ATE210145T1 - Neue kationische cholesterin derivate mit zyklischen polaren gruppen - Google Patents
Neue kationische cholesterin derivate mit zyklischen polaren gruppenInfo
- Publication number
- ATE210145T1 ATE210145T1 AT97920357T AT97920357T ATE210145T1 AT E210145 T1 ATE210145 T1 AT E210145T1 AT 97920357 T AT97920357 T AT 97920357T AT 97920357 T AT97920357 T AT 97920357T AT E210145 T1 ATE210145 T1 AT E210145T1
- Authority
- AT
- Austria
- Prior art keywords
- polar groups
- cholesterol derivatives
- new cationic
- cationic cholesterol
- cyclic polar
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63120396A | 1996-04-12 | 1996-04-12 | |
PCT/US1997/006066 WO1997039019A1 (en) | 1996-04-12 | 1997-04-11 | Novel cationic cholesteryl derivatives containing cyclic polar groups |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE210145T1 true ATE210145T1 (de) | 2001-12-15 |
Family
ID=24530212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97920357T ATE210145T1 (de) | 1996-04-12 | 1997-04-11 | Neue kationische cholesterin derivate mit zyklischen polaren gruppen |
Country Status (8)
Country | Link |
---|---|
US (1) | US6927213B2 (de) |
EP (1) | EP0904282B1 (de) |
AT (1) | ATE210145T1 (de) |
CA (1) | CA2251543A1 (de) |
DE (1) | DE69708868T2 (de) |
DK (1) | DK0904282T3 (de) |
ES (1) | ES2165050T3 (de) |
WO (1) | WO1997039019A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
EP0910343A1 (de) | 1996-07-03 | 1999-04-28 | University Of Pittsburgh | Emulsionsformulierungen für hydrophile wirkstoffe |
US5925628A (en) * | 1997-03-31 | 1999-07-20 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5912239A (en) * | 1997-04-04 | 1999-06-15 | Genzyme Corporation | Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules |
US5948925A (en) * | 1997-05-06 | 1999-09-07 | Genzyme Corporation | Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids |
US5952516A (en) * | 1997-05-08 | 1999-09-14 | Genzyme Corporation | Cationic amphiphiles containing multiplesteroid lipophilic groups |
US5942634A (en) * | 1997-05-09 | 1999-08-24 | Genzyme Corporation | Cationic amphiphiles for cell transfections |
GB0015624D0 (en) * | 2000-06-26 | 2000-08-16 | Nat Cancer Centre | Materials and methods relating to improved gene delivery |
GB2372502B (en) * | 2000-12-12 | 2004-10-13 | Imperial College | Carbohydrate compounds containing cholesterol and their use |
DE10109897A1 (de) * | 2001-02-21 | 2002-11-07 | Novosom Ag | Fakultativ kationische Liposomen und Verwendung dieser |
DE10109898A1 (de) | 2001-02-21 | 2002-09-05 | Novosom Gmbh | Lipide mit veränderlicher Ladung |
US7858117B2 (en) | 2002-02-21 | 2010-12-28 | Novosom Ag | Amphoteric liposomes and their use |
CA2724408A1 (en) * | 2008-05-19 | 2009-11-26 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising novel cationic lipids |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE589491A (de) * | 1959-04-10 | |||
US3459766A (en) | 1965-03-12 | 1969-08-05 | Du Pont | 2,2,5,5-tetrakis(polyfluoromethyl)imidazolidines and their preparation |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US4958013A (en) | 1989-06-06 | 1990-09-18 | Northwestern University | Cholesteryl modified oligonucleotides |
US5100662A (en) | 1989-08-23 | 1992-03-31 | The Liposome Company, Inc. | Steroidal liposomes exhibiting enhanced stability |
US5676954A (en) | 1989-11-03 | 1997-10-14 | Vanderbilt University | Method of in vivo delivery of functioning foreign genes |
WO1993003709A1 (en) | 1991-08-16 | 1993-03-04 | Vical, Inc. | Composition and method for treating cystic fibrosis |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
JP2990624B2 (ja) * | 1991-10-21 | 1999-12-13 | 味の素株式会社 | 油溶性n−長鎖アシル中性アミノ酸エステル及びそれらを含む香粧品及び外用医薬基剤 |
US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
WO1993024640A2 (en) | 1992-06-04 | 1993-12-09 | The Regents Of The University Of California | Methods and compositions for in vivo gene therapy |
US5646126A (en) | 1994-02-28 | 1997-07-08 | Epoch Pharmaceuticals | Sterol modified oligonucleotide duplexes having anticancer activity |
CA2186118C (en) | 1994-03-23 | 2010-10-19 | Richard W. Hanson | Compacted nucleic acids and their delivery to cells |
US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
US6071890A (en) * | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
US5635487A (en) | 1994-12-29 | 1997-06-03 | Wolff; Jon A. | Amphipathic, micellar delivery systems for biologically active polyions |
US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
GB9515356D0 (en) | 1995-07-26 | 1995-09-20 | Medical Res Council | Improvements in or relating to delivery of nucleic acid |
WO1997004748A2 (en) * | 1995-08-01 | 1997-02-13 | Advanced Therapies, Inc. | Enhanced artificial viral envelopes for cellular delivery of therapeutic substances |
US6120794A (en) | 1995-09-26 | 2000-09-19 | University Of Pittsburgh | Emulsion and micellar formulations for the delivery of biologically active substances to cells |
EP0910343A1 (de) | 1996-07-03 | 1999-04-28 | University Of Pittsburgh | Emulsionsformulierungen für hydrophile wirkstoffe |
CA2264140A1 (en) | 1996-08-26 | 1998-03-05 | Transgene S.A. | Cationic lipid-nucleic acid complexes |
US6271209B1 (en) | 1998-04-03 | 2001-08-07 | Valentis, Inc. | Cationic lipid formulation delivering nucleic acid to peritoneal tumors |
-
1997
- 1997-04-11 DE DE69708868T patent/DE69708868T2/de not_active Expired - Fee Related
- 1997-04-11 WO PCT/US1997/006066 patent/WO1997039019A1/en active IP Right Grant
- 1997-04-11 AT AT97920357T patent/ATE210145T1/de not_active IP Right Cessation
- 1997-04-11 CA CA002251543A patent/CA2251543A1/en not_active Abandoned
- 1997-04-11 DK DK97920357T patent/DK0904282T3/da active
- 1997-04-11 EP EP97920357A patent/EP0904282B1/de not_active Expired - Lifetime
- 1997-04-11 ES ES97920357T patent/ES2165050T3/es not_active Expired - Lifetime
-
2003
- 2003-05-29 US US10/449,158 patent/US6927213B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0904282B1 (de) | 2001-12-05 |
DE69708868D1 (de) | 2002-01-17 |
DK0904282T3 (da) | 2002-03-04 |
ES2165050T3 (es) | 2002-03-01 |
WO1997039019A1 (en) | 1997-10-23 |
DE69708868T2 (de) | 2002-07-18 |
US20030203871A1 (en) | 2003-10-30 |
US6927213B2 (en) | 2005-08-09 |
CA2251543A1 (en) | 1997-10-23 |
EP0904282A1 (de) | 1999-03-31 |
AU2457397A (en) | 1997-11-07 |
AU715376B2 (en) | 2000-02-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69708868D1 (de) | Neue kationische cholesterin derivate mit zyklischen polaren gruppen | |
CU23048A3 (es) | Aminoacidos ciclicos y derivados de los mismos, utiles como agentes farmaceuticos | |
ATE270557T1 (de) | Hochkonzentrierte, lyophilisierte und flüssige faktor-ix formulierungen | |
DE3581992D1 (de) | Milchsaeurederivat, dieses enthaltende fluessigkristallkomposition und fluessigkristalleinrichtung. | |
FR2678615B1 (fr) | Benzofuranne-2-ones thiomethylees, leur preparation et leur application comme stabilisants de matieres organiques. | |
DE69730218D1 (de) | Fusogene liposomen | |
FI970810A (fi) | Ionipolymeerejä sisältäviä biologisesti aktiivisia anioneja | |
DE69831589D1 (de) | Zusammenfügung von knorpelmatrizen unter verwendung isolierter chondrozyten | |
EE9900147A (et) | Oksadiasoolid, nende saamismeetodid ja kasutamine ravimitena | |
ES2132253T3 (es) | Lipidos cationicos. | |
PT1017659E (pt) | Tetra-hidronaftalenos substituidos e compostos analogos | |
CO5271726A1 (es) | Composicion farmaceutica soluble en agua en un complejo ionico y el uso de la misma | |
DE3580283D1 (de) | Biologisch wirksame substanz mit hormonellen eigenschaften, verfahren zu ihrer herstellung und verwendung von histonen fuer medizinische zwecke. | |
DK0767798T3 (da) | Sterolderivater anvendt til regulering af meiose | |
ES2117426T3 (es) | Forma cristalina de la sal anhidra compuesta de los acidos 7-((1a,5a,6a)-6-amino-3-azabiciclo(3.1.0.)hex-3-il)-6-fluoro-1-(2,4-difluorofenil)-1,4-dihidro-4-oxo-1,8-naftiridina-3-carboxilico y metanosulfonico. | |
FI990134A0 (fi) | Pyridatsino-(4,5-beta)-kinoliini-5-oksidijohdannaisia, niiden valmistus ja niiden käyttö glysiiniantagonisteina | |
UA26431A (uk) | Похідhі сиh-ізомеру цефалоспориhу, їх оптичhо активhі аhтиподи або рацемічhа суміш, а також їх фармацевтичhо прийhятhі кислотhо-адитивhі солі | |
FR2567884B1 (fr) | Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant | |
DE60031663D1 (de) | Flammschutzmittel, verfahren zu dessen herstellung und flammschutzmittelharzzusammensetzung dieses enthaltend | |
DE59804752D1 (de) | Herstellung von Perylen-3,4-dicarbonsäureanhydriden | |
DE3688397D1 (de) | 3-(2-aminoethyl)indol und -indolinderivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen. | |
DE3783145D1 (de) | Rekombinantes dns-plasmid zur herstellung von xanthangummi. | |
DE3750271D1 (de) | Substituierte Thiacycloalkeno [3,2-b] pyridine, Methode zur Herstellung, Zubereitungen und Methode zu ihrer Anwendung. | |
DE69812438T2 (de) | Zusammensetzung zur herstellung von brennstoff-briketts | |
DK0842193T3 (da) | Somatostatin-analoge cykliske peptider med hæmmende aktivitet på væksthormon |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |