JP2001510793A5 - - Google Patents
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- Publication number
- JP2001510793A5 JP2001510793A5 JP2000503829A JP2000503829A JP2001510793A5 JP 2001510793 A5 JP2001510793 A5 JP 2001510793A5 JP 2000503829 A JP2000503829 A JP 2000503829A JP 2000503829 A JP2000503829 A JP 2000503829A JP 2001510793 A5 JP2001510793 A5 JP 2001510793A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- methyl
- carbon atoms
- transplantation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI001789A IT1293795B1 (it) | 1997-07-28 | 1997-07-28 | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| IT97A01789 | 1997-07-28 | ||
| PCT/EP1998/004924 WO1999004770A2 (en) | 1997-07-28 | 1998-07-22 | A pharmaceutical composition active in reducing production of mcp-1 protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009270715A Division JP5086322B2 (ja) | 1997-07-28 | 2009-11-09 | Ｍｃｐ−１プロテインの増加生産によって特徴付けられる障害の処置のための薬剤組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001510793A JP2001510793A (ja) | 2001-08-07 |
| JP2001510793A5 true JP2001510793A5 (https=) | 2006-01-05 |
| JP4651191B2 JP4651191B2 (ja) | 2011-03-16 |
Family
ID=11377642
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000503829A Expired - Fee Related JP4651191B2 (ja) | 1997-07-28 | 1998-07-22 | Ｍｃｐ−１タンパク質の生成を減らす際に活性がある薬剤組成物 |
| JP2009270715A Expired - Fee Related JP5086322B2 (ja) | 1997-07-28 | 2009-11-09 | Ｍｃｐ−１プロテインの増加生産によって特徴付けられる障害の処置のための薬剤組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009270715A Expired - Fee Related JP5086322B2 (ja) | 1997-07-28 | 2009-11-09 | Ｍｃｐ−１プロテインの増加生産によって特徴付けられる障害の処置のための薬剤組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6534534B1 (https=) |
| EP (1) | EP1005332B1 (https=) |
| JP (2) | JP4651191B2 (https=) |
| AR (1) | AR016382A1 (https=) |
| AT (1) | ATE251902T1 (https=) |
| AU (1) | AU744492B2 (https=) |
| CA (1) | CA2300289C (https=) |
| DE (1) | DE69819012T2 (https=) |
| DK (1) | DK1005332T3 (https=) |
| ES (1) | ES2207858T3 (https=) |
| IT (1) | IT1293795B1 (https=) |
| PT (1) | PT1005332E (https=) |
| SI (1) | SI1005332T1 (https=) |
| WO (1) | WO1999004770A2 (https=) |
| ZA (1) | ZA986636B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
| US7238711B1 (en) | 1999-03-17 | 2007-07-03 | Cambridge University Technical Services Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
| ITMI20062254A1 (it) * | 2006-11-24 | 2008-05-25 | Acraf | Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca |
| HRP20191953T8 (hr) * | 2008-03-07 | 2021-06-25 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | DERIVATI 1-BENZIL-3-HIDROKSIMETILINDAZOLA I NJIHOVA UPORABA U LIJEČENJU BOLESTI KOJE SE BAZIRAJU NA EKSPRESIJI MCP-1, CX3CR1 i P40 |
| EP2262777B8 (en) * | 2008-03-07 | 2016-05-04 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. | 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1 and cx3cr1 |
| WO2009109613A2 (en) | 2008-03-07 | 2009-09-11 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 |
| EA019060B1 (ru) | 2009-08-03 | 2013-12-30 | Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. | Способ получения 1-бензил-3-гидроксиметил-1н-индазола и его производных и необходимые промежуточные соединения с магнием |
| UA108742C2 (uk) * | 2009-09-23 | 2015-06-10 | Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1 | |
| WO2011106611A2 (en) | 2010-02-25 | 2011-09-01 | Prairie Ventures, L.L.C. | System and method for anatomical pathology sample handling, storage, and analysis |
| US8999292B2 (en) | 2012-05-01 | 2015-04-07 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| ES2789849T3 (es) * | 2014-05-15 | 2020-10-26 | Translatum Medicus Inc | Composiciones y procedimientos para el tratamiento y diagnóstico de trastornos oculares |
| EP3942934A1 (en) | 2015-06-12 | 2022-01-26 | Vettore, LLC | Mct4 inhibitors for treating disease |
| US10214492B2 (en) | 2016-12-12 | 2019-02-26 | Vettore, LLC | Heterocyclic inhibitors of MCT4 |
| WO2020261158A1 (en) | 2019-06-25 | 2020-12-30 | Translatum Medicus Inc. | Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1230441B (it) * | 1989-02-07 | 1991-10-23 | Acraf | Eteri della serie dell'indazolo |
| US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
| IT1253703B (it) * | 1991-04-22 | 1995-08-23 | Angelini Francesco Ist Ricerca | Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie |
| WO1994009128A1 (en) | 1992-10-22 | 1994-04-28 | Mallinckrodt Medical, Inc. | Therapeutic treatment for inhibiting vascular restenosis |
| US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
| JPH08333262A (ja) * | 1995-04-07 | 1996-12-17 | Chugai Pharmaceut Co Ltd | 免疫抑制剤 |
| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| DE19538402A1 (de) * | 1995-10-14 | 1997-04-17 | Boehringer Mannheim Gmbh | Lipidalkohole als neue immunsuppressive und antivirale Arzneimittel |
| JPH09165339A (ja) * | 1995-10-27 | 1997-06-24 | American Home Prod Corp | ラパマイシンを付与したドナー脾細胞を用いる臓器移植の延長 |
| IT1276031B1 (it) * | 1995-10-31 | 1997-10-24 | Angelini Ricerche Spa | Composizione farmaceutica per il trattamento delle malattie autoimmuni |
| US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| IT1293795B1 (it) * | 1997-07-28 | 1999-03-10 | Angelini Ricerche Spa | Farmaco attivo nel ridurre la produzione di proteina mcp-1 |
-
1997
- 1997-07-28 IT IT97MI001789A patent/IT1293795B1/it active IP Right Grant
-
1998
- 1998-07-22 US US09/463,666 patent/US6534534B1/en not_active Expired - Lifetime
- 1998-07-22 DE DE69819012T patent/DE69819012T2/de not_active Expired - Lifetime
- 1998-07-22 PT PT98943862T patent/PT1005332E/pt unknown
- 1998-07-22 DK DK98943862T patent/DK1005332T3/da active
- 1998-07-22 CA CA002300289A patent/CA2300289C/en not_active Expired - Fee Related
- 1998-07-22 WO PCT/EP1998/004924 patent/WO1999004770A2/en not_active Ceased
- 1998-07-22 AT AT98943862T patent/ATE251902T1/de active
- 1998-07-22 JP JP2000503829A patent/JP4651191B2/ja not_active Expired - Fee Related
- 1998-07-22 AU AU91601/98A patent/AU744492B2/en not_active Ceased
- 1998-07-22 EP EP98943862A patent/EP1005332B1/en not_active Expired - Lifetime
- 1998-07-22 ES ES98943862T patent/ES2207858T3/es not_active Expired - Lifetime
- 1998-07-22 SI SI9830573T patent/SI1005332T1/xx unknown
- 1998-07-24 ZA ZA986636A patent/ZA986636B/xx unknown
- 1998-07-28 AR ARP980103695A patent/AR016382A1/es unknown
-
2009
- 2009-11-09 JP JP2009270715A patent/JP5086322B2/ja not_active Expired - Fee Related
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