JP2001518803A5 - - Google Patents

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Publication number
JP2001518803A5
JP2001518803A5 JP1998545776A JP54577698A JP2001518803A5 JP 2001518803 A5 JP2001518803 A5 JP 2001518803A5 JP 1998545776 A JP1998545776 A JP 1998545776A JP 54577698 A JP54577698 A JP 54577698A JP 2001518803 A5 JP2001518803 A5 JP 2001518803A5
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JP
Japan
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JP1998545776A
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Japanese (ja)
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JP2001518803A (ja
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Priority claimed from US08/910,367 external-priority patent/US5948653A/en
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JP54577698A 1997-03-21 1998-03-16 相同的組換えを用いる配列の改変 Ceased JP2001518803A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4117397P 1997-03-21 1997-03-21
US60/041,173 1997-03-21
US08/910,367 US5948653A (en) 1997-03-21 1997-08-13 Sequence alterations using homologous recombination
US08/910,367 1997-08-13
PCT/US1998/005223 WO1998042727A1 (en) 1997-03-21 1998-03-16 Sequence alterations using homologous recombination

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JP2001518803A JP2001518803A (ja) 2001-10-16
JP2001518803A5 true JP2001518803A5 (enExample) 2005-11-10

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JP54577698A Ceased JP2001518803A (ja) 1997-03-21 1998-03-16 相同的組換えを用いる配列の改変

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US (3) US5948653A (enExample)
EP (1) EP0977771A4 (enExample)
JP (1) JP2001518803A (enExample)
AU (1) AU6562098A (enExample)
CA (1) CA2284280A1 (enExample)
WO (1) WO1998042727A1 (enExample)

Families Citing this family (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020108136A1 (en) * 1997-03-21 2002-08-08 Sri Transgenic animals produced by homologous sequence targeting
US20040019916A1 (en) * 1992-04-24 2004-01-29 Zarling David A. In vivo homologous sequence targeting in eukaryotic cells
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US20070009930A1 (en) * 1996-12-18 2007-01-11 Maxygen, Inc. Methods and compositions for polypeptide engineering
US7148054B2 (en) * 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
EP2261373A3 (en) 1997-01-17 2011-12-14 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
WO1999021977A1 (en) * 1997-10-24 1999-05-06 Life Technologies, Inc. Recombinational cloning using nucleic acids having recombination sites
WO1999029902A1 (en) 1997-12-08 1999-06-17 California Institute Of Technology Method for creating polynucleotide and polypeptide sequences
WO1999037755A2 (en) * 1997-12-11 1999-07-29 Pangene Corporation The use of consensus sequences for targeted homologous gene isolation and recombination in gene families
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
US6004804A (en) * 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
WO2000009755A2 (en) * 1998-08-12 2000-02-24 Pangene Corporation Domain specific gene evolution
WO2000042560A2 (en) 1999-01-19 2000-07-20 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides
IL144657A0 (en) 1999-02-11 2002-06-30 Maxygen Inc High throughput mass spectrometry
US20030124505A1 (en) * 1999-03-22 2003-07-03 Jain Sarita Kumari High-throughput gene cloning and phenotypic screening
US6703240B1 (en) 1999-04-13 2004-03-09 Maxygar, Inc. Modified starch metabolism enzymes and encoding genes for improvement and optimization of plant phenotypes
AU4657500A (en) * 1999-04-21 2000-11-02 Pangene Corporation Locked nucleic acid hybrids and methods of use
WO2001000819A1 (en) * 1999-06-25 2001-01-04 Chauhan, Sarita Targeted gene replacements in enteric bacteria using linear dna
US20020152494A1 (en) * 1999-09-14 2002-10-17 Sargent Roy Geoffrey Production of recombinant organisms
EP1230269A2 (en) 1999-11-03 2002-08-14 Maxygen, Inc. Antibody diversity generation
US7820878B2 (en) * 1999-11-19 2010-10-26 Kyowa Hakko Kirin Co., Ltd. Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
US6686180B2 (en) 2000-04-04 2004-02-03 Baxter International Inc. Method for the production of bacterial toxins
US7045314B2 (en) * 2000-04-04 2006-05-16 Baxter International Inc. Method for the production of bacterial toxins
US20020061530A1 (en) * 2000-07-31 2002-05-23 Belotserkovskii Boris P. Enhanced targeting of DNA sequences by recombinase protein and single-stranded homologous DNA probes using DNA analog activation
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
CN1462176A (zh) * 2000-08-28 2003-12-17 Bionox株式会社 通过扰乱Ran/Ran－粘合蛋白介导的细胞过程而产生高产量,超多产转基因植物的方法
AU2001296471A1 (en) * 2000-09-28 2002-04-08 Pangene Corporation High-throughput gene cloning and phenotypic screening
US20030096401A1 (en) * 2000-11-28 2003-05-22 Huse William D. Eukaryotic expression libraries and methods of use
JP4616988B2 (ja) * 2000-12-20 2011-01-19 株式会社アイシン・コスモス研究所 三本鎖ｄｎａ形成技術を応用したｄｎａ多型検出方法
AU2002238376B2 (en) * 2001-01-10 2007-05-10 Lonza Cologne Gmbh Modular transfection systems based on nucleoprotein filaments
US20020150566A1 (en) * 2001-03-23 2002-10-17 Kun-Liang Guan Method of inhibiting cancerous cell proliferation using Ras mutants of GDP-bound conformation
WO2002079495A2 (en) * 2001-03-27 2002-10-10 University Of Delaware Genomics applications for modified oligonucleotides
CA2444649C (en) 2001-04-20 2012-10-02 The Penn State Research Foundation Methods for nucleic acid manipulation
BR0209989A (pt) * 2001-05-30 2005-04-12 Chromos Molecular Systems Inc Plataformas baseadas em cromossomas
AU2002355155A1 (en) * 2001-07-24 2003-02-17 Affinium Pharmaceuticals Inc. Methods for gene disruption and uses thereof
DE60222914T2 (de) * 2001-07-27 2008-07-24 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden
WO2003022220A2 (en) * 2001-09-07 2003-03-20 The Regents Of The University Of California Method of generating a transgenic livestock animal
WO2003027264A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Coisogenic eukaryotic cell collections
US7468244B2 (en) * 2001-09-27 2008-12-23 University Of Delaware Polymorphism detection and separation
US20030082551A1 (en) * 2001-09-28 2003-05-01 Zarling David A. High-throughput gene cloning and phenotypic screening
CA2462113C (en) 2001-10-01 2013-01-29 Dyax Corp. Multi-chain eukaryotic display vectors and uses thereof
AU2003216507A1 (en) 2002-03-01 2003-09-16 Maxygen, Inc. Methods, systems, and software for identifying functional bio-molecules
AU2003213846A1 (en) 2002-03-09 2003-09-29 Maxygen, Inc. Optimization of crossover points for directed evolution
CA2482481A1 (en) * 2002-04-16 2003-10-30 Promega Corporation Method to enhance homologous recombination
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
EA010903B1 (ru) 2002-04-19 2008-12-30 Дайверса Корпорейшн Фосфолипазы, нуклеиновые кислоты, кодирующие их, и способы их получения и применения
AU2003253622A1 (en) * 2002-06-05 2003-12-22 The Regents Of The University Of California Methods for promoting homologous recombination
US20050233993A1 (en) * 2002-06-05 2005-10-20 Kadonaga James T Methods for promoting homologous recombination
CN101967490B (zh) 2002-06-14 2014-07-16 先正达公司 木聚糖酶、编码木聚糖酶的核酸以及制备和应用它们的方法
CA2489595C (en) * 2002-06-14 2013-05-28 Simon E. Hufton Recombination of nucleic acid library members
US9321832B2 (en) 2002-06-28 2016-04-26 Domantis Limited Ligand
MXPA05001287A (es) 2002-08-06 2005-08-03 Verdia Llc Variantes de amino oxidasa ap1.
AU2003290689A1 (en) * 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
WO2004069190A2 (en) * 2003-01-31 2004-08-19 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiency disorders
US7446098B2 (en) * 2003-02-18 2008-11-04 Mount Sinai School Of Medicine Of New York University Combination therapy for treating protein deficiencies
CA2920416A1 (en) 2003-03-06 2004-10-28 Basf Enzymes Llc Amylases, nucleic acids encoding them and methods for making and using them
MX295545B (es) 2003-03-07 2012-02-03 Diversa Corp Hidrolasas, acidos nucleicos que las codifican, y metodos para hacerlas y usarlas.
DK1613733T3 (en) 2003-04-04 2015-08-31 Basf Enzymes Llc PEKTATLYASER, nucleic acids encoding them, and methods for making and using the
JP2007500514A (ja) 2003-04-29 2007-01-18 パイオニア ハイ−ブレッド インターナショナル， インコーポレイテッド 新規なグリホセートｎ−アセチルトランスフェラーゼ（ｇａｔ）遺伝子
EP1484410B1 (en) * 2003-06-05 2011-11-02 Ajinomoto Co., Inc. Fermentation methods using modified bacteria with increased byproduct uptake.
BRPI0412279A (pt) 2003-07-02 2006-09-19 Diversa Corp glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos
EP2484687A3 (en) 2003-08-08 2012-11-14 Life Technologies Corporation Methods and compositions for seamless cloning of nucleic acid molecules
CA2535526C (en) 2003-08-11 2015-09-29 Diversa Corporation Laccases, nucleic acids encoding them and methods for making and using them
ATE469984T1 (de) 2003-12-01 2010-06-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
WO2005062812A2 (en) * 2003-12-22 2005-07-14 The Johns Hopkins University A rAAV-BASED SYSTEM FOR SOMATIC CELL GENE DISRUPTION
WO2005104835A2 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
CA2735315A1 (en) 2004-06-09 2005-12-29 Pioneer Hi-Bred International, Inc. Plastid transit peptides
EP2468853B1 (en) 2004-06-16 2015-04-01 DSM IP Assets B.V. Method for enzymatic decolorization of pheophytin
EP1614755A1 (en) * 2004-07-07 2006-01-11 ARTEMIS Pharmaceuticals GmbH Target transgenesis of short hairpin RNA expression cassette using recombinase mediated cassette exchange
CA2614769A1 (en) 2005-03-10 2006-09-21 Verenium Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
CN102943085A (zh) 2005-03-15 2013-02-27 维莱尼姆公司 纤维素酶、编码它们的核酸及其制备和应用的方法
US8715988B2 (en) 2005-03-28 2014-05-06 California Institute Of Technology Alkane oxidation by modified hydroxylases
EP3441090A1 (en) 2005-05-17 2019-02-13 Amicus Therapeutics, Inc. A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives
US20100119525A1 (en) * 2005-08-01 2010-05-13 Mount Sinai Schoool Of Medicine Of New York University Method for extending longevity using npc1l1 antagonists
EP2216403A3 (en) 2006-02-02 2010-11-24 Verenium Corporation Esterases and related nucleic acids and methods
NZ595497A (en) 2006-02-10 2013-09-27 Verenium Corp Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them
EP2548954A1 (en) 2006-02-14 2013-01-23 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
AU2007223913B2 (en) 2006-03-07 2013-06-13 Cargill, Incorporated Aldolases, nucleic acids encoding them and methods for making and using them
EP1999256B1 (en) 2006-03-07 2012-03-07 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them
MX369001B (es) 2006-08-04 2019-10-24 Basf Enzymes Llc Glucanasas, acidos nucleicos que las codifican, y metodos para hacerlas y usarlas.
ITMO20060269A1 (it) * 2006-09-06 2008-03-07 Sacmi Cooperativa Meccanici Imola Soc Coop Metodi di stampaggio a compressione
EP2617823B1 (en) 2006-09-21 2015-07-01 BASF Enzymes LLC Phytases, nucleic acids encoding them and methods for making and using them
PL2057274T3 (pl) 2006-09-21 2014-05-30 Dsm Ip Assets Bv Fosfolipazy, kodujące je kwasy nukleinowe i sposoby ich wytwarzania i stosowania
ES2575912T3 (es) 2006-12-21 2016-07-04 Basf Enzymes Llc Amilasas y glucoamilasas, ácidos nucleicos que las codifican y métodos para formarlas y utilizarlas
WO2008095033A2 (en) 2007-01-30 2008-08-07 Verenium Corporation Enzymes for the treatment of lignocellulosics, nucleic acids encoding them and methods for making and using them
NZ584967A (en) 2007-10-03 2012-08-31 Verenium Corp Xylanases, nucleic acids encoding them and methods for making and using them
WO2009052214A2 (en) 2007-10-15 2009-04-23 Complete Genomics, Inc. Sequence analysis using decorated nucleic acids
PL2238242T3 (pl) 2008-01-03 2015-06-30 Basf Enzymes Llc Transferazy i oksydoreduktazy, kwasy nukleinowe kodujące je oraz sposoby ich wytwarzania i zastosowania
US8541220B2 (en) 2008-01-03 2013-09-24 Verenium Corporation Isomerases, nucleic acids encoding them and methods for making and using them
SI2252313T1 (sl) 2008-02-12 2015-08-31 Amicus Therapeutics, Inc. Postopek napovedovanja odgovora na zdravljenje bolezni s farmakološkim spremljevalcem
WO2009143397A2 (en) 2008-05-23 2009-11-26 E. I. Du Pont De Nemours And Company Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
US8198062B2 (en) 2008-08-29 2012-06-12 Dsm Ip Assets B.V. Hydrolases, nucleic acids encoding them and methods for making and using them
CN105274125A (zh) 2008-09-26 2016-01-27 托卡根公司 基因治疗载体和胞嘧啶脱氨酶
WO2010056746A1 (en) * 2008-11-11 2010-05-20 Amicus Therapeutics, Inc. Therapy regimens, dosing regimens and stable medicaments for the treatment of pompe disease
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9309566B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Methods, compositions, systems, apparatuses and kits for nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
BRPI1011160A8 (pt) 2009-05-21 2018-01-02 Verenium Corp Fitases, preparação de proteína que as compreende, e seus usos
DK2462230T3 (en) * 2009-08-03 2015-10-19 Recombinetics Inc METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
CA2805937A1 (en) 2010-08-13 2012-02-16 Pioneer Hi-Bred International, Inc. Chimeric promoters and methods of use
CN103370425B (zh) 2010-12-17 2019-03-19 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
US9528124B2 (en) 2013-08-27 2016-12-27 Recombinetics, Inc. Efficient non-meiotic allele introgression
WO2012116274A2 (en) 2011-02-25 2012-08-30 Recombinetics, Inc. Genetically modified animals and methods for making the same
US10920242B2 (en) 2011-02-25 2021-02-16 Recombinetics, Inc. Non-meiotic allele introgression
CA2872096A1 (en) 2012-05-04 2013-11-07 E. I. Du Pont De Nemours And Company Compositions and methods comprising sequences having meganuclease activity
AR091482A1 (es) 2012-06-21 2015-02-04 Recombinetics Inc Celulas modificadas geneticamente y metodos par su obtencion
US10058078B2 (en) 2012-07-31 2018-08-28 Recombinetics, Inc. Production of FMDV-resistant livestock by allele substitution
WO2014070673A1 (en) 2012-10-29 2014-05-08 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
US20140287419A1 (en) 2013-03-14 2014-09-25 Arzeda Corp. Compositions Having Dicamba Decarboxylase Activity and Methods of Use
EP2970935A1 (en) 2013-03-14 2016-01-20 Pioneer Hi-Bred International, Inc. Compositions having dicamba decarboxylase activity and methods of use
WO2014150914A2 (en) 2013-03-15 2014-09-25 Pioneer Hi-Bred International, Inc. Phi-4 polypeptides and methods for their use
EP3032942B1 (en) 2013-08-16 2020-03-11 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CA2923726C (en) 2013-09-13 2024-01-30 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
EP3060682B1 (en) 2013-10-25 2023-08-30 Livestock Improvement Corporation Limited Genetic markers and uses therefor
EP3087088B1 (en) 2013-12-23 2022-05-25 University Of Rochester Methods and compositions for ribosomal synthesis of macrocyclic peptides
BR112016018103B1 (pt) 2014-02-07 2024-01-16 E.I. Du Pont De Nemours And Company Polipeptídeo e seu uso, polinucleotídeo, composição, proteína de fusão, método para controlar uma população, método para inibir o crescimento, método para controlar a infestação, método para obtenção de uma planta ou célula vegetal, construto
CN106536545A (zh) 2014-02-07 2017-03-22 先锋国际良种公司 杀昆虫蛋白及其使用方法
US10435706B2 (en) 2014-10-16 2019-10-08 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
US10231460B2 (en) 2015-01-15 2019-03-19 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
MX376048B (es) 2015-03-11 2025-03-07 Corteva Agriscience Llc Combinaciones insecticidas de pip-72 y métodos de uso.
WO2016176191A1 (en) * 2015-04-27 2016-11-03 The Trustees Of The University Of Pennsylvania Dual aav vector system for crispr/cas9 mediated correction of human disease
EP3892315A1 (en) 2015-05-18 2021-10-13 The Board of Trustees of the Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
WO2016186986A1 (en) 2015-05-19 2016-11-24 Pioneer Hi Bred International Inc Insecticidal proteins and methods for their use
US11198709B2 (en) 2015-08-06 2021-12-14 E. I. Du Pont De Nemours And Company Plant derived insecticidal proteins and methods for their use
US20180325119A1 (en) 2015-12-18 2018-11-15 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
US11008585B2 (en) 2016-05-04 2021-05-18 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
PH12018502706B1 (en) 2016-07-01 2024-05-24 Pioneer Hi Bred Int Insecticidal proteins from plants and methods for their use
CN109863167B (zh) 2016-11-01 2022-12-23 先锋国际良种公司 杀昆虫蛋白及其使用方法
US11174295B2 (en) 2016-12-14 2021-11-16 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
CA3046226A1 (en) 2016-12-22 2018-06-28 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
WO2018148001A1 (en) 2017-02-08 2018-08-16 Pioneer Hi-Bred International Inc Insecticidal combinations of plant derived insecticidal proteins and methods for their use
BR112019023628A2 (pt) 2017-05-11 2020-06-02 Pioneer Hi-Bred International, Inc. Polipeptídeo inseticida recombinante, proteína inseticida quimérica, proteína de fusão, composição agrícola, polinucleotídeo recombinante, construto de dna, planta transgênica, método para inibir o crescimento ou exterminar uma praga de inseto ou população de praga, método para controlar os danos por praga de inseto, método para controlar infestação de praga e método para melhorar o rendimento de uma cultura
WO2019040335A1 (en) 2017-08-19 2019-02-28 University Of Rochester MICHELOLID DERIVATIVES, PREPARATION METHODS AND THEIR USE AS ANTICANCER AND ANTI-INFLAMMATORY AGENTS
EP4659582A2 (en) 2018-03-14 2025-12-10 Pioneer Hi-Bred International, Inc. Insecticidal proteins from plants and methods for their use
MX2020009435A (es) 2018-03-14 2020-11-11 Pioneer Hi Bred Int Proteinas con actividad insecticida de plantas y metodos para sus usos.
CA3149955A1 (en) 2019-09-06 2021-03-11 Kumar DHANASEKHARAN Method for capturing and purification of biologics
CN115151643A (zh) 2020-01-10 2022-10-04 加利福尼亚大学董事会 用于产生橄榄醇酸和橄榄醇酸类似物的生物合成平台
WO2022015619A2 (en) 2020-07-14 2022-01-20 Pioneer Hi-Bred International, Inc. Insecticidal proteins and methods for their use
KR20230042754A (ko) 2020-08-07 2023-03-29 아미쿠스 세라퓨틱스, 인코포레이티드 소포 표적화 단백질 및 이의 용도
EP4363437A1 (en) 2021-07-01 2024-05-08 Amicus Therapeutics, Inc. Neurotensin variants and tagged proteins comprising neurotensin or sortilin propeptide
WO2023173084A1 (en) 2022-03-11 2023-09-14 University Of Rochester Cyclopeptibodies and uses thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873191A (en) * 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4888274A (en) * 1985-09-18 1989-12-19 Yale University RecA nucleoprotein filament and methods
US4950599A (en) * 1987-01-29 1990-08-21 Wolf Bertling Method for exchanging homologous DNA sequences in a cell using polyoma encapsulated DNA fragments
DE69034263D1 (de) * 1989-07-25 2009-04-02 Cell Genesys Inc Homologe Rekombination für universelle Donorzellen und chimerische Säugetierzellen
US5501967A (en) * 1989-07-26 1996-03-26 Mogen International, N.V./Rijksuniversiteit Te Leiden Process for the site-directed integration of DNA into the genome of plants
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
ES2127458T3 (es) * 1989-11-06 1999-04-16 Cell Genesys Inc Produccion de proteinas utilizando recombinacion homologa.
US5272071A (en) * 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5451513A (en) * 1990-05-01 1995-09-19 The State University of New Jersey Rutgers Method for stably transforming plastids of multicellular plants
FI941016L (fi) * 1990-05-07 1994-05-03 Daikin Indsutries Ltd Kaksois-D-silmukan muodostumisen diagnostiset sovellutukset
US5273881A (en) * 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
EP0535144A4 (en) * 1990-06-12 1993-08-11 Baylor College Of Medicine Method for homologous recombination in animal and plant cells
US5614396A (en) * 1990-06-14 1997-03-25 Baylor College Of Medicine Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
US5580734A (en) * 1990-07-13 1996-12-03 Transkaryotic Therapies, Inc. Method of producing a physical map contigous DNA sequences
AU664976B2 (en) * 1990-08-29 1995-12-14 Gene Pharming Europe Bv Homologous recombination in mammalian cells
JP2739378B2 (ja) * 1990-11-09 1998-04-15 アメリカ合衆国 Ｄｎａに標的を定める方法
US5510473A (en) * 1990-11-09 1996-04-23 The United States Of American As Represented By The Secretary Of Health And Human Services Cloning of the recA gene from thermus aquaticus YT-1
WO1992015694A1 (en) * 1991-03-08 1992-09-17 The Salk Institute For Biological Studies Flp-mediated gene modification in mammalian cells, and compositions and cells useful therefor
CA2092695A1 (en) 1991-05-15 1992-11-16 Oliver Smithies Genomic modifications with homologous dna targeting
EP0661979A4 (en) * 1991-08-21 1995-09-13 Microprobe Corp CROSSLINKED OLIGONUCLEOTIDES FOR ENZYMATIC MEDIATED TRIPLE STRAND FORMATION.
US5506098A (en) * 1991-09-04 1996-04-09 Daikin Industries, Ltd. In situ hybridization method
AU2778992A (en) * 1991-10-07 1993-05-03 Idaho Research Foundation Inc., The Genetic construct for selection of homologous recombinants on a single selective medium
JP3571337B2 (ja) * 1992-02-11 2004-09-29 セル ジェネシス，インコーポレーテッド 遺伝子標的現象による同型遺伝子接合
US5459072A (en) * 1992-02-25 1995-10-17 Regents Of The University Of Minnesota Food-grade integration vectors for industrial bacterial strains
DE69333955D1 (de) * 1992-04-24 2006-02-02 Stanford Res Inst Int Targeting homologer sequenzen in eukaryotenzellen
WO1994004032A1 (en) * 1992-08-21 1994-03-03 The Regents Of The University Of California Composition and method for altering dna sequences by homologous recombination
US5468629A (en) * 1993-04-13 1995-11-21 Calhoun; Cornelia Method of promoting in vitro homologous recombination transfection in mammalian cells using the RecA protein
US5571688A (en) * 1993-05-06 1996-11-05 Mekalanos; John J. Method of detecting gene expression
US5731411A (en) * 1993-07-12 1998-03-24 The United States Of America As Represented By The Department Of Health And Human Services Promotion of homologous DNA pairing by RecA-derived peptides
DK0733059T3 (da) * 1993-12-09 2000-10-16 Univ Jefferson Forbindelser og fremgangsmåder til site-rettede mutationer i eukaryote celler
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
JPH08140685A (ja) * 1994-11-22 1996-06-04 Takara Shuzo Co Ltd 部位特異的変異導入方法
KR19990035820A (ko) * 1995-07-21 1999-05-25 잭 스피겔 리콤비나아제 에이를 이용한 유전자 클로닝 방법
EP0842289B1 (en) * 1995-07-26 2004-10-20 Mixis France S.A. Homologous recombination in mismatch repair inactivated eukaryotic cells
US5948653A (en) * 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination

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