JP2001514189A5 - - Google Patents
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- Publication number
- JP2001514189A5 JP2001514189A5 JP2000507706A JP2000507706A JP2001514189A5 JP 2001514189 A5 JP2001514189 A5 JP 2001514189A5 JP 2000507706 A JP2000507706 A JP 2000507706A JP 2000507706 A JP2000507706 A JP 2000507706A JP 2001514189 A5 JP2001514189 A5 JP 2001514189A5
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- xaa
- amino acid
- flp
- acid residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000008186 Collagen Human genes 0.000 description 12
- 108010035532 Collagen Proteins 0.000 description 12
- 229920001436 collagen Polymers 0.000 description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 125000000539 amino acid group Chemical group 0.000 description 4
- KZMRGTASBWZPFC-SCSAIBSYSA-N (2r)-1-fluoropyrrolidine-2-carboxylic acid Chemical compound OC(=O)[C@H]1CCCN1F KZMRGTASBWZPFC-SCSAIBSYSA-N 0.000 description 3
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical class O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000012359 Methanesulfonyl chloride Substances 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- VPAYJEUHKVESSD-UHFFFAOYSA-N trifluoroiodomethane Chemical compound FC(F)(F)I VPAYJEUHKVESSD-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/918,223 | 1997-08-25 | ||
| US08/918,223 US5973112A (en) | 1997-08-25 | 1997-08-25 | Collagen mimics |
| PCT/US1998/014284 WO1999010381A1 (en) | 1997-08-25 | 1998-07-09 | Collagen mimics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001514189A JP2001514189A (ja) | 2001-09-11 |
| JP2001514189A5 true JP2001514189A5 (https=) | 2009-08-27 |
| JP4514328B2 JP4514328B2 (ja) | 2010-07-28 |
Family
ID=25440014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000507706A Expired - Lifetime JP4514328B2 (ja) | 1997-08-25 | 1998-07-09 | コラーゲン擬似物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5973112A (https=) |
| EP (1) | EP1007568B1 (https=) |
| JP (1) | JP4514328B2 (https=) |
| AT (1) | ATE371672T1 (https=) |
| AU (1) | AU8480698A (https=) |
| CA (1) | CA2301175C (https=) |
| DE (1) | DE69838331T2 (https=) |
| WO (1) | WO1999010381A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2452593C (en) * | 2001-07-12 | 2015-02-03 | Arexis Ab | Triple polypeptide complexes |
| JP5070442B2 (ja) * | 2002-02-28 | 2012-11-14 | 株式会社Ｐｈｇ | 新規なポリペプチドおよびその製造方法 |
| WO2005000872A2 (en) * | 2003-06-23 | 2005-01-06 | Wisconsin Alumni Research Foundation | Collagen mimics |
| WO2005078085A1 (ja) * | 2004-02-16 | 2005-08-25 | Techno Network Shikoku Co., Ltd. | コラーゲン様構造を有するポリペプチド |
| JP5601437B2 (ja) * | 2004-02-16 | 2014-10-08 | 株式会社テクノネットワーク四国 | コラーゲン様構造を有するポリペプチド |
| US9758569B2 (en) * | 2006-05-26 | 2017-09-12 | Wisconsin Alumni Research Foundation | Collagen mimics |
| CN101072380B (zh) * | 2007-06-08 | 2010-12-08 | 华为技术有限公司 | 内容下发方法及系统、网络设备、移动数据业务管理平台 |
| US20090299034A1 (en) * | 2007-08-01 | 2009-12-03 | Mabel Alamino Cejas | Collagen-related peptides |
| CA2695288A1 (en) | 2007-08-01 | 2009-02-05 | Ethicon, Inc. | Collagen-related peptides and uses thereof |
| US7858741B2 (en) * | 2008-02-06 | 2010-12-28 | Wisconsin Alumni Research Foundation | Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues |
| US20100021527A1 (en) * | 2008-07-25 | 2010-01-28 | Chunlin Yang | Collagen-related peptides and uses thereof and hemostatic foam substrates |
| BR112019021056B1 (pt) | 2017-04-06 | 2022-11-22 | Sustain Holdings, Llc | Usos de uma composição que compreende um peptídeo mimético de colágeno para o tratamento ou a prevenção de uma doença, distúrbio ou ferida ocular |
| EP3958889B1 (en) | 2019-04-22 | 2025-01-08 | Sustain Holdings, LLC | Collagen mimetic peptide compositions for treating a posterior segment ocular disease or disorder involving the retina, retinal blood vessels, retinal nerves or optic nerve |
| CN117903293B (zh) * | 2024-03-19 | 2025-01-07 | 如凤凰再生科技发展(成都)有限公司 | 一种具有热稳定性和促进自身胶原生成的三螺旋胶原蛋白及其制备方法和用途 |
| CN119019539B (zh) * | 2024-09-04 | 2025-07-18 | 上海欣肽生物科技有限公司 | 一种长链类胶原蛋白多肽的迭代指数合成方法 |
-
1997
- 1997-08-25 US US08/918,223 patent/US5973112A/en not_active Expired - Lifetime
-
1998
- 1998-07-09 JP JP2000507706A patent/JP4514328B2/ja not_active Expired - Lifetime
- 1998-07-09 CA CA2301175A patent/CA2301175C/en not_active Expired - Lifetime
- 1998-07-09 AT AT98935594T patent/ATE371672T1/de not_active IP Right Cessation
- 1998-07-09 EP EP98935594A patent/EP1007568B1/en not_active Expired - Lifetime
- 1998-07-09 DE DE69838331T patent/DE69838331T2/de not_active Expired - Lifetime
- 1998-07-09 AU AU84806/98A patent/AU8480698A/en not_active Abandoned
- 1998-07-09 WO PCT/US1998/014284 patent/WO1999010381A1/en not_active Ceased
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