JP2001513550A5 - - Google Patents
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- Publication number
- JP2001513550A5 JP2001513550A5 JP2000507355A JP2000507355A JP2001513550A5 JP 2001513550 A5 JP2001513550 A5 JP 2001513550A5 JP 2000507355 A JP2000507355 A JP 2000507355A JP 2000507355 A JP2000507355 A JP 2000507355A JP 2001513550 A5 JP2001513550 A5 JP 2001513550A5
- Authority
- JP
- Japan
- Prior art keywords
- vaginal
- suppository
- following ingredients
- vaginal suppository
- combine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006216 vaginal suppository Substances 0.000 description 12
- 229940120293 Vaginal Suppository Drugs 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 201000009910 diseases by infectious agent Diseases 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-Hydroxybenzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- ATZHGRNFEFVDDJ-UHFFFAOYSA-M 4-propylbenzoate Chemical compound CCCC1=CC=C(C([O-])=O)C=C1 ATZHGRNFEFVDDJ-UHFFFAOYSA-M 0.000 description 1
- KDLRVYVGXIQJDK-AWPVFWJPSA-N Clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229940066842 Petrolatum Drugs 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000240 adjuvant Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 229960002227 clindamycin Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- -1 fatty acid ester Chemical class 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
- 239000000003 vaginal tablet Substances 0.000 description 1
Description
この医薬組成物は、活性成分に加えて医薬的に許容され得る担体または助剤を含み得る。好ましい投薬形体は、膣坐剤、膣錠剤、膣坐剤、膣リング、若しくは、軟膏、クリームまたはゲルのような半固形膣用製品である。
その他の、膣坐剤のための助剤としては、以下のものが知られる：
ゼラチン、グリセロール、ポリエチレングリコール、固脂、セトステアリルアルコールポリエチレングリコールエーテル、ドデシル硫酸ナトリウム、グリセロール（モノ,ジ,トリ）脂肪酸エステル（C12〜C18）-ポリエチレングリコールドデシルエーテル混合物、パラフィン、４-ヒドロキシ安息香酸エチル、４-ヒドロキシ安息香酸プロピル及びワセリン。
ゼラチン、グリセロール、ポリエチレングリコール、固脂、セトステアリルアルコールポリエチレングリコールエーテル、ドデシル硫酸ナトリウム、グリセロール（モノ,ジ,トリ）脂肪酸エステル（C12〜C18）-ポリエチレングリコールドデシルエーテル混合物、パラフィン、４-ヒドロキシ安息香酸エチル、４-ヒドロキシ安息香酸プロピル及びワセリン。
実施例１２：
膣坐剤（１００／２０）：
各膣坐剤ごと、以下の成分を一まとめにする：
膣坐剤（１００／２０）：
各膣坐剤ごと、以下の成分を一まとめにする：
実施例１３：
膣坐剤（１００／２０）：
各膣坐剤ごと、以下の成分を一まとめにする：
膣坐剤（１００／２０）：
各膣坐剤ごと、以下の成分を一まとめにする：
実施例１４：
膣坐剤／坐剤：
各膣坐剤ごと、以下の成分を一まとめにする：
膣坐剤／坐剤：
各膣坐剤ごと、以下の成分を一まとめにする：
実施例１５：
膣坐剤（１００／２０）：
各膣坐剤ごと、以下の成分を一まとめにする：
膣坐剤（１００／２０）：
各膣坐剤ごと、以下の成分を一まとめにする：
新しく製造した２０ｍｇのクリンダマイシン及び１００ｍｇのクロトリマゾールを含有する膣坐剤を用いた６日間にわたる治療後、２３人の患者が感染から完全に回復した。その後、二次感染は見受けられなかった。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19737348A DE19737348C2 (de) | 1997-08-27 | 1997-08-27 | Neue Clindamycin und Clotrimazol enthaltende pharmazeutische Zusammensetzung |
| DE19737348.8 | 1997-08-27 | ||
| PCT/EP1998/005454 WO1999009964A2 (de) | 1997-08-27 | 1998-08-27 | Pharmazeutische zusammensetzung enthaltend clindamycin und clotrimazol, zur behandlung vaginaler infektion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001513550A JP2001513550A (ja) | 2001-09-04 |
| JP2001513550A5 true JP2001513550A5 (ja) | 2009-12-10 |
Family
ID=7840348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000507355A Pending JP2001513550A (ja) | 1997-08-27 | 1998-08-27 | 新規医薬組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6537970B1 (ja) |
| EP (1) | EP1009414B1 (ja) |
| JP (1) | JP2001513550A (ja) |
| AT (1) | ATE308328T1 (ja) |
| AU (1) | AU9534398A (ja) |
| DE (2) | DE19737348C2 (ja) |
| WO (1) | WO1999009964A2 (ja) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8709482B2 (en) | 2004-08-05 | 2014-04-29 | Ferring B.V. | Stabilised prostaglandin composition |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI232111B (en) * | 1999-08-06 | 2005-05-11 | Upjohn Co | Intravaginal clindamycin ovule composition |
| US20030073647A1 (en) * | 2001-08-28 | 2003-04-17 | Chao Robert S. | Crystaline clindamycin free base |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| AU2003290071A1 (en) * | 2002-12-18 | 2004-07-09 | Ferrer Internacional, S.A. | Pharmaceutical compositions of sertaconazole for vaginal use |
| MXPA05008571A (es) * | 2005-08-12 | 2007-02-12 | Leopoldo Espinosa Abdala | Formulaciones farmaceuticas solidas, semisolidas, en suspension, en solucion, en emulsion o en jarabe conteniendo clindamicina y uno o mas de los miembros de la familia de los azoles. |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| BRPI0713203A2 (pt) * | 2006-07-12 | 2012-04-03 | Controlled Therapeutics Scotland Ltda | inserto, métodos, embalagem, dispositivo recuperável e dispositivo inserìvel |
| GB0620685D0 (en) * | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| US8603513B2 (en) * | 2007-06-28 | 2013-12-10 | The Procter & Gamble Company | Article comprising calcium for reducing the production of TSST-1 |
| EP2130531A1 (en) * | 2008-06-04 | 2009-12-09 | Rolf Kullgren AB | Vaginal suppository comprising lactic acid |
| US20100285095A1 (en) * | 2009-05-05 | 2010-11-11 | Kimberly Ann Nemeth | Hygiene Article Having Calcium Sugar Acid Salt |
| US20100285096A1 (en) * | 2009-05-05 | 2010-11-11 | Fancheng Wang | Hygiene Article Having Calcium Sugar Phosphate |
| WO2011027247A1 (en) | 2009-09-03 | 2011-03-10 | Sulur Subramaniam Vanangamudi | An antifungal cream comprising terbinafine hydrochloride |
| WO2011101826A1 (en) | 2010-02-22 | 2011-08-25 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, terbinafine and dexamethasone, and a process to make it |
| WO2012049542A1 (en) | 2010-10-15 | 2012-04-19 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, mometasone as a corticosteroid and clotrimazol as antifungal agent, and a process to make it |
| WO2012049544A1 (en) | 2010-10-15 | 2012-04-19 | Sulur Subramaniam Vanangamudi | A medicinal fusidic acid cream made using sodium fusidate and incorporating a biopolymer, a hydrocortisone acetate as a corticosteroid, and clotrimazole as an antifungal agent, and a process to make it |
| CN103830198B (zh) * | 2012-11-28 | 2016-05-18 | 南京亿华药业有限公司 | 一种克霉唑阴道片及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4318853A (en) | 1980-01-31 | 1982-03-09 | The Upjohn Company | 9β,11β-Epoxy-5β-corticoids |
| US5160737A (en) | 1988-05-03 | 1992-11-03 | Perio Products Ltd. | Liquid polymer composition, and method of use |
-
1997
- 1997-08-27 DE DE19737348A patent/DE19737348C2/de not_active Expired - Fee Related
-
1998
- 1998-08-27 JP JP2000507355A patent/JP2001513550A/ja active Pending
- 1998-08-27 US US09/486,348 patent/US6537970B1/en not_active Expired - Fee Related
- 1998-08-27 DE DE59813162T patent/DE59813162D1/de not_active Expired - Lifetime
- 1998-08-27 EP EP98948878A patent/EP1009414B1/de not_active Expired - Lifetime
- 1998-08-27 AT AT98948878T patent/ATE308328T1/de active
- 1998-08-27 AU AU95343/98A patent/AU9534398A/en not_active Abandoned
- 1998-08-27 WO PCT/EP1998/005454 patent/WO1999009964A2/de active IP Right Grant
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8709482B2 (en) | 2004-08-05 | 2014-04-29 | Ferring B.V. | Stabilised prostaglandin composition |
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