JP2001507571A - クローン化グルカゴン様ペプチド2受容体 - Google Patents
クローン化グルカゴン様ペプチド2受容体Info
- Publication number
- JP2001507571A JP2001507571A JP52605098A JP52605098A JP2001507571A JP 2001507571 A JP2001507571 A JP 2001507571A JP 52605098 A JP52605098 A JP 52605098A JP 52605098 A JP52605098 A JP 52605098A JP 2001507571 A JP2001507571 A JP 2001507571A
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- glp
- polynucleotide
- dna
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.GLP-2受容体をコードする単離されたポリヌクレオチド。 2.配列番号12のアミノ酸67〜553のアミノ酸配列を有するヒトGLP-2受容体をコ ードする、請求項1に記載の単離されたポリヌクレオチド。 3.配列番号11のヌクレオチド318〜1780を含む、請求項2に記載の単離された ポリヌクレオチド。 4.配列番号2のアミノ酸67〜550のアミノ酸配列を有するラットGLP-2受容体を コードする、請求項1に記載の単離されたポリヌクレオチド。 5.配列番号1のヌクレオチド335〜1789を有する、請求項4に記載の単離され たポリヌクレオチド。 6.請求項3または5に記載のポリヌクレオチドと高ストリンジェンシー条件下 でハイブリダイズする、単離されたポリヌクレオチド。 7.少なくとも15個のヌクレオチドを含むオリゴヌクレオチドであって、請求項 1〜6のいずれかに記載のポリヌクレオチドと選択的にハイブリダイズするポリ ヌクレオチド配列を有する該オリゴヌクレオチド。 8.前記オリゴヌクレオチドのヌクレオチド配列が請求項3または5に記載のポ リヌクレオチドの1領域に完全に一致する、請求項7に記載のオリゴヌクレオチ ド。 9.前記オリゴヌクレオチドのヌクレオチド配列が請求項3および5に記載のポ リヌクレオチドに共通する1領域に完全に一致する、請求項7に記載のオリゴヌ クレオチド。 10.標識化形態の、請求項1〜6のいずれかに記載のポリヌクレオチドから選択 されるポリヌクレオチド、および請求項7〜9のいずれかに記載のオリゴヌクレ オチド。 11.GLP-2受容体をコードする、請求項1〜6のいずれかに記載のポリヌクレオ チド、および該ポリヌクレオチドの発現をために機能しうる形でそれに連結され た発現制御エレメントを含む組換えポリヌクレオチド。 12.請求項1〜6のいずれかに記載のポリヌクレオチドを発現しうる形 で細胞に組み込むことによって遺伝子工学的に作製された該細胞。 13.哺乳動物細胞である、請求項11に記載の細胞。 14.GLP-2受容体に選択的に結合する抗体。 15.組換えGLP-2受容体。 16.配列番号2のアミノ酸67〜553を含む、請求項15に記載のGLP-2受容体。 17.配列番号12のアミノ酸67〜550を含む、請求項15に記載のGLP-2受容体。 18.以下の工程を含む、GLP-2受容体リガンドの同定方法: (1)候補リガンドを請求項12に記載の細胞または該細胞から得た膜調製物と共 にインキュベートする工程;及び、次に (2)GLP-2受容体と候補リガンドとの結合が起こったかどうかを確認する工程。 19.請求項18に記載の方法によって同定されたGLP-2受容体リガンド。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76722496A | 1996-12-13 | 1996-12-13 | |
US08/767,224 | 1996-12-13 | ||
US78772197A | 1997-01-24 | 1997-01-24 | |
US08/787,721 | 1997-01-24 | ||
US08/845,546 | 1997-04-24 | ||
US08/845,546 US6077949A (en) | 1996-12-13 | 1997-04-24 | Cloned glucagon-like peptide 2 receptors |
PCT/CA1997/000969 WO1998025955A2 (en) | 1996-12-13 | 1997-12-15 | Cloned glucagon-like peptide-2 receptors |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001507571A true JP2001507571A (ja) | 2001-06-12 |
JP2001507571A5 JP2001507571A5 (ja) | 2005-07-14 |
JP4106094B2 JP4106094B2 (ja) | 2008-06-25 |
Family
ID=27419634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52605098A Expired - Fee Related JP4106094B2 (ja) | 1996-12-13 | 1997-12-15 | クローン化グルカゴン様ペプチド2受容体 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0946591B1 (ja) |
JP (1) | JP4106094B2 (ja) |
AT (1) | ATE358682T1 (ja) |
AU (1) | AU722821B2 (ja) |
CA (1) | CA2274989C (ja) |
DE (1) | DE69737561T2 (ja) |
DK (2) | DK0946591T3 (ja) |
ES (1) | ES2287959T3 (ja) |
WO (1) | WO1998025955A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003519195A (ja) * | 1999-12-30 | 2003-06-17 | エヌピーエス アレリックス コーポレーション | Glp−2製剤 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8592553B2 (en) | 1996-12-13 | 2013-11-26 | Nps Pharmaceuticals, Inc. | Cloned glucagon-like peptide-2 receptors |
WO2001079290A2 (en) * | 2000-04-13 | 2001-10-25 | 1149336 Ontario Inc. | Glp-2 receptor gene promoter and uses thereof |
DE60134251D1 (de) | 2000-09-18 | 2008-07-10 | Sanos Bioscience As | Verwendung von glp-2-peptiden |
US7371721B2 (en) | 2000-09-18 | 2008-05-13 | Sanos Bioscience A/S | Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes |
WO2019086559A1 (fr) | 2017-10-31 | 2019-05-09 | Adocia | Composition comprenant un agoniste du recepteur du glp-2 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK39892D0 (da) * | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
CA2168448A1 (en) * | 1993-08-09 | 1995-02-16 | Michael P. Graziano | Human glucagon-like 1 peptide receptor |
US5990077A (en) * | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
-
1997
- 1997-12-15 DE DE69737561T patent/DE69737561T2/de not_active Expired - Lifetime
- 1997-12-15 AT AT97951013T patent/ATE358682T1/de not_active IP Right Cessation
- 1997-12-15 AU AU54712/98A patent/AU722821B2/en not_active Ceased
- 1997-12-15 JP JP52605098A patent/JP4106094B2/ja not_active Expired - Fee Related
- 1997-12-15 DK DK97951013T patent/DK0946591T3/da active
- 1997-12-15 ES ES97951013T patent/ES2287959T3/es not_active Expired - Lifetime
- 1997-12-15 CA CA2274989A patent/CA2274989C/en not_active Expired - Fee Related
- 1997-12-15 EP EP97951013A patent/EP0946591B1/en not_active Expired - Lifetime
- 1997-12-15 WO PCT/CA1997/000969 patent/WO1998025955A2/en active IP Right Grant
-
1999
- 1999-06-11 DK DKPA199900825A patent/DK177593B1/da not_active IP Right Cessation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003519195A (ja) * | 1999-12-30 | 2003-06-17 | エヌピーエス アレリックス コーポレーション | Glp−2製剤 |
JP5001498B2 (ja) * | 1999-12-30 | 2012-08-15 | エヌピーエス ファーマシューティカルズ インコーポレイテッド | Glp−2製剤 |
JP2014159463A (ja) * | 1999-12-30 | 2014-09-04 | Nps Pharmaceuticals Inc | Glp−2製剤 |
Also Published As
Publication number | Publication date |
---|---|
WO1998025955A2 (en) | 1998-06-18 |
DE69737561T2 (de) | 2008-03-06 |
ATE358682T1 (de) | 2007-04-15 |
DE69737561D1 (de) | 2007-05-16 |
AU722821B2 (en) | 2000-08-10 |
CA2274989A1 (en) | 1998-06-18 |
DK177593B1 (da) | 2013-11-11 |
CA2274989C (en) | 2012-01-31 |
AU5471298A (en) | 1998-07-03 |
ES2287959T3 (es) | 2007-12-16 |
JP4106094B2 (ja) | 2008-06-25 |
EP0946591A2 (en) | 1999-10-06 |
EP0946591B1 (en) | 2007-04-04 |
WO1998025955A3 (en) | 1998-07-30 |
DK0946591T3 (da) | 2007-08-13 |
DK199900825A (da) | 1999-08-04 |
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