JP2001503755A - Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用およびデリバリー装置 - Google Patents

Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用およびデリバリー装置

Info

Publication number
JP2001503755A
JP2001503755A JP52114098A JP52114098A JP2001503755A JP 2001503755 A JP2001503755 A JP 2001503755A JP 52114098 A JP52114098 A JP 52114098A JP 52114098 A JP52114098 A JP 52114098A JP 2001503755 A JP2001503755 A JP 2001503755A
Authority
JP
Japan
Prior art keywords
vegf
drug
nucleic acid
protein
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP52114098A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001503755A5 (enExample
Inventor
マーティン,ジョン・フランシス
ユレ―ヘルットゥアラ,セッポ
バーカー,スティーブン・ジョージ・エドワード
Original Assignee
ユーロジーン・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9622852.3A external-priority patent/GB9622852D0/en
Priority claimed from GBGB9709494.0A external-priority patent/GB9709494D0/en
Priority claimed from GBGB9717791.9A external-priority patent/GB9717791D0/en
Application filed by ユーロジーン・リミテッド filed Critical ユーロジーン・リミテッド
Publication of JP2001503755A publication Critical patent/JP2001503755A/ja
Publication of JP2001503755A5 publication Critical patent/JP2001503755A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44Oxidoreductases (1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • A61K38/1866Vascular endothelial growth factor [VEGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y114/00Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Peptides Or Proteins (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • External Artificial Organs (AREA)
JP52114098A 1996-11-01 1997-11-03 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用およびデリバリー装置 Withdrawn JP2001503755A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB9622852.3A GB9622852D0 (en) 1996-11-01 1996-11-01 Treatment of intimal hyperplasma
GB9622852.3 1996-11-01
GBGB9709494.0A GB9709494D0 (en) 1997-05-09 1997-05-09 Delivery device and method
GB9709494.0 1997-05-09
GBGB9717791.9A GB9717791D0 (en) 1997-08-21 1997-08-21 Treatment of intimal hyperplasia
GB9717791.9 1997-08-21
PCT/GB1997/003015 WO1998020027A2 (en) 1996-11-01 1997-11-03 Therapeutic use of an agent that stimulates no or prostacyclin production and delivery device

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2008004349A Division JP4783797B2 (ja) 1996-11-01 2008-01-11 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用および送達装置
JP2011236266A Division JP2012031196A (ja) 1996-11-01 2011-10-27 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用および送達装置

Publications (2)

Publication Number Publication Date
JP2001503755A true JP2001503755A (ja) 2001-03-21
JP2001503755A5 JP2001503755A5 (enExample) 2005-06-16

Family

ID=27268562

Family Applications (3)

Application Number Title Priority Date Filing Date
JP52114098A Withdrawn JP2001503755A (ja) 1996-11-01 1997-11-03 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用およびデリバリー装置
JP2008004349A Expired - Fee Related JP4783797B2 (ja) 1996-11-01 2008-01-11 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用および送達装置
JP2011236266A Pending JP2012031196A (ja) 1996-11-01 2011-10-27 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用および送達装置

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008004349A Expired - Fee Related JP4783797B2 (ja) 1996-11-01 2008-01-11 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用および送達装置
JP2011236266A Pending JP2012031196A (ja) 1996-11-01 2011-10-27 Noまたはプロスタサイクリン産生を刺激する薬剤の治療的使用および送達装置

Country Status (14)

Country Link
US (1) US7320679B2 (enExample)
EP (2) EP1488761A1 (enExample)
JP (3) JP2001503755A (enExample)
KR (1) KR100695590B1 (enExample)
AT (1) ATE287271T1 (enExample)
AU (1) AU729420B2 (enExample)
CA (1) CA2270286C (enExample)
DE (1) DE69732304T2 (enExample)
ES (1) ES2235227T3 (enExample)
HU (1) HU223957B1 (enExample)
NO (1) NO326303B1 (enExample)
PL (1) PL189744B1 (enExample)
PT (1) PT941116E (enExample)
WO (1) WO1998020027A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009502226A (ja) * 2005-07-22 2009-01-29 アーク・セラピューティックス・リミテッド ステント

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423125B2 (en) 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
US20080305999A1 (en) * 1996-11-01 2008-12-11 John Francis Martin Therapeutic use of growth factor, and delivery device, especially for the treatment of intimal hyperplasia
WO1999017798A1 (en) * 1997-10-02 1999-04-15 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Methods for the modulation of neovascularization and/or the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
GB9809082D0 (en) 1998-04-28 1998-06-24 Eurogene Limited Delivery device
ES2216630T3 (es) * 1998-09-09 2004-10-16 Scios Inc Metodos de tratar la hipertension dependiente de la sal.
US6596699B2 (en) 1998-09-22 2003-07-22 Biosurface Engineering Technologies, Inc. Nucleic acid coating compositions and methods
US6958147B1 (en) 1998-10-26 2005-10-25 Licentia Ltd Use of VEGF-C to prevent restenosis
FR2792531B1 (fr) * 1999-04-26 2003-01-31 Aventis Pharma Sa Utilisation d'adenovirus recombinant defectif comprenant un acide nucleique codant pour un facteur angiogenique pour le traitement de l'hypertension arterielle pulmonaire
JP2002543097A (ja) * 1999-04-26 2002-12-17 アバンテイス・フアルマ・エス・アー 肺動脈高血圧を治療するための血管新生促進因子をコードする核酸を含む組換え欠陥アデノウイルスの使用
IL148826A0 (en) * 1999-09-23 2002-09-12 An Go Gen Inc Cell-based gene therapy for the pulmonary system
WO2001032695A2 (en) * 1999-11-02 2001-05-10 Genentech, Inc. MODULATION OF eNOS ACTIVITY AND THERAPEUTIC USES THEREOF
US7078382B1 (en) 1999-11-02 2006-07-18 Genentech, Inc. Modulation of eNOS activity and therapeutic uses thereof
SE0000285D0 (sv) * 1999-12-07 2000-01-31 Mika Lahtinen Medical implant
AU2001239884B2 (en) 2000-02-25 2006-08-10 Vegenics Limited Materials and methods involving hybrid vascular endothelial growth factor DNAs and proteins and screening methods for modulators
GB0012997D0 (en) * 2000-05-26 2000-07-19 Eurogene Limited Gene delivery
WO2002096469A2 (en) * 2001-05-29 2002-12-05 Ark Therapeutics Ltd. Gene delivery via a baculovirus vector
EP2572674A3 (en) * 2001-07-06 2013-08-07 Syntach AG Implantable blood pressure regulator device
SE0102578L (sv) * 2001-07-20 2003-01-21 Oeyvind Reitan Förändring av en stents egenskaper för att förhindra restenos
AU2003273391A1 (en) * 2003-06-18 2005-01-04 Georg-August-Universitat Gottingen Use of a vegf receptor gene or gene product
WO2007022287A2 (en) 2005-08-15 2007-02-22 Vegenics Limited Modified vegf and pdgf with improved angiogenic properties
ATE476986T1 (de) * 2006-01-18 2010-08-15 Gen Hospital Corp Verfahren zur steigerung der lymphatischen funktion
US8721711B2 (en) 2007-06-20 2014-05-13 Oregon Health & Science University Graft having microporous membrane for uniform fluid infusion
US8808255B2 (en) 2007-12-14 2014-08-19 Oregon Health & Science University Drug delivery cuff
DE102008002396A1 (de) 2008-06-12 2009-12-17 Biotronik Vi Patent Ag Implantierbares Wirkstoffreservoir und Vorrichtung mit einem implantierbaren Wirkstoffreservoir
PT2814513T (pt) * 2012-02-14 2018-03-02 Univ California Entrega sistémica e expressão regulada de genes parácrinos para doenças cardiovasculares e outras doenças
WO2013135266A1 (en) 2012-03-12 2013-09-19 Gemvax As Treatment of non-small cell lung carcinoma by active immunotherapy
IN2015DN00934A (enExample) 2012-08-01 2015-06-12 United Therapeutics Corp
AU2014205557B2 (en) 2013-01-09 2017-08-10 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US11571444B2 (en) 2016-10-24 2023-02-07 United Therapeutics Corporation Enhancement of MSC immunomodulatory properties by treprostinil
WO2020204601A1 (ko) * 2019-04-05 2020-10-08 한국세라믹기술원 Csq-태그를 이용한 단백질의 발현 및 정제 방법
IT201900012537A1 (it) * 2019-07-22 2021-01-22 Milano Politecnico Dispositivo di condizionamento per condizionare un tratto esposto di un vaso sanguigno e metodo

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
WO1994023668A1 (en) * 1993-04-14 1994-10-27 Emory University A device for local drug delivery and methods for using the same
WO1994028721A1 (en) * 1993-06-11 1994-12-22 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122317A (en) * 1980-02-29 1981-09-25 Koken:Kk Drug transporting material and its preparation
US5201728A (en) * 1991-05-03 1993-04-13 Giampapa Vincent C Subcutaneous implantable multiple-agent delivery system
US5326568A (en) * 1991-05-03 1994-07-05 Giampapa Vincent C Method of tissue-specific delivery
US5653744A (en) * 1995-04-27 1997-08-05 Khouri Biomedical Research, Inc. Device and method for vascular anastomosis
US5830879A (en) * 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
WO1994023668A1 (en) * 1993-04-14 1994-10-27 Emory University A device for local drug delivery and methods for using the same
WO1994028721A1 (en) * 1993-06-11 1994-12-22 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN4007020786, ASAHARA, T., et al., "Local Delivery of Vascular Endothelial Growth Factor Accelerates Reendothelialization and Attenuates", Circulation, 19950601, Vol.91, No.11, p.2793−2801, US *
JPN4007020787, BURKE, P.A., et al., "VASCULAR ENDOTHELIAL GROWTHFACTOR CAUSES ENDOTHELIAL PROLIFERATION AFTER VASCULAR INJURY", Biochemical and Biophysical Research Communications, 19950206, Vol.207, No.1, p.348−354, US *
JPN6008039621, VON DER LEYEN, H.E., et al., "Gene therapy inhibiting neointimal vascular lesion: In vivo transfer of endothelial cell nitric oxid", Proceedings of the National Academy of Sciences of the United States of America, 199502, Vol.92, p.1137−1141, US, National Academy of Sciences;Washington *
JPN6008039625, BOOTH, R.F.G., et al., "Rapid development of atherosclerotic lesions in the rabbit carotid artery induced by perivascular ma", Atherosclerosis, 1989, Vol.76, p.257−268 *
JPN6008039626, LAITINEN, M., et al., "Local Adventitial VEGF gene Transfer Reduces Neointima Formation in Rabbit Carotid Arteries", CIRCULATION, 1996, Vol.94, No.8 SUPPL., p.I−637 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009502226A (ja) * 2005-07-22 2009-01-29 アーク・セラピューティックス・リミテッド ステント

Also Published As

Publication number Publication date
DE69732304T2 (de) 2005-06-02
HUP9902867A2 (hu) 1999-12-28
KR100695590B1 (ko) 2007-03-14
US7320679B2 (en) 2008-01-22
HUP9902867A3 (en) 2001-12-28
WO1998020027A2 (en) 1998-05-14
KR20000052999A (ko) 2000-08-25
NO992106D0 (no) 1999-04-30
DE69732304D1 (de) 2005-02-24
NO326303B1 (no) 2008-11-03
JP2012031196A (ja) 2012-02-16
NO992106L (no) 1999-06-30
PL333272A1 (en) 1999-11-22
AU4790697A (en) 1998-05-29
CA2270286A1 (en) 1998-05-14
AU729420B2 (en) 2001-02-01
EP0941116A2 (en) 1999-09-15
US20030225020A1 (en) 2003-12-04
JP4783797B2 (ja) 2011-09-28
ES2235227T3 (es) 2005-07-01
JP2008155036A (ja) 2008-07-10
WO1998020027A3 (en) 1998-10-08
ATE287271T1 (de) 2005-02-15
CA2270286C (en) 2009-03-03
HU223957B1 (hu) 2005-03-29
EP0941116B1 (en) 2005-01-19
EP1488761A1 (en) 2004-12-22
PL189744B1 (pl) 2005-09-30
HK1108845A1 (zh) 2008-05-23
PT941116E (pt) 2005-05-31

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