KR20010024123A - 6-원 고리를 갖는 화합물, 그의 제조 방법 및의약물로서의 용도 - Google Patents

6-원 고리를 갖는 화합물, 그의 제조 방법 및의약물로서의 용도 Download PDF

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Publication number
KR20010024123A
KR20010024123A KR1020007002880A KR20007002880A KR20010024123A KR 20010024123 A KR20010024123 A KR 20010024123A KR 1020007002880 A KR1020007002880 A KR 1020007002880A KR 20007002880 A KR20007002880 A KR 20007002880A KR 20010024123 A KR20010024123 A KR 20010024123A
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KR
South Korea
Prior art keywords
compound
group
groups
carbon atoms
independently
Prior art date
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Ceased
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KR1020007002880A
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English (en)
Korean (ko)
Inventor
노르베르트 베. 비스코프베르거
테렌스 씨. 달
엠. 히치콕 마이클 제이.
초웅 유. 킴
윌라드 류
홍타오 리우
로저 지. 밀즈
매튜 에이. 윌리암즈
Original Assignee
헨슬레이 맥스 디.
길리애드 사이언시즈, 인코포레이티드
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Application filed by 헨슬레이 맥스 디., 길리애드 사이언시즈, 인코포레이티드 filed Critical 헨슬레이 맥스 디.
Publication of KR20010024123A publication Critical patent/KR20010024123A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/16—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
KR1020007002880A 1997-09-17 1998-09-15 6-원 고리를 갖는 화합물, 그의 제조 방법 및의약물로서의 용도 Ceased KR20010024123A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5930897P 1997-09-17 1997-09-17
US93864497A 1997-09-26 1997-09-26
US6019597P 1997-09-26 1997-09-26
US60/059,308 1997-09-26
US60/060,195 1997-09-26
US08/938,644 1997-09-26
PCT/US1998/019355 WO1999014185A1 (en) 1997-09-17 1998-09-15 Compounds containing six-membered rings, processes for their preparation, and their use as medicaments

Publications (1)

Publication Number Publication Date
KR20010024123A true KR20010024123A (ko) 2001-03-26

Family

ID=27369627

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007002880A Ceased KR20010024123A (ko) 1997-09-17 1998-09-15 6-원 고리를 갖는 화합물, 그의 제조 방법 및의약물로서의 용도

Country Status (15)

Country Link
EP (1) EP1015417A1 (enrdf_load_stackoverflow)
JP (1) JP2001516739A (enrdf_load_stackoverflow)
KR (1) KR20010024123A (enrdf_load_stackoverflow)
CN (1) CN1272105A (enrdf_load_stackoverflow)
AR (1) AR013960A1 (enrdf_load_stackoverflow)
AU (1) AU747702B2 (enrdf_load_stackoverflow)
BR (1) BR9812649A (enrdf_load_stackoverflow)
CA (1) CA2303323A1 (enrdf_load_stackoverflow)
EA (1) EA003989B1 (enrdf_load_stackoverflow)
ID (1) ID25516A (enrdf_load_stackoverflow)
IL (1) IL134691A0 (enrdf_load_stackoverflow)
IN (1) IN190983B (enrdf_load_stackoverflow)
NZ (1) NZ502988A (enrdf_load_stackoverflow)
TR (1) TR200000723T2 (enrdf_load_stackoverflow)
WO (1) WO1999014185A1 (enrdf_load_stackoverflow)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1040094T1 (sl) * 1997-12-17 2009-10-31 Biocryst Pharm Inc Substituirane ciklopentanske in ciklopentenske spojine, uporabne kot inhibitorji nevraminidaze
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
EP1059283B1 (en) * 1999-06-11 2003-05-28 F. Hoffmann-La Roche Ag Process for preparing neuraminidase inhibitor ro-64-0796
WO2001028981A1 (en) * 1999-10-19 2001-04-26 Abbott Laboratories 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
JP2001131144A (ja) * 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6403824B2 (en) * 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
AU2001252578A1 (en) * 2000-04-25 2001-11-07 Sankyo Company Limited Preventives for influenza
WO2002092555A1 (fr) * 2001-05-11 2002-11-21 Sankyo Company, Limited Derives d'acides sialiques
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
BRPI0620737A2 (pt) 2005-12-28 2011-11-22 Hoffmann La Roche intermediário de epóxido na sìntese do tamiflu
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
EP2499201B1 (en) * 2009-11-11 2017-05-10 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
DE102011117128A1 (de) 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza
RU2469020C1 (ru) * 2011-11-08 2012-12-10 Александр Васильевич Иващенко (3r,4r,5s)-5-амино-4-ациламино-3-(1-этил-пропокси)-циклогекс-1-ен-карбоновые кислоты, их эфиры и способ применения
CN102659615B (zh) * 2012-05-09 2014-05-07 中国药科大学 奥司他韦衍生物、其制备方法及其医药用途
RU2520836C1 (ru) * 2013-02-27 2014-06-27 Александр Васильевич Иващенко (3r,4r,5s)-4-амино-5-(2,2-дифторацетиламино)-3-(1-этилпропокси)-циклогекс-1-енкарбоновая кислота и ее эфиры, способ их получения и применения
RU2633085C2 (ru) * 2014-05-20 2017-10-11 Российская Федерация, от имени которой выступает Федеральное государственное казенное учреждение "Войсковая часть 68240" Противовирусное лекарственное средство в виде капсул и способ его получения
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN108047076B (zh) * 2017-12-26 2020-05-08 杭州新博思生物医药有限公司 一种奥司他韦对映异构体的制备方法
CN110194728B (zh) * 2019-06-19 2021-04-30 湖南华腾制药有限公司 磷酸奥司他韦中间体的连续化合成方法
CN114057599A (zh) * 2020-07-29 2022-02-18 广州市恒诺康医药科技有限公司 神经氨酸酶抑制剂类化合物、其药物组合物及其用途
CN116375595A (zh) * 2023-03-31 2023-07-04 重庆医药高等专科学校 一种磷酸奥司他韦的制备方法及精制方法
CN117105801A (zh) * 2023-07-24 2023-11-24 四川青木制药有限公司 一种奥司他韦及其磷酸盐的制备方法及其中间体
CN116666669B (zh) * 2023-07-25 2023-10-03 四川大学 VN负载的Ir团簇及其制备方法与其在催化剂中的用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP249A (en) * 1990-04-24 1993-03-17 Biota Scient Management Pty Ltd Anti-viral compounds.
WO1992006691A1 (en) * 1990-10-19 1992-04-30 Biota Scientific Management Pty. Ltd. Anti-viral compounds that bind the active site of influenza neuramidase and display in vivo activity against orthomyxovirus and paramyxovirus
SI9620042A (sl) * 1995-02-27 1998-12-31 Gilead Sciences, Inc. Novi selektivni inhibitorji virusnih ali bakterijskih neuraminidaz
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
ATE215062T1 (de) * 1996-08-23 2002-04-15 Gilead Sciences Inc Verfahren zur herstellung von cyclohexen- carboxylatderivate

Also Published As

Publication number Publication date
EA200000332A1 (ru) 2000-10-30
ID25516A (id) 2000-10-05
AU9569498A (en) 1999-04-05
IN190983B (enrdf_load_stackoverflow) 2003-09-06
BR9812649A (pt) 2000-08-22
AR013960A1 (es) 2001-01-31
TR200000723T2 (tr) 2001-06-21
AU747702B2 (en) 2002-05-16
CA2303323A1 (en) 1999-03-25
IL134691A0 (en) 2001-04-30
WO1999014185A1 (en) 1999-03-25
NZ502988A (en) 2002-08-28
CN1272105A (zh) 2000-11-01
EP1015417A1 (en) 2000-07-05
EA003989B1 (ru) 2003-12-25
JP2001516739A (ja) 2001-10-02

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