JP2001505191A5 - - Google Patents

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Publication number
JP2001505191A5
JP2001505191A5 JP1998520553A JP52055398A JP2001505191A5 JP 2001505191 A5 JP2001505191 A5 JP 2001505191A5 JP 1998520553 A JP1998520553 A JP 1998520553A JP 52055398 A JP52055398 A JP 52055398A JP 2001505191 A5 JP2001505191 A5 JP 2001505191A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998520553A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001505191A (ja
JP3626503B2 (ja
Filing date
Publication date
Priority claimed from US08/739,109 external-priority patent/US5859228A/en
Priority claimed from US08/870,930 external-priority patent/US6168778B1/en
Priority claimed from US08/897,351 external-priority patent/US6051698A/en
Application filed filed Critical
Priority claimed from PCT/US1997/018944 external-priority patent/WO1998018480A1/en
Publication of JP2001505191A publication Critical patent/JP2001505191A/ja
Application granted granted Critical
Publication of JP3626503B2 publication Critical patent/JP3626503B2/ja
Publication of JP2001505191A5 publication Critical patent/JP2001505191A5/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP52055398A 1996-10-25 1997-10-17 血管内皮増殖因子(vegf)核酸リガンド複合体 Expired - Lifetime JP3626503B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/739,109 US5859228A (en) 1995-05-04 1996-10-25 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US08/739,109 1996-10-25
US08/870,930 US6168778B1 (en) 1990-06-11 1997-06-06 Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US08/870,930 1997-06-06
US08/897,351 US6051698A (en) 1997-06-06 1997-07-21 Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US08/897,351 1997-07-21
PCT/US1997/018944 WO1998018480A1 (en) 1996-10-25 1997-10-17 Vascular endothelial growth factor (vegf) nucleic acid ligand complexes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004301813A Division JP4160038B2 (ja) 1996-10-25 2004-10-15 血管内皮増殖因子(vegf)核酸リガンド複合体

Publications (3)

Publication Number Publication Date
JP2001505191A JP2001505191A (ja) 2001-04-17
JP3626503B2 JP3626503B2 (ja) 2005-03-09
JP2001505191A5 true JP2001505191A5 (enExample) 2005-06-16

Family

ID=27419245

Family Applications (2)

Application Number Title Priority Date Filing Date
JP52055398A Expired - Lifetime JP3626503B2 (ja) 1996-10-25 1997-10-17 血管内皮増殖因子(vegf)核酸リガンド複合体
JP2004301813A Expired - Lifetime JP4160038B2 (ja) 1996-10-25 2004-10-15 血管内皮増殖因子(vegf)核酸リガンド複合体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004301813A Expired - Lifetime JP4160038B2 (ja) 1996-10-25 2004-10-15 血管内皮増殖因子(vegf)核酸リガンド複合体

Country Status (18)

Country Link
EP (2) EP1685842A3 (enExample)
JP (2) JP3626503B2 (enExample)
KR (1) KR100514929B1 (enExample)
AT (1) ATE318143T1 (enExample)
AU (1) AU733674B2 (enExample)
CA (1) CA2269072C (enExample)
DE (3) DE69735292T2 (enExample)
DK (1) DK0957929T3 (enExample)
ES (1) ES2259188T3 (enExample)
FR (1) FR06C0021I2 (enExample)
GE (1) GEP20094799B (enExample)
IL (2) IL129497A0 (enExample)
LU (1) LU91252I2 (enExample)
NL (1) NL300234I2 (enExample)
NZ (1) NZ334859A (enExample)
PT (1) PT957929E (enExample)
RU (1) RU2177950C2 (enExample)
WO (1) WO1998018480A1 (enExample)

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US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
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ATE516366T1 (de) 2002-07-25 2011-07-15 Archemix Corp Regulierte aptamer-therapeutika
US9303262B2 (en) 2002-09-17 2016-04-05 Archemix Llc Methods for identifying aptamer regulators
US8039443B2 (en) 2002-11-21 2011-10-18 Archemix Corporation Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
WO2006050498A2 (en) 2004-11-02 2006-05-11 Archemix Corp. Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US10100316B2 (en) 2002-11-21 2018-10-16 Archemix Llc Aptamers comprising CPG motifs
WO2004050899A2 (en) 2002-12-03 2004-06-17 Archemix Corporation Method for in vitro selection of 2’-substituted nucleic acids
RU2234097C1 (ru) * 2003-03-05 2004-08-10 Московский областной научно-исследовательский клинический институт Способ диагностики саркомы капоши
FR2852606A1 (fr) * 2003-03-18 2004-09-24 Inst Nat Sante Rech Med Moyens pour inhiber simultanement l'expression de plusieurs genes impliques dans une pathologie
EP1620547B1 (en) 2003-04-21 2014-06-18 Archemix LLC Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
CL2004001996A1 (es) * 2003-08-08 2005-05-06 Eyetech Pharmaceuticals Inc Aptameros anti-vegf (factor de crecimiento endotelial vascular) con bloqueo nucleotidico 5'-5' o 3'-3' invertido, composicion que lo contiene, util para trastornos de neovascularizacion.
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
HUE050481T2 (hu) 2004-02-12 2020-12-28 Archemix Llc Aptamer terapeutikumok, amelyek használhatók komplementtel kapcsolatos rendellenességek kezelésében
MXPA06011965A (es) * 2004-04-13 2007-04-17 Osi Eyetech Inc Conjugados biologicamente activos mejorados.
US7579450B2 (en) 2004-04-26 2009-08-25 Archemix Corp. Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
AU2005282380A1 (en) 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US7566701B2 (en) 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
AU2006265896B2 (en) 2005-06-30 2012-05-31 Archemix Corp. Materials and methods for the generation of fully 2'-modified nucleic acid transcripts
US8101385B2 (en) 2005-06-30 2012-01-24 Archemix Corp. Materials and methods for the generation of transcripts comprising modified nucleotides
JP2009510182A (ja) * 2005-07-28 2009-03-12 (オーエスアイ)アイテツク・インコーポレーテツド シクリトールリンカーポリマー抱合体
CA2620182A1 (en) 2005-08-22 2007-03-01 Dennis A. Carson Tlr agonists
KR100877824B1 (ko) 2005-11-11 2009-01-12 한국생명공학연구원 E2epf ucp-vhl 상호작용 및 그 용도
EP1966242A1 (en) * 2005-12-06 2008-09-10 Domantis Limited Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
EP1968643A2 (en) * 2005-12-16 2008-09-17 Diatos Cell penetrating peptide conjugates for delivering of nucleic acids into a cell
US20090175930A1 (en) * 2006-01-11 2009-07-09 Nobuhiro Yagi Composition Suppressing The Expression of Target Gene in Eyeball and Medicament For Treating of Disease in Eyeball
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EP2510946B1 (en) 2007-02-07 2015-08-05 The Regents of The University of California Conjugates of synthetic tlr agonists and uses therefor
US20110229498A1 (en) 2008-05-08 2011-09-22 The Johns Hopkins University Compositions and methods for modulating an immune response
WO2010065671A2 (en) * 2008-12-04 2010-06-10 Curna, Inc. Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
PT2414322T (pt) * 2009-03-20 2022-12-07 Egen Inc Derivados de poliamina
EP2504436A1 (en) 2009-11-23 2012-10-03 INSERM - Institut National de la Santé et de la Recherche Médicale Aptamers directed against the matrix protein-1 of type a influenza viruses and uses thereof
TWI510246B (zh) 2010-04-30 2015-12-01 Molecular Partners Ag 抑制vegf-a受體交互作用的經修飾結合性蛋白質
JP5927194B2 (ja) * 2010-09-24 2016-06-01 マリンクロッド エルエルシー 治療ナノキャリアおよび/または診断ナノキャリアのターゲティングのためのアプタマーコンジュゲート
WO2013153138A1 (en) 2012-04-11 2013-10-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
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AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
CA2907636C (en) 2013-03-22 2018-02-06 The University Of Tokyo Aptamer to il-17 and use thereof
SI4374873T1 (sl) 2013-07-12 2026-01-30 Astellas Us Llc Sredstvo za uporabo pri zdravljenju ali preprečevanju oftalmoloških stanj
BR112016004153A2 (pt) 2013-08-28 2019-09-17 Caris Life Sciences Switzerland Holdings Gmbh "método para caracterizar uma doença ou distúrbio, kit, composição, método para gerar uma biblioteca de entrada, oligonucleotídeo, pluralidade de oligonucleotídeos e método para identificar um aptâmero
CN106999511A (zh) 2014-12-11 2017-08-01 拜耳医药保健有限责任公司 具有小的活动性脉络膜新生血管病变的年龄相关性黄斑变性的治疗
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US20180066262A1 (en) 2015-03-09 2018-03-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2017004243A1 (en) 2015-06-29 2017-01-05 Caris Science, Inc. Therapeutic oligonucleotides
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
WO2017046140A1 (en) 2015-09-18 2017-03-23 Bayer Pharma Aktiengesellschaft Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
AU2017235661B2 (en) 2016-03-18 2023-06-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
IL298701B2 (en) 2016-05-25 2024-03-01 Caris Science Inc Oligonucleotide probes and uses thereof
EP3332812A1 (en) 2016-12-07 2018-06-13 Rheinische Friedrich-Wilhelms-Universität Bonn Nucleic acid-based assembly and use of the assembly in cancer therapy
TW201904610A (zh) 2017-06-14 2019-02-01 德商拜耳製藥公司 用於治療新生血管型青光眼之非抗體vegf拮抗劑
TW201906635A (zh) 2017-07-04 2019-02-16 日商第一三共股份有限公司 伴隨視細胞變性的視網膜變性的疾病用藥
WO2019210097A1 (en) * 2018-04-25 2019-10-31 Vitrisa Therapeutics, Inc. Aptamers with stability, potency or half-life for enhanced safety and efficacy
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