ES2165050T3 - Nuevos derivados cationicos de colesterilo que contienen grupos polares ciclicos. - Google Patents
Nuevos derivados cationicos de colesterilo que contienen grupos polares ciclicos.Info
- Publication number
- ES2165050T3 ES2165050T3 ES97920357T ES97920357T ES2165050T3 ES 2165050 T3 ES2165050 T3 ES 2165050T3 ES 97920357 T ES97920357 T ES 97920357T ES 97920357 T ES97920357 T ES 97920357T ES 2165050 T3 ES2165050 T3 ES 2165050T3
- Authority
- ES
- Spain
- Prior art keywords
- cholesterile
- polar groups
- cationic derivatives
- new cationic
- cyclical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE SON DERIVADOS DE CATIONICOS DE COLESTERILO, LOS CUALES TIENEN UNA ESTRUCTURA CICLICA QUE CONTIENE NITROGENO, COMO GRUPO DE CABEZA POLAR. DICHOS COMPUESTOS SON UTILES PARA SUMINISTRAR SUSTANCIAS BIOLOGICAMENTE ACTIVAS A CELULAS, Y PARA TRASNFECTAR ACIDOS NUCLEICOS AL INTERIOR DE CELULAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63120396A | 1996-04-12 | 1996-04-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2165050T3 true ES2165050T3 (es) | 2002-03-01 |
Family
ID=24530212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97920357T Expired - Lifetime ES2165050T3 (es) | 1996-04-12 | 1997-04-11 | Nuevos derivados cationicos de colesterilo que contienen grupos polares ciclicos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US6927213B2 (es) |
EP (1) | EP0904282B1 (es) |
AT (1) | ATE210145T1 (es) |
CA (1) | CA2251543A1 (es) |
DE (1) | DE69708868T2 (es) |
DK (1) | DK0904282T3 (es) |
ES (1) | ES2165050T3 (es) |
WO (1) | WO1997039019A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
AU727447B2 (en) | 1996-07-03 | 2000-12-14 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5912239A (en) * | 1997-04-04 | 1999-06-15 | Genzyme Corporation | Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948925A (en) * | 1997-05-06 | 1999-09-07 | Genzyme Corporation | Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids |
US5952516A (en) * | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
GB0015624D0 (en) * | 2000-06-26 | 2000-08-16 | Nat Cancer Centre | Materials and methods relating to improved gene delivery |
GB2372502B (en) * | 2000-12-12 | 2004-10-13 | Imperial College | Carbohydrate compounds containing cholesterol and their use |
DE10109898A1 (de) * | 2001-02-21 | 2002-09-05 | Novosom Gmbh | Lipide mit veränderlicher Ladung |
DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
US7858117B2 (en) | 2002-02-21 | 2010-12-28 | Novosom Ag | Amphoteric liposomes and their use |
WO2009142893A2 (en) * | 2008-05-19 | 2009-11-26 | The University Of North Carolina At Chapel Hill | Methods and compositions for the delivery of bioactive compounds |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL104586C (es) * | 1959-04-10 | |||
US3459766A (en) | 1965-03-12 | 1969-08-05 | Du Pont | 2,2,5,5-tetrakis(polyfluoromethyl)imidazolidines and their preparation |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4958013A (en) | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
US5100662A (en) | 1989-08-23 | 1992-03-31 | The Liposome Company, Inc. | Steroidal liposomes exhibiting enhanced stability |
US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
WO1993003709A1 (en) | 1991-08-16 | 1993-03-04 | Vical, Inc. | Composition and method for treating cystic fibrosis |
US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
JP2990624B2 (ja) * | 1991-10-21 | 1999-12-13 | 味の素株式会社 | 油溶性n−長鎖アシル中性アミノ酸エステル及びそれらを含む香粧品及び外用医薬基剤 |
US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
WO1993025673A1 (en) | 1992-06-04 | 1993-12-23 | The Regents Of The University Of California | In vivo gene therapy with intron-free sequence of interest |
US5646126A (en) | 1994-02-28 | 1997-07-08 | Epoch Pharmaceuticals | Sterol modified oligonucleotide duplexes having anticancer activity |
US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
ATE410518T1 (de) | 1994-03-23 | 2008-10-15 | Univ Ohio | Kompaktnukleinsäure und ihre verabreichung in zellen |
US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US5635487A (en) | 1994-12-29 | 1997-06-03 | Wolff; Jon A. | Amphipathic, micellar delivery systems for biologically active polyions |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
GB9515356D0 (en) | 1995-07-26 | 1995-09-20 | Medical Res Council | Improvements in or relating to delivery of nucleic acid |
AU6691496A (en) * | 1995-08-01 | 1997-02-26 | Advanced Therapies, Inc. | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
AU727447B2 (en) | 1996-07-03 | 2000-12-14 | University Of Pittsburgh | Emulsion formulations for hydrophilic active agents |
ES2208936T3 (es) | 1996-08-26 | 2004-06-16 | Transgene S.A. | Complejos de lipidos cationicos-acidos nucleicos. |
US6271209B1 (en) | 1998-04-03 | 2001-08-07 | Valentis, Inc. | Cationic lipid formulation delivering nucleic acid to peritoneal tumors |
-
1997
- 1997-04-11 DK DK97920357T patent/DK0904282T3/da active
- 1997-04-11 EP EP97920357A patent/EP0904282B1/en not_active Expired - Lifetime
- 1997-04-11 WO PCT/US1997/006066 patent/WO1997039019A1/en active IP Right Grant
- 1997-04-11 CA CA002251543A patent/CA2251543A1/en not_active Abandoned
- 1997-04-11 AT AT97920357T patent/ATE210145T1/de not_active IP Right Cessation
- 1997-04-11 DE DE69708868T patent/DE69708868T2/de not_active Expired - Fee Related
- 1997-04-11 ES ES97920357T patent/ES2165050T3/es not_active Expired - Lifetime
-
2003
- 2003-05-29 US US10/449,158 patent/US6927213B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0904282A1 (en) | 1999-03-31 |
DK0904282T3 (da) | 2002-03-04 |
AU715376B2 (en) | 2000-02-03 |
EP0904282B1 (en) | 2001-12-05 |
AU2457397A (en) | 1997-11-07 |
US6927213B2 (en) | 2005-08-09 |
ATE210145T1 (de) | 2001-12-15 |
WO1997039019A1 (en) | 1997-10-23 |
DE69708868T2 (de) | 2002-07-18 |
CA2251543A1 (en) | 1997-10-23 |
US20030203871A1 (en) | 2003-10-30 |
DE69708868D1 (de) | 2002-01-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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