JP2001520509A - 自己免疫細胞療法:細胞組成物、方法およびヒト疾患の治療への応用 - Google Patents
自己免疫細胞療法:細胞組成物、方法およびヒト疾患の治療への応用Info
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US50666895A | 1995-07-25 | 1995-07-25 | |
US506,668 | 1995-07-26 | ||
PCT/US1996/012170 WO1997005239A1 (fr) | 1995-07-25 | 1996-07-24 | Immunotherapie par cellules autologues: compositions cellulaires , methodes et application au traitement d'une maladie humaine |
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JP2001520509A true JP2001520509A (ja) | 2001-10-30 |
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JP50770697A Ceased JP2001520509A (ja) | 1995-07-25 | 1996-07-24 | 自己免疫細胞療法:細胞組成物、方法およびヒト疾患の治療への応用 |
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EP (1) | EP0852618A1 (fr) |
JP (1) | JP2001520509A (fr) |
AU (1) | AU6649996A (fr) |
CA (1) | CA2227327A1 (fr) |
WO (1) | WO1997005239A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005108554A1 (fr) * | 2004-05-11 | 2005-11-17 | Shukokai Incorporated | Immunocyte adoptif pour vaccin antitumoral et similaire |
JP2008120724A (ja) * | 2006-11-10 | 2008-05-29 | Japan Science & Technology Agency | Th2型アレルギー性疾患治療薬及び感染症治療薬 |
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---|---|---|---|---|
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Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340565C (fr) * | 1989-06-29 | 1999-05-25 | Thomas B. Okarma | Dispositif et methode pour capter et recuperer des cellules |
EP1553168A3 (fr) * | 1993-06-04 | 2011-04-06 | The United States of America as represented by The Secretary of The Navy | Procédé pour la stimulation sélective de la prolifération des cellules T |
-
1996
- 1996-07-24 JP JP50770697A patent/JP2001520509A/ja not_active Ceased
- 1996-07-24 WO PCT/US1996/012170 patent/WO1997005239A1/fr not_active Application Discontinuation
- 1996-07-24 EP EP96926117A patent/EP0852618A1/fr not_active Withdrawn
- 1996-07-24 CA CA002227327A patent/CA2227327A1/fr not_active Abandoned
- 1996-07-25 AU AU66499/96A patent/AU6649996A/en not_active Abandoned
Cited By (6)
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WO2005108554A1 (fr) * | 2004-05-11 | 2005-11-17 | Shukokai Incorporated | Immunocyte adoptif pour vaccin antitumoral et similaire |
US7655393B2 (en) | 2004-05-11 | 2010-02-02 | Shukokai Incorporated | Adoptive immune cells for tumor vaccines |
US8075882B2 (en) | 2004-05-11 | 2011-12-13 | Shukokai Incorporated | Adoptive immune cells for tumor vaccines |
JP2008120724A (ja) * | 2006-11-10 | 2008-05-29 | Japan Science & Technology Agency | Th2型アレルギー性疾患治療薬及び感染症治療薬 |
JP2021058200A (ja) * | 2015-05-13 | 2021-04-15 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
JP7101751B2 (ja) | 2015-05-13 | 2022-07-15 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
Also Published As
Publication number | Publication date |
---|---|
AU6649996A (en) | 1997-02-26 |
EP0852618A1 (fr) | 1998-07-15 |
CA2227327A1 (fr) | 1997-02-13 |
WO1997005239A1 (fr) | 1997-02-13 |
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