JP2001517423A5 - - Google Patents

Download PDF

Info

Publication number
JP2001517423A5
JP2001517423A5 JP2000512854A JP2000512854A JP2001517423A5 JP 2001517423 A5 JP2001517423 A5 JP 2001517423A5 JP 2000512854 A JP2000512854 A JP 2000512854A JP 2000512854 A JP2000512854 A JP 2000512854A JP 2001517423 A5 JP2001517423 A5 JP 2001517423A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000512854A
Other languages
English (en)
Japanese (ja)
Other versions
JP4257030B2 (ja
JP2001517423A (ja
Filing date
Publication date
Priority claimed from GBGB9720054.7A external-priority patent/GB9720054D0/en
Application filed filed Critical
Publication of JP2001517423A publication Critical patent/JP2001517423A/ja
Publication of JP2001517423A5 publication Critical patent/JP2001517423A5/ja
Application granted granted Critical
Publication of JP4257030B2 publication Critical patent/JP4257030B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

JP2000512854A 1997-09-19 1998-09-21 ペプチド Expired - Fee Related JP4257030B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9720054.7 1997-09-19
GBGB9720054.7A GB9720054D0 (en) 1997-09-19 1997-09-19 Biological products
PCT/GB1998/002851 WO1999015549A2 (en) 1997-09-19 1998-09-21 Peptide sequences as hinge regions in proteins like immunoglobulin fragments and their use in medicine

Publications (3)

Publication Number Publication Date
JP2001517423A JP2001517423A (ja) 2001-10-09
JP2001517423A5 true JP2001517423A5 (enExample) 2006-01-05
JP4257030B2 JP4257030B2 (ja) 2009-04-22

Family

ID=10819407

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000512854A Expired - Fee Related JP4257030B2 (ja) 1997-09-19 1998-09-21 ペプチド

Country Status (9)

Country Link
US (1) US6642356B1 (enExample)
EP (1) EP1015495B1 (enExample)
JP (1) JP4257030B2 (enExample)
AT (1) ATE257160T1 (enExample)
AU (1) AU9174398A (enExample)
DE (1) DE69820885T2 (enExample)
ES (1) ES2212340T3 (enExample)
GB (1) GB9720054D0 (enExample)
WO (1) WO1999015549A2 (enExample)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
US7122351B2 (en) * 2001-10-19 2006-10-17 Zymogenetics, Inc. Dimerized PDGF-D and materials and methods for producing it
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
AU2004252171B2 (en) * 2003-06-27 2011-04-21 Biogen Ma Inc. Modified binding molecules comprising connecting peptides
GB0315450D0 (en) 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
GB0315457D0 (en) * 2003-07-01 2003-08-06 Celltech R&D Ltd Biological products
JP4833850B2 (ja) 2003-11-21 2011-12-07 ユセベ ファルマ ソシエテ アノニム Il−17活性阻害による多発性硬化症を治療するための方法
WO2005087810A2 (en) * 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
AU2006203889A1 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. CRIPTO binding molecules
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
US8008443B2 (en) 2005-04-26 2011-08-30 Medimmune, Llc Modulation of antibody effector function by hinge domain engineering
US8129505B2 (en) 2005-09-14 2012-03-06 Ucb Pharma S.A. Comb polymers
GB0614780D0 (en) 2006-07-25 2006-09-06 Ucb Sa Biological products
MY166021A (en) 2007-03-22 2018-05-21 Biogen Ma Inc Binding proteins,including antibodies,antibody derivatives and antibody fragments,that specifically bind cd154 and uses thereof
GB0717337D0 (en) 2007-09-06 2007-10-17 Ucb Pharma Sa Method of treatment
CA2700714C (en) 2007-09-26 2018-09-11 Ucb Pharma S.A. Dual specificity antibody fusions
ES2667258T3 (es) 2009-09-10 2018-05-10 Ucb Biopharma Sprl Anticuerpos multivalentes
GB0916630D0 (en) 2009-09-22 2009-11-04 Secr Defence Antibody
GB201005063D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
GB0920324D0 (en) 2009-11-19 2010-01-06 Ucb Pharma Sa Antibodies
GB201000467D0 (en) 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
ES2717883T3 (es) 2010-03-25 2019-06-26 Ucb Biopharma Sprl Moléculas de DVD-LG estabilizadas con disulfuro
GB201005064D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
EP2565667A1 (en) 2011-08-31 2013-03-06 Friedrich-Alexander-Universität Erlangen-Nürnberg Direction of arrival estimation using watermarked audio signals and microphone arrays
EP2753697A1 (en) 2011-09-05 2014-07-16 ETH Zürich Biosynthetic gene cluster for the production of peptide/protein analogues
BR112014011304B1 (pt) 2011-11-11 2022-03-03 UCB Biopharma SRL Anticorpos de ligação com albumina e fragmentos de ligação dos mesmos, proteína de fusão de anticorpo bi-específico, polinucleotídeo, célula hospedeira, processo de produção de anticorpo ou fragamento do mesmo, formulação farmacêutica e uso
US9540442B2 (en) 2012-08-02 2017-01-10 Jn Biosciences Llc Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece
TW201619188A (zh) 2014-03-05 2016-06-01 優稀美生物醫藥公司 多聚體Fc蛋白質
MA47395A (fr) 2015-05-27 2019-12-11 Ucb Biopharma Sprl Méthode pour le traitement d'une maladie neurologique
CN108136012B (zh) 2015-08-07 2022-10-04 伊麦吉纳博公司 靶向分子的抗原结合构建体
WO2017096361A1 (en) 2015-12-04 2017-06-08 Merrimack Pharmaceuticals, Inc. Disulfide-stabilized fabs
US11266745B2 (en) 2017-02-08 2022-03-08 Imaginab, Inc. Extension sequences for diabodies
AU2018382586B2 (en) 2017-12-14 2025-01-16 CSL Behring Lengnau AG Recombinant IgG Fc multimers for the treatment of neuromyelitis optica
GB201804243D0 (en) * 2018-03-16 2018-05-02 Liverpool School Tropical Medicine Hinge sequences
CN118459594A (zh) 2018-06-01 2024-08-09 诺华股份有限公司 针对bcma的结合分子及其用途
JP7489407B2 (ja) 2019-05-21 2024-05-23 ノバルティス アーゲー Cd19結合分子及びその使用
EP3972993A1 (en) 2019-05-21 2022-03-30 Novartis AG Variant cd58 domains and uses thereof
US20220396631A1 (en) 2019-05-21 2022-12-15 Lu HUANG Trispecific binding molecules against bcma and uses thereof
US12215148B2 (en) 2019-08-08 2025-02-04 Regeneron Pharmaceuticals, Inc. Antigen binding molecule formats
WO2021048330A1 (en) 2019-09-13 2021-03-18 CSL Behring Lengnau AG Recombinant igg fc multimers for the treatment of immune complex-mediated kidney disorders
AU2020379735A1 (en) 2019-11-05 2022-05-26 Regeneron Pharmaceuticals, Inc. N-terminal SCFV multispecific binding molecules
WO2021127495A1 (en) 2019-12-20 2021-06-24 Regeneron Pharmaceuticals, Inc. Novel il2 agonists and methods of use thereof
WO2021195513A1 (en) 2020-03-27 2021-09-30 Novartis Ag Bispecific combination therapy for treating proliferative diseases and autoimmune disorders
WO2021231447A1 (en) 2020-05-12 2021-11-18 Regeneron Pharmaceuticals, Inc. Novel il10 agonists and methods of use thereof
KR20230086765A (ko) 2020-10-13 2023-06-15 얀센 바이오테크 인코포레이티드 분화 클러스터 iv 및/또는 viii을 조절하기 위한 바이오-조작된 t 세포 매개 면역, 물질 및 기타 방법
AU2021374083A1 (en) 2020-11-06 2023-06-01 Novartis Ag Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
US20240025993A1 (en) 2020-11-06 2024-01-25 Novartis Ag Cd19 binding molecules and uses thereof
MX2023012974A (es) 2021-05-04 2023-11-15 Regeneron Pharma Agonistas multiespecificos de receptores del fgf21 y sus usos.
EP4373851A2 (en) 2021-07-19 2024-05-29 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
JP2024534787A (ja) 2021-08-16 2024-09-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 新規なil27受容体アゴニスト及びその使用方法
JP2024544534A (ja) 2021-11-11 2024-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Cd20-pd1結合分子及びその使用方法
US20250340668A1 (en) 2022-05-11 2025-11-06 Regeneron Pharmaceuticals, Inc. Multispecific binding molecule proproteins and uses thereof
JP2025519158A (ja) 2022-05-27 2025-06-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッド インターロイキン-2プロタンパク質及びその使用
US20230391844A1 (en) 2022-06-04 2023-12-07 Regeneron Pharmaceuticals, Inc. Interleukin-2 proproteins and uses thereof
US20240067691A1 (en) 2022-08-18 2024-02-29 Regeneron Pharmaceuticals, Inc. Interferon receptor agonists and uses thereof
JP2025529805A (ja) 2022-08-18 2025-09-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド インターフェロンプロタンパク質及びその使用
EP4634220A2 (en) 2022-12-16 2025-10-22 Regeneron Pharmaceuticals, Inc. Antigen-binding molecules that bind to aav particles and uses
WO2024138191A1 (en) 2022-12-23 2024-06-27 Regeneron Pharmaceuticals, Inc. Ace2 fusion proteins and uses thereof
US20240247069A1 (en) 2023-01-13 2024-07-25 Regeneron Pharmaceuticals, Inc. Fgfr3 binding molecules and methods of use thereof
EP4649088A1 (en) 2023-01-13 2025-11-19 Regeneron Pharmaceuticals, Inc. Il12 receptor agonists and methods of use thereof
US20240287186A1 (en) 2023-02-28 2024-08-29 Regeneron Pharmaceuticals, Inc. T cell activators and methods of use thereof
KR20250156759A (ko) 2023-02-28 2025-11-03 리제너론 파아마슈티컬스, 인크. 다가 항스파이크 단백질 결합 분자 및 이의 용도
WO2024182451A2 (en) 2023-02-28 2024-09-06 Regeneron Pharmaceuticals, Inc. Multivalent anti-spike protein binding molecules and uses thereof
US20240400687A1 (en) 2023-05-10 2024-12-05 Regeneron Pharmaceuticals, Inc. Cd20-pd1 binding molecules and methods of use thereof
WO2024238415A1 (en) 2023-05-12 2024-11-21 Regeneron Pharmaceuticals, Inc. Interferon receptor antagonists and uses thereof
EP4630457A1 (en) 2023-08-18 2025-10-15 Regeneron Pharmaceuticals, Inc. Bispecific antigen-binding molecules and uses thereof
WO2025106469A1 (en) 2023-11-14 2025-05-22 Regeneron Pharmaceuticals, Inc. Engineered heavy chain variable domains and uses thereof
US20250179137A1 (en) 2023-12-05 2025-06-05 Regeneron Pharmaceuticals, Inc. Il18 receptor agonists and methods of use thereof
WO2025133290A1 (en) 2023-12-21 2025-06-26 Temper Bio Protein for immune regulation
WO2025199243A1 (en) 2024-03-20 2025-09-25 Regeneron Pharmaceuticals, Inc. Trivalent multispecific binding molecules and methods of use thereof
WO2025240335A1 (en) 2024-05-13 2025-11-20 Regeneron Pharmaceuticals, Inc. Fgfr3 binding molecules and methods of use thereof
US20250361309A1 (en) 2024-05-24 2025-11-27 Regeneron Pharmaceuticals, Inc. Tumor-targeted split il12 receptor agonists
WO2025255480A1 (en) 2024-06-07 2025-12-11 Regeneron Pharmaceuticals, Inc. Tetravalent multispecific binding molecules and methods of use thereof
WO2025255452A2 (en) 2024-06-07 2025-12-11 Regeneron Pharmaceuticals, Inc. Antigen-binding molecules that bind to aav particles and uses thereof
WO2025259718A2 (en) 2024-06-11 2025-12-18 Regeneron Pharmaceuticals, Inc. Vegf antagonists and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284898A3 (de) * 1987-04-02 1990-06-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hinge-Peptid, Verfahren zu seiner Herstellung und seine Verwendung zur Herstellung synthetischer Immunogene
NZ255041A (en) * 1992-07-13 1996-11-26 Bionebraska Inc Preparation of a recombinant single copy polypeptide or portion thereof modified with a terminal alpha amino carbon reactive group and reactive side chain groups involving biologically added protective groups

Similar Documents

Publication Publication Date Title
JP2001517423A5 (enExample)
JP2003520279A5 (enExample)
JP2000133215A5 (enExample)
JP2000052899A5 (enExample)
JP2002532892A5 (enExample)
JP2002501108A5 (enExample)
JP2002540767A5 (enExample)
JP2001015154A5 (enExample)
JPH11140398A5 (enExample)
JP2000343526A5 (enExample)
JP2002521318A5 (enExample)
JP2002536520A5 (enExample)
JP2000252171A5 (enExample)
JP2002029946A5 (enExample)
JPH11303709A5 (enExample)
JP2001131407A5 (enExample)
JP2000275740A5 (enExample)
JP2001100043A5 (enExample)
JP2001514219A5 (enExample)
JP2001000144A5 (enExample)
JP2000303131A5 (enExample)
JPH11260920A5 (enExample)
JPH11228602A5 (enExample)
JP2002097406A5 (enExample)
JP2002502840A5 (enExample)