JP2001520189A5 - - Google Patents

Info

Publication number

JP2001520189A5

JP2001520189A5 JP2000516661A JP2000516661A JP2001520189A5 JP 2001520189 A5 JP2001520189 A5 JP 2001520189A5 JP 2000516661 A JP2000516661 A JP 2000516661A JP 2000516661 A JP2000516661 A JP 2000516661A JP 2001520189 A5 JP2001520189 A5 JP 2001520189A5

Authority

JP

Japan

Prior art keywords

hydrogen

independently

taxane

compound

taxanes

Prior art date

1998-10-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 229940123237 Taxane Drugs 0.000 description 17
• 229910052739 hydrogen Inorganic materials 0.000 description 16
• 239000001257 hydrogen Substances 0.000 description 16
• 125000004435 hydrogen atom Chemical class [H]* 0.000 description 16
• 150000001875 compounds Chemical class 0.000 description 9
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 9
• 239000003638 chemical reducing agent Substances 0.000 description 8
• 239000003223 protective agent Substances 0.000 description 8
• 150000003839 salts Chemical class 0.000 description 7
• 229930012538 Paclitaxel Natural products 0.000 description 6
• 229960001592 paclitaxel Drugs 0.000 description 6
• 239000008194 pharmaceutical composition Substances 0.000 description 6
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 6
• KQYGMURBTJPBPQ-UHFFFAOYSA-L disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)CCSSCCS([O-])(=O)=O KQYGMURBTJPBPQ-UHFFFAOYSA-L 0.000 description 5
• 201000004384 Alopecia Diseases 0.000 description 4
• 206010012735 Diarrhoea Diseases 0.000 description 4
• 206010028813 Nausea Diseases 0.000 description 4
• 206010047700 Vomiting Diseases 0.000 description 4
• 229910001413 alkali metal ion Chemical group 0.000 description 4
• 125000000217 alkyl group Chemical group 0.000 description 4
• 231100000360 alopecia Toxicity 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 4
• 239000003814 drug Substances 0.000 description 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
• 230000008693 nausea Effects 0.000 description 4
• 125000003396 thiol group Chemical group [H]S* 0.000 description 4
• 231100000419 toxicity Toxicity 0.000 description 4
• 230000001988 toxicity Effects 0.000 description 4
• 230000008673 vomiting Effects 0.000 description 4
• 206010028980 Neoplasm Diseases 0.000 description 3
• 201000011510 cancer Diseases 0.000 description 3
• 239000006186 oral dosage form Substances 0.000 description 3
• 239000006201 parenteral dosage form Substances 0.000 description 3
• 230000001681 protective effect Effects 0.000 description 3
• 206010065553 Bone marrow failure Diseases 0.000 description 2
• 206010020751 Hypersensitivity Diseases 0.000 description 2
• 206010029155 Nephropathy toxic Diseases 0.000 description 2
• 206010029350 Neurotoxicity Diseases 0.000 description 2
• 206010044221 Toxic encephalopathy Diseases 0.000 description 2
• 208000026935 allergic disease Diseases 0.000 description 2
• 238000006243 chemical reaction Methods 0.000 description 2
• 231100000226 haematotoxicity Toxicity 0.000 description 2
• 230000009610 hypersensitivity Effects 0.000 description 2
• 231100000417 nephrotoxicity Toxicity 0.000 description 2
• 230000007694 nephrotoxicity Effects 0.000 description 2
• 231100000228 neurotoxicity Toxicity 0.000 description 2
• 230000007135 neurotoxicity Effects 0.000 description 2
• 239000000725 suspension Substances 0.000 description 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
• 229960003668 docetaxel Drugs 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1