JP2001506668A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2001506668A5 JP2001506668A5 JP1998528380A JP52838098A JP2001506668A5 JP 2001506668 A5 JP2001506668 A5 JP 2001506668A5 JP 1998528380 A JP1998528380 A JP 1998528380A JP 52838098 A JP52838098 A JP 52838098A JP 2001506668 A5 JP2001506668 A5 JP 2001506668A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogenolysis
- tosyl
- benzyloxycarbonyl
- acyl
- groups include
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002252 acyl group Chemical group 0.000 description 2
- 125000006242 amine protecting group Chemical group 0.000 description 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 2
- 238000007327 hydrogenolysis reaction Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9626845.3A GB9626845D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
| GB9626852.9 | 1996-12-24 | ||
| GB9626846.1 | 1996-12-24 | ||
| GBGB9626846.1A GB9626846D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
| GBGB9626852.9A GB9626852D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
| GB9626845.3 | 1996-12-24 | ||
| GBGB9720536.3A GB9720536D0 (en) | 1997-09-27 | 1997-09-27 | Chemical compounds |
| GB9720536.3 | 1997-09-27 | ||
| GBGB9722730.0A GB9722730D0 (en) | 1997-10-29 | 1997-10-29 | Chemical compounds |
| GB9722730.0 | 1997-10-29 | ||
| PCT/EP1997/007197 WO1998028319A1 (en) | 1996-12-24 | 1997-12-22 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001506668A JP2001506668A (ja) | 2001-05-22 |
| JP2001506668A5 true JP2001506668A5 (https=) | 2007-11-08 |
| JP4156035B2 JP4156035B2 (ja) | 2008-09-24 |
Family
ID=27517393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52838098A Expired - Fee Related JP4156035B2 (ja) | 1996-12-24 | 1997-12-22 | ２−（プリン−９−イル）−テトラヒドロフラン−３，４−ジオール誘導体 |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6426337B1 (https=) |
| EP (1) | EP0948509B1 (https=) |
| JP (1) | JP4156035B2 (https=) |
| KR (1) | KR20000069682A (https=) |
| CN (1) | CN1246124A (https=) |
| AP (1) | AP1105A (https=) |
| AR (1) | AR011044A1 (https=) |
| AT (1) | ATE226212T1 (https=) |
| AU (1) | AU733684B2 (https=) |
| BG (1) | BG63310B1 (https=) |
| BR (1) | BR9714082A (https=) |
| CA (1) | CA2275271A1 (https=) |
| CO (1) | CO4940488A1 (https=) |
| CZ (1) | CZ230999A3 (https=) |
| DE (1) | DE69716468T2 (https=) |
| DK (1) | DK0948509T3 (https=) |
| EA (1) | EA001714B1 (https=) |
| EE (1) | EE04019B1 (https=) |
| ES (1) | ES2186015T3 (https=) |
| GE (1) | GEP20022656B (https=) |
| HU (1) | HUP0000673A3 (https=) |
| ID (1) | ID22271A (https=) |
| IL (1) | IL130547A0 (https=) |
| IS (1) | IS5089A (https=) |
| NO (1) | NO312840B1 (https=) |
| NZ (1) | NZ336332A (https=) |
| OA (1) | OA11071A (https=) |
| PE (1) | PE27499A1 (https=) |
| PL (1) | PL334218A1 (https=) |
| PT (1) | PT948509E (https=) |
| SI (1) | SI0948509T1 (https=) |
| SK (1) | SK86599A3 (https=) |
| TR (1) | TR199901905T2 (https=) |
| TW (1) | TW528755B (https=) |
| WO (1) | WO1998028319A1 (https=) |
| YU (1) | YU29099A (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
| PE20000270A1 (es) * | 1998-02-14 | 2000-05-20 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| GB9813540D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| GB9813554D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
| AU750462B2 (en) * | 1998-06-23 | 2002-07-18 | Glaxo Group Limited | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
| GB9930082D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
| US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
| GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
| WO2002072067A2 (en) * | 2001-03-12 | 2002-09-19 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
| JP2002338593A (ja) * | 2001-05-22 | 2002-11-27 | Ajinomoto Co Inc | β−Ｄ−リボフラノース誘導体又はその光学異性体の製造方法 |
| PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
| SI2612862T1 (sl) | 2004-05-13 | 2017-04-26 | Icos Corporation | Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta |
| GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| CN103087133B (zh) * | 2004-05-26 | 2016-09-14 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| CN101437526A (zh) * | 2004-09-20 | 2009-05-20 | 伊诺泰克制药公司 | 嘌呤衍生物及其用法 |
| GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
| GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| RU2421464C2 (ru) | 2005-10-21 | 2011-06-20 | Новартис Аг | Человеческие антитела к il-13 и их терапевтическое применение |
| GB0523845D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel salts |
| EA015683B1 (ru) * | 2005-11-30 | 2011-10-31 | Инотек Фармасьютикалз Корпорейшн | Производные пурина и способы их применения |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
| WO2008037477A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as p13k lipid kinase inhibitors |
| CN101522682A (zh) | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
| MX2010007604A (es) | 2008-01-11 | 2010-08-02 | Novartis Ag | Pirimidinas como inhibidores de cinasa. |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| CN102271683B (zh) | 2008-11-13 | 2014-07-09 | 吉里德卡利斯托加公司 | 恶性血液病的治疗 |
| PT2391366E (pt) | 2009-01-29 | 2013-02-05 | Novartis Ag | Benzimidazoles substituídos para o tratamento de astrocitomas |
| CN102458410A (zh) * | 2009-04-20 | 2012-05-16 | 吉联亚·卡利斯托加有限责任公司 | 治疗实体瘤的方法 |
| EA201270184A1 (ru) | 2009-07-21 | 2012-08-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Лечение расстройств печени ингибиторами pi3k |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| JP5781510B2 (ja) | 2009-08-12 | 2015-09-24 | ノバルティス アーゲー | ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用 |
| PE20121148A1 (es) | 2009-08-17 | 2012-09-07 | Intellikine Llc | Compuestos heterociclicos y usos de los mismos |
| JP5775871B2 (ja) | 2009-08-20 | 2015-09-09 | ノバルティス アーゲー | ヘテロ環式オキシム化合物 |
| JP2013513562A (ja) * | 2009-12-09 | 2013-04-22 | グラクソ グループ リミテッド | 新規の医療用使用 |
| LT2523669T (lt) | 2010-01-11 | 2017-04-25 | Inotek Pharmaceuticals Corporation | Akispūdžio mažinimo būdas, derinys ir rinkinys |
| PH12012501906A1 (en) | 2010-03-26 | 2013-01-14 | Inotek Pharmaceuticals Corp | Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| WO2012096866A2 (en) * | 2011-01-10 | 2012-07-19 | Inverseon, Inc. | Use of beta-adrenergic inverse agonists for smoking cessation |
| WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
| WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
| WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
| EA026655B1 (ru) | 2011-09-15 | 2017-05-31 | Новартис Аг | 6-ЗАМЕЩЕННЫЕ 3-(ХИНОЛИН-6-ИЛТИО)[1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ c-MET ТИРОЗИНКИНАЗЫ |
| CA2856803A1 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
| PT2807178T (pt) | 2012-01-26 | 2017-08-08 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação |
| SI2834241T1 (sl) | 2012-03-05 | 2021-06-30 | Gilead Calistoga Llc | Polimorfne oblike (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilkinazolin-4(3H)-ONA |
| JP2015512425A (ja) | 2012-04-03 | 2015-04-27 | ノバルティス アーゲー | チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用 |
| ES2660822T3 (es) * | 2012-09-21 | 2018-03-26 | Rhode Island Hospital | Inhibidores de beta-hidrolasa para tratamiento del cáncer |
| NZ630759A (en) | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
| EP2968340A4 (en) | 2013-03-15 | 2016-08-10 | Intellikine Llc | COMBINING KINASE INHIBITORS AND USES THEREOF |
| WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
| WO2015095601A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| US9708327B2 (en) | 2013-12-20 | 2017-07-18 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one |
| EP3154960A1 (en) | 2014-06-13 | 2017-04-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| ES2831416T3 (es) | 2014-07-31 | 2021-06-08 | Novartis Ag | Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR |
| TWI767937B (zh) | 2016-09-09 | 2022-06-21 | 美商卡利泰拉生物科技公司 | 外核苷酸酶抑制劑及其使用方法 |
| AU2019288495B2 (en) | 2018-06-21 | 2024-02-08 | Antengene Therapeutics Limited | Ectonucleotidase inhibitors and methods of use thereof |
| KR20220024629A (ko) * | 2019-06-20 | 2022-03-03 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 엑토뉴클레오티다제 억제제 및 이의 사용 방법 |
| TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE768925A (fr) | 1970-06-30 | 1971-11-03 | Takeda Chemical Industries Ltd | Derives d'adenosine et procede de preparation |
| DE2034785A1 (de) | 1970-07-14 | 1972-01-20 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | Adenosin 5 carbonsäurederivate |
| CA1019727A (en) | 1971-03-18 | 1977-10-25 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
| BE789773A (fr) | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
| US3864483A (en) | 1972-03-22 | 1975-02-04 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
| CA1082695A (en) | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Process for preparing adenosine-5'-carboxamides |
| US3966917A (en) | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
| DE2621470A1 (de) * | 1976-05-14 | 1977-12-01 | Pharma Waldhof Gmbh & Co | Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung |
| US4167565A (en) | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
| AU8379182A (en) | 1981-06-04 | 1982-12-09 | Procter & Gamble Company, The | Composition of salicylates and purine derivatives |
| CA1239397A (en) | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
| DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
| US4496643A (en) | 1984-03-23 | 1985-01-29 | Eastman Kodak Company | Two-component dry electrostatic developer composition containing onium charge control agent |
| EP0300145A3 (en) | 1984-04-18 | 1989-08-30 | Whitby Research Incorporated | N-6 phenyl substituted adenosine derivatives as cardiac vasodilators |
| US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
| US4663313A (en) | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
| AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
| US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
| US4755594A (en) | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
| US5106837A (en) | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
| US4767747A (en) | 1986-08-28 | 1988-08-30 | Warner-Lambert Company | Method for treating congestive heart failure with N6 -acenaphthyl adenosine |
| WO1988003147A1 (en) | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
| AU8274187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
| NL8702926A (nl) | 1986-12-15 | 1988-07-01 | Sandoz Ag | Nieuwe furanuronzuurderivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
| PT86660B (pt) | 1987-02-04 | 1992-02-28 | Ciba Geigy Ag | Processo para a preparacao de derivados de adenosina-5'-carboxamida |
| US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| US4962194A (en) | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
| US5219840A (en) | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
| LU87181A1 (fr) | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
| JPH0725785B2 (ja) | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
| US5055569A (en) | 1989-10-19 | 1991-10-08 | G. D. Searle & Co. | N-(6)-substituted adenosine compounds |
| IE903747A1 (en) | 1989-10-19 | 1991-04-24 | Searle & Co | Method of treating gastrointestinal motility disorders |
| US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
| US5280015A (en) | 1990-09-05 | 1994-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides |
| SG80526A1 (en) | 1990-09-25 | 2001-05-22 | Rhone Poulenc Rorer Int | Compounds having antihypertensive and anti- ischemic properies |
| FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| FR2687678B1 (fr) | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
| US5424297A (en) | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
| WO1994002497A1 (en) | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Sulfo-derivatives of adenosine |
| GB9301000D0 (en) | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
| EP0684953A4 (en) | 1993-02-03 | 1999-12-22 | Gensia Inc | ADENOSINE KINASE INHIBITORS COMPRISING LYXOFURANOSYL DERIVATIVES. |
| DE69428536T2 (de) | 1993-07-13 | 2002-06-06 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | A3 -adenosin -rezeptor agonisten |
| US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
| WO1995018817A1 (fr) | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
| GB9414193D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
| GB9414208D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
-
1997
- 1997-12-16 TW TW086118941A patent/TW528755B/zh active
- 1997-12-22 NZ NZ336332A patent/NZ336332A/xx unknown
- 1997-12-22 PL PL97334218A patent/PL334218A1/xx unknown
- 1997-12-22 ES ES97953888T patent/ES2186015T3/es not_active Expired - Lifetime
- 1997-12-22 AR ARP970106111A patent/AR011044A1/es not_active Application Discontinuation
- 1997-12-22 JP JP52838098A patent/JP4156035B2/ja not_active Expired - Fee Related
- 1997-12-22 CN CN97181854A patent/CN1246124A/zh active Pending
- 1997-12-22 DK DK97953888T patent/DK0948509T3/da active
- 1997-12-22 EE EEP199900312A patent/EE04019B1/xx not_active IP Right Cessation
- 1997-12-22 YU YU29099A patent/YU29099A/sh unknown
- 1997-12-22 IL IL13054797A patent/IL130547A0/xx unknown
- 1997-12-22 AP APAP/P/1999/001572A patent/AP1105A/en active
- 1997-12-22 CZ CZ992309A patent/CZ230999A3/cs unknown
- 1997-12-22 KR KR1019997005729A patent/KR20000069682A/ko not_active Ceased
- 1997-12-22 AT AT97953888T patent/ATE226212T1/de not_active IP Right Cessation
- 1997-12-22 US US09/331,526 patent/US6426337B1/en not_active Expired - Lifetime
- 1997-12-22 AU AU57622/98A patent/AU733684B2/en not_active Ceased
- 1997-12-22 PT PT97953888T patent/PT948509E/pt unknown
- 1997-12-22 HU HU0000673A patent/HUP0000673A3/hu unknown
- 1997-12-22 SI SI9730455T patent/SI0948509T1/xx unknown
- 1997-12-22 EP EP97953888A patent/EP0948509B1/en not_active Expired - Lifetime
- 1997-12-22 DE DE69716468T patent/DE69716468T2/de not_active Expired - Lifetime
- 1997-12-22 BR BR9714082-1A patent/BR9714082A/pt not_active IP Right Cessation
- 1997-12-22 ID IDW990575A patent/ID22271A/id unknown
- 1997-12-22 WO PCT/EP1997/007197 patent/WO1998028319A1/en not_active Ceased
- 1997-12-22 EA EA199900494A patent/EA001714B1/ru not_active IP Right Cessation
- 1997-12-22 GE GEAP19974870A patent/GEP20022656B/en unknown
- 1997-12-22 CA CA002275271A patent/CA2275271A1/en not_active Abandoned
- 1997-12-22 TR TR1999/01905T patent/TR199901905T2/xx unknown
- 1997-12-22 SK SK865-99A patent/SK86599A3/sk unknown
- 1997-12-23 CO CO97074732A patent/CO4940488A1/es unknown
- 1997-12-23 PE PE1997001160A patent/PE27499A1/es not_active Application Discontinuation
-
1999
- 1999-06-22 IS IS5089A patent/IS5089A/is unknown
- 1999-06-22 BG BG103518A patent/BG63310B1/bg unknown
- 1999-06-22 OA OA9900139A patent/OA11071A/en unknown
- 1999-06-23 NO NO19993114A patent/NO312840B1/no unknown
-
2001
- 2001-12-19 US US10/025,678 patent/US6528494B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2001506668A5 (https=) | ||
| DE69509624D1 (de) | Verfahren zur Herstellung von 1-(2'-Deoxy-2',2'-difluoro-D-ribofuranosyl)-4-amino-pyrimidin-2-on-hydrochlorid | |
| FR2820739B1 (fr) | Derive d'acide amine et gelifiant, composition de gel et cosmetique le contenant, et procedes de preparation correspondants | |
| JP2000512339A5 (https=) | ||
| BR9916857A (pt) | 4 heteroaril diarilaminas | |
| DE69634473D1 (de) | Universelles Nachrichtenablieferungssystem | |
| BR0009480A (pt) | Soluções de poliuretano com unidades de estrutura de alcoxissilano | |
| HUP0104756A2 (hu) | Poliol/olaj szuszpenziók a fehérjék folyamatos kibocsátásához | |
| DK0914440T3 (da) | Nukleinsyrevaccination mod parvovirusinfektioner | |
| DE60013021D1 (de) | Herstellung von S,S und R,S Aminosäuren-Isosteren | |
| IT1276965B1 (it) | Dispositivo indipendente dall'apparato motore principale, impiegabile come organo di manovra attivo, per navi | |
| DE69828191D1 (de) | Verfahren zur herstellung von 2,6-dialkylnaphthalin | |
| TR200001102T2 (tr) | İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları. | |
| HUT77004A (hu) | Antiaritmiás szerekként felhasználható nitro-benzamidok, előállításuk és ezeket tartalmazó gyógyszerkészítmények | |
| ATE211489T1 (de) | Chitosan enthaltende zusammensetzung | |
| IT1284097B1 (it) | Processo in sospensione per la preparazione di copolimeri elastomerici dell'etilene | |
| DE59802620D1 (de) | Verfahren zur Herstellung von trans-(R,R)-Actinol | |
| MX9605854A (es) | Utilizacion de un poliholosido en una composicion limpiadora o desmaquillante, y composicion que lo contiene. | |
| IT1293535B1 (it) | Perfezionamento nel procedimento di attacco chimico anisotropo dell'ossido di silicio, in particolare nella fabbricazione di | |
| TR199700109A2 (tr) | Sübstitüe edilmis olan tiofenilalkenil karbonik asit guanidid'leri, bunlarin üretilmesine mahsus usul, bunlarin ilac veya diyagnostik olarak kullanilmalari ve bunlari iceren ilac. | |
| DE59812284D1 (de) | Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethyl-piperidin | |
| JP2002511904A5 (https=) | ||
| FR2766819B1 (fr) | Nouvelles sulfonamides derivees d'anilines substituees utiles comme medicaments | |
| CA2130124A1 (en) | Anomeric fluororibosyl amines | |
| FR2753968B1 (fr) | Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |