JP2001503735A - 親水性活性試薬のためのエマルジョン処方物 - Google Patents

親水性活性試薬のためのエマルジョン処方物

Info

Publication number
JP2001503735A
JP2001503735A JP50452498A JP50452498A JP2001503735A JP 2001503735 A JP2001503735 A JP 2001503735A JP 50452498 A JP50452498 A JP 50452498A JP 50452498 A JP50452498 A JP 50452498A JP 2001503735 A JP2001503735 A JP 2001503735A
Authority
JP
Japan
Prior art keywords
emulsion
lipid
biologically active
film
hydrophilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP50452498A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001503735A5 (enExample
Inventor
ハーング，リーフ
壽史 原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of JP2001503735A publication Critical patent/JP2001503735A/ja
Publication of JP2001503735A5 publication Critical patent/JP2001503735A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50452498A 1996-07-03 1997-07-03 親水性活性試薬のためのエマルジョン処方物 Ceased JP2001503735A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67686796A 1996-07-03 1996-07-03
US08/676,867 1996-07-03
PCT/US1997/012544 WO1998000110A1 (en) 1996-07-03 1997-07-03 Emulsion formulations for hydrophilic active agents

Publications (2)

Publication Number Publication Date
JP2001503735A true JP2001503735A (ja) 2001-03-21
JP2001503735A5 JP2001503735A5 (enExample) 2004-12-09

Family

ID=24716366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50452498A Ceased JP2001503735A (ja) 1996-07-03 1997-07-03 親水性活性試薬のためのエマルジョン処方物

Country Status (6)

Country Link
US (3) US6610321B2 (enExample)
EP (1) EP0910343A1 (enExample)
JP (1) JP2001503735A (enExample)
AU (1) AU727447B2 (enExample)
CA (1) CA2259179C (enExample)
WO (1) WO1998000110A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514103A (ja) * 2002-11-01 2006-04-27 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド ジオデート送達媒体
JP2008505972A (ja) * 2004-07-12 2008-02-28 エスディー ファーマシューティカルズ インコーポレイティッド 高水溶性薬物を送達するための組成物
JP2010505748A (ja) * 2006-07-24 2010-02-25 シング−ブルーマー アンド カンパニー， インコーポレイテッド オストワルド熟成を減少させた水不溶性の医薬品物質の固体ナノ粒子処方物
JP2011500671A (ja) * 2007-10-17 2011-01-06 韓国科学技術院 核酸遺伝子伝達用低密度リポタンパク質類似（ＬＤＬ−ｌｉｋｅ）陽イオン性ナノ粒子、その製造方法、及びこれを用いた核酸遺伝子の伝達方法
JP5085313B2 (ja) * 2005-01-28 2012-11-28 協和発酵キリン株式会社 被覆微粒子の製造方法

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008202A (en) 1995-01-23 1999-12-28 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6120794A (en) 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
US20010009904A1 (en) * 1997-12-30 2001-07-26 Jon A. Wolff Process of delivering a polynucleotide to a cell via the vascular system
US6258792B1 (en) 1996-04-12 2001-07-10 University Of Pittsburgh Cationic cholesteryl derivatives containing cyclic polar groups
EP0904282B1 (en) 1996-04-12 2001-12-05 University Of Pittsburgh Novel cationic cholesteryl derivatives containing cyclic polar groups
JP2001503735A (ja) * 1996-07-03 2001-03-21 ユニバーシティ オブ ピッツバーグ 親水性活性試薬のためのエマルジョン処方物
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
ATE321882T1 (de) 1997-07-01 2006-04-15 Isis Pharmaceuticals Inc Zusammensetzungen und verfahren zur verabreichung von oligonukleotiden über die speiseröhre
US6989264B2 (en) * 1997-09-05 2006-01-24 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of released recombinant AAV vectors
ES2374290T3 (es) * 1998-03-20 2012-02-15 Commonwealth Scientific And Industrial Research Organisation Genes sintéticos y constructos genéticos que comprenden los mismos.
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
CA2329130A1 (en) * 1998-05-21 1999-11-25 Isis Pharmaceuticals Inc. Compositions and methods for non-parenteral delivery of oligonucleotides
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
FR2797188A1 (fr) * 1999-08-04 2001-02-09 Univ Paris Nord Laboratoire De Composes lipidiques cationiques et leurs utilisation pour le transfert de substances d'interet therapeutique chargees negativement
US6423885B1 (en) 1999-08-13 2002-07-23 Commonwealth Scientific And Industrial Research Organization (Csiro) Methods for obtaining modified phenotypes in plant cells
CA2424619C (en) * 2000-10-04 2010-05-18 Kyowa Hakko Kogyo Co., Ltd. Method for coating fine particles with lipid membrane
ES2294147T5 (es) * 2001-07-27 2011-04-04 N.V. Nutricia Composiciones enterales para la prevención y/o tratamiento de la sepsis.
US20030059899A1 (en) * 2001-09-26 2003-03-27 Murali Sastry Method for the hydrophobisation of DNA molecules
AU2003287526A1 (en) * 2002-11-06 2004-06-03 Protein-stabilized liposomal formulations of pharmaceutical agents
KR100703872B1 (ko) * 2003-10-10 2007-04-09 주식회사 삼양사 양친성 블록 공중합체 및 이를 포함하는 약물 전달용고분자 조성물
EA200600877A1 (ru) * 2003-10-31 2006-12-29 Тева Фармасьютикал Индастриз, Лтд. Наночастицы для доставки лекарств
US7348802B2 (en) * 2004-06-15 2008-03-25 Stmicroelectronics Pvt. Ltd. Differential receiver
KR20060119739A (ko) * 2005-05-18 2006-11-24 엘지전자 주식회사 구간 통과시간에 대한 예측정보를 제공하고 이를 이용하는방법 및 장치
KR20060119746A (ko) * 2005-05-18 2006-11-24 엘지전자 주식회사 교통상태에 대한 정보를 제공하고 이를 이용하는 방법 및장치
KR20060119742A (ko) * 2005-05-18 2006-11-24 엘지전자 주식회사 도로 정보를 제공하고 이를 이용하는 방법 및 장치
KR20060119743A (ko) * 2005-05-18 2006-11-24 엘지전자 주식회사 구간 속도에 대한 예측정보를 제공하고 이를 이용하는 방법및 장치
KR100711866B1 (ko) * 2005-05-18 2007-04-25 엘지전자 주식회사 소통상태에 대한 예측정보를 제공하고 이를 이용하는 방법및 장치
KR20060119741A (ko) * 2005-05-18 2006-11-24 엘지전자 주식회사 소통상태의 추이정보를 제공하고 이를 이용하는 방법 및장치
US8711850B2 (en) * 2005-07-08 2014-04-29 Lg Electronics Inc. Format for providing traffic information and a method and apparatus for using the format
KR101254219B1 (ko) * 2006-01-19 2013-04-23 엘지전자 주식회사 링크 식별 방법 및 링크 식별 장치
US8877206B2 (en) * 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
WO2009129227A1 (en) 2008-04-17 2009-10-22 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
CA2724408A1 (en) * 2008-05-19 2009-11-26 The University Of North Carolina At Chapel Hill Methods and compositions comprising novel cationic lipids
WO2011017137A2 (en) * 2009-08-03 2011-02-10 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating insects
DK2566505T3 (da) * 2010-05-06 2020-01-20 Alphacore Pharma Llc Fremføring af kolesterylester til steroidogene væv
PL2590676T3 (pl) 2010-07-06 2017-02-28 Glaxosmithkline Biologicals Sa Wirionopodobne cząstki dostarczające dla autoreplikujących się cząsteczek rna
EP2591114B1 (en) 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
BR112013000244A2 (pt) 2010-07-06 2016-05-17 Novartis Ag lipossomas com lipídeos apresentando pka vantajoso para administração de rna
US9770463B2 (en) * 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
ES2649896T3 (es) 2010-07-06 2018-01-16 Glaxosmithkline Biologicals Sa Emulsiones catiónicas de aceite en agua
RS63315B1 (sr) 2010-08-31 2022-07-29 Glaxosmithkline Biologicals Sa Pegilovani lipozomi za isporuku rnk koja kodira imunogen
CA2814386C (en) 2010-10-11 2019-08-20 Novartis Ag Antigen delivery platforms
US9655845B2 (en) 2011-07-06 2017-05-23 Glaxosmithkline Biologicals, S.A. Oil-in-water emulsions that contain nucleic acids
CA2840989A1 (en) 2011-07-06 2013-01-10 Novartis Ag Immunogenic combination compositions and uses thereof
MX350258B (es) 2011-07-06 2017-08-31 Novartis Ag Emulsiones cationicas de aceite en agua.
CN105163753B (zh) 2012-06-15 2018-12-21 Pds生物科技公司 阳离子脂质疫苗组合物和使用方法
KR101493930B1 (ko) 2012-09-12 2015-02-16 사회복지법인 삼성생명공익재단 표적지향형 난용성 약물 전달체
EP2897639A4 (en) 2012-09-21 2016-05-04 Frank Bedu-Addo IMPROVED VACCINATE COMPOSITIONS AND METHODS OF USE
US10821175B2 (en) 2014-02-25 2020-11-03 Merck Sharp & Dohme Corp. Lipid nanoparticle vaccine adjuvants and antigen delivery systems
CA3005251A1 (en) 2015-11-13 2017-05-18 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
CA3062591A1 (en) 2017-05-08 2018-11-15 Gritstone Oncology, Inc. Alphavirus neoantigen vectors
JP7653013B2 (ja) 2018-01-04 2025-03-28 アイコニック セラピューティクス リミテッド ライアビリティ カンパニー 抗組織因子抗体、抗体薬物コンジュゲート、及び関連する方法
CN109316599A (zh) * 2018-08-24 2019-02-12 上海交通大学医学院附属瑞金医院 一种抑肽酶或其突变体、衍生物、类似物或其组成片段的应用
MX2021014525A (es) 2019-05-30 2022-03-17 Gritstone Bio Inc Adenovirus modificados.
US11638754B2 (en) 2020-02-14 2023-05-02 Merck Sharp & Dohme Llc HPV vaccine
CA3187258A1 (en) 2020-08-06 2022-02-10 Karin Jooss Multiepitope vaccine cassettes
TW202245835A (zh) 2021-02-04 2022-12-01 美商默沙東有限責任公司 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物
MX2024002144A (es) 2021-08-19 2024-04-23 Merck Sharp & Dohme Llc Nueva nanoparticula lipidica termostable y metodos de uso de la misma.
TW202513091A (zh) 2023-06-09 2025-04-01 美商默沙東有限責任公司 用於人類乳突病毒疫苗之奈米乳液佐劑組合物

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545412A (en) 1985-01-07 1996-08-13 Syntex (U.S.A.) Inc. N-[1, (1-1)-dialkyloxy]-and N-[1, (1-1)-dialkenyloxy]-alk-1-yl-n,n,n-tetrasubstituted ammonium lipids and uses therefor
US5374548A (en) 1986-05-02 1994-12-20 Genentech, Inc. Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
US5540933A (en) 1985-05-31 1996-07-30 La Jolla Cancer Research Foundation Isolation and use of fibronectin receptor
SE456136B (sv) 1985-06-17 1988-09-12 Oncholab Ab Forfarande for framstellning av en med ett lipofilt biologiskt aktivt emne bemengd berare pa basis av rekonstituerat ldl (lagdensitetslipoprotein)
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
DE3908047A1 (de) * 1989-03-13 1990-09-20 Desitin Arzneimittel Gmbh Hochdisperse pharmazeutische zusammensetzung
FR2649321A1 (fr) 1989-07-07 1991-01-11 Inst Nat Sante Rech Med Compositions a base de derives nucleotidiques, leurs procedes de preparation, et leurs utilisations notamment en tant que compositions pharmaceutiques
US5676954A (en) 1989-11-03 1997-10-14 Vanderbilt University Method of in vivo delivery of functioning foreign genes
FR2664500B1 (fr) 1990-07-13 1994-10-28 Lille Ii Universite Droit Sant Procede de preparation d'une lipoproteine modifiee par incorporation d'une substance active lipophile, lipoproteine modifiee ainsi obtenue et composition pharmaceutique ou cosmetique la contenant.
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5756353A (en) 1991-12-17 1998-05-26 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol-and liposome-based delivery
IL101241A (en) 1992-03-16 1997-11-20 Yissum Res Dev Co Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier
BR9201168A (pt) 1992-04-02 1994-04-12 Zerbini E J Fundacao Microemulsoes usadas como velculo para carregar quimioterapicos as celulas neoplasicas
AU4528493A (en) 1992-06-04 1994-01-04 Regents Of The University Of California, The In vivo gene therapy with intron-free sequence of interest
AU6254494A (en) 1993-02-16 1994-09-14 Virginia Tech Intellectual Properties, Inc. Polyelectrolyte dna conjugation and genetic transformation of an animal
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
AU696455C (en) 1994-03-23 2006-03-02 Case Western Reserve University Compacted nucleic acids and their delivery to cells
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
US5851510A (en) 1994-05-16 1998-12-22 The Board Of Regents Of The University Of Michigan Hepatocyte-selective oil-in-water emulsion
US5635487A (en) 1994-12-29 1997-06-03 Wolff; Jon A. Amphipathic, micellar delivery systems for biologically active polyions
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US6120794A (en) 1995-09-26 2000-09-19 University Of Pittsburgh Emulsion and micellar formulations for the delivery of biologically active substances to cells
EP0904282B1 (en) 1996-04-12 2001-12-05 University Of Pittsburgh Novel cationic cholesteryl derivatives containing cyclic polar groups
JP2001503735A (ja) * 1996-07-03 2001-03-21 ユニバーシティ オブ ピッツバーグ 親水性活性試薬のためのエマルジョン処方物

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006514103A (ja) * 2002-11-01 2006-04-27 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド ジオデート送達媒体
JP2012072138A (ja) * 2002-11-01 2012-04-12 Biodelivery Sciences Internatl Inc ジオデート送達媒体
JP2008505972A (ja) * 2004-07-12 2008-02-28 エスディー ファーマシューティカルズ インコーポレイティッド 高水溶性薬物を送達するための組成物
JP5085313B2 (ja) * 2005-01-28 2012-11-28 協和発酵キリン株式会社 被覆微粒子の製造方法
JP2010505748A (ja) * 2006-07-24 2010-02-25 シング−ブルーマー アンド カンパニー， インコーポレイテッド オストワルド熟成を減少させた水不溶性の医薬品物質の固体ナノ粒子処方物
JP2011500671A (ja) * 2007-10-17 2011-01-06 韓国科学技術院 核酸遺伝子伝達用低密度リポタンパク質類似（ＬＤＬ−ｌｉｋｅ）陽イオン性ナノ粒子、その製造方法、及びこれを用いた核酸遺伝子の伝達方法

Also Published As

Publication number Publication date
US6890557B2 (en) 2005-05-10
WO1998000110A1 (en) 1998-01-08
CA2259179C (en) 2008-09-23
US6610321B2 (en) 2003-08-26
US20050142184A1 (en) 2005-06-30
AU727447B2 (en) 2000-12-14
US20020127272A1 (en) 2002-09-12
US20030224041A1 (en) 2003-12-04
CA2259179A1 (en) 1998-01-08
EP0910343A1 (en) 1999-04-28
AU3731997A (en) 1998-01-21

Similar Documents

Publication Publication Date Title
JP2001503735A (ja) 親水性活性試薬のためのエマルジョン処方物
EP0852490B1 (en) Emulsion formulations for the delivery of nucleic acids to cells
JP3026271B2 (ja) 活性薬剤の制御放出に用いる多小胞リポソームの調製
Frezard Liposomes: from biophysics to the design of peptide vaccines
US7491409B1 (en) Encapsulation of bioactive complexes in liposomes
US5932241A (en) Cationic lipid DNA complexes for gene targeting
CN101583346A (zh) 用于穿膜药物递送系统的皂化蛋白c和相关蛋白及肽的促融合性质
JPH10506395A (ja) 二層安定化成分及びプログラムできる融合性リポソームの形成のためへのそれらの使用
KR20020033665A (ko) 유전자 또는 약물을 효과적으로 전달하는 지질미립구,제형 및 이들의 제조방법
EP1257294A2 (en) Carrier particles for drug delivery and process for preparation
WO2003057190A1 (en) Efficient nucleic acid encapsulation into medium sized liposomes
EP0634926A1 (en) Composition for therapeutic or diagnostic use, process for its preparation and its use
JP2001511171A (ja) 安定化したカチオン性トランスフェクション用物質／核酸粒子の配合物
WO1991007973A1 (en) Fat emulsion
JPWO1991007973A1 (ja) 脂肪乳剤
AU2799101A (en) Emulsion formulations for hydrophilic active agents
KR100342835B1 (ko) 유전자 또는 약물을 효과적으로 전달하는 지방유제, 제형 및 이들의 제조방법
US20060062839A1 (en) Efficient liposomal encapsulation under mild conditions
JP3074731B2 (ja) 脂肪乳剤
AU721245B2 (en) Emulsion and micellar formulations for the delivery of biologically active substances to cells
AU6137100A (en) Emulsion and micellar formulations for the delivery of biologically active substances to cells
WO2025226068A1 (ko) 핵산 분자의 흡입 전달용 지질 나노복합체
WO2003057189A1 (en) Efficient liposomal encapsulation under mild conditions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040303

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040303

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080115

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20080617

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080729