JP2001502349A - 造影剤におけるまたはこれに関する改良 - Google Patents

造影剤におけるまたはこれに関する改良

Info

Publication number
JP2001502349A
JP2001502349A JP10519116A JP51911698A JP2001502349A JP 2001502349 A JP2001502349 A JP 2001502349A JP 10519116 A JP10519116 A JP 10519116A JP 51911698 A JP51911698 A JP 51911698A JP 2001502349 A JP2001502349 A JP 2001502349A
Authority
JP
Japan
Prior art keywords
emulsion
gas
dispersion
combination preparation
microbubbles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10519116A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001502349A5 (enExample
Inventor
エーステンセン,ヨニー
エリクセン,モーテン
フリグスタード,シーグムンド
ロングヴェド,ポール
Original Assignee
ニユコメド・イメージング・アクシエセルカペト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9621884.7A external-priority patent/GB9621884D0/en
Priority claimed from GBGB9708239.0A external-priority patent/GB9708239D0/en
Application filed by ニユコメド・イメージング・アクシエセルカペト filed Critical ニユコメド・イメージング・アクシエセルカペト
Publication of JP2001502349A publication Critical patent/JP2001502349A/ja
Publication of JP2001502349A5 publication Critical patent/JP2001502349A5/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927Diagnostic contrast agent
    • Y10S977/928X-ray agent
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927Diagnostic contrast agent
    • Y10S977/929Ultrasound contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP10519116A 1996-10-21 1997-10-21 造影剤におけるまたはこれに関する改良 Pending JP2001502349A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9621884.7A GB9621884D0 (en) 1996-10-21 1996-10-21 Improvements in or relating to contrast agents
GB9621884.7 1996-10-21
GBGB9708239.0A GB9708239D0 (en) 1997-04-23 1997-04-23 Improvements in or relating to contrast agents
GB9708239.0 1997-04-23
PCT/GB1997/002898 WO1998017324A2 (en) 1996-10-21 1997-10-21 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
JP2001502349A true JP2001502349A (ja) 2001-02-20
JP2001502349A5 JP2001502349A5 (enExample) 2005-06-16

Family

ID=26310262

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10519116A Pending JP2001502349A (ja) 1996-10-21 1997-10-21 造影剤におけるまたはこれに関する改良

Country Status (26)

Country Link
US (3) US6375931B2 (enExample)
EP (2) EP1264604B1 (enExample)
JP (1) JP2001502349A (enExample)
KR (1) KR20000052652A (enExample)
CN (1) CN1106859C (enExample)
AP (1) AP885A (enExample)
AT (2) ATE381353T1 (enExample)
AU (1) AU745047B2 (enExample)
BG (1) BG103402A (enExample)
BR (1) BR9712370A (enExample)
CA (1) CA2269319C (enExample)
CZ (1) CZ140999A3 (enExample)
DE (2) DE69738406T2 (enExample)
EE (1) EE03749B1 (enExample)
ES (1) ES2197336T3 (enExample)
HU (1) HU224218B1 (enExample)
ID (1) ID21681A (enExample)
IL (1) IL129423A (enExample)
MX (1) MXPA99003664A (enExample)
NO (1) NO991869L (enExample)
NZ (1) NZ335265A (enExample)
PL (1) PL332820A1 (enExample)
RU (1) RU2204415C2 (enExample)
SK (1) SK283210B6 (enExample)
TR (1) TR199901544T2 (enExample)
WO (1) WO1998017324A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532619A (ja) * 2004-04-13 2007-11-15 ケンブリッジ バイオスタビリティ リミテッド 懸濁したガラス粒子を含有する液体
JP2022514063A (ja) * 2018-12-21 2022-02-09 ジーイー・ヘルスケア・アクスイェ・セルスカプ 超音波造影剤およびそれを使用する方法

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
DE69724599T2 (de) * 1996-03-12 2004-08-05 The Board Of Regents Of The University Of Nebraska, Lincoln Zusammensetzung zur zielortspezifischen verabreichung eines medikamentes und verfahren zur anwendung
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
ES2189974T3 (es) * 1996-09-11 2003-07-16 Imarx Pharmaceutical Corp Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador.
CZ140999A3 (cs) * 1996-10-21 1999-09-15 Nycomed Imaging As Směsný prostředek pro použití jako kontrastní činidlo
GB9708246D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Improvements in or relating to ultrasound imaging
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
JP2001520207A (ja) * 1997-10-21 2001-10-30 ニユコメド・イメージング・アクシエセルカペト 微小血管に標的設定された造影剤および血管拡張剤による超音波造影
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19805012A1 (de) * 1998-02-07 1999-08-12 Thomas Gieselmann Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung
US20040170564A1 (en) * 1998-04-22 2004-09-02 Roald Skurtveit Ultrasound contrast agent dispersions comprising gas and destabilising agent
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
GB9808582D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or relating to contrast agents
GB9808581D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or relating to contrast agents
GB9813568D0 (en) * 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
NO20010234D0 (no) * 2001-01-12 2001-01-12 Nycomed Imaging As Perfusjon avbildningsbilde
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
US20080193490A1 (en) * 2002-02-14 2008-08-14 Andreas Hirsch Use of Carbon Nanotube for Drug Delivery
US20040166152A1 (en) * 2002-02-14 2004-08-26 Andreas Hirsch Use of buckysome or carbon nanotube for drug delivery
ES2506142T3 (es) 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US20090060992A1 (en) * 2002-05-08 2009-03-05 University Of Central Florida Research Foundation, Inc., Preparation of magneto-vesicles with DOPE/DDAB layers
US7623903B2 (en) * 2002-05-17 2009-11-24 Wacker Frank K Double contrast technique for MRI-guided vascular interventions
AU2003270689A1 (en) * 2002-09-19 2004-04-08 New York University Control of nitric oxide bioactivity by perfluorocarbons
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
WO2004068405A2 (en) * 2003-01-25 2004-08-12 Oraevsky Alexander A High contrast optoacoustical imaging using nanoparticles
US7378081B2 (en) 2003-01-29 2008-05-27 Vincon Research Enterprises, Llc Composition and method for direct visualization of the human appendix
US20040146461A1 (en) * 2003-01-29 2004-07-29 Vincenzo Giuliano Oral contrast media composition for computerized axial tomographic examinations and method
TW200423949A (en) * 2003-01-31 2004-11-16 Otsuka Pharma Co Ltd Auxiliary agent used for the cancer medical treatment by dielectric heating, and cancer medical treatment method
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
AU2004210221B2 (en) * 2003-02-04 2008-11-20 Bracco Suisse S.A. Ultrasound contrast agents and process for the preparation thereof
EP2949658B1 (en) 2003-03-03 2018-08-08 Dyax Corp. Peptides that specifically bind HGF receptor (cMet) and uses thereof
US20040258760A1 (en) * 2003-03-20 2004-12-23 Wheatley Margaret A. Isolated nanocapsule populations and surfactant-stabilized microcapsules and nanocapsules for diagnostic imaging and drug delivery and methods for their production
US20080299047A1 (en) * 2003-07-31 2008-12-04 National Cheng Kung University Method for preparation of water-soluble and dispersed iron oxide nanoparticles and application thereof
SE526838C2 (sv) * 2003-11-27 2005-11-08 Xcounter Ab Undersökningsmetod och anordning för detektion av joniserande strålning
CN100563718C (zh) * 2003-12-22 2009-12-02 伯拉考开发股份有限公司 用于反差成像的充气微囊组件
RU2346693C2 (ru) * 2004-01-27 2009-02-20 Си Ви Терапьютикс, Инк. Визуализация перфузии миокарда с использованием агонистов аденозиновых рецепторов
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
JP4837663B2 (ja) * 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
US8034222B2 (en) * 2004-10-26 2011-10-11 The Regents Of The University Of California Conducting polymer nanowire sensors
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
US20070167861A1 (en) * 2005-11-29 2007-07-19 Lopez George A Cardiac output measurement devices and methods
KR101658439B1 (ko) 2005-12-09 2016-09-21 브라코 스위스 에스.에이. 표적화 벡터-포스포리피드 컨쥬게이트
WO2007100885A2 (en) * 2006-02-28 2007-09-07 E. I. Du Pont De Nemours And Company Azeotropic compositions comprising fluorinated compounds for cleaning applications
CN100400105C (zh) * 2006-05-11 2008-07-09 上海交通大学 水性基质的消化道ct阴性造影剂及其制备方法
JP4279328B2 (ja) * 2007-05-07 2009-06-17 株式会社日立製作所 超音波撮像システム
RU2387365C2 (ru) * 2007-08-15 2010-04-27 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) Способ исследования состояния кожи методом оптической когерентной томографии
KR100957560B1 (ko) * 2007-10-18 2010-05-11 한국생명공학연구원 양자점 나노입자를 함유한 퍼플루오르카본 나노에멀젼 및그 제조방법
RU2367443C1 (ru) * 2008-02-28 2009-09-20 Общество с ограниченной ответственностью "Битеп" Средство на основе природных фосфолипидов
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010038161A2 (en) * 2008-09-30 2010-04-08 Koninklijke Philips Electronics, N.V. Perfusion imaging
US9072490B2 (en) * 2010-12-20 2015-07-07 Toshiba Medical Systems Corporation Image processing apparatus and image processing method
ITRM20110022A1 (it) * 2011-01-21 2012-07-22 Gaio Paradossi Metodo per la preparazione di microbolle comprendenti un agente di contrasto
RU2454174C2 (ru) * 2011-03-16 2012-06-27 Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "МНИОИ им. П.А. Герцена" Минздравсоцразвития России) Способ диагностики опухолей шейки матки
RU2453270C1 (ru) * 2011-03-31 2012-06-20 Федеральное государственное учреждение "Московский научно-исследовательский онкологический институт им. П.А. Герцена Министерства здравоохранения и социального развития Российской Федерации" (ФГУ "МНИОИ им. П.А. Герцена" Минздравсоцразвития России) Способ исследования терминального отдела толстой кишки
RU2485976C2 (ru) * 2011-05-17 2013-06-27 Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО СибГМУ Минздравсоцразвития России) Контрастное средство для ультразвуковой визуализации
CA2871684C (en) * 2012-04-30 2021-01-05 Ge Healthcare As Method for filling a container with a foamable composition
MX354719B (es) * 2012-06-26 2018-03-16 Ge Healthcare As Preparacion de una composicion que comprende microburbujas de gas.
CN103100093B (zh) * 2013-01-23 2015-05-06 中山大学附属第三医院 一种负载小干扰rna的纳米级脂质微泡超声造影剂及制备方法
SI3049117T1 (sl) 2013-09-27 2022-11-30 Exact Therapeutics As Dostava zdravil, posredovana z ultrazvokom
KR102618877B1 (ko) 2014-12-31 2023-12-28 랜티우스 메디컬 이메징, 인크. 지질-캡슐화된 기체 마이크로스피어 조성물 및 관련 방법
IL262647B2 (en) 2016-05-04 2023-03-01 Lantheus Medical Imaging Inc Methods and devices for preparing sharpness factors for ultrasound
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US11642172B2 (en) * 2019-03-05 2023-05-09 Biosense Webster (Israel) Ltd. Showing catheter in brain
US12005130B2 (en) 2019-10-16 2024-06-11 Agitated Solutions Inc. Generating microbubbles for bubble studies
US11191888B1 (en) 2020-05-18 2021-12-07 Agitated Solutions Inc. Syringe-based microbubble generator
RU2744825C1 (ru) * 2020-06-03 2021-03-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Смоленский государственный медицинский университет" министерства здравоохранения Российской Федерации Способ определения времени течения артериальной фазы эхоконтрастирования печени, почек и селезенки
US20220079499A1 (en) * 2020-09-14 2022-03-17 Biosense Webster (Israel) Ltd. Identification of ablation gaps

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5070877A (en) * 1988-08-11 1991-12-10 Medco Research, Inc. Novel method of myocardial imaging
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5117830A (en) * 1990-11-08 1992-06-02 Whitby Research, Inc. Method of determining viability of tissue
SK281535B6 (sk) * 1993-01-25 2001-04-09 Sonus Pharmaceuticals, Inc. Kontrastné médium na ultrazvukové zobrazovanie a spôsob jeho prípravy
US5362478A (en) * 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
US5798091A (en) * 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
JP3559849B2 (ja) * 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US5560364A (en) * 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
CZ140999A3 (cs) * 1996-10-21 1999-09-15 Nycomed Imaging As Směsný prostředek pro použití jako kontrastní činidlo
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007532619A (ja) * 2004-04-13 2007-11-15 ケンブリッジ バイオスタビリティ リミテッド 懸濁したガラス粒子を含有する液体
JP2022514063A (ja) * 2018-12-21 2022-02-09 ジーイー・ヘルスケア・アクスイェ・セルスカプ 超音波造影剤およびそれを使用する方法

Also Published As

Publication number Publication date
DE69721331D1 (de) 2003-05-28
NZ335265A (en) 2000-07-28
WO1998017324A2 (en) 1998-04-30
CN1238699A (zh) 1999-12-15
BR9712370A (pt) 1999-08-31
ATE238073T1 (de) 2003-05-15
HUP0000282A3 (en) 2001-09-28
US20050118104A1 (en) 2005-06-02
US6783752B2 (en) 2004-08-31
KR20000052652A (ko) 2000-08-25
EP1007100B1 (en) 2003-04-23
US20010002993A1 (en) 2001-06-07
WO1998017324A3 (en) 1998-06-25
MXPA99003664A (es) 2002-06-11
EP1264604B1 (en) 2007-12-19
US6375931B2 (en) 2002-04-23
HUP0000282A2 (hu) 2000-05-28
ATE381353T1 (de) 2008-01-15
RU2204415C2 (ru) 2003-05-20
DE69721331T2 (de) 2004-05-06
IL129423A (en) 2003-01-12
CA2269319A1 (en) 1998-04-30
TR199901544T2 (xx) 1999-09-21
AU4714797A (en) 1998-05-15
US20040141921A1 (en) 2004-07-22
CN1106859C (zh) 2003-04-30
AP885A (en) 2000-11-03
SK52099A3 (en) 2000-01-18
ID21681A (id) 1999-07-08
IL129423A0 (en) 2000-02-17
DE69738406T2 (de) 2008-12-04
EP1264604A2 (en) 2002-12-11
DE69738406D1 (de) 2008-01-31
NO991869D0 (no) 1999-04-19
EE9900158A (et) 1999-12-15
SK283210B6 (sk) 2003-03-04
CA2269319C (en) 2008-03-18
PL332820A1 (en) 1999-10-11
EP1007100A2 (en) 2000-06-14
AU745047B2 (en) 2002-03-07
AP9901511A0 (en) 1999-06-30
CZ140999A3 (cs) 1999-09-15
EP1264604A3 (en) 2004-03-10
HU224218B1 (hu) 2005-06-28
NO991869L (no) 1999-06-02
BG103402A (bg) 2000-01-31
ES2197336T3 (es) 2004-01-01
EE03749B1 (et) 2002-06-17

Similar Documents

Publication Publication Date Title
CA2269319C (en) Improvements in or relating to contrast agents
EP1073473B1 (en) Improvements in or relating to contrast agents
JP4916969B2 (ja) ガス状のフッ化化合物充填脂微小球
KR20000029639A (ko) 고분자-지질로마이크로캡슐화된가스영상화제
JP2000513357A (ja) 造影剤の投与速度を調節することによる診断的画像化の改良法
US20040131547A1 (en) Contrast agents
JP2002512208A (ja) 造影剤における改良または造影剤に関する改良
EP1079865B1 (en) Ultrasound contrast agent dispersions comprising gas and destabilising agent
US20040170564A1 (en) Ultrasound contrast agent dispersions comprising gas and destabilising agent
MXPA00010301A (en) Improvements in or relating to contrast agents
CZ20003896A3 (cs) Kombinovaný prostředek

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040907

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040907

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080401

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080701

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20081014