JP2001505191A5 - - Google Patents

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Publication number
JP2001505191A5
JP2001505191A5 JP1998520553A JP52055398A JP2001505191A5 JP 2001505191 A5 JP2001505191 A5 JP 2001505191A5 JP 1998520553 A JP1998520553 A JP 1998520553A JP 52055398 A JP52055398 A JP 52055398A JP 2001505191 A5 JP2001505191 A5 JP 2001505191A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998520553A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001505191A (ja
JP3626503B2 (ja
Filing date
Publication date
Priority claimed from US08/739,109 external-priority patent/US5859228A/en
Priority claimed from US08/870,930 external-priority patent/US6168778B1/en
Priority claimed from US08/897,351 external-priority patent/US6051698A/en
Application filed filed Critical
Priority claimed from PCT/US1997/018944 external-priority patent/WO1998018480A1/en
Publication of JP2001505191A publication Critical patent/JP2001505191A/ja
Application granted granted Critical
Publication of JP3626503B2 publication Critical patent/JP3626503B2/ja
Publication of JP2001505191A5 publication Critical patent/JP2001505191A5/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP52055398A 1996-10-25 1997-10-17 血管内皮増殖因子(vegf)核酸リガンド複合体 Expired - Lifetime JP3626503B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/739,109 US5859228A (en) 1995-05-04 1996-10-25 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US08/739,109 1996-10-25
US08/870,930 1997-06-06
US08/870,930 US6168778B1 (en) 1990-06-11 1997-06-06 Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US08/897,351 1997-07-21
US08/897,351 US6051698A (en) 1997-06-06 1997-07-21 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
PCT/US1997/018944 WO1998018480A1 (en) 1996-10-25 1997-10-17 Vascular endothelial growth factor (vegf) nucleic acid ligand complexes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004301813A Division JP4160038B2 (ja) 1996-10-25 2004-10-15 血管内皮増殖因子(vegf)核酸リガンド複合体

Publications (3)

Publication Number Publication Date
JP2001505191A JP2001505191A (ja) 2001-04-17
JP3626503B2 JP3626503B2 (ja) 2005-03-09
JP2001505191A5 true JP2001505191A5 (enExample) 2005-06-16

Family

ID=27419245

Family Applications (2)

Application Number Title Priority Date Filing Date
JP52055398A Expired - Lifetime JP3626503B2 (ja) 1996-10-25 1997-10-17 血管内皮増殖因子(vegf)核酸リガンド複合体
JP2004301813A Expired - Lifetime JP4160038B2 (ja) 1996-10-25 2004-10-15 血管内皮増殖因子(vegf)核酸リガンド複合体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004301813A Expired - Lifetime JP4160038B2 (ja) 1996-10-25 2004-10-15 血管内皮増殖因子(vegf)核酸リガンド複合体

Country Status (18)

Country Link
EP (2) EP0957929B1 (enExample)
JP (2) JP3626503B2 (enExample)
KR (1) KR100514929B1 (enExample)
AT (1) ATE318143T1 (enExample)
AU (1) AU733674B2 (enExample)
CA (1) CA2269072C (enExample)
DE (3) DE122006000029I2 (enExample)
DK (1) DK0957929T3 (enExample)
ES (1) ES2259188T3 (enExample)
FR (1) FR06C0021I2 (enExample)
GE (1) GEP20094799B (enExample)
IL (2) IL129497A0 (enExample)
LU (1) LU91252I2 (enExample)
NL (1) NL300234I2 (enExample)
NZ (1) NZ334859A (enExample)
PT (1) PT957929E (enExample)
RU (1) RU2177950C2 (enExample)
WO (1) WO1998018480A1 (enExample)

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US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
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US9303262B2 (en) 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
US8039443B2 (en) 2002-11-21 2011-10-18 Archemix Corporation Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
WO2004050899A2 (en) 2002-12-03 2004-06-17 Archemix Corporation Method for in vitro selection of 2’-substituted nucleic acids
RU2234097C1 (ru) * 2003-03-05 2004-08-10 Московский областной научно-исследовательский клинический институт Способ диагностики саркомы капоши
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
WO2004094614A2 (en) 2003-04-21 2004-11-04 Archemix Corp. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
CL2004001996A1 (es) * 2003-08-08 2005-05-06 Eyetech Pharmaceuticals Inc Aptameros anti-vegf (factor de crecimiento endotelial vascular) con bloqueo nucleotidico 5'-5' o 3'-3' invertido, composicion que lo contiene, util para trastornos de neovascularizacion.
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
ES2674129T3 (es) 2004-02-12 2018-06-27 Archemix Llc Agentes terapéuticos de base aptámeros útiles en el tratamiento de trastornos relacionados con complemento
JP2007532662A (ja) * 2004-04-13 2007-11-15 (オーエスアイ)アイテツク・インコーポレーテツド 高分子量の立体的な基へ抱合された核酸アプタマー
US7579450B2 (en) 2004-04-26 2009-08-25 Archemix Corp. Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
WO2006029258A2 (en) 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US7566701B2 (en) 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
EP1807107B1 (en) 2004-11-02 2011-09-07 Archemix Corp. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
MX2007016561A (es) 2005-06-30 2008-03-10 Archemix Corp Materiales y metodos para la generacion de transcriptos de acido nucleico completamente modificados en la posicion 2.
US8101385B2 (en) 2005-06-30 2012-01-24 Archemix Corp. Materials and methods for the generation of transcripts comprising modified nucleotides
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EP1931352B1 (en) 2005-08-22 2016-04-13 The Regents of The University of California Tlr agonists
KR100877824B1 (ko) 2005-11-11 2009-01-12 한국생명공학연구원 E2epf ucp-vhl 상호작용 및 그 용도
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JP5425642B2 (ja) 2007-02-07 2014-02-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 合成tlrアゴニストの結合体およびそのための使用
US20110229498A1 (en) 2008-05-08 2011-09-22 The Johns Hopkins University Compositions and methods for modulating an immune response
ES2600781T3 (es) * 2008-12-04 2017-02-10 Curna, Inc. Tratamiento para enfermedades relacionadas con el factor de crecimiento del endotelio vascular (vegf) mediante la inhibición de transcritos antisentido naturales de vegf
KR101800833B1 (ko) 2009-03-20 2017-11-23 씨엘에스엔 래버러토리스, 인코퍼레이티드 폴리아민 유도체
WO2011061351A1 (en) 2009-11-23 2011-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Aptamers directed against the matrix protein-1 of type a influenza viruses and uses thereof
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制vegf-a受體交互作用的經修飾結合性蛋白質
WO2012040524A1 (en) * 2010-09-24 2012-03-29 Mallinckrodt Llc Aptamer conjugates for targeting of therapeutic and/or diagnostic nanocarriers
US20150337308A1 (en) 2012-04-11 2015-11-26 Chu De Bordeaux Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
ES2912033T3 (es) 2012-10-23 2022-05-24 Caris Science Inc Aptámeros y usos de los mismos
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JP6249453B2 (ja) 2013-03-22 2017-12-20 国立大学法人 東京大学 Il−17に対するアプタマー及びその使用
EP3019243A4 (en) 2013-07-12 2017-03-15 Ophthotech Corporation Methods for treating or preventing ophthalmological conditions
CN105980615A (zh) 2013-08-28 2016-09-28 卡里斯生命科学瑞士控股有限公司 寡核苷酸探针及其用途
PL3230316T3 (pl) 2014-12-11 2022-05-02 Bayer Healthcare Llc Leczenie zwyrodnienia plamki żółtej związanego z wiekiem z małą aktywną zmianą neowaskularyzacji naczyniówki
WO2016108264A1 (ja) 2014-12-29 2016-07-07 株式会社ボナック 核酸分子を安定に含有する組成物
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
IL256634B2 (en) 2015-06-29 2025-08-01 Caris Science Inc Therapeutic oligonucleotides
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
WO2017046140A1 (en) 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
EP4339288A3 (en) 2016-03-18 2024-06-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
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EP3332812A1 (en) 2016-12-07 2018-06-13 Rheinische Friedrich-Wilhelms-Universität Bonn Nucleic acid-based assembly and use of the assembly in cancer therapy
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
TW201906635A (zh) 2017-07-04 2019-02-16 日商第一三共股份有限公司 伴隨視細胞變性的視網膜變性的疾病用藥
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