JP2001512459A5 - - Google Patents

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Publication number
JP2001512459A5
JP2001512459A5 JP1998535896A JP53589698A JP2001512459A5 JP 2001512459 A5 JP2001512459 A5 JP 2001512459A5 JP 1998535896 A JP1998535896 A JP 1998535896A JP 53589698 A JP53589698 A JP 53589698A JP 2001512459 A5 JP2001512459 A5 JP 2001512459A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998535896A
Other languages
English (en)
Japanese (ja)
Other versions
JP4446023B2 (ja
JP2001512459A (ja
Filing date
Publication date
Priority claimed from US08/800,108 external-priority patent/US6110935A/en
Application filed filed Critical
Publication of JP2001512459A publication Critical patent/JP2001512459A/ja
Publication of JP2001512459A5 publication Critical patent/JP2001512459A5/ja
Application granted granted Critical
Publication of JP4446023B2 publication Critical patent/JP4446023B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP53589698A 1997-02-13 1998-02-13 Ampaレセプタの活性を高めるベンゾフラザン化合物 Expired - Fee Related JP4446023B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/800,108 US6110935A (en) 1997-02-13 1997-02-13 Benzofurazan compounds for enhancing glutamatergic synaptic responses
US08/800,108 1997-02-13
PCT/US1998/002713 WO1998035950A1 (en) 1997-02-13 1998-02-13 Benzofurazan compounds which enhance ampa receptor activity

Publications (3)

Publication Number Publication Date
JP2001512459A JP2001512459A (ja) 2001-08-21
JP2001512459A5 true JP2001512459A5 (enExample) 2005-08-11
JP4446023B2 JP4446023B2 (ja) 2010-04-07

Family

ID=25177504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53589698A Expired - Fee Related JP4446023B2 (ja) 1997-02-13 1998-02-13 Ampaレセプタの活性を高めるベンゾフラザン化合物

Country Status (24)

Country Link
US (3) US6110935A (enExample)
EP (2) EP1428534B1 (enExample)
JP (1) JP4446023B2 (enExample)
KR (1) KR100544295B1 (enExample)
CN (1) CN1085206C (enExample)
AT (2) ATE326221T1 (enExample)
AU (1) AU737802C (enExample)
BR (1) BR9807333B1 (enExample)
CA (1) CA2279319C (enExample)
CZ (1) CZ299765B6 (enExample)
DE (2) DE69823803T2 (enExample)
DK (2) DK0960105T3 (enExample)
ES (2) ES2264078T3 (enExample)
GB (1) GB2325225B (enExample)
HU (1) HUP0002303A3 (enExample)
ID (1) ID22342A (enExample)
IL (1) IL131200A (enExample)
NO (1) NO318935B1 (enExample)
NZ (1) NZ336980A (enExample)
PL (1) PL199135B1 (enExample)
PT (2) PT960105E (enExample)
RU (1) RU2189984C2 (enExample)
TR (1) TR199901941T2 (enExample)
WO (1) WO1998035950A1 (enExample)

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Publication number Priority date Publication date Assignee Title
IN188837B (enExample) 1998-05-22 2002-11-09 Torrent Pharmaceuticals Ltd
AU2002366756A1 (en) * 2001-12-20 2003-07-09 Alangudi Sankaranarayanan Use of benzofuroxan derivatives as antiplatelet agents
BRPI0406736A (pt) * 2003-01-13 2005-12-20 Cortex Pharma Inc Método de tratar declìnico cognitivo devido à privação de sono e estresse
JP4829791B2 (ja) * 2003-05-23 2011-12-07 バジリア ファルマスーチカ アーゲー フラザノベンゾイミダゾール
EP1715863B1 (en) * 2004-01-26 2012-05-09 Cortex Pharmaceuticals, Inc. Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors
EP2061471A4 (en) * 2006-08-31 2012-02-01 Univ Alberta PROCESS FOR INHIBITING RESTRICTED DEPRESSION WITH POSITIVE ALLOSTER AMPA RECEPTOR MODULATORS
EP2114158B1 (en) * 2007-01-03 2012-08-08 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
CN101616592B (zh) * 2007-01-03 2013-06-05 瑟维尔实验室 用于提高谷氨酸能突触响应的3-取代的-[1,2,3]-苯并三嗪酮化合物
TW200911768A (en) * 2007-05-17 2009-03-16 Cortex Pharma Inc Di-substituted amides for enhancing glutamatergic synaptic responses
US8168632B2 (en) 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
US8263591B2 (en) 2007-08-10 2012-09-11 Cortex Pharmaceuticals, Inc. Bicyclic amides for enhancing glutamatergic synaptic responses
US8071914B2 (en) * 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2010087981A2 (en) * 2009-02-02 2010-08-05 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
EP2544688B1 (en) 2010-03-02 2016-09-07 President and Fellows of Harvard College Methods and compositions for treatment of angelman syndrome
US20110257186A1 (en) * 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
CA2829006A1 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
CN102633731B (zh) * 2012-03-13 2014-04-30 四川大学华西医院 6-喹喔啉甲酸酰胺化合物、制备方法和应用
KR101421032B1 (ko) * 2012-12-28 2014-07-22 주식회사 레고켐 바이오사이언스 (2-메틸-1-(3-메틸벤질)-1H-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법
CA2915405A1 (en) 2013-06-13 2014-12-18 Veroscience Llc Compositions and methods for treating metabolic disorders
CN107286114B (zh) 2016-04-13 2020-08-18 中国人民解放军军事医学科学院毒物药物研究所 Ampa受体增效剂的脑靶向前药及其医药用途

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
US3981864A (en) * 1973-09-08 1976-09-21 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
FR2499991A1 (fr) * 1981-02-19 1982-08-20 Sandoz Sa Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
SU1657189A1 (ru) * 1988-05-23 1991-06-23 Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср Способ коррекции апато-абулических состо ний при шизофрении
SU1587050A1 (ru) * 1988-12-23 1990-08-23 Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DK1156043T3 (da) * 1992-07-24 2004-03-01 Univ California Lægemidler, der forøger synaptiske reaktioner formidlet af ampa-receptorer
ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
US5650409A (en) * 1995-06-02 1997-07-22 Cortex Pharmaceuticals, Inc. Benzoyl piperidines/pyrrolidines for enhancing synaptic response
US5736543A (en) * 1996-04-03 1998-04-07 The Regents Of The University Of California Benzoxazines for enhancing synaptic response
US5985871A (en) 1997-12-24 1999-11-16 Cortex Pharmaceuticals, Inc. Benzoxazine compounds for enhancing synaptic response

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