JP2001510791A - 半透性プラグを備えた浸透投与系 - Google Patents
半透性プラグを備えた浸透投与系Info
- Publication number
- JP2001510791A JP2001510791A JP2000503827A JP2000503827A JP2001510791A JP 2001510791 A JP2001510791 A JP 2001510791A JP 2000503827 A JP2000503827 A JP 2000503827A JP 2000503827 A JP2000503827 A JP 2000503827A JP 2001510791 A JP2001510791 A JP 2001510791A
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- Prior art keywords
- semi
- osmotic
- liquid
- permeable body
- enclosure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Closures For Containers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5368997P | 1997-07-25 | 1997-07-25 | |
| US60/053,689 | 1997-07-25 | ||
| PCT/US1998/014812 WO1999004767A2 (en) | 1997-07-25 | 1998-07-24 | Osmotic delivery system with semipermeable plug |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005204469A Division JP2005306885A (ja) | 1997-07-25 | 2005-07-13 | 半透性プラグを備えた浸透投与系 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001510791A true JP2001510791A (ja) | 2001-08-07 |
| JP2001510791A5 JP2001510791A5 (enExample) | 2009-04-09 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000503827A Pending JP2001510791A (ja) | 1997-07-25 | 1998-07-24 | 半透性プラグを備えた浸透投与系 |
| JP2005204469A Withdrawn JP2005306885A (ja) | 1997-07-25 | 2005-07-13 | 半透性プラグを備えた浸透投与系 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005204469A Withdrawn JP2005306885A (ja) | 1997-07-25 | 2005-07-13 | 半透性プラグを備えた浸透投与系 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US6287295B1 (enExample) |
| EP (1) | EP1011642B1 (enExample) |
| JP (2) | JP2001510791A (enExample) |
| KR (1) | KR100600462B1 (enExample) |
| CN (1) | CN1198602C (enExample) |
| AR (1) | AR016543A1 (enExample) |
| AT (2) | ATE425739T1 (enExample) |
| AU (1) | AU8658998A (enExample) |
| CA (1) | CA2297801C (enExample) |
| CO (1) | CO4970812A1 (enExample) |
| DE (2) | DE69840679D1 (enExample) |
| MY (1) | MY125849A (enExample) |
| TW (1) | TW450817B (enExample) |
| WO (1) | WO1999004767A2 (enExample) |
| ZA (1) | ZA986631B (enExample) |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| EP1736145B1 (en) | 1997-12-30 | 2011-12-21 | Intarcia Therapeutics, Inc | Beneficial agent delivery system with membrane plug |
| ES2196918T3 (es) | 1998-12-31 | 2003-12-16 | Alza Corp | Sistema de suministro osmotico dotado de piston con economia de espacio.. |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| US7919109B2 (en) | 1999-02-08 | 2011-04-05 | Intarcia Therapeutics, Inc. | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| US6541021B1 (en) * | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) * | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6436091B1 (en) * | 1999-11-16 | 2002-08-20 | Microsolutions, Inc. | Methods and implantable devices and systems for long term delivery of a pharmaceutical agent |
| US7074803B2 (en) * | 2001-03-02 | 2006-07-11 | Durect Corporation | Opioid formulations |
| US6491684B1 (en) * | 2001-05-22 | 2002-12-10 | Durect Corporation | Fluid delivery device having a water generating electrochemical/chemical pump and associated method |
| US7163688B2 (en) * | 2001-06-22 | 2007-01-16 | Alza Corporation | Osmotic implant with membrane and membrane retention means |
| US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
| US7790905B2 (en) | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
| US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
| WO2004078161A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazeptine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| US20050025791A1 (en) * | 2002-06-21 | 2005-02-03 | Julius Remenar | Pharmaceutical compositions with improved dissolution |
| JP4906233B2 (ja) | 2002-03-01 | 2012-03-28 | ユニバーシティー オブ サウス フロリダ | 少なくとも１種の有効薬剤成分を含有する多構成要素固相 |
| US7896867B2 (en) * | 2002-05-01 | 2011-03-01 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method |
| US7470267B2 (en) * | 2002-05-01 | 2008-12-30 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an anionic exchange membrane and associated method |
| WO2007005565A2 (en) * | 2002-05-01 | 2007-01-11 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method |
| US20060116663A1 (en) * | 2002-05-01 | 2006-06-01 | Joshi Ashok V | Electro-osmotic fluid delivery device and method |
| US7458965B2 (en) * | 2002-05-01 | 2008-12-02 | Microlin, Llc | Fluid delivery device having an electrochemical pump with an ion-exchange membrane and associated method |
| NZ537136A (en) * | 2002-06-17 | 2007-07-27 | Alza Corp | Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle |
| WO2004002565A1 (en) * | 2002-06-26 | 2004-01-08 | Alza Corporation | Minimally compliant, volume efficient piston for osmotic drug delivery systems |
| DE10233622A1 (de) * | 2002-07-24 | 2004-02-12 | Disetronic Licensing Ag | Infusionspumpe, Verfahren, Steuerprogramm und Halbleiterbauelement zur dosierten Verabreichung einer medizinischen Flüssigkeit |
| KR20050088196A (ko) * | 2002-12-19 | 2005-09-02 | 알자 코포레이션 | 안정한 비수성 단일 상 겔 및 이식가능한 장치로부터전달하기 위한 이의 제형 |
| US7731947B2 (en) * | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
| US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
| EP2339328A3 (en) | 2002-12-30 | 2011-07-13 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of celecoxib |
| KR20050120767A (ko) * | 2003-03-31 | 2005-12-23 | 알자 코포레이션 | 삼투성 전달 시스템 및 삼투성 전달 시스템의 기동 시간감소 방법 |
| TW200507893A (en) * | 2003-03-31 | 2005-03-01 | Alza Corp | Osmotic pump with means for dissipating internal pressure |
| US20040214893A1 (en) * | 2003-04-11 | 2004-10-28 | Matthew Peterson | Gabapentin compositions |
| WO2005000786A1 (en) | 2003-05-23 | 2005-01-06 | Transform Pharmaceuticals, Inc. | Sertraline compositions |
| US7858110B2 (en) * | 2003-08-11 | 2010-12-28 | Endo Pharmaceuticals Solutions, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US20090208540A1 (en) * | 2003-08-11 | 2009-08-20 | Indevus Pharmaceuticals, Inc. | Implantable device for the delivery of naltrexone and methods of use thereof |
| CA2437639C (en) | 2003-08-11 | 2016-07-05 | Valera Pharmaceuticals, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US7632245B1 (en) * | 2003-08-18 | 2009-12-15 | Medrad, Inc. | Devices, systems and methods for delivery of a fluid into a patient during a magnetic resonance procedure |
| US7217351B2 (en) * | 2003-08-29 | 2007-05-15 | Beta Micropump Partners Llc | Valve for controlling flow of a fluid |
| US8257963B2 (en) * | 2007-06-01 | 2012-09-04 | Depuy Mitek, Inc. | Chondrocyte container and method of use |
| US7897384B2 (en) * | 2003-09-08 | 2011-03-01 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| US7927599B2 (en) * | 2003-09-08 | 2011-04-19 | Ethicon, Inc. | Chondrocyte therapeutic delivery system |
| MXPA06003454A (es) * | 2003-09-26 | 2006-08-31 | Johnson & Johnson | Formulaciones de liberacion controlada de analgesicos opioides y no opiodes. |
| CN1897924B (zh) | 2003-09-26 | 2011-09-21 | 阿尔扎公司 | 能提供高载药量的药物包衣和提供它的方法 |
| WO2005030182A1 (en) | 2003-09-26 | 2005-04-07 | Alza Corporation | Controlled release formulations exhibiting an ascending rate of release |
| US7241457B2 (en) | 2003-09-30 | 2007-07-10 | Alza Corporation | Osmotically driven active agent delivery device providing an ascending release profile |
| AU2004287402A1 (en) * | 2003-10-31 | 2005-05-19 | Alza Corporation | Osmotic pump with self-retaining, fast-start membrane plug |
| US20050113410A1 (en) * | 2003-11-03 | 2005-05-26 | Mark Tawa | Pharmaceutical salts of zafirlukast |
| AU2004289218A1 (en) * | 2003-11-06 | 2005-05-26 | Alza Corporation | Modular imbibition rate reducer for use with implantable osmotic pump |
| WO2005051298A2 (en) | 2003-11-19 | 2005-06-09 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| US20060004037A1 (en) * | 2004-03-25 | 2006-01-05 | Transform Pharmaceuticals, Inc. | Novel tricyclic compounds and related methods of treatment |
| US20050266087A1 (en) * | 2004-05-25 | 2005-12-01 | Gunjan Junnarkar | Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium |
| EP1765379A4 (en) * | 2004-06-17 | 2009-05-27 | Transform Pharmaceuticals Inc | PHARMACEUTICAL CO-CRYSTAL COMPOSITIONS AND RELEVANT USE METHOD |
| US20060020253A1 (en) * | 2004-07-26 | 2006-01-26 | Prescott Anthony D | Implantable device having reservoir with controlled release of medication and method of manufacturing the same |
| US8541026B2 (en) * | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
| US8779175B2 (en) * | 2004-10-25 | 2014-07-15 | Synthonics, Inc. | Coordination complexes, pharmaceutical solutions comprising coordination complexes, and methods of treating patients |
| AU2005309601A1 (en) | 2004-11-23 | 2006-06-01 | Neuromolecular Pharmaceuticals, Inc. | Composition comprising a sustained release coating or matrix and an NMDA receptor antagonist, method for administration such NMDA antagonist to a subject |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| EP1845968A2 (en) | 2004-11-24 | 2007-10-24 | Neuromolecular Pharmaceuticals, Inc | Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease |
| US20060160783A1 (en) * | 2004-12-30 | 2006-07-20 | Transform Pharmaceuticals, Inc. | Novel omeprazole forms and related methods |
| US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
| JP2008528698A (ja) * | 2005-02-03 | 2008-07-31 | インターシア セラピューティクス，インコーポレイティド | 埋め込み可能なインターフェロン含有デバイス |
| WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
| WO2006094106A2 (en) | 2005-02-28 | 2006-09-08 | Sangamo Biosciences, Inc. | Anti-angiogenic methods and compositions |
| US7959938B2 (en) | 2005-03-15 | 2011-06-14 | Intarcia Therapeutics, Inc. | Polyoxaester suspending vehicles for use with implantable delivery systems |
| EP1874282B1 (en) | 2005-04-06 | 2010-09-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for treatment of cns disorders |
| US8348930B2 (en) * | 2005-07-01 | 2013-01-08 | Microlin, Llc | Fluid delivery device with a diffusion membrane and electrochemical pump |
| WO2007044910A1 (en) * | 2005-10-13 | 2007-04-19 | Duke University | Compositions for the treatment and prevention of heart disease and methods of using same |
| US20070179613A1 (en) * | 2006-01-30 | 2007-08-02 | Sdgi Holdings, Inc. | Passive lubricating prosthetic joint |
| EP2319558B1 (en) | 2006-03-14 | 2014-05-21 | University Of Southern California | Mems device for delivery of therapeutic agents |
| ATE481963T1 (de) | 2006-05-30 | 2010-10-15 | Intarcia Therapeutics Inc | Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem |
| US9474645B2 (en) * | 2006-06-21 | 2016-10-25 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
| CN101505694B (zh) * | 2006-06-21 | 2012-02-22 | 庄臣及庄臣视力保护公司 | 用于递送活性试剂的泪点塞 |
| AU2007284759B2 (en) * | 2006-08-09 | 2010-10-28 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
| US9114133B2 (en) | 2006-08-25 | 2015-08-25 | U.S. Dept. Of Veterans Affairs | Method of improving diastolic dysfunction |
| US20080154242A1 (en) * | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Delivery device for a fluid |
| US20080154243A1 (en) * | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Delivery device for a fluid |
| US20080152510A1 (en) * | 2006-12-20 | 2008-06-26 | Beta Micropump Partners Llc | Valve for controlling flow of a primary fluid |
| DK2129654T3 (da) | 2007-02-09 | 2014-08-25 | Metabasis Therapeutics Inc | Antagonister af glucagonreceptoren |
| MX2009011123A (es) | 2007-04-23 | 2009-11-02 | Intarcia Therapeutics Inc | Formulaciones de suspensiones de peptidos insulinotropicos y sus usos. |
| MX2010001784A (es) | 2007-08-13 | 2010-03-15 | Metabasis Therapeutics Inc | Activadores novedosos de la glucocinasa. |
| EP2666510B1 (en) | 2007-12-20 | 2017-10-18 | University Of Southern California | Apparatus for controlled delivery of therapeutic agents |
| JP2011511782A (ja) | 2008-02-12 | 2011-04-14 | アボット・ラボラトリーズ | 長期放出性ヒドロコドンアセトアミノフェンならびにその関連方法および用途 |
| DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
| CN102202719B (zh) | 2008-05-08 | 2014-11-26 | 迷你泵有限责任公司 | 可植入泵和用于可植入泵的插管 |
| US9199035B2 (en) | 2008-05-08 | 2015-12-01 | Minipumps, Llc. | Drug-delivery pumps with dynamic, adaptive control |
| EP2323716B1 (en) | 2008-05-08 | 2015-03-04 | MiniPumps, LLC | Drug-delivery pumps |
| US9333297B2 (en) | 2008-05-08 | 2016-05-10 | Minipumps, Llc | Drug-delivery pump with intelligent control |
| PL2799428T3 (pl) | 2008-08-13 | 2017-05-31 | Metabasis Therapeutics, Inc. | Antagoniści glukagonu |
| WO2010025412A2 (en) | 2008-08-28 | 2010-03-04 | Microlin, Llc | Apparatus and method for delivering beneficial liquids at steady rate |
| CA2739181C (en) | 2008-09-30 | 2017-03-14 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the delivery of risperidone and methods of use thereof |
| WO2010039643A1 (en) * | 2008-09-30 | 2010-04-08 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the delivery of histrelin and methods of use thereof |
| US20100092566A1 (en) * | 2008-10-15 | 2010-04-15 | Alessi Thomas R | Highly concentrated drug particles, formulations, suspensions and uses thereof |
| BRPI1006755A2 (pt) * | 2009-04-07 | 2019-03-26 | Koninl Philips Electronics Nv | dispositivo de administração de droga |
| US8808257B2 (en) * | 2009-08-31 | 2014-08-19 | Johnson & Johnson Vision Care, Inc. | Methods and apparatus for pulsatile release of medicaments from a punctal plug |
| KR102093612B1 (ko) | 2009-09-28 | 2020-03-26 | 인타르시아 세라퓨틱스 인코포레이티드 | 실질 항정상태 약물 전달의 신속 확립 및/또는 종결 |
| RU2012117898A (ru) | 2009-09-30 | 2013-11-10 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Кофакторы и способы их применения индивидуумами |
| BR112012013487A2 (pt) | 2009-12-02 | 2017-10-03 | Adamas Pharmaceuticals Inc | Composições de amantadina e métodos de uso |
| US8038650B2 (en) * | 2010-02-22 | 2011-10-18 | Microsert Ltd. | Slow release liquid drug delivery device |
| CA2794565C (en) | 2010-04-08 | 2018-08-21 | Emory University | Substituted androst-4-ene diones |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| US9585930B2 (en) | 2011-03-20 | 2017-03-07 | Trustees Of Boston University | Therapeutic agent for emphysema and COPD |
| US20140227293A1 (en) | 2011-06-30 | 2014-08-14 | Trustees Of Boston University | Method for controlling tumor growth, angiogenesis and metastasis using immunoglobulin containing and proline rich receptor-1 (igpr-1) |
| WO2013012760A1 (en) | 2011-07-15 | 2013-01-24 | Numeta Sciences, Inc. | Compositions and methods for modulating metabolic pathways |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| CN108295058A (zh) | 2012-11-13 | 2018-07-20 | 纽斯尔特科学公司 | 用于增强能量代谢的组合物和方法 |
| WO2014113404A1 (en) | 2013-01-15 | 2014-07-24 | Nusirt Sciences, Inc. | Treating pulmonary conditions |
| CN104001261A (zh) * | 2013-02-27 | 2014-08-27 | 重庆市北碚区精神卫生中心 | 一种皮下给药装置 |
| US10137287B2 (en) * | 2013-03-05 | 2018-11-27 | Taris Biomedical Llc | Drug delivery devices and methods for controlled drug release through device orifice |
| US9486573B2 (en) | 2013-03-14 | 2016-11-08 | Bayer Healthcare Llc | Fluid delivery system and method of fluid delivery to a patient |
| KR20150130455A (ko) | 2013-03-15 | 2015-11-23 | 뉴서트 사이언시스, 인크. | 지질 수준을 감소시키는 류신 및 니코틴산 |
| US10154971B2 (en) | 2013-06-17 | 2018-12-18 | Adamas Pharma, Llc | Methods of administering amantadine |
| WO2015009673A2 (en) | 2013-07-17 | 2015-01-22 | Bayer Medical Care Inc. | Cartridge-based in-bore infuser |
| WO2015027146A1 (en) | 2013-08-22 | 2015-02-26 | The General Hospital Corporation | Inhibitors of human 12/15-lipoxygenase |
| AU2015222754B2 (en) | 2014-02-27 | 2020-06-25 | Nusirt Sciences Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| JP2017519000A (ja) | 2014-06-12 | 2017-07-13 | リガンド・ファーマシューティカルズ・インコーポレイテッド | グルカゴンアンタゴニスト |
| US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
| KR102650751B1 (ko) | 2015-06-03 | 2024-03-22 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
| AU2016349381B2 (en) | 2015-11-05 | 2023-02-23 | The General Hospital Corporation | Intrathecal delivery of nucleic acid sequences encoding ABCD1 for treatment of adrenomyeloneuropathy |
| MX2018008021A (es) | 2015-12-30 | 2018-11-09 | Adamas Pharmaceuticals Inc | Metodos y composiciones para el tratamiento de trastornos relacionados con convulsiones. |
| CA3024479A1 (en) | 2016-05-16 | 2017-11-23 | Intarcia Therapeutics, Inc. | Glucagon-receptor selective polypeptides and methods of use thereof |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| JP7626362B2 (ja) | 2016-10-20 | 2025-02-07 | ペプトロン インコーポレイテッド | 中枢神経系に神経保護ポリペプチドを送達する方法 |
| MX2019008006A (es) | 2017-01-03 | 2019-08-29 | Intarcia Therapeutics Inc | Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco. |
| CN110545838A (zh) | 2017-03-08 | 2019-12-06 | 因塔西亚制药公司 | 用于从药物递送装置施用致恶心化合物的设备和方法 |
| WO2018200885A1 (en) | 2017-04-26 | 2018-11-01 | Neurocentria, Inc. | Magnesium compositions and methods of use |
| CN109583550A (zh) * | 2017-09-28 | 2019-04-05 | 振锋企业股份有限公司 | 非接触式数据载体 |
| WO2019160940A1 (en) | 2018-02-13 | 2019-08-22 | Ligand Pharmaceuticals Incorporated | Glucagon receptor antagonists |
| USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
| CN113195524A (zh) | 2018-10-11 | 2021-07-30 | 因塔西亚治疗公司 | 人类胰淀素类似物多肽和使用方法 |
| CN110613888B (zh) * | 2019-07-24 | 2022-03-08 | 南京中医药大学 | 耳塞式鼓室给药装置 |
| ES1247524Y (es) * | 2019-12-20 | 2020-08-28 | Probodelt S L | Dispositivo atrayente para dipteros |
| WO2025160155A1 (en) | 2024-01-22 | 2025-07-31 | The Broad Institute, Inc. | Epigenetic targeting of prion diseases |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732865A (en) | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
| US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US3995632A (en) | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
| US3987790A (en) * | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4256108A (en) * | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4243030A (en) | 1978-08-18 | 1981-01-06 | Massachusetts Institute Of Technology | Implantable programmed microinfusion apparatus |
| US4373527B1 (en) | 1979-04-27 | 1995-06-27 | Univ Johns Hopkins | Implantable programmable medication infusion system |
| US4340054A (en) | 1980-12-29 | 1982-07-20 | Alza Corporation | Dispenser for delivering fluids and solids |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4490256A (en) * | 1982-11-26 | 1984-12-25 | Sartorius Gmbh | Apparatus for static membrane filtration |
| US4552561A (en) | 1982-12-23 | 1985-11-12 | Alza Corporation | Body mounted pump housing and pump assembly employing the same |
| US4639244A (en) | 1983-05-03 | 1987-01-27 | Nabil I. Rizk | Implantable electrophoretic pump for ionic drugs and associated methods |
| US4610686A (en) * | 1983-11-02 | 1986-09-09 | Alza Corporation | Controlled delivery of haloperidol by an osmotic delivery system |
| US4615698A (en) * | 1984-03-23 | 1986-10-07 | Alza Corporation | Total agent osmotic delivery system |
| US4865845A (en) | 1986-03-21 | 1989-09-12 | Alza Corporation | Release rate adjustment of osmotic or diffusional delivery devices |
| US4874388A (en) | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
| US5034229A (en) | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US5180591A (en) | 1990-07-11 | 1993-01-19 | Alza Corporation | Delivery device with a protective sleeve |
| US5151093A (en) | 1990-10-29 | 1992-09-29 | Alza Corporation | Osmotically driven syringe with programmable agent delivery |
| GB9027422D0 (en) * | 1990-12-18 | 1991-02-06 | Scras | Osmotically driven infusion device |
| US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5223265A (en) | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5209746A (en) * | 1992-02-18 | 1993-05-11 | Alza Corporation | Osmotically driven delivery devices with pulsatile effect |
| US5308348A (en) | 1992-02-18 | 1994-05-03 | Alza Corporation | Delivery devices with pulsatile effect |
| US5456679A (en) | 1992-02-18 | 1995-10-10 | Alza Corporation | Delivery devices with pulsatile effect |
| US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| CA2166116A1 (en) * | 1993-06-23 | 1995-01-12 | John F. Mills | Method and apparatus for sealing implantable, membrane encapsulation devices |
| US5458888A (en) * | 1994-03-02 | 1995-10-17 | Andrx Pharmaceuticals, Inc. | Controlled release tablet formulation |
| US5678999A (en) * | 1994-08-08 | 1997-10-21 | Cicare; Augusto Ulderico | System for training helicopter pilots |
| US5690952A (en) * | 1995-06-07 | 1997-11-25 | Judy A. Magruder et al. | Implantable system for delivery of fluid-sensitive agents to animals |
| ES2246004T3 (es) | 1996-02-02 | 2006-02-01 | Alza Corporation | Liberacion prolongada de un agente activo usando un sistema implantable. |
-
1998
- 1998-07-23 MY MYPI98003363A patent/MY125849A/en unknown
- 1998-07-24 CA CA002297801A patent/CA2297801C/en not_active Expired - Fee Related
- 1998-07-24 KR KR1020007000797A patent/KR100600462B1/ko not_active Expired - Fee Related
- 1998-07-24 EP EP98937963A patent/EP1011642B1/en not_active Expired - Lifetime
- 1998-07-24 CN CNB988075237A patent/CN1198602C/zh not_active Expired - Fee Related
- 1998-07-24 TW TW087112143A patent/TW450817B/zh not_active IP Right Cessation
- 1998-07-24 US US09/121,878 patent/US6287295B1/en not_active Expired - Lifetime
- 1998-07-24 DE DE69840679T patent/DE69840679D1/de not_active Expired - Lifetime
- 1998-07-24 DE DE69837439T patent/DE69837439D1/de not_active Expired - Lifetime
- 1998-07-24 CO CO98042276A patent/CO4970812A1/es unknown
- 1998-07-24 JP JP2000503827A patent/JP2001510791A/ja active Pending
- 1998-07-24 AU AU86589/98A patent/AU8658998A/en not_active Abandoned
- 1998-07-24 AT AT07003466T patent/ATE425739T1/de not_active IP Right Cessation
- 1998-07-24 AT AT98937963T patent/ATE357911T1/de not_active IP Right Cessation
- 1998-07-24 ZA ZA986631A patent/ZA986631B/xx unknown
- 1998-07-24 WO PCT/US1998/014812 patent/WO1999004767A2/en not_active Ceased
- 1998-07-24 AR ARP980103662A patent/AR016543A1/es unknown
-
2001
- 2001-05-18 US US09/859,428 patent/US6923800B2/en not_active Expired - Lifetime
-
2005
- 2005-07-13 JP JP2005204469A patent/JP2005306885A/ja not_active Withdrawn
- 2005-08-02 US US11/196,758 patent/US20050281877A1/en not_active Abandoned
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| US6923800B2 (en) | 2005-08-02 |
| US20010027311A1 (en) | 2001-10-04 |
| DE69837439D1 (de) | 2007-05-10 |
| CA2297801C (en) | 2009-10-27 |
| ZA986631B (en) | 1999-02-10 |
| EP1011642B1 (en) | 2007-03-28 |
| KR20010022224A (ko) | 2001-03-15 |
| CA2297801A1 (en) | 1999-02-04 |
| JP2005306885A (ja) | 2005-11-04 |
| CN1198602C (zh) | 2005-04-27 |
| TW450817B (en) | 2001-08-21 |
| CN1265031A (zh) | 2000-08-30 |
| EP1011642A2 (en) | 2000-06-28 |
| DE69840679D1 (de) | 2009-04-30 |
| ATE357911T1 (de) | 2007-04-15 |
| CO4970812A1 (es) | 2000-11-07 |
| US20050281877A1 (en) | 2005-12-22 |
| MY125849A (en) | 2006-08-30 |
| KR100600462B1 (ko) | 2006-07-13 |
| WO1999004767A2 (en) | 1999-02-04 |
| US6287295B1 (en) | 2001-09-11 |
| ATE425739T1 (de) | 2009-04-15 |
| WO1999004767A3 (en) | 1999-04-22 |
| HK1028739A1 (en) | 2001-03-02 |
| AR016543A1 (es) | 2001-07-25 |
| AU8658998A (en) | 1999-02-16 |
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