JP2001516739A - ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用 - Google Patents

６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用

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Publication number
JP2001516739A
JP2001516739A JP2000511738A JP2000511738A JP2001516739A JP 2001516739 A JP2001516739 A JP 2001516739A JP 2000511738 A JP2000511738 A JP 2000511738A JP 2000511738 A JP2000511738 A JP 2000511738A JP 2001516739 A JP2001516739 A JP 2001516739A
Authority
JP
Japan
Prior art keywords
group
independently
carbon atoms
compound
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2000511738A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001516739A5 (enrdf_load_stackoverflow
Inventor
ノーバート ダブリュー． ビスチョフバーガー，
テレンス シー． ダール，
マイケル ジェイ． エム． ヒッチコック，
チョン ユー． キム，
ウィリアード レウ，
ホンタオ リウ，
ロジャー ジー． ミルズ，
マシュー エイ． ウイリアムズ，
Original Assignee
ギリアード サイエンシーズ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ギリアード サイエンシーズ， インコーポレイテッド filed Critical ギリアード サイエンシーズ， インコーポレイテッド
Publication of JP2001516739A publication Critical patent/JP2001516739A/ja
Publication of JP2001516739A5 publication Critical patent/JP2001516739A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
JP2000511738A 1997-09-17 1998-09-15 ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用 Withdrawn JP2001516739A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US93864497A 1997-09-26 1997-09-26
US6019597P 1997-09-26 1997-09-26
US60/059,308 1997-09-26
US60/060,195 1997-09-26
US08/938,644 1997-09-26
PCT/US1998/019355 WO1999014185A1 (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments

Publications (2)

Publication Number Publication Date
JP2001516739A true JP2001516739A (ja) 2001-10-02
JP2001516739A5 JP2001516739A5 (enrdf_load_stackoverflow) 2006-01-05

Family

ID=27369627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000511738A Withdrawn JP2001516739A (ja) 1997-09-17 1998-09-15 ６員環を含む化合物、それらの調製プロセス、および医薬としてのそれらの使用

Country Status (15)

Country Link
EP (1) EP1015417A1 (enrdf_load_stackoverflow)
JP (1) JP2001516739A (enrdf_load_stackoverflow)
KR (1) KR20010024123A (enrdf_load_stackoverflow)
CN (1) CN1272105A (enrdf_load_stackoverflow)
AR (1) AR013960A1 (enrdf_load_stackoverflow)
AU (1) AU747702B2 (enrdf_load_stackoverflow)
BR (1) BR9812649A (enrdf_load_stackoverflow)
CA (1) CA2303323A1 (enrdf_load_stackoverflow)
EA (1) EA003989B1 (enrdf_load_stackoverflow)
ID (1) ID25516A (enrdf_load_stackoverflow)
IL (1) IL134691A0 (enrdf_load_stackoverflow)
IN (1) IN190983B (enrdf_load_stackoverflow)
NZ (1) NZ502988A (enrdf_load_stackoverflow)
TR (1) TR200000723T2 (enrdf_load_stackoverflow)
WO (1) WO1999014185A1 (enrdf_load_stackoverflow)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008163035A (ja) * 1997-12-17 2008-07-17 Biocryst Pharmaceuticals Inc ノイラミニダーゼ阻害剤として有用な置換シクロペンタン及びシクロペンテン化合物
JP2009522227A (ja) * 2005-12-28 2009-06-11 エフ．ホフマン−ラ ロシュ アーゲー タミフルの合成におけるエポキシド中間体
JP2011510914A (ja) * 2008-01-04 2011-04-07 エフ．ホフマン−ラ ロシュ アーゲー リン酸オセルタミビルの多形相
JP2013510928A (ja) * 2009-11-11 2013-03-28 スリーエム イノベイティブ プロパティズ カンパニー ポリマー組成物並びにその製造方法及び物品

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
EP1059283B1 (en) * 1999-06-11 2003-05-28 F. Hoffmann-La Roche Ag Process for preparing neuraminidase inhibitor ro-64-0796
WO2001028981A1 (en) * 1999-10-19 2001-04-26 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
AU2001252578A1 (en) * 2000-04-25 2001-11-07 Sankyo Company Limited Preventives for influenza
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
CN102659615B (zh) * 2012-05-09 2014-05-07 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
RU2520836C1 (ru) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения
RU2633085C2 (ru) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Противовирусное лекарственное средство в виде капсул и способ его получения
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN108047076B (zh) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728B (zh) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
CN114057599A (zh) * 2020-07-29 2022-02-18 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN117105801A (zh) * 2023-07-24 2023-11-24 四川青木制药有限公司 一种奥司他韦及其磷酸盐的制备方法及其中间体
CN116666669B (zh) * 2023-07-25 2023-10-03 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
SI9620042A (sl) * 1995-02-27 1998-12-31 Gilead Sciences, Inc. Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
ATE215062T1 (de) * 1996-08-23 2002-04-15 Gilead Sciences Inc Verfahren zur herstellung von cyclohexen- carboxylatderivate

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008163035A (ja) * 1997-12-17 2008-07-17 Biocryst Pharmaceuticals Inc ノイラミニダーゼ阻害剤として有用な置換シクロペンタン及びシクロペンテン化合物
JP2009522227A (ja) * 2005-12-28 2009-06-11 エフ．ホフマン−ラ ロシュ アーゲー タミフルの合成におけるエポキシド中間体
JP2011510914A (ja) * 2008-01-04 2011-04-07 エフ．ホフマン−ラ ロシュ アーゲー リン酸オセルタミビルの多形相
JP2013510928A (ja) * 2009-11-11 2013-03-28 スリーエム イノベイティブ プロパティズ カンパニー ポリマー組成物並びにその製造方法及び物品

Also Published As

Publication number Publication date
EA200000332A1 (ru) 2000-10-30
ID25516A (id) 2000-10-05
AU9569498A (en) 1999-04-05
IN190983B (enrdf_load_stackoverflow) 2003-09-06
BR9812649A (pt) 2000-08-22
AR013960A1 (es) 2001-01-31
TR200000723T2 (tr) 2001-06-21
AU747702B2 (en) 2002-05-16
CA2303323A1 (en) 1999-03-25
IL134691A0 (en) 2001-04-30
WO1999014185A1 (en) 1999-03-25
NZ502988A (en) 2002-08-28
CN1272105A (zh) 2000-11-01
KR20010024123A (ko) 2001-03-26
EP1015417A1 (en) 2000-07-05
EA003989B1 (ru) 2003-12-25

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