JP2001514762A5 - - Google Patents

Download PDF

Info

Publication number
JP2001514762A5
JP2001514762A5 JP1999503325A JP50332599A JP2001514762A5 JP 2001514762 A5 JP2001514762 A5 JP 2001514762A5 JP 1999503325 A JP1999503325 A JP 1999503325A JP 50332599 A JP50332599 A JP 50332599A JP 2001514762 A5 JP2001514762 A5 JP 2001514762A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1999503325A
Other languages
English (en)
Japanese (ja)
Other versions
JP4124830B2 (ja
JP2001514762A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/012430 external-priority patent/WO1998057159A1/en
Publication of JP2001514762A publication Critical patent/JP2001514762A/ja
Publication of JP2001514762A5 publication Critical patent/JP2001514762A5/ja
Application granted granted Critical
Publication of JP4124830B2 publication Critical patent/JP4124830B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP50332599A 1997-06-12 1998-06-12 分析物の検出のための電気的方法 Expired - Lifetime JP4124830B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4948997P 1997-06-12 1997-06-12
US60/049,489 1997-06-12
PCT/US1998/012430 WO1998057159A1 (en) 1997-06-12 1998-06-12 Electronic methods for the detection of analytes

Publications (3)

Publication Number Publication Date
JP2001514762A JP2001514762A (ja) 2001-09-11
JP2001514762A5 true JP2001514762A5 (enExample) 2005-12-22
JP4124830B2 JP4124830B2 (ja) 2008-07-23

Family

ID=21960096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50332599A Expired - Lifetime JP4124830B2 (ja) 1997-06-12 1998-06-12 分析物の検出のための電気的方法

Country Status (9)

Country Link
US (7) US7560237B2 (enExample)
EP (1) EP0988534B1 (enExample)
JP (1) JP4124830B2 (enExample)
AT (1) ATE498838T1 (enExample)
AU (1) AU744503B2 (enExample)
CA (1) CA2293744A1 (enExample)
DE (1) DE69842134D1 (enExample)
DK (1) DK0988534T3 (enExample)
WO (1) WO1998057159A1 (enExample)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
US9155496B2 (en) 1997-03-04 2015-10-13 Dexcom, Inc. Low oxygen in vivo analyte sensor
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
CA2293744A1 (en) 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes
US7390667B2 (en) 1997-12-22 2008-06-24 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC phase angle measurements
US7407811B2 (en) 1997-12-22 2008-08-05 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC excitation
US7494816B2 (en) 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
AU764926B2 (en) * 1998-01-27 2003-09-04 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8346337B2 (en) 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) * 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
DE69939464D1 (de) * 1998-05-06 2008-10-16 Clinical Micro Sensors Inc Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US20050244954A1 (en) * 1998-06-23 2005-11-03 Blackburn Gary F Binding acceleration techniques for the detection of analytes
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) * 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
EP1140360A1 (en) * 1998-12-30 2001-10-10 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
WO2002043864A2 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
WO2001054813A2 (en) * 2000-01-11 2001-08-02 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6326486B1 (en) 1999-05-03 2001-12-04 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae
EP1177317B1 (en) 1999-05-03 2006-08-09 Gen-Probe Incorporated POLYNUCLEOTIDE PROBES FOR exclusive DETECTION AND QUANTITATION OF STAPHYLOCOCCUS
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
CA2370123C (en) 1999-05-03 2010-09-14 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of actinomycetes
JP2003530822A (ja) * 1999-07-20 2003-10-21 クリニカル・マイクロ・センサーズ・インコーポレイテッド 電子的核酸検出の増幅
ES2319380T3 (es) * 1999-07-26 2009-05-07 Clinical Micro Sensors, Inc. Determinacion de secuencias de acido nucleico usando la deteccion electronica.
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US20020034744A1 (en) * 2000-03-27 2002-03-21 Creager Stephen E. Compositions and methods for detecting redox-active molecules in solution
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
JP4382265B2 (ja) * 2000-07-12 2009-12-09 日本電気株式会社 酸化シリコン膜の形成方法及びその形成装置
US6560471B1 (en) 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
EP1397068A2 (en) * 2001-04-02 2004-03-17 Therasense, Inc. Blood glucose tracking apparatus and methods
US6861224B2 (en) * 2001-11-02 2005-03-01 Fujitsu Limited Protein detecting device
US8364229B2 (en) * 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US7138121B2 (en) * 2003-01-23 2006-11-21 Spangler Brenda D Biosensors utilizing dendrimer-immobilized ligands and there use thereof
US7597793B2 (en) 2003-06-20 2009-10-06 Roche Operations Ltd. System and method for analyte measurement employing maximum dosing time delay
US7604721B2 (en) 2003-06-20 2009-10-20 Roche Diagnostics Operations, Inc. System and method for coding information on a biosensor test strip
US7488601B2 (en) 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
US7452457B2 (en) 2003-06-20 2008-11-18 Roche Diagnostics Operations, Inc. System and method for analyte measurement using dose sufficiency electrodes
GB0316075D0 (en) * 2003-07-09 2003-08-13 Molecular Sensing Plc Protease detection assay
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US9135402B2 (en) 2007-12-17 2015-09-15 Dexcom, Inc. Systems and methods for processing sensor data
US7591801B2 (en) 2004-02-26 2009-09-22 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US7774145B2 (en) * 2003-08-01 2010-08-10 Dexcom, Inc. Transcutaneous analyte sensor
US8160669B2 (en) 2003-08-01 2012-04-17 Dexcom, Inc. Transcutaneous analyte sensor
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20060003382A1 (en) * 2004-05-10 2006-01-05 Amanda Eckermann Compositions and methods for analyte detection
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip
US7556723B2 (en) 2004-06-18 2009-07-07 Roche Diagnostics Operations, Inc. Electrode design for biosensor
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
US8133178B2 (en) 2006-02-22 2012-03-13 Dexcom, Inc. Analyte sensor
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US7935309B2 (en) * 2005-04-15 2011-05-03 Worcester Polytechnic Institute Multi-transduction mechanism based microfluidic analyte sensors
EP1913374B1 (en) 2005-07-20 2019-01-09 Ascensia Diabetes Care Holdings AG Method for signalling the user to add additional sample to a test strip, method for measuring the temperature of a sample and methods for determining the concentration of an analyte based on gated amperometry
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP4086090B2 (ja) * 2005-09-29 2008-05-14 Toto株式会社 光電流を用いた被検物質の特異的検出方法、それに用いられる電極、測定用セルおよび測定装置
US9757061B2 (en) 2006-01-17 2017-09-12 Dexcom, Inc. Low oxygen in vivo analyte sensor
US20080071158A1 (en) * 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
JP4321599B2 (ja) * 2007-02-06 2009-08-26 セイコーエプソン株式会社 検出素子
JP4301316B2 (ja) * 2007-03-30 2009-07-22 ダイキン工業株式会社 スクロール部材及びその製造方法、並びに圧縮機構及びスクロール圧縮機
US20200037874A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8197650B2 (en) * 2007-06-07 2012-06-12 Sensor Innovations, Inc. Silicon electrochemical sensors
US8562558B2 (en) 2007-06-08 2013-10-22 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
EP4159114B1 (en) 2007-10-09 2024-04-10 DexCom, Inc. Integrated insulin delivery system with continuous glucose sensor
US8951400B2 (en) 2007-10-17 2015-02-10 Ohmx Corporation Chemistry used in biosensors
CA2702969A1 (en) 2007-10-17 2009-04-23 Ohmx Corporation Electrochemical assay for the detection of enzymes
US8417312B2 (en) 2007-10-25 2013-04-09 Dexcom, Inc. Systems and methods for processing sensor data
US7820391B2 (en) 2007-11-06 2010-10-26 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof
US9839395B2 (en) 2007-12-17 2017-12-12 Dexcom, Inc. Systems and methods for processing sensor data
US9143569B2 (en) * 2008-02-21 2015-09-22 Dexcom, Inc. Systems and methods for processing, transmitting and displaying sensor data
US8682408B2 (en) * 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
WO2011034668A1 (en) 2009-08-07 2011-03-24 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
JP2011232328A (ja) * 2010-04-09 2011-11-17 Hitachi Ltd 生体物質検出アレイ、計測装置および計測方法
JP2013528379A (ja) 2010-05-21 2013-07-11 オームクス コーポレーション Psa酵素活性アッセイによる癌の検出
EP2580581A4 (en) * 2010-06-11 2014-08-06 Labmaster Oy COST-EFFECTIVE ELECTRODECHIP VARIANTS AND METHOD FOR ANALYZING AND REFERENCING MULTIPLE ANALYSTS BASED ON A CATHODE ELECTROLUMINESCENCE
WO2012083258A2 (en) 2010-12-16 2012-06-21 Sensor Innovations, Inc. Electrochemical sensors
WO2013059293A1 (en) 2011-10-17 2013-04-25 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
US9340567B2 (en) 2011-11-04 2016-05-17 Ohmx Corporation Chemistry used in biosensors
CA2860739A1 (en) 2012-01-09 2013-07-18 Ohmx Corporation Enzyme cascade methods for e-trace assay signal amplification
US9048431B2 (en) 2012-05-07 2015-06-02 California Instistute Of Technology Electronic devices employing aligned organic polymers
EP2877592B1 (en) 2012-07-27 2016-09-21 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
WO2014018899A1 (en) 2012-07-27 2014-01-30 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
EP3919174A3 (en) 2012-10-24 2022-03-09 Genmark Diagnostics Inc. Integrated multiplex target analysis
JP6351702B2 (ja) 2013-03-15 2018-07-04 ジェンマーク ダイアグノスティクス, インコーポレイテッド 変形可能流体容器を操作するためのシステム、方法、および装置
GB201314402D0 (en) 2013-08-12 2013-09-25 Isis Innovation Capacitance Spectroscopic Method and Electrode
WO2015042493A2 (en) 2013-09-20 2015-03-26 Ohmx Corporation Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9470634B1 (en) * 2013-12-10 2016-10-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Electride mediated surface enhanced Raman scattering (SERS)
US9880121B2 (en) 2014-04-29 2018-01-30 Ohmx Corporation Bioelectronic binding assay using peak profiling
US20160041118A1 (en) 2014-08-11 2016-02-11 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) assay with multiplexing capabilities
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
WO2016077364A2 (en) 2014-11-11 2016-05-19 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US10883000B1 (en) * 2016-03-09 2021-01-05 The Regents Of The University Of California Chemically modified surfaces with self-assembled aromatic functionalities
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
WO2019040769A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS
CN212438615U (zh) 2017-10-24 2021-02-02 德克斯康公司 可穿戴设备
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
AU2021349959A1 (en) * 2020-09-24 2023-05-04 University Of Cincinnati Small volume aptamer sensing without solution impedance or analyte depletion
US20230358737A1 (en) * 2020-09-24 2023-11-09 University Of Cincinnati Continuously chemically enhanced aptamer sensors
AU2023207104A1 (en) 2022-01-13 2024-08-29 Canary Medical Switzerland Ag Analyte and environment sensors

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5078830A (enExample) * 1973-11-16 1975-06-26
SE407115B (sv) * 1975-10-06 1979-03-12 Kabi Ab Forfarande och metelektroder for studium av enzymatiska och andra biokemiska reaktioner
US4819658A (en) * 1982-02-11 1989-04-11 American Telephone And Telegraph Company, At&T Bell Laboratories Method and apparatus for measuring the temperature profile of a surface
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US4735907A (en) * 1985-03-18 1988-04-05 Eastman Kodak Company Stabilized fluorescent rare earth labels and labeled physiologically reactive species
EP0213825A3 (en) * 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
GB2217447A (en) 1988-04-21 1989-10-25 Atomic Energy Authority Uk Bonding to metal surfaces
US4920047A (en) * 1988-05-20 1990-04-24 General Electric Company Electrical detection of the immune reaction
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5874316A (en) * 1989-01-27 1999-02-23 Australian Membrane Biotechnology Research Institute Receptor membranes and ionophore gating
US5089112A (en) * 1989-03-20 1992-02-18 Associated Universities, Inc. Electrochemical biosensor based on immobilized enzymes and redox polymers
US4964972A (en) * 1989-03-30 1990-10-23 Yeda Research And Development Company Limited Ionic recognition and selective response in self assembling monolayer membranes on electrodes
US5491097A (en) * 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5320725A (en) * 1989-08-02 1994-06-14 E. Heller & Company Electrode and method for the detection of hydrogen peroxide
US5262035A (en) * 1989-08-02 1993-11-16 E. Heller And Company Enzyme electrodes
US5324457A (en) * 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
EP0440118A3 (en) * 1990-01-31 1992-02-26 Fujikura Ltd. Electric insulated wire and cable using the same
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
US5108573A (en) 1990-06-05 1992-04-28 The United States Of America As Represented By The United States Department Of Energy Morphology in electrochemically grown conducting polymer films
US5763191A (en) * 1990-12-12 1998-06-09 Boehringer Mannheim Gmbh Universal binding film
US5180968A (en) * 1991-03-01 1993-01-19 Research Foundation Of State University Of New York Method and apparatus for compensation of double layer charging current in electrochemical cells
CA2050057A1 (en) * 1991-03-04 1992-09-05 Adam Heller Interferant eliminating biosensors
US5171853A (en) 1991-08-05 1992-12-15 North Carolina State University Process of cleaving nucleic acids with oxoruthenium(IV) complexes
US5187096A (en) * 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5391272A (en) * 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
IL102930A (en) * 1992-08-25 1997-03-18 Yissum Res Dev Co Electrobiochemical analytical method and electrodes
WO1994020841A1 (en) * 1993-03-05 1994-09-15 University Of Wollongong Pulsed electrochemical detection using polymer electroactive electrodes
US5952172A (en) * 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) * 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
IL108726A (en) * 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor
US5780324A (en) 1994-03-30 1998-07-14 Denso Corporation Method of manufacturing a vertical semiconductor device
US5824483A (en) 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US5506420A (en) * 1994-09-14 1996-04-09 The Regents Of The University Of California Semiconductor bio-electronic devices incorporating biochemical stabilization layers
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
DE4442253A1 (de) * 1994-11-28 1996-05-30 Bayer Corp N D Ges D Staates I Elektrochemischer Enzymbiosensor
JPH11502617A (ja) * 1995-03-10 1999-03-02 メソ スケール テクノロジーズ,エルエルシー 多重アレイの多重特異的な電気化学発光試験
US5534132A (en) * 1995-05-04 1996-07-09 Vreeke; Mark Electrode and method for the detection of an affinity reaction
US5972199A (en) * 1995-10-11 1999-10-26 E. Heller & Company Electrochemical analyte sensors using thermostable peroxidase
JP2000513811A (ja) 1996-05-22 2000-10-17 オーストラリアン メンブレイン アンド バイオテクノロジィ リサーチ インスティチュート 核酸センサー
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6096273A (en) * 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US6060327A (en) * 1997-05-14 2000-05-09 Keensense, Inc. Molecular wire injection sensors
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
CA2293744A1 (en) 1997-06-12 1998-12-17 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes
US5922183A (en) * 1997-06-23 1999-07-13 Eic Laboratories, Inc. Metal oxide matrix biosensors
US6686150B1 (en) * 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6063573A (en) * 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
AU764926B2 (en) * 1998-01-27 2003-09-04 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
DE69939464D1 (de) * 1998-05-06 2008-10-16 Clinical Micro Sensors Inc Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten
US20030087228A1 (en) 1998-05-06 2003-05-08 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
US6269150B1 (en) * 1998-06-11 2001-07-31 Lucent Technologies, Inc. Reliable, unattended, automated testing system and method for complex telecommunication systems
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6761816B1 (en) * 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) * 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) * 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US6753143B2 (en) * 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
AU2002367849A1 (en) * 2001-04-03 2003-10-20 Clinical Micro Sensors, Inc. Nucleic acid reactions using labels with different redox potentials
US7658700B2 (en) * 2004-08-09 2010-02-09 Tate Maloy Training device for exercising muscle groups of the entire body

Similar Documents

Publication Publication Date Title
JP2000510751A5 (enExample)
JP2000509635A5 (enExample)
JP2000509637A5 (enExample)
JP2000509912A5 (enExample)
JP2002511741A5 (enExample)
JP2000509942A5 (enExample)
JP2001514762A5 (enExample)
JP2002514962A5 (enExample)
JP2002516613A5 (enExample)
JP2000509587A5 (enExample)
JP2000507433A5 (enExample)
JP2000508866A5 (enExample)
JP2000510793A5 (enExample)
JP2000508022A5 (enExample)
JP2000508841A5 (enExample)
JP2000508680A5 (enExample)
JP2000509804A5 (enExample)
JP2000509853A5 (enExample)
JP2000509755A5 (enExample)
JP2000510247A5 (enExample)
JP2000510969A5 (enExample)
JP2000508102A5 (enExample)
JP2000508836A5 (enExample)
JP2000509818A5 (enExample)
JP2000509520A5 (enExample)