), mannen-ro ( Rosmarinus officinalis L.), calendula ( Cal )
endula officinalis L.), Calendula (Calendula arv
ensis L.), cornflower ( Centaurea cyanus L.),
Japanese horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), A plant belonging to the genus Aloe ( Aloe spp.), Quince ( Cydonia oblonga Mill.),
Cucumber ( Cucumis sativus L.), coltsfoot ( Tuss
ilago farfara L.), below mallow ( Althaea offici)
nalis L.), a plant belonging to the genus Hypericum ( Hypericum s)
pp.), salvia ( Salvia officinalis L.) and its variants ( Salvia officinalis var. tenuior ), Hamamelis ( Hamamelis virginiana L.), and witch hazel ( Hamamelis j.
aponica Sieb. et Zucc.), Thymus
vulgaris L.), Potentilla torment
illa ), licorice ( Glycyrrhiza uralensis Fisher, Gl
ycyrrhiza glabra L. and its variants, Glycyrrhiza echin
ata L., Glycyrrhiza glandulifera Reg. et Herd.),
A plant belonging to the genus Lily ( Lilium spp.), Parsley ( Petrose )
linum crispum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume),
Inubuna ( Fagus japonica Maxim.), Ginkgo ( Ginkg
o biloba L.), ivy (Hedera tobleri Nakai), ivy (Hederahelix L.) and Roman chamomile (Anthemis nobilis L.) 1, two or more extracts selected from the group of plants consisting of, or (C) Fennel ( Fo
eniculum vulgare Miller, horse chestnut ( Aesculus turbi )
nata Blume) and / or Aesculus h
ippocastanum L.), carrot ( Daucus carota L.) extraction mixture, and (D) chamomile ( Matricaria chamomi )
lla L.), hops ( Humulus lupulus L.), Achillea millefolium ( Achillea millefolium L.), melissa ( M
elissa officinalis L.), Mistletoe ( Viscum coloratu )
m Nakai var.lutescens Miyabe et Kudo or Viscum al
bum L. var. lutescens Makino), Mannenrou ( Rosm
arinus officinalis L.), Calendula ( Calendula )
officinalis L.), calendula ( Calendula arvensis )
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), A plant belonging to the genus Aloe ( Aloe
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago fa
rfara L.), below mallow ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.)
p.), salvia ( Salvia officinalis L.) and its variants ( Salvia officinalis var. tenuior ), Hamamelis ( Hamamelis virginiana L.), and witch hazel ( Hamamelis j.
aponica Sieb. et Zucc.), Thymus
vulgaris L.), Potentilla torment
illa ), licorice ( Glycyrrhiza uralensis Fisher, Gl
ycyrrhiza glabra L. and its variants, Glycyrrhiza echin
ata L., Glycyrrhiza glandulifera Reg. et Herd.),
A plant belonging to the genus Lily ( Lilium spp.), Parsley ( Petrose )
linum crispum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume),
Inubuna ( Fagus japonica Maxim.), Ginkgo ( Ginkg
o biloba L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemis nobilis L.) 1, two or more extracts selected from the group of plants consisting of, or (E ) One or more species of chamomile ( Matricaria chamomilla L.), Yarrow ( Achillea millefolium L.), and plants belonging to the genus Hypericum ( Hypericum spp.), Butterbur dandelion ( Tussilago farfara L.), biloba oil ( Al )
thaea officinalis L.), Salvia ( Salvia officinali )
s L.) and / or its variants ( Salvia officinalis var.
tenuior ) and (F) Fennel ( Foni )
culum vulgare Miller, hop ( Humulus lupulus )
L.), Melissa ( Melissa officinalis L.), Mistletoe ( Viscum coloratum Nakai var. Lutescens Miyabe et
Kudo or Viscum album L. var. Lutescens Makino),
Horse chestnut ( Aesculus turbinata Blume), Horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucu
scarota L.), Mannenrou ( Rosmarinus officinalis )
L.), calendula officinalis ( Calendula officinalis)
L.), calendula ( Calendula arvensis L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum a.
rvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptu)
s spp.), a plant belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis s
ativus L.), Hamamelis virginiana
L.), witch hazel ( Hamamelis japonica Sieb. Et Zuc
c.), Tati thyme (Thymus vulgaris L.), Torumentira (Potentilla tormentilla), licorice (Gl
ycyrrhiza uralensis Fisher, Glycyrrhiza glabra L.
And its variants, Glycyrrhiza echinata L., Glycyrrhiza
glandulifera Reg. et Herd.), a plant belonging to the genus Lily ( Lilium spp.), parsley ( Petroselinum crispum (Mil
l.) Nym. ex AWHill.), a plant belonging to the genus Linden ( T
ilia spp.), a plant belonging to the genus Birch ( Betula sp.)
p.), Beech ( Fagus crenata Blume), Inubuna ( Fagus
japonica Maxim.), Ginkgo ( Ginkgo biloba L.),
Kizuta ( Hedera tobleri Nakai), Western Kizuta ( He
dera helix L.) and Roman chamomile ( Anthemis nobili)
s L.) or one or more extracts selected from the plant group consisting of: (G) Salvia officinalis
L.) and / or its variants ( Salvia officinalis var. T.
enuior ), Hamamelis ( Hamamelis virginiana L.),
Tati thyme (Thymus vulgaris L.), Torumentira (Potentilla tormentilla), rosemary (Rosm
arinus officinalis L.) and (H) chamomile ( Matricaria chamomilla L.), fennel ( Fo )
eniculum vulgare Miller), hop ( Humulus lupulus )
L.), Achillea millefolium
L.), Melissa ( Melissa officinalis L.) and Mistletoe ( Viscum coloratum Nakai var. Lutescens Miyabe e.)
t Kudo or Viscum album L. var.lutescens Makin
o), horse chestnut ( Aesculus turbinata Blume), horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucus carota L.), calendula of Calendula of
ficinalis L.), calendula ( Calendula a rvensis)
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), A plant belonging to the genus Aloe ( Aloe
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago )
farfara L.), below mallow ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.)
p.), witch hazel ( Hamamelis japonica Sieb. et Zuc
c.), licorice ( Glycyrrhiza uralensis Fisher, Glyc
yrrhiza glabra L. and its variants, Glycyrrhiza echinat
a L., Glycyrrhiza glandulifera Reg. et Herd.), a plant belonging to the genus Lily ( Lilium spp.), parsley ( Petroseli
num crispum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume), inupuna ( Fagus japonica Maxim.), Ginkgo ( Ginkgo
biloba L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (A
nthemis nobilis L.), and one or more extracts selected from the group of plants consisting of
More than one species are used in combination in the base for external preparation for skin.

Further, in the present invention, the skin condition can be further improved by using a combination of two or more of the skin external preparations obtained above.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The plant extract mixture (A) used in the invention according to claim 1 of the present invention is
icaria chamomilla L.), fennel (Foeniculum vul
gare Miller), Hop ( Humulus lupulus L.), Achillea millefolium ( Achillea millefolium L.), Melissa ( Melissa officinalis L.) and Mistletoe ( Viscum )
coloratum Nakai var.lutescens Miyabe et Kudo or
Viscum album L. var. Lutescens Makino).

[0009] chamomile (Matricaria chamomilla L.) is a one-year grass or biennial grass belongs to the Asteraceae (Compositae), a MotoHara plant of herbal "chamomile (Chamomillae Flos)". Each part, such as leaves, stems, roots, and flower heads, and whole plants can be used, but it is preferable to use flower heads.

Fennel ( Feniculum vulgare Mille)
r) is a perennial herb belonging to the Umbelliferae family, which is the base plant of the herbal medicine " Foniculi Fructus ". The leaves, stems, roots, flowers, fruits and other parts and whole plants can be used. It is preferred to use fruits.

[0011] Hop ( Humulus lupulus L.) is a dioecious perennial herb belonging to the mulberry family ( Moraceae ) and is the base plant of the herbal medicine "hop ( Lupuli Strobilus )".
Although various parts such as leaves, stems, roots, flowers and whole plants can be used, it is preferable to use female spikes.

Achillea millefo
lium L.) is a perennial plant belonging to the Compositae family.
Although various parts such as leaves, stems, roots, and flowers can be used, it is preferable to use flowers or whole plants.

[0013] Melissa (Melissa officinalis L.) is a perennial plant belonging to the Labiatae (Labiatae), leaves, stems, roots, it is possible to use the site and the whole plant flowers, etc., it is preferable to use a leaf.

Mistletoe ( Viscum coloratum Nakai var.
lutescens Miyabe et Kudo or Viscum album L. var. l
utescens Makino) is a dioecious evergreen semi-parasitic shrub belonging to the family Mistletoe ( Loranthaceae ), which can use leaves, branches, flowers, fruits, seeds, and other parts. Preferably, it is used.

The above-mentioned six kinds of plants may be subjected to extraction at the same time. Alternatively, each of the above-mentioned extracts may be mixed after being individually extracted. In addition, "MS Extract (Complex VII)" (Maruzen Pharmaceutical Co., Ltd.), "Sef Plant Complex" (Kurtrichter Co., Ltd.)
And other commercially available products.

In the invention according to claim 1 of the present invention,
Each plant constituting the plant group of (B) used in combination with the extraction mixture of (A) will be described below.

Aesculus turbinata Blume and Aesculus hippocastanum L. are deciduous trees belonging to the family Aesculus ( Hippocastanaceae ).
Each part such as leaves, branches, bark, flowers and fruits and whole trees can be used, but it is preferable to use leaves, barks or fruits.

Carrot ( Daucus carota L.) is a perennial herb belonging to the Umbelliferae family, and can use various parts such as leaves, stems and roots, and whole plants, but preferably uses roots.

Mannenrou ( Rosmarinus officinalis)
L.) is an evergreen shrub belonging to the Labiatae (Labiatae), leaves,
Each part such as a branch, bark, flower and the like and the whole tree can be used, but it is preferable to use leaves.

Calendula officinalis
L.) and calendula ( Calendula arvensis L.) are annual or biennial herbs belonging to the Compositae family.
Although various parts such as leaves, stems, flowers, and roots and whole plants can be used, it is preferable to use flowers.

Knapweed ( Centaurea cyanus L.) is an annual plant belonging to the family Asteraceae ( Compositae ) and its leaves, stems, flowers,
Although various parts such as roots and whole plants can be used, it is preferable to use flowers.

The horsetail ( Equisetum arvense L.) is a perennial fern plant belonging to the family Equisetaceae ( Equisetaceae ), and it is possible to use all parts of the rhizome, spore stem, vegetative stem and whole plant, but it is preferable to use whole plant. .

Examples of plants belonging to the genus Eucalyptus include Eucalyptus globulus Labill. And related plants, and these are plants belonging to the family Myrtac.
eae ) is an evergreen tree belonging to the herbal medicine "eucalyptus oil"
( Oleum Eucalypti ). Closely related plants include Eucalyptus polybractea RTBaker, Eucalyptus
dives Schauer. In addition, Lemon Eucalyptus ( Eucalyptus citriodora Hook.), Eucalyptus piperi
ta Sm., Eucalyptus gunnii Hook. fil., Eucalyptus m
acarthuri Decne. Et Maiden, Eucalyptus rostrata Sc
hlecht., Eucalyptus staigeriana FvM, etc. can also be used, and one or more of these are selected for extraction. Each part such as a leaf, a branch, a bark, a flower, a fruit and the like and the whole tree can be used, but it is preferable to use a leaf.

The plant belonging to the genus Aloe is Liliacea.
e ) is a woody succulent plant belonging to the herbal medicine "Aloe" ( Alo
e ) Used as a base plant. Aloe ferox Mill., A
loe africana Mill., Aloe spicata Baker, Aloe arbor
escens Mill., Aloe succotrina Lam., Aloe plicatili
s Mill., Aloe bainesii Th. Dyer., Aloe marlothii Bg
r., Aloe perryi Baker, Aloe vera L., Aloe barbaden
sis Mill. and Aloe arborescens Mill.
var. natalensis Berg.) and the like.
A species or two or more species are selected and used. For extraction, various parts such as leaves, inflorescences and flowers and whole plants can be used, but it is preferable to use leaves.

Quince ( Cydonia oblonga Mill.) Is a deciduous tree belonging to the family Rosaceae , and its leaves, branches, bark,
Each part such as flowers and fruits and whole trees can be used,
It is preferred to use leaves or fruits.

Cucumber ( Cucumis sativus L.) is a vine annual belonging to Cucurbitaceae , and its leaves, stems,
Each part such as flowers and fruits and whole plants can be used,
It is preferred to use fruits.

Coltsfoot ( Tussilago farfara L.) is a perennial herb belonging to the family Asteraceae ( Compositae ) and has leaves, stems,
Although various parts such as flowers and roots and whole plants can be used, leaves or flowers are preferably used.

Below-Oil ( Althaea officinalis)
L.) is a perennial plant belonging to the Malvaceae family ( Malvaceae ).
Each part such as stem, flower, root and the like and whole plant can be used, but it is preferable to use leaf or root.

[0029] Examples of the plants belonging to the genus Hypericum, St. John's wort (Hypericum erectum Thunb.), Hypericum perforatum L., Tomoesou (Hyper to be produced in Europe
icumascyron L.) and these are the Hypericum family ( Gu
One or more perennials belonging to ttiferae ) are selected and used. Each site such as leaves, stems, flowers, and roots and the whole plant can be used for extraction, but it is preferable to use the whole plant.

[0030] Salvia (Salvia officinalis L.) and its variants is Salvia officinalis var. Tenuior can be used in a perennial plant belonging to the Labiatae (Labiatae), leaves, stems, flowers, each site and all the grass roots, etc. However, it is preferable to use leaves.

Hamamelis virginiana L.
And witch hazel ( Hamamelis japonica Sieb. Et Zucc.) Are deciduous trees belonging to the hamaceae family ( Hamamelidaceae ).
Each part such as a branch, bark, flower and the like and the whole tree can be used, but it is preferable to use leaves.

Thymus vulgaris L.
Small shrub, the leaves of evergreen belonging to the Labiatae (Labiatae),
Although all parts such as stems, flowers, roots and the whole plant can be used, it is preferable to use the whole plant.

[0033] Potentilla tormentill
a ) is a perennial herb belonging to the Rosaceae family, with leaves,
Although various parts such as stems, flowers, and roots and whole plants can be used, roots are preferably used.

Licorice ( Glycyrrhiza uralensis Fishe)
r, Glycyrrhiza glabra L. and its variants, Glycyrrhiza
echinata L., Glycyrrhiza glandulifera Reg. et Her
d.) is a perennial herb belonging to the leguminous family ( Leguminosae ), and is the base plant of the crude drug " Glycyrrhizae Radix ". Variants of Glycyrrhiza glabra L. include Glycyrrhi
za glabra var. typica Regel et Herder, Glycyrrhiza
glabra var. violacea Boiss., Glycyrrhiza glabra va
r. pallida Boiss. 1 or 2 from above
Select and use more than one species. For extraction, various parts such as leaves, stems, flowers, and roots and whole plants can be used, but roots are preferably used.

Plants belonging to the genus Lily include Lily ( Lili)
um auratum Lindl.), Madonna lily ( Lilium candid)
um L.), Japanese lily ( Lilium concolor Salisb.), Takasago lily ( Lilium formosanum Wallace), Sasa lily ( L
ilium japonicum Thunb. ex Houtt.), Lili
um lancifolium Thunb.), Lilium leicht
linii Hook. f. var. maximowiczii Baker), lily (Lilium longiflorum Thunb.), Iwatoyuri (Lil
ium maculatum Thunb.), kurumeuri ( Lilium medeolo )
ides A. Gray, Lilium regale Wil
s.), Lilium rebellum Baker, Lilium speciosum Thunb. These are perennials belonging to the lily family ( Liliaceae ), and one or more species are selected and used. For extraction, various parts such as leaves, stems, flowers, and bulbs and whole plants can be used, but it is preferable to use bulbs.

Parsley ( Petroselinum crispum (Mill.) N
ym. ex AWHill.) is a two-year or perennial plant belonging to the Umbelliferae family, and can use leaves, stems, flowers, fruits, and other parts and whole plants, but preferably uses leaves and stems. .

[0037] to the plant belonging to the Tilia genus, American linden (Tilia americana L.), Tilia cordata (Tili
a cordata Mill.), Tilia europae
a L.), linden ( Tilia japonica Simonk.), herring tree ( Tilia kiusiana Makinoet Shiras.), squid ( Tilia maximowicziana Shiras.), bodaige ( Tilia miqueliana Maxim.), and nuts ( Tilia )
platyphyllos Scop.). These are deciduous trees belonging to the linden family ( Tiliaceae ).
Select and use more than one species. Extraction includes leaves, branches, bark,
Each part such as flowers and fruits and whole trees can be used,
It is preferred to use flowers or fruits.

Plants belonging to the birch genus include birch birch ( Betula ermanii Cham.) And water birch ( Betula grossa Si
eb. et Zucc.), Sweet birch ( Betula lenta)
L.), Red birch ( Betula maximowicziana Rege)
l), red birch ( Betula nigra L.), paper birch ( Betula papyrifera Marsh.), silver birch ( Be
tula pendula Roth.), Birch ( Betula platyphylla )
Sukatchev var. Japonica Hara.), European birch (Betula pubescens Ehrh,), Onoorekanba (Betu
la schmidtii Regel), Himalayan paper birch ( Betu
la utilis D. Don). These are birch families ( Bet
ulaceae ), and one or two or more species are selected and used. For extraction, each part such as leaves, branches, bark, flowers, fruits and the like and the whole tree can be used, but it is preferable to use leaves or bark.

The beech (Fagus crenata Blume) and Fagus japonica (Fagus japonica Maxim.) Is a deciduous tree belonging to the beech family (Fagaceae), it is possible to use leaves, branches, bark, flowers, each site and all the trees of fruit, etc. However, it is preferable to use leaves, bark or sprouts.

Ginkgo biloba L. is a dioecious deciduous tree belonging to the ginkgo family Ginkgoaceae .
Each site such as leaves, branches, bark, flowers, and seeds and whole trees can be used, but it is preferable to use leaves or seeds.

Hizera ( Hedera tobleri Nakai) and Hizera ( Hedera helix L.) are known as Araliacea.
e ) An evergreen vine plant belonging to ( e ), which can use leaves, stems, flowers, berries, and other parts and whole plants, but preferably uses leaves and stems.

Roman chamomile ( Anthemis nobilis L.)
Is a perennial herb belonging to the family Asteraceae ( Compositae ), with leaves, stems,
Although various parts such as flowers and roots and whole plants can be used, it is preferable to use flowers.

Next, the plant extract mixture (C) used in the external preparation for skin according to claim 2 is a fennel ( Fonicul)
um vulgare Miller, horse chestnut ( Aesculus turbinata )
Blume and / or Aesculus hippoc
astanum L.) and carrot ( Daucus carota L.). These plants may be subjected to extraction at the same time. Alternatively, each of the obtained extracts may be mixed after being individually extracted. In addition, commercially available products such as “MS Extract (Complex X)” (manufactured by Maruzen Pharmaceutical Co., Ltd.) and “Ches Plant Complex” (manufactured by Kurtrichter Co., Ltd.) can also be used.

In the external preparation for skin according to claim 2, (C)
The plant group of (D) used in combination with the plant extract mixture of Chamomile ( Matricaria chamomilla L.) and hop ( Humulus lu
pulus L.), Achillea millefo
lium L.), Melissa ( Melissa officinalis L.), Mistletoe ( Viscum coloratum Nakai var. lutescens Miya
be et Kudo or Viscum album L. var.lutescens Makin
o), Mannenrou ( Rosmarinus officinalis L.), Calendula officinalis ( Calendula officinalis L.), Calendula ( Calendula arvensis L.), Knapweed ( Centaur
ea cyanus L.), horsetail ( Equisetum arvense L.), plants belonging to the genus Eucalyptus ( Eucalyptus spp.), plants belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia obl .)
onga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago farfara L.), beetle mallow ( Althaea officinalis L.), a plant belonging to the genus Hypericum ( Hypericum spp.), salvia ( Salvia officinal )
is L.) and its variants ( Salvia officinalis var. tenui)
or ), Hamamelis ( Hamamelis virginiana L.), Witch Hazel ( Hamamelis japonica Sieb. et Zucc.), Thymus vulgaris L., Tormentilla ( P
otentilla tormentilla ), licorice ( Glycyrrhiza ura )
lensis Fisher, Glycyrrhiza glabra L. and its variants,
Glycyrrhizaechinata L., Glycyrrhiza glandulifera R
eg. et Herd.), a plant belonging to the genus Lily ( Lilium sp.
p.), parsley ( Petroselinum crispum (Mill.) Nym. ex
AWHill.), A plant belonging to the genus Linden ( Tilia sp.
p.), plants belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume), and cattle beech ( Fagus japonica )
Maxim.), Ginkgo ( Ginkgo biloba L.), Kizuta ( He
dera tobleri Nakai), Hedera helix
L.) and Roman chamomile ( Anthemis nobilis L.).

The plant extract mixture of (E) used in the external preparation for skin according to claim 3 is preferably a chamomile ( Matricaria).
chamomilla L.), Achillea millefolium ( Achillea m)
illefolium L.), a plant belonging to the genus Hypericum ( Hyper
icum spp.) or two or more species of coltsfoot ( Tussi
lago farfara L.), below mallow ( Althaea officin)
alis L.), salvia ( Salvia officinalis L.) and / or
Alternatively, it can be obtained from each plant of a variety thereof ( Salvia officinalis var. Tenuior ). These plants may be subjected to extraction at the same time. Alternatively, each of the obtained extracts may be mixed after being individually extracted. In addition, "mixed extract (12)"
Commercial products such as (Maruzen Pharmaceutical Co., Ltd.) can also be used.

In the external preparation for skin according to claim 3, (E)
The plant group (F) used in combination with the plant extract mixture of fennel ( Feniculum vulgare Miller) and hop ( Humulus )
lupulus L.), Melissa ( Melissa officinalis )
L.), Mistletoe ( Viscum coloratum Nakai var. Lutesc)
ens Miyabe et Kudo or Viscum album L. var.lutesce
ns Makino), horse chestnut ( Aesculus turbinata Blume),
Horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucus carota L.), mannenrou ( Rosmarin
us officinalis L.), Calendula off
icinalis L.), calendula ( Calendula arvensis )
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), A plant belonging to the genus Aloe ( Aloe
spp.), Quince ( Cydonia oblonga Mill.), Cucumber ( Cucumis sativus L.), Hamamelis vi.
rginiana L.) and witch hazel ( Hamamelis japonica Sieb.)
et Zucc.), Thymus vulgaris
L.), Potentilla tormentilla , Glycyrrhiza uralensis Fisher, Glycyrrhiza
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. et Herd.) , a plant belonging to the lily genus (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), cattle beech ( Fagus japonica Maxim.), ginkgo ( Ginkgo biloba )
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.).

Further, the plant extract mixture (G) used in the external preparation for skin according to claim 4 is Salvia o.
fficinalis L.) and / or its variants ( Salvia officina)
lis var. tenuior ), Hamamelis virginian
a L.), Thymus vulgaris (Thymus vulgaris L.), Torumentira (Potentilla tormentilla), obtained from each plant of rosemary (Rosmarinus officinalis L.). These plants may be subjected to extraction at the same time. Alternatively, each of the obtained extracts may be mixed after being individually extracted. In addition, "MS Extract (Complex X
VI) "(manufactured by Maruzen Pharmaceutical Co., Ltd.) and the like.

The external preparation for skin according to claim 4 (G)
The plant group of (H) used in combination with the plant extract mixture of Chamomile ( Matricaria chamomilla L.) and Fennel ( Foenic )
ulumvulgare Miller), hops ( Humulus lupulus )
L.), Achillea millefolium
L.), Melissa ( Melissa officinalis L.) and Mistletoe ( Viscum coloratum Nakai var. Lutescens Miyabe e.)
t Kudo or Viscum album L. var.lutescens Makin
o), horse chestnut ( Aesculus turbinata Blume), horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucus carota L.), calendula of Calendula of
ficinalis L.), calendula ( Calendula arvensis )
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), A plant belonging to the genus Aloe ( Aloe
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago )
farfara L.), below mallow ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.)
p.), witch hazel ( Hamamelis japonica Sieb. et Zuc
c.), licorice ( Glycyrrhiza uralensis Fisher, Glycy
rrhiza glabra L. and its variants, Glycyrrhiza echinata
L., Glycyrrhiza glandulifera Reg. Et Herd.), A plant belonging to the genus Lily ( Lilium spp.), Parsley ( Petroseli )
num crispum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betula spp.), beech ( Fagus crenata Blume), inupuna ( Fagus japonica Maxim.), Ginkgo ( Ginkgo
biloba L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (A
nthemis nobilis L.).

In the present invention, each of the plants constituting the above (A) to (H) may be subjected to extraction as it is, but in consideration of the extraction efficiency, processing such as shredding, drying, and pulverization was performed. Preferably, the extraction is performed later. The extraction is performed by immersion in an extraction solvent. Stirring may be performed to increase the extraction efficiency, or homogenization may be performed in an extraction solvent. The extraction temperature is 5
It is appropriate that the temperature is from about ° C to the boiling point of the extraction solvent or lower. The extraction time varies depending on the type of the extraction solvent and the extraction temperature, but is suitably about 4 hours to 14 days.

As an extraction solvent, in addition to water, methanol,
Lower alcohols such as ethanol, propanol and isopropanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, dipropylene glycol and glycerin; ethers such as ethyl ether and propyl ether; esters such as ethyl acetate and butyl acetate And polar organic solvents such as ketones such as acetone and ethyl methyl ketone, and one or more of these can be selected and used. Further, physiological saline, phosphate buffer, phosphate buffered saline, or the like may be used.

The extract of each of the plants constituting the above (A) to (H) with the above solvent can be contained as it is in the external preparation for skin according to the present invention. It may be used after being dissolved again in a polar solvent, or subjected to purification treatment such as decolorization, deodorization, desalting, etc. within a range that does not impair their skin physiological function improving effect, or after fractionation treatment by column chromatography. . For preservation, it can be freeze-dried after the purification treatment and dissolved in a solvent before use. Further, it can also be used by being encapsulated in vesicles such as liposomes, microcapsules and the like.

In each of the inventions according to claims 1 to 4 of the present application, together with each combination of the above plant extracts,
One or more anti-inflammatory agents are used.

Examples of anti-inflammatory agents include cortisone, hydrocortisone, prednisolone, methylprednisolone, dexamethasone, betamethasone, triamcinolone, triamcinolone acetonide, fluocinolone acetonide,
Steroidal anti-inflammatory agents such as fluocinonide, beclomethasone and their phosphates, propionates, acetates, and succinates; salicylic acid and salicylic acid derivatives such as aspirin, salicylamide, ethenzamide, and methyl salicylate; indoles such as indomethacin and sulindac Acetic acid derivatives, pyrazolidinedione derivatives such as phenylbutazone and oxyphenbutazone, anthranilic acid derivatives such as mefenamic acid and flufenamic acid, propionic acid derivatives such as ibuprofen, ketoprofen and naproxen;
Non-steroidal anti-inflammatory drugs such as phenylacetic acid derivatives such as diclofenac and fenbufen; benzothiazine derivatives such as piroxicam; salts and derivatives such as glycyrrhizic acid and dipotassium glycyrrhizinate and monoammonium glycyrrhizinate; stearyl glycyrrhetinate and stearyl glycyrrhetinate; glycyrrhetinyl stearate; Salts and derivatives such as disodium 3-succinyloxyglycyrrhetinate, azulene derivatives such as guaiazulene, ethyl guaiazulenesulfonate, sodium guaiazulenesulfonate and camazulene, allantoin, aloin, aloe-emodin, shikonin and isobutyl shikonin, acetyl shikonin, isovaleryl shikonin Such as ginsenoside R _a1 , ginsenoside R _a2 , ginsenoside R _b1, etc. Noshido, and 20-ginsenoside derivatives such as glucosides Gin Seno glucoside R _f, paeoniflorin, paeonol and Peonoshido, like paeonol derivatives such Peonorido.

[0054] Also as an anti-inflammatory agent in the present invention, lithospermum (Lithospermi Radix), carrots (Ginseng Radi
x), peony (Paeoniae Radix), moutan bark (Mouta
Herbal extracts used as anti-inflammatory agents, such as n Cortex ) and kujin ( Sophorae Radix ), can also be used.

The external preparation for skin according to the present invention can be provided in various forms such as lotions, emulsions, gels, creams, ointments, powders, granules and the like. Also, skin cosmetics such as lotion, milky lotion, cream, serum, pack, etc.
Makeup base lotion, base makeup such as makeup base cream, foundation of various dosage forms such as milky liquid, oily and solid, makeup cosmetics such as eye color, cheek color, etc., cleansing cream, cleansing lotion, cleansing foam It can also be provided as a skin cleanser such as facial cleansing soap and body shampoo, and a hair cosmetic such as hair shampoo, hair rinse and hair treatment.

The external preparation for skin according to the present invention includes, in addition to one or more of the plant extracts and anti-inflammatory agents of the above-mentioned groups (A) to (H), an oily component, a surfactant, It should also contain raw materials for general pharmaceuticals and cosmetics such as humectants, pigments, ultraviolet absorbers, antioxidants, fragrances, antibacterial and antifungal agents, and physiologically active ingredients such as skin cell activators and whitening agents. Can be.

Further, in the invention according to claim 5 of the present application, two or more kinds are selected from the above-mentioned skin external preparations according to claims 1 to 4 of the present invention, and a combination thereof is used. To provide care. By such a skin care method, the physiological function of the skin is synergistically and comprehensively improved, the condition of the skin is improved, and the skin is kept more healthy. The external preparation for skin can be arbitrarily selected, but one or more skin cosmetics and one or more skin cleansers, one or more skin cosmetics and one or more base cosmetics, and / or makeup It is preferable to use one or more types of up cosmetics or a combination of the above and one or more types of skin cleansing agents.

[0058]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, preparation examples of each plant extract used in the present invention will be described below.

[Plant Extract Mixture 1] Chamomile ( Matricar
ia chamomilla L.) flowers, fennel (Foeniculum vul
gare Miller) Fruit, Hops ( Humulus lupulus L.)
The female spikes, Achillea millefoli
um L.) flowers, Melissa ( Melissa officinalis L.) leaves, and mistletoe ( Viscum coloratum Nakai var. lute)
scens Miyabe et Kudo or Viscum album L. var. lutes
cens Makino) 200 g each of dried and crushed fruit
3% at 20 ° C in 1 liter of each volume% aqueous ethanol solution
After stirring and extracting for one day, the filtrate was collected by filtration and mixed with each other in the same volume to obtain a plant extraction mixture 1.

[Plant extract mixture 2] Fennel ( Foenic
ulum vulgare Miller fruit, horse chestnut ( Aes)
culus hippocastanum L.) bark and carrot ( Daucus)
carota L.) roots were dried and pulverized, and mixed with ethanol and 1,3-butylene glycol (volume ratio = 1: 1)
After leaving still in 2.5 liters at room temperature for 5 days, the filtrate was collected by filtration and used as plant extract mixture 2.

[Plant Extract Mixture 3] Chamomile ( Matricar
ia chamomilla L.), 200 g of Achillea millefolium L. flower, 225 g of coltsfoot ( Tussilago farfara L.) flower, and 180 g of root of common beetle ( Althaea officinalis L.), dried, crushed, and dried. After standing at room temperature for 5 days in 3 liters of 1,3-butylene glycol, the mixture is filtered to collect the filtrate.
On the other hand, 220 g of whole plant of Hypericum erectum Thunb. And 300 g of leaves of Salvia officinalis L. were homogenized in 2.5 liters of 50% by volume ethanol aqueous solution at 15 ° C., then stirred and extracted for 24 hours, and centrifuged. Thereafter, the supernatant is filtered to collect the filtrate. This filtrate and the filtrate were mixed at a volume ratio of 2: 1 to obtain a plant extraction mixture 3.

[Plant Extract Mixture 4] Salvia o
fficinalis L.) leaves, 250 g, Hamamelis
leaf 250g, Thymus vulgaris of virginiana L.) (Th
Ymus vulgaris whole plant 300g of L.), root 250g of Torumentira (Potentilla tormentilla), dried leaves 280g of rosemary (Rosmarinus officinalis L.), and triturated at 15 ℃ with ethanol 2 liters of 7
It was allowed to stand for a day and extracted. The filtrate was collected by filtration, concentrated and dried to dryness, and then dissolved in 500 ml of 50% by volume ethanol to obtain a plant extraction mixture 4.

Next, with respect to the plants shown in Table 1, 250 g of each part shown in Table 1 was dried and pulverized, allowed to stand at room temperature for 5 days in 1.5 liter of the solvent shown in Table 1, and then filtered. The liquid was collected and used as an extract of each plant.

[0064]

[Table 1]

For the plants shown in Table 2, 200 g of each part shown in Table 2 was finely cut, and the solvent 1 shown in Table 2 was cut.
After stirring and extracting at 20 ° C. for 3 days with liter and filtering,
The filtrate was concentrated to 1/3 volume to obtain an extract of each plant.

[0066]

[Table 2]

Subsequently, with respect to the plants shown in Table 3, 230 g of each part shown in Table 3 was finely cut and crushed, followed by stirring and extraction with 1 liter of the solvent shown in Table 3 at 20 ° C. for 3 days, followed by filtration. It was concentrated to dryness and then freeze-dried to obtain an extract of each plant.

[0068]

[Table 3]

Next, the formulations of Examples of the external preparation for skin according to the present invention are shown below.

[Examples 1 to 4] Cleansing cream (1) Stearic acid 2.00 (% by weight) (2) Cetanol 3.00 (3) Vaseline 10.00 (4) Liquid paraffin 38.00 (5) ) Isopropyl myristate 10.00 (6) Tocopherol acetate 0.10 (7) Glyceryl monostearate 2.50 (8) Polyoxyethylene (20E.O.) sorbitan 2.50 Monostearate (9) Glycyrrhetin Stearyl acid 0.20 (10) Propylene glycol 5.00 (11) Potassium hydroxide 0.10 (12) Methyl parahydroxybenzoate 0.10 (13) Plant extract mixture shown in Table 4 0.05 (14) Table 4 Plant extract shown in Table 4 Amount shown in Table 4 (15) Purified water Amount to make total amount 100.00 (16) Fragrance 0.10 Production method: Oil of (1) to (9) Mix the phase components, heat and dissolve to 70 ° C
And On the other hand, the aqueous phase components (10) to (15)
Heat to 0 ° C. After preliminarily emulsifying the oil phase by gradually adding the oil phase to the aqueous phase component, the mixture is uniformly emulsified with a homomixer,
After cooling, add (16) at 40 ° C. and mix.

[0071]

[Table 4]

Examples 5 to 8 Cleansing Lotion (1) Ethanol 15.00 (% by weight) (2) Polyoxyethylene (20E.O.) Sorbitan 1.00 Monolaurate (3) Polyoxyethylene 10. Polyoxypropylene 1.50 block polymer (4) Methyl paraoxybenzoate 0.10 (5) Guaiazulene 0.05 (6) Fragrance 0.05 (7) Glycerin 5.00 (8) 1,3-butylene glycol 00 (9) Plant extract mixture shown in Table 5 0.01 (10) Plant extract shown in Table 5 Amount shown in Table 5 (11) Amount to make the total amount of purified water 100.00 Production method: (2) ) To (6) are dissolved to form an alcohol phase.
On the other hand, (7) to (11) are mixed and dissolved to form an aqueous phase, and the alcohol phase is added to the aqueous phase to be solubilized.

[0073]

[Table 5]

[Examples 9 to 12] Cleansing foam (1) Stearic acid 10.00 (% by weight) (2) Palmitic acid 10.00 (3) Myristic acid 12.00 (4) Lauric acid 4.00 (5) Jojoba oil 2.00 (6) Polyethylene glycol 10.00 (average molecular weight 1,500) (7) Glycerin 15.00 (8) Sodium guaiazulene sulfonate 0.15 (9) Potassium hydroxide 6.00 ( 10) Methyl paraoxybenzoate 0.10 (11) Purified water Amount to make the total amount 100.00 (12) Glyceryl monostearic acid 2.00 ester (13) Polyoxyethylene (20E.O.) Sorbitan 2.00 Mono Stearic acid ester (14) Plant extract mixture shown in Table 6 0.02 (15) Plant extract shown in Table 6 Amount shown in Table 6 (16) Fragrance 0 Preparation: (1) mixing to (7), and heated and dissolved to 70 ° C..
(8) to (10) are dissolved in (11), and the oil phase is added with stirring to allow a sufficient neutralization reaction. Then (12), (13)
Is added, and the mixture is cooled and (14) to (16) are preliminarily mixed and homogenized at 40 ° C., and then added and mixed.

[0075]

[Table 6]

[Examples 13 to 16] Lotion (1) Ethanol 10.00 (% by weight) (2) Polyoxyethylene (20E.O.) Sorbitan 0.50 Monolaurate (3) Jojoba oil 0 .10 (4) Methyl paraoxybenzoate 0.10 (5) Fragrance 0.05 (6) 1,3-butylene glycol 6.00 (7) Glycerin 4.00 (8) Sodium pyrrolidonecarboxylate 0.25 (9 ) Allantoin 0.10 (10) Plant extract mixture shown in Table 7 0.01 (11) Plant extract shown in Table 7 Amount shown in Table 7 (12) Purified water Amount to make total amount 100.00 Production method: (1 ) Is dissolved in (2) to (5) to form an alcohol phase.
On the other hand, (6) to (12) are uniformly mixed and dissolved to form an aqueous phase.
The alcohol phase is added to the aqueous phase and mixed uniformly.

[0077]

[Table 7]

[Examples 17 to 20] Emulsion (1) Cetanol 1.00 (% by weight) (2) Beeswax 0.50 (3) Vaseline 2.00 (4) Squalane 6.00 (5) Dimethylpoly Siloxane 2.00 (6) Polyoxyethylene (20E.O.) Sorbitan 1.00 Monostearate (7) Glyceryl monostearate 1.00 (8) Glycerin 4.00 (9) 1,3-butylene Glycol 4.00 (10) Dipotassium glycyrrhizinate 0.25 (11) Methyl paraoxybenzoate 0.10 (12) Purified water Amount to make total amount 100.00 (13) Carboxyvinyl polymer 10.00 (1.0 weight (14) Potassium hydroxide 0.10 (15) Ethanol 5.00 (16) Fragrance 0.10 (17) Plant extract mixture shown in Table 8 0.04 ( 18) Plant extract shown in Table 8 Amount shown in Table 8 Production method: The oil phase components (1) to (7) were mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (8) to (12) are mixed and dissolved to 75 ° C. After adding the above oil phase and pre-emulsifying, add (13), then add (14) to increase the viscosity, cool, add (15) to (18) at 40 ° C and mix. .

[0079]

[Table 8]

[Examples 21 to 24] Cream (1) Cetanol 5.00 (% by weight) (2) Stearic acid 3.00 (3) Vaseline 5.00 (4) Squalane 10.00 (5) Glyceryl Tri-2-ethylhexanoic acid 7.00 ester (6) Propylene glycol monostearic acid 3.00 ester (7) Polyoxyethylene (20E.O.) cetyl ether 3.00 (8) d-δ-tocopherol 0.15 (9) Stearyl glycyrrhetinate 0.20 (10) 1,3-butylene glycol 5.00 (11) Glycerin 5.00 (12) Potassium hydroxide 0.30 (13) Plant extract mixture shown in Table 9 0.02 (14) Plant extract shown in Table 9 Amount shown in Table 9 (15) Amount of purified water to make total amount 100.00 (16) Sicon extract 0.05 (17) Fragrance 0.10 Production method: (1)- (9) Mixing the oil phase components were heated and dissolved, 70 ° C.
And On the other hand, after mixing and dissolving the aqueous phase components (10) to (15), the mixture is heated to 70 ° C., and the oil phase is added thereto to emulsify. After cooling, (16) and (17) are added and mixed at 40 ° C. The sicon extract (16) was prepared from sicon ( Lithospermi Radi
x ) 200 g was dried and pulverized, immersed in 1 liter of a 50% by volume aqueous ethanol solution, allowed to stand at 25 ° C. for 7 days, and then filtered to collect a filtrate.

[0081]

[Table 9]

[Examples 25 to 28] Packing agent (1) polyvinyl alcohol 15.00 (% by weight) (2) carboxymethyl cellulose 5.00 (3) 1,3-butylene glycol 5.00 (4) glycyrrhizin Monoammonium acid 0.20 (5) Plant extract mixture shown in Table 10 0.02 (6) Plant extract shown in Table 10 Amount shown in Table 10 (7) Purified water Amount to make total amount 100.00 (8) Ethanol 12.00 (9) Methyl parahydroxybenzoate 0.10 (10) Polyoxyethylene (10E.O.) oleyl ether 0.50 (11) Fragrance 0.10 Production method: (3)-(6) ) Is added and heated to 70 ° C., then
Add (1) and (2) and dissolve. (9) to (11) are added to (8), dissolved, and added to the aqueous phase to solubilize.

[0083]

[Table 10]

Example 29 Lotion Agent (1) Ethanol 20.000 (% by weight) (2) Polyoxyethylene (60E.O.) hydrogenated castor oil 0.500 (3) Methyl paraoxybenzoate 0.100 ( 4) Dipropylene glycol 5.000 (5) 1,3-butylene glycol 10.000 (6) Camazulene 0.200 (7) Peony extract 0.100 (8) Plant extract mixture 4 0.020 (9) Rome Chamomile extract 0.001 (10) Fennel extract 0.001 (11) Hop extract 0.001 (12) Achillea millefolium extract 0.001 (13) Melissa extract 0.001 (14) Mistletoe extract 0 0.001 (15) Horsetail extract 0.002 (16) Parsley extract 0.002 (17) Fujudaiju extract 0.010 (18) Birch extract 0 010 (19) Beech extract 0.010 (20) Purified water 64.040 Production method: (1) to (6) are mixed and dissolved, and (7) to (19) are sequentially added and dissolved. , (20) and uniformly mixed and dissolved. Note peony extract (7), peony (Pae
(oniae Radix ) was dried, pulverized, immersed in 1 liter of a 50% by volume aqueous ethanol solution, allowed to stand at 25 ° C. for 7 days, and then filtered to collect a filtrate.

Example 30 Water-in-oil emulsion (1) Microcrystalline wax 1.000 (% by weight) (2) Beeswax 2.000 (3) Lanolin 2.000 (4) Liquid paraffin 20.000 (5) ) Squalane 10.000 (6) Sorbitan sesquioleate 4.000 (7) Polyoxyethylene (20E.O.) Sorbitan 1.000 Monooleate (8) Propylene glycol 7.000 (9) Dipotassium glycyrrhizinate 0.500 (10) Methyl paraoxybenzoate 0.100 (11) Plant extract mixture 2 0.050 (12) Hamamelis extract 0.020 (13) Parsley extract 0.005 (14) Fujudaijue extract (15) Birch extract 0.005 (16) Beech extract 0.005 (17) Purified water 52.210 (18) Kuddin extract 0.100 Production method: The oil phase components (1) to (7) were mixed and dissolved by heating.
° C. On the other hand, the aqueous phase components (8) to (17) are mixed and dissolved by heating to 70 ° C. This aqueous phase was added to the oil phase, emulsified with a homogenizer, and then cooled.
8) Add and mix. The jinjin extract (18) was obtained by drying and crushing 200 g of jinjin ( Sophorae Radix ), immersing it in 1 liter of a 50% by volume aqueous ethanol solution, allowing it to stand at 25 ° C. for 7 days, and filtering to collect the filtrate. I got it.

[Example 31] Oil-in-water cream (1) Beeswax 6.00 (wt%) (2) Cetanol 5.00 (3) Reduced lanolin 8.00 (4) Squalane 27.50 (5) Glyceryl Fatty acid ester 4.00 (6) Lipophilic glyceryl monostearate 2.00 (7) Polyoxyethylene (20E.O.) sorbitan 5.00 Monolaurate (8) Propylene glycol 5.00 (9) Paraoxy Methyl benzoate 0.10 (10) Purified water 37.08 (11) Plant extract mixture 4 0.10 (12) Chamomile extract 0.01 (13) Achillea millefolium extract 0.01 (14) Coltsfoot extract 0 .01 (15) Below mallow extract 0.01 (16) Hypericum extract 0.01 (17) Ginkgo extract 0.05 (18) Aloin .02 (19) moutan bark extract 0.05 (20) Ginseng extract 0.05 Preparation: (1) mixing the oil phase component to (7), dissolved by heating 75
° C. On the other hand, the aqueous phase components (8) to (10) are mixed and dissolved, and heated to 75 ° C. Next, the oil phase component is added to the aqueous phase component, preliminarily emulsified, and then uniformly emulsified by a homomixer. After cooling, (11) to (20) are preliminarily mixed, homogenized, and added and mixed at 40 ° C. I do. The extract of buttonpi (19) was prepared by drying and pulverizing 200 g of buttonpi ( Moutan Cortex ), immersing it in 1 liter of a 50% by volume aqueous ethanol solution, allowing it to stand at 25 ° C for 7 days, and filtering to collect the filtrate. The carrot extract of (20) was obtained from Ginseng Rade
ix ) 225 g of 225 g in 50 l of warm water
The mixture was extracted by stirring for an hour and filtered to collect the filtrate.

With respect to the examples of the present invention, use tests were conducted by female panelists who exhibited remarkable skin roughness symptoms.
The use test was conducted using a panel of 20 persons per group, and blinded to each group, each of Example 15, Example 17, Example 31, and Comparative Example 15, Comparative Example 17, and Comparative Example 31, which will be described later. Example 28 and Comparative Example 28 to be described later were used twice a day for one month at a frequency of three times a week for one month. Comparative Example 15, Comparative Example 17, Comparative Example 28 and Comparative Example 31 were prepared by blending a plant extract and an anti-inflammatory agent as shown in Table 11 in Example 15, Example 17, Example 28 and Example 31, The total amount was adjusted to 100% by weight with purified water. Further, among the skin external preparation groups of Example Group 1, Example Group 2, Comparative Example Group 1 and Comparative Example Group 2 of the present invention shown in Table 12, cleansing foam, lotion, milky lotion and cream were used in the morning, and at night. The skin was groomed for one month using cleansing cream, cleansing lotion, cleansing foam, lotion, milky lotion, and cream. further,
During the one-month use period, the pack was used twice a week. In Comparative Example Group 1 and Comparative Example Group 2, all the plant extracts contained in each of the skin external preparations constituting Example Group 1 and Example Group 2 are shown in Table 1.
2 was prepared in place of the plant extract shown in FIG.

[0088]

[Table 11]

[0089]

[Table 12]

For each group of panelists, the skin condition was observed and the water content of the stratum corneum was measured before and after the start of the use test, and the familiarity of the skin was evaluated for each sample.
In addition, during the use test period, interviews were conducted to determine whether there was any skin irritation or abnormalities such as erythema and rash when the sample was used. The skin condition was evaluated and scored according to the evaluation criteria shown in Table 13, and the average value of 20 persons was calculated and shown. The water content of the stratum corneum was indicated by a measured value (μ muo) of skin surface conductance. The ease of familiarity with the skin, the feeling of skin irritation, and the presence or absence of skin abnormalities were scored according to the evaluation criteria shown in Table 14, and the average value of 20 subjects was calculated. These results are summarized in Table 15.

[0091]

[Table 13]

[0092]

[Table 14]

[0093]

[Table 15]

[0094] In Table 15, the skin condition was improved to almost good condition and the water content of the stratum corneum was significantly increased in the groups using Example 15, Example 17, Example 28 and Example 31 of the present invention. Is admitted. Further, in the group using Example Group 1 and Example Group 2, further remarkable improvement in skin condition and increase in water content of the stratum corneum were observed. In contrast, Comparative Example 15, which contained only plant extract mixture 2,
Comparative Example 17 containing only plant extract mixture 1, Comparative Example 28 containing an extract such as monoammonium glycyrrhizinate and Fennel, but not containing plant extract mixture 3
In each of the use groups of Comparative Example 31 containing only an anti-inflammatory agent consisting of aloin, red bean extract and carrot extract, the skin condition was improved, but the degree was not sufficient, but the increase in the water content of the stratum corneum was observed. Were significantly smaller than the corresponding groups using the examples. Even in the group using Comparative Example Group 1 and Comparative Example Group 2 composed of only one kind of plant extract and a skin external preparation containing an anti-inflammatory agent, the improvement of the skin condition and the increase of the water content of the stratum corneum were performed. It was clearly smaller than the use groups of Example Group 1 and Example Group 2.

Further, in each of the examples of the present invention and the group of examples, it was evaluated that the adaptability to the skin was good, and as compared with the corresponding comparative example and comparative example group, respectively. Evaluation was also significantly higher. In addition, for each sample subjected to the use test this time, no problematic skin irritation or skin abnormality was observed as shown in Table 15, but in Examples and Examples of the present invention,
The tendency of skin irritation was reduced as compared with the corresponding comparative example and comparative example group, respectively.

Note that each embodiment of the present invention was performed at 25 ° C.
When stored for 6 months, no change in state such as coloring, smelling, agglomeration, precipitation or deposition of content components, or phase separation was observed at all.

[0097]

As described in detail above, the present invention has a high skin moisturizing effect, a beautiful skin effect, and a skin roughness improving effect,
In addition, it was possible to obtain a skin external preparation which had good compatibility with the skin, and was excellent in formulation stability and safety.

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] September 19, 2000 (2009.1.
9)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0045

[Correction method] Change

[Correction contents]

Further, the plant extract mixture (E) used in the external preparation for skin according to claim 3 is preferably a chamomile ( Matricar).
ia chamomilla L.), Achillea ( Achillea )
millefolium L.), a plant belonging to the genus Hypericum ( Hyp)
ericum spp.) or two or more kinds of coltsfoot ( Tus
silago farfara L.), Below Oy ( Althaea offic)
inalis L.), salvia ( Salvia officinalis L.) and / or its variant ( Salvia officinalis var. tenuior )
Obtained from each plant. These plants may be subjected to extraction at the same time. Alternatively, each of the obtained extracts may be mixed after being individually extracted. In addition, "mixed plant extract (1
2) "(manufactured by Maruzen Pharmaceutical Co., Ltd.) and the like.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 45/06 A61K 45/06 F-term (Reference) 4C083 AA082 AA111 AA112 AA122 AB032 AB052 AC012 AC022 AC032 AC072 AC102 AC122 AC182 AC242 AC342 AC352 AC392 AC402 AC432 AC482 AC642 AC682 AC792 AD042 AD052 AD092 AD112 AD152 AD272 AD662 BB60 CC02 CC04 CC05 CC07 CC24 DD08 DD23 DD27 DD31 DD32 DD33 EE01 EE10 EE12 4C084 AA24 MA02 MA63 NA14 ZA891 ZB112 ZB2AB AB4 AB8 AB AB38 AB40 AB57 AB59 AB85 AB86 AC01 BA11 CA04 CA05 MA08 MA63 NA14 ZA89 ZB21

Claims (5)

[Claims] 1. The following (A) and (B) and one of the anti-inflammatory agents
An external preparation for skin comprising at least one species. (A) Chamomile (Matricaria chamomilla L.) 、 Wiki
Leopard (Foeniculum vulgare Miller), Hop (Humulus
 lupulus L.), Achillea millefolium (Achillea mill
efolium L.), Melissa (Melissa officinalis L.)
Mistletoe (Viscum coloratum Nakai var.lutescens 
Miyabe et Kudo orViscum album L. var.lutescens Ma
kino) extraction mixture. (B) Horse chestnut (Aesculus turbinata Blume), Seyo
Uchinoki (Aesculus hippocastanum L.), carrot
(Daucus carota L.), Mannenrou (Rosmarinus off
icinalis L.), Tokinsenka (Calendula officinal
is L.), calendula (Calendula arvensis L.), yag
Rumagiku (Centaurea cyanus L.), horsetail (Equisetum
 arvense L.), a plant belonging to the genus Eucalyptus (Eucalyp
tus spp.), a plant belonging to the genus Aloe (Aloe spp.), Ma
Rumero (Cydonia oblonga Mill.), Cucumber (Cucumis
 sativus L.), coltsfoot (Tussilago farfara 
L.), Below Oy (Althaea officinalis L.), Oh
A plant belonging to the genus HypericumHypericum spp.), salvi
A (Salvia officinalis L.) and its variants (Salvia of
ficinalis var.tenuior), Hamamelis (Hamamelis vi
rginiana L.), Mansaku (Hamamelis japonica Sieb.
et Zucc.),Thymus vulgaris
L.), Tormentilla (Potentilla tormentilla), Mosquito
Elephant (Glycyrrhiza uralensis Fisher,Glycyrrhiza 
glabra L. and its variants,Glycyrrhiza echinataL.,Gly
cyrrhiza glandulifera Reg. Et Herd.), Belonging to the genus Lily
PlantsLilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. Ex A.W.Hill.) Belongs to the genus Linden
PlantsTilia spp.), a plant belonging to the genus Birch (Betu
la spp.), beech (Fagus crenata Blume), Inubuna
(Fagus japonica Maxim.), Ginkgo (Ginkgo biloba
 L.), Kizuta (Hedera tobleri Nakai)
Shreds (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis One or two selected from the plant group consisting of L.)
More than species extract. 2. The following (C) and (D) and one of the anti-inflammatory agents:
An external preparation for skin comprising at least one species. (C) fennel (Foeniculum vulgare Miller), horse chestnut (Aesculus turbinata Blume) and / or horse chestnut (Aesculus hippocastanum L.), extraction mixture of carrot (Daucus carota L.). (D) Chamomile ( Matricaria chamomilla L.), hop ( Humulus lupulus L.), Achillea millefolium ( Achi
llea millefolium L.), Melissa officinal
is L.), Mistletoe ( Viscum coloratum Nakai var. lut)
escens Miyabe etKudo or Viscum album L. var. lutes
cens Makino), Mannenrou ( Rosmarinus officinali )
s L.), Calendula officinalis
L.), calendula ( Calendula arvensis L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum a.
rvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptu)
s spp.), a plant belonging to the genus Aloe ( Aloe spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis s
ativus L.), coltsfoot ( Tussilago farfara )
L.), beetle mallow ( Althaea officinalis L.), a plant belonging to the genus Hypericum ( Hypericum spp.), Salvia ( Salvia officinalis L.) and its variants ( Salvia of Salvia officinalis L.)
ficinalis var. tenuior ), Hamamelis vi
rginiana L.) and witch hazel ( Hamamelis japonica Sieb.)
et Zucc.), Thymus vulgaris
L.), Torumentira (Potentilla tormentilla), licorice (Glycyrrhizauralensis Fisher, Glycyrrhiza g
labra L. and its variants, Glycyrrhiza echinata L., Gly
cyrrhiza glandulifera Reg. et Herd.) , a plant belonging to the lily genus (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), cattle beech ( Fagus japonica Maxim.), ginkgo ( Ginkgo biloba )
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemi
s nobilis L.) or one or two selected from a plant group consisting of
More than species extract. 3. The following (E) and (F) and one of the anti-inflammatory agents:
An external preparation for skin comprising at least one species. (E) One or two of a plant belonging to the genus Hypericum spp. ( Matricaria chamomilla L.), Achillea millefolium L., or Hypericum spp.
More than species, coltsfoot ( Tussilago farfara L.), below mallow ( Althaea officinalis L.), salvia ( Sa
lvia officinalis L.) and / or its variants ( Salvia of
ficinalis var. tenuior ). (F) Fennel ( Feniculum vulgare Miller), Hop ( Humulus lupulus L.), Melissa ( Melissa offi )
cinalis L.), mistletoe ( Viscum coloratum Nakai va)
r. lutescens Miyabe et Kudo or Viscum album L. va
r. lutescens Makino), horse chestnut ( Aesculus turbinat )
a Blume), Aesculus hippocastanu ( Aesculus hippocastanu)
m L.), carrot ( Daucus carota L.), mannenrow ( Rosmarinusofficinalis L.), calendula ( Cale
ndula officinalis L.), calendula ( Calendula arve )
nsis L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), a plant belonging to the genus Aloe ( A
loe spp.), Quince ( Cydonia oblonga Mill.), Cucumber ( Cucumis sativus L.), Hamameli
s virginiana L.) and witch hazel ( Hamamelis japonica Si)
eb. et Zucc.), Thymus vulgaris
L.), Potentilla tormentilla , Glycyrrhiza uralensis Fisher, Glycyrrhiza
glabra L. and its variants, Glycyrrhiza echinata L., Gl
ycyrrhiza glandulifera Reg. et Herd.) , a plant belonging to the lily genus (Lilium spp.), parsley (Petroselinum cris
pum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betu
la spp.), beech ( Fagus crenata Blume), and beech ( F
agus japonica Maxim.) Ginkgo ( Ginkgo biloba )
L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (Anthemis
nobilis L.), one or more extracts selected from the plant group consisting of: 4. The following (G) and (H) and one of the anti-inflammatory agents:
An external preparation for skin comprising at least one species. (G) Salvia (Salvia officinalis L.) and / or its variants (Salvia offici nalis var. Tenuior) , Hamamelis (Hamamelis virginiana L.), Thymus vulgaris (Thymus vulgaris L.), Torumentira (Potentil
la tormentilla ), Mannenrou ( Rosmarinus officin )
alis L.). (H) Chamomile ( Matricaria chamomilla L.), Fennel ( Feniculum vulgare Miller), Hop ( Humulus )
lupulus L.), Achillea mill ( Achillea mill)
efolium L.), melissa ( Melissa officinalis L.) and mistletoe ( Viscum coloratum Nakai var. lutescens)
Miyabe et Kudo or Viscum album L. var.lutescens Ma
kino), horse chestnut ( Aesculus turbinata Blume), horse chestnut ( Aesculus hippocastanum L.), carrot ( Daucus carota L.), calendula ( Calendula )
officinalis L.), calendula ( Calendula arvensis )
L.), cornflower ( Centaurea cyanus L.), horsetail ( Equisetum arvense L.), a plant belonging to the genus Eucalyptus ( Eucalyptus spp.), A plant belonging to the genus Aloe ( Aloe
spp.), quince ( Cydonia oblonga Mill.), cucumber ( Cucumis sativus L.), coltsfoot ( Tussilago f.
arfara L.), below mallow ( Althaea officinalis)
L.), a plant belonging to the genus Hypericum ( Hypericum sp.)
p.), witch hazel ( Hamamelis japonica Sieb. et Zuc
c.), licorice ( Glycyrrhiza uralensis Fisher, Glyc
yrrhiza glabra L. and its variants, Glycyrrhiza echinat
a L., Glycyrrhiza glandulifera Reg. et Herd.), a plant belonging to the genus Lily ( Lilium spp.), parsley ( Petroseli
num crispum (Mill.) Nym. ex AWHill.), a plant belonging to the genus Linden ( Tilia spp.), a plant belonging to the genus Birch ( Betula spp.), beech ( Faguscrenata Blume), Inubuna ( Fagus japonica Maxim.), ginkgo ( Ginkgo
biloba L.), ivy (Hedera tobleri Nakai), ivy (Hedera helix L.) and Roman chamomile (An
themis nobilis L.) or one or more extracts selected from the group of plants consisting of: 5. A method for caring for the skin, comprising using two or more kinds selected from the external preparation for skin according to claim 1 in combination.