JP2001502291A - ナノ粒子分散体を含有するエアロゾル - Google Patents
ナノ粒子分散体を含有するエアロゾルInfo
- Publication number
- JP2001502291A JP2001502291A JP08525798A JP52579896A JP2001502291A JP 2001502291 A JP2001502291 A JP 2001502291A JP 08525798 A JP08525798 A JP 08525798A JP 52579896 A JP52579896 A JP 52579896A JP 2001502291 A JP2001502291 A JP 2001502291A
- Authority
- JP
- Japan
- Prior art keywords
- aerosol
- therapeutic
- particles
- agent
- diagnostic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0476—Particles, beads, capsules, spheres
- A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
- A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. その表面上に表面改質剤をもつ、不溶性の治療又は診断剤粒子を含むナノ 粒子の水性分散体の滴を含むエアロゾル。 2. 治療剤が、ベクロメタゾン・ジプロピオネートである、請求項1に記載の エアロゾル。 3. 診断剤が、安息香酸、3,5−ビス(アセチルアミノ)−2,4,6−ト リヨード−,4−(エチル−3−エトキシ−2−ブテノエート)エステル(WIN 6 8209)である、請求項1に記載のエアロゾル。 4. その表面上に表面改質剤をもつ、不溶性の治療又は診断剤粒子を含むナノ 粒子の水性分散体のエアロゾルの形成方法であって、以下の段階: a)上記ナノ粒子の懸濁液を用意し;そして b)上記懸濁液を噴霧してエアロゾルを形成する、 を含む方法。 5. 以下の段階: a)その表面上に表面改質剤をもつ不溶性の治療剤粒子を含むナノ粒子水性分 散体のエアロゾルを形成し;そして b)哺乳類の呼吸系に上記エアロゾルを投与する、 を含む哺乳類の治療方法。 6. エアロゾルが、それが肺に達するようなやり方で投与される、請求項5に 記載の方法。 7. ナノ粒子が、ベクロメタゾンを含む、請求項6に記載の方法。 8. 以下の段階: a)その表面上に表面改質剤をもつ不溶性診断用イメージング剤 粒子を含むナノ粒子の水性分散体のエアロゾルを形成し; b)哺乳類の呼吸系に上記エアロゾルを投与し;そして c)上記呼吸系内の上記イメージング剤を画像形成する、 を含む、哺乳類の診断方法。 9. 診断用イメージング剤が、安息香酸、3,5−ビス(アセチルアミノ)− 2,4,6−トリヨード−,4−(エチル−3−エトシキ−2−ブテノエート) エステル(WIN 68209)である、請求項8に記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39410395A | 1995-02-24 | 1995-02-24 | |
US08/394,103 | 1995-02-24 | ||
US58968196A | 1996-01-19 | 1996-01-19 | |
US08/589,681 | 1996-01-19 | ||
PCT/US1996/002346 WO1996025918A1 (en) | 1995-02-24 | 1996-02-23 | Aerosols containing nanoparticle dispersions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007230718A Division JP2007314581A (ja) | 1995-02-24 | 2007-09-05 | ナノ粒子分散体を含有するエアロゾル |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001502291A true JP2001502291A (ja) | 2001-02-20 |
JP4484247B2 JP4484247B2 (ja) | 2010-06-16 |
Family
ID=27014591
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52579896A Expired - Lifetime JP4484247B2 (ja) | 1995-02-24 | 1996-02-23 | ナノ粒子分散体を含有するエアロゾル |
JP2007230718A Withdrawn JP2007314581A (ja) | 1995-02-24 | 2007-09-05 | ナノ粒子分散体を含有するエアロゾル |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007230718A Withdrawn JP2007314581A (ja) | 1995-02-24 | 2007-09-05 | ナノ粒子分散体を含有するエアロゾル |
Country Status (8)
Country | Link |
---|---|
US (6) | US6264922B1 (ja) |
EP (1) | EP0810853B1 (ja) |
JP (2) | JP4484247B2 (ja) |
AT (1) | ATE274341T1 (ja) |
AU (1) | AU4990696A (ja) |
CA (1) | CA2213638C (ja) |
DE (1) | DE69633222T2 (ja) |
WO (1) | WO1996025918A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004534074A (ja) * | 2001-06-14 | 2004-11-11 | ヤゴテック アーゲー | 新規組成物 |
Families Citing this family (177)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69633222T2 (de) | 1995-02-24 | 2005-09-08 | Elan Pharma International Ltd. | Nanopartikel-dispersionen enthaltende aerosole |
US20050004049A1 (en) * | 1997-03-11 | 2005-01-06 | Elan Pharma International Limited | Novel griseofulvin compositions |
GB9710604D0 (en) * | 1997-05-22 | 1997-07-16 | Nycomed Imaging As | Contrast media |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
US6653519B2 (en) * | 1998-09-15 | 2003-11-25 | Nanoscale Materials, Inc. | Reactive nanoparticles as destructive adsorbents for biological and chemical contamination |
US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US20080213378A1 (en) * | 1998-10-01 | 2008-09-04 | Elan Pharma International, Ltd. | Nanoparticulate statin formulations and novel statin combinations |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
CA2348871C (en) | 1998-11-02 | 2009-04-14 | John G. Devane | Multiparticulate modified release composition |
US20080102121A1 (en) * | 1998-11-02 | 2008-05-01 | Elan Pharma International Limited | Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone |
US20090297602A1 (en) * | 1998-11-02 | 2009-12-03 | Devane John G | Modified Release Loxoprofen Compositions |
US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US20040141925A1 (en) * | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
US6969529B2 (en) | 2000-09-21 | 2005-11-29 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers |
EG23951A (en) * | 1999-03-25 | 2008-01-29 | Otsuka Pharma Co Ltd | Cilostazol preparation |
US6156294A (en) | 1999-11-28 | 2000-12-05 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
US6676930B2 (en) | 1999-11-28 | 2004-01-13 | Scientific Development And Research, Inc. | Composition and method for treatment of otitis media |
GB0003935D0 (en) * | 2000-02-08 | 2000-04-12 | King S College London | Formulation for dry powder inhaler |
US20030224058A1 (en) * | 2002-05-24 | 2003-12-04 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
US7998507B2 (en) | 2000-09-21 | 2011-08-16 | Elan Pharma International Ltd. | Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors |
US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
GB0024271D0 (en) * | 2000-09-25 | 2000-11-15 | Colaco Camilo | Improved methods and compositions for pulmonary delivery of actives |
PL199420B1 (pl) * | 2000-10-09 | 2008-09-30 | 3M Innovative Properties Co | Medyczne preparaty aerozolowe |
US20030096013A1 (en) * | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US6869617B2 (en) * | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US7193084B2 (en) * | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
US6976647B2 (en) * | 2001-06-05 | 2005-12-20 | Elan Pharma International, Limited | System and method for milling materials |
EP1401401B1 (en) * | 2001-06-22 | 2005-03-30 | Marie Lindner | Method for high through put screening using a small scale mill or microfluidics |
US20030054042A1 (en) * | 2001-09-14 | 2003-03-20 | Elaine Liversidge | Stabilization of chemical compounds using nanoparticulate formulations |
US20030095928A1 (en) * | 2001-09-19 | 2003-05-22 | Elan Pharma International Limited | Nanoparticulate insulin |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
WO2003030872A2 (en) * | 2001-10-12 | 2003-04-17 | Elan Pharma International Ltd. | Compositions having a combination of particles for immediate release and for controlled release |
US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
CA2465793A1 (en) * | 2001-11-07 | 2003-05-15 | Taffy Williams | Methods for vascular imaging using nanoparticulate contrast agents |
CA2465779A1 (en) * | 2001-11-20 | 2003-05-30 | Advanced Inhalation Research, Inc. | Compositions for sustained action product delivery |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
DE60332212D1 (de) * | 2002-02-04 | 2010-06-02 | Elan Pharma Int Ltd | Arzneistoffnanopartikel mit lysozym-oberflächenstabilisator |
US20040101566A1 (en) * | 2002-02-04 | 2004-05-27 | Elan Pharma International Limited | Novel benzoyl peroxide compositions |
JP2005526095A (ja) * | 2002-03-20 | 2005-09-02 | エラン ファーマ インターナショナル,リミティド | 脆砕性の低い急速溶解投与剤型 |
US20040076586A1 (en) * | 2002-03-28 | 2004-04-22 | Reinhard Koening | Compositions and methods for delivering pharmaceutically active agents using nanoparticulates |
US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
US20040105889A1 (en) * | 2002-12-03 | 2004-06-03 | Elan Pharma International Limited | Low viscosity liquid dosage forms |
EP2263650A3 (en) | 2002-04-12 | 2013-12-25 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
US20100226989A1 (en) * | 2002-04-12 | 2010-09-09 | Elan Pharma International, Limited | Nanoparticulate megestrol formulations |
US7101576B2 (en) * | 2002-04-12 | 2006-09-05 | Elan Pharma International Limited | Nanoparticulate megestrol formulations |
DE60325718D1 (de) * | 2002-05-06 | 2009-02-26 | Elan Pharma Int Ltd | Nystatin-nanopartikelzusammensetzungen |
US7279129B2 (en) * | 2002-05-14 | 2007-10-09 | Nanoscale Corporation | Method and apparatus for control of chemical or biological warfare agents |
US20070264348A1 (en) * | 2002-05-24 | 2007-11-15 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
WO2003103632A1 (en) * | 2002-06-10 | 2003-12-18 | Elan Pharma International, Ltd. | Nanoparticulate polycosanol formulations and novel polycosanol combinations |
EP1551457A1 (en) * | 2002-07-16 | 2005-07-13 | Elan Pharma International Limited | Liquid dosage compositions of stable nanoparticulate active agents |
CA2498207C (en) * | 2002-09-11 | 2012-03-13 | Elan Pharma International Ltd. | Gel-stabilized nanoparticulate active agent compositions |
ES2365012T3 (es) * | 2002-11-12 | 2011-09-20 | Elan Pharma International Limited | Formas farmacéuticas sólidas de desintegración rápida que no son friables y que comprenden pululano. |
US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
EP1569623B1 (en) | 2002-12-13 | 2008-10-15 | Jagotec Ag | A topical nanoparticulate spironolactone formulation |
AU2003297151A1 (en) * | 2002-12-17 | 2004-07-22 | Elan Pharma International Ltd. | Milling microgram quantities of nanoparticulate candidate compounds |
US7390505B2 (en) * | 2003-01-31 | 2008-06-24 | Elan Pharma International, Ltd. | Nanoparticulate topiramate formulations |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
EP1625333A1 (en) | 2003-05-21 | 2006-02-15 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
CA2523035C (en) * | 2003-05-22 | 2011-04-26 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
CA2534924A1 (en) * | 2003-08-08 | 2005-02-24 | Elan Pharma International Ltd. | Novel metaxalone compositions |
EP1686962B9 (en) * | 2003-11-05 | 2012-10-03 | Elan Pharma International Limited | Nanoparticulate compositions having a peptide as a surface stabilizer |
AU2003285133A1 (en) | 2003-11-05 | 2005-06-24 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Biofunctionalized quantum dots for biological imaging |
EP1711163A2 (en) * | 2004-02-05 | 2006-10-18 | Baxter International Inc. | Dispersions prepared by use of self-stabilizing agents |
WO2005088655A1 (en) * | 2004-03-12 | 2005-09-22 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | A magnetoresistive medium |
US7659237B2 (en) * | 2004-04-29 | 2010-02-09 | Advanced Biocatalytics Corp. | Increasing surface-active properties of surfactants |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
EP1789018A1 (en) | 2004-08-27 | 2007-05-30 | The Dow Chemical Company | Enhanced delivery of drug compositions to treat life threatening infections |
AU2005307797B2 (en) * | 2004-11-16 | 2011-06-02 | Alkermes Pharma Ireland Limited | Injectable nanoparticulate olanzapine formulations |
CN1301747C (zh) * | 2004-11-30 | 2007-02-28 | 深圳市海王英特龙生物技术股份有限公司 | 一种蛋白药物微囊及其吸入性气雾剂 |
UA89513C2 (uk) * | 2004-12-03 | 2010-02-10 | Элан Фарма Интернешнл Лтд. | Стабільна композиція з наночастинок ралоксифену гідрохлориду |
US20080145430A1 (en) * | 2004-12-08 | 2008-06-19 | Santipharp Panmai | Ophthalmic Nanoparticulate Formulation Of A Cyclooxygenase-2 Selective Inhibitor |
JP2008524239A (ja) * | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミティド | ナノ粒子のタクロリムス製剤 |
JP2008524393A (ja) * | 2004-12-21 | 2008-07-10 | バクスター・インターナショナル・インコーポレイテッド | ポリアルコキシスルホネート表面改変因子 |
WO2006069098A1 (en) * | 2004-12-22 | 2006-06-29 | Elan Pharma International Ltd. | Nanoparticulate bicalutamide formulations |
EA200701442A1 (ru) * | 2005-01-06 | 2008-02-28 | Элан Фарма Интернэшнл Лтд. | Композиции наночастиц кандесартана |
EP1853234A2 (en) | 2005-02-15 | 2007-11-14 | Elan Pharma International Limited | Aerosol and injectable formulations of nanoparticulate benzodiazepine |
CA2598288A1 (en) * | 2005-03-03 | 2006-09-14 | Elan Pharma International Limited | Nanoparticulate compositions of heterocyclic amide derivatives |
WO2006099121A2 (en) * | 2005-03-10 | 2006-09-21 | Elan Pharma International Limited | Formulations of a nanoparticulate finasteride, dutasteride and tamsulosin hydrochloride, and mixtures thereof |
CN101175480A (zh) * | 2005-03-16 | 2008-05-07 | 伊兰制药国际有限公司 | 纳米微粒白三烯受体拮抗剂/皮质类固醇制剂 |
JP2008533173A (ja) * | 2005-03-17 | 2008-08-21 | エラン ファーマ インターナショナル リミテッド | ナノ粒子ビスホスホネート組成物 |
JP2008534509A (ja) * | 2005-03-23 | 2008-08-28 | エラン ファーマ インターナショナル リミテッド | ナノ粒子副腎皮質ステロイドおよび抗ヒスタミン薬の製剤 |
US20060246141A1 (en) * | 2005-04-12 | 2006-11-02 | Elan Pharma International, Limited | Nanoparticulate lipase inhibitor formulations |
EA200702216A1 (ru) | 2005-04-12 | 2008-08-29 | Элан Фарма Интернэшнл Лимитед | Композиции в форме наночастиц с контролируемым высвобождением, содержащие циклоспорин |
WO2006110811A1 (en) * | 2005-04-12 | 2006-10-19 | Elan Pharma International Limited | Nanoparticulate quinazoline derivative formulations |
US20090081297A1 (en) * | 2005-04-27 | 2009-03-26 | Cook Robert O | Use of surface tension reducing agents in aerosol formulations |
MX2007014163A (es) * | 2005-05-10 | 2008-01-24 | Elan Pharma Int Ltd | Formulaciones de nanoparticulas de clopidogrel. |
US20110064803A1 (en) * | 2005-05-10 | 2011-03-17 | Elan Pharma International Limited. | Nanoparticulate and controlled release compositions comprising vitamin k2 |
PT2594272T (pt) | 2005-05-18 | 2018-07-31 | Horizon Orphan Llc | Fluoroquinolonas aerossolizadas e suas utilizações |
US8524734B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
US20100028439A1 (en) * | 2005-05-23 | 2010-02-04 | Elan Pharma International Limited | Nanoparticulate stabilized anti-hypertensive compositions |
US20070042049A1 (en) * | 2005-06-03 | 2007-02-22 | Elan Pharma International, Limited | Nanoparticulate benidipine compositions |
AU2006309295B2 (en) * | 2005-06-03 | 2012-04-26 | Elan Pharma International Limited | Nanoparticulate acetaminophen formulations |
ATE459341T1 (de) * | 2005-06-03 | 2010-03-15 | Elan Pharma Int Ltd | Nanoteilchenförmige imatinib-mesylat- formulierungen |
EP1954253A4 (en) | 2005-06-08 | 2011-07-27 | Elan Pharma Int Ltd | NANOTEILIC AND CONTROLLED RELEASED COMPOSITIONS WITH CEFDITORS |
ATE446742T1 (de) * | 2005-06-09 | 2009-11-15 | Elan Pharma Int Ltd | Nanopartikuläre ebastinformulierungen |
EA200800041A1 (ru) * | 2005-06-13 | 2008-04-28 | Элан Фарма Интернэшнл Лтд. | Составы с наночастицами клопидогреля, содержащие комбинацию клопидогреля и аспирина |
EP1931340A2 (en) * | 2005-06-15 | 2008-06-18 | Elan Pharma International Limited | Nanoparticulate azelnidipine formulations |
US20090180964A1 (en) * | 2005-06-24 | 2009-07-16 | Rao Papineni | Transmucosal delivery of optical, spect, multimodal,drug or biological cargo laden nanoparticle(s) in small animals or humans |
US20070015719A1 (en) * | 2005-07-07 | 2007-01-18 | Elan Pharma International Limited | Nanoparticulate clarithromycin formulations |
CA2615378C (en) * | 2005-07-15 | 2015-02-17 | Map Pharmaceuticals, Inc. | Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof |
WO2007019346A1 (en) | 2005-08-04 | 2007-02-15 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
WO2007033239A2 (en) * | 2005-09-13 | 2007-03-22 | Elan Pharma International, Limited | Nanoparticulate tadalafil formulations |
EP2279727A3 (en) | 2005-09-15 | 2011-10-05 | Elan Pharma International Limited | Nanoparticulate aripiprazole formulations |
US7858609B2 (en) | 2005-11-28 | 2010-12-28 | Marinus Pharmaceuticals | Solid ganaxolone formulations and methods for the making and use thereof |
US20070185066A1 (en) * | 2005-12-20 | 2007-08-09 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070160542A1 (en) * | 2005-12-20 | 2007-07-12 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070249572A1 (en) * | 2005-12-20 | 2007-10-25 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids |
US20070178049A1 (en) * | 2005-12-20 | 2007-08-02 | Verus Pharmaceuticals, Inc. | Systems and methods for the delivery of corticosteroids having an enhanced pharmacokinetic profile |
US20070197486A1 (en) * | 2005-12-20 | 2007-08-23 | Verus Pharmaceuticals, Inc. | Methods and systems for the delivery of corticosteroids |
EP1820493A3 (en) * | 2006-02-10 | 2008-05-07 | PARI Pharma GmbH | Aerosols for sinunasal drug delivery |
JP2009526860A (ja) * | 2006-02-15 | 2009-07-23 | ティカ レーケメデル アーベー | 安定したコルチコステロイド混合物 |
US8367112B2 (en) * | 2006-02-28 | 2013-02-05 | Alkermes Pharma Ireland Limited | Nanoparticulate carverdilol formulations |
KR100792557B1 (ko) * | 2006-04-05 | 2008-01-09 | 한남대학교 산학협력단 | 나노 캡슐화를 이용하여 제조된 지질 핵 및 고분자 쉘구조를 갖는 단백질 약물 전달용 나노 미립구 |
JP2009538927A (ja) * | 2006-05-30 | 2009-11-12 | エラン ファーマ インターナショナル,リミティド | ナノ粒子状のポサコナゾール製剤 |
WO2008008733A2 (en) * | 2006-07-10 | 2008-01-17 | Elan Pharma International Ltd. | Nanoparticulate sorafenib formulations |
JP2009543803A (ja) * | 2006-07-12 | 2009-12-10 | エラン・ファルマ・インターナショナル・リミテッド | モダフィニルのナノ粒子製剤 |
BRPI0717721A2 (pt) * | 2006-11-28 | 2013-10-29 | Marinus Pharmaceuticals | "partículas complexadas de drogas, composição farmacêutica, uso de uma composição farmacêutica, partículas complexadas de droga estabilizadas no tamanho, método para a preparação de partículas estabilizadas da droga, composição farmacêutica sólida, comprimido oral ingerível e composição líquida em nanopartículas estabilizadas no tamanho" |
ES2594867T3 (es) | 2007-03-09 | 2016-12-23 | Alexza Pharmaceuticals, Inc. | Unidad de calentamiento para usar en un dispositivo de administración de fármaco |
EP3398611B1 (en) | 2007-04-18 | 2020-08-12 | Particle Sciences, Inc. | Aerosol dispersions of particles with active pharmaceutical ingredients |
EP1992371A1 (de) * | 2007-05-15 | 2008-11-19 | Occlutech GmbH | Bioresorbierbare röntgenopake Polymermaterialien und daraus hergestellte Occlussionsinstrumente |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
EP2030644A1 (en) | 2007-08-31 | 2009-03-04 | PARI Pharma GmbH | Aerosols for sinunasal drug delivery |
MX2010003935A (es) * | 2007-10-12 | 2010-09-24 | Map Pharmaceuticals Inc | Suministro de farmaco por inhalacion. |
WO2009117401A2 (en) * | 2008-03-21 | 2009-09-24 | Elan Pharama International Limited | Compositions for site-specific delivery of imatinib and methods of use |
US9027633B2 (en) * | 2008-03-24 | 2015-05-12 | Auburn University | Nanoparticle-enhanced phase change materials (NEPCM) with improved thermal energy storage |
US20090311335A1 (en) * | 2008-06-12 | 2009-12-17 | Scott Jenkins | Combination of a triptan and an nsaid |
HUE038428T2 (hu) | 2008-10-07 | 2018-10-29 | Horizon Orphan Llc | Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében |
SI2346509T1 (sl) | 2008-10-07 | 2020-08-31 | Horizon Orphan Llc | Inhalacija levofloksacina za zmanjšanje vnetja pljuč |
EP2396070A4 (en) | 2009-02-12 | 2012-09-19 | Incept Llc | ACTIVE COMPOSITION WITH HYDROGEL PLUGS |
WO2010099508A1 (en) | 2009-02-26 | 2010-09-02 | Theraquest Biosciences, Inc. | Extended release oral pharmaceutical compositions of 3-hydroxy-n-methylmorphinan and method of use |
US20100291221A1 (en) * | 2009-05-15 | 2010-11-18 | Robert Owen Cook | Method of administering dose-sparing amounts of formoterol fumarate-budesonide combination particles by inhalation |
US20100316725A1 (en) | 2009-05-27 | 2010-12-16 | Elan Pharma International Ltd. | Reduction of flake-like aggregation in nanoparticulate active agent compositions |
FR2945950A1 (fr) | 2009-05-27 | 2010-12-03 | Elan Pharma Int Ltd | Compositions de nanoparticules anticancereuses et procedes pour les preparer |
CN102497857A (zh) | 2009-06-19 | 2012-06-13 | 纳米模型匈牙利有限公司 | 纳米结构的西地那非碱、其药学可接受的盐和共结晶、它们的组合物、其制备方法和包含它们的药物组合物 |
BR112012004692B8 (pt) | 2009-09-04 | 2021-05-25 | Mpex Pharmaceuticals Inc | solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano |
WO2011146583A2 (en) | 2010-05-19 | 2011-11-24 | Elan Pharma International Limited | Nanoparticulate cinacalcet formulations |
US10092552B2 (en) | 2011-01-31 | 2018-10-09 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
US9205150B2 (en) | 2011-12-05 | 2015-12-08 | Incept, Llc | Medical organogel processes and compositions |
EP2601973A1 (en) | 2011-12-09 | 2013-06-12 | Laboratoires SMB SA | Dry powder formulation of azole derivative for inhalation |
GB201205632D0 (en) * | 2012-03-30 | 2012-05-16 | Vectura Ltd | Method and apparatus |
EP2877164B1 (en) | 2012-07-24 | 2023-07-05 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds |
WO2015017728A1 (en) | 2013-07-31 | 2015-02-05 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
WO2016178876A2 (en) | 2015-05-01 | 2016-11-10 | Cocrystal Pharma, Inc. | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
KR20230050474A (ko) | 2016-08-11 | 2023-04-14 | 오비드 테라퓨틱스 인크. | 간질 장애의 치료를 위한 방법 및 조성물 |
US10391105B2 (en) | 2016-09-09 | 2019-08-27 | Marinus Pharmaceuticals Inc. | Methods of treating certain depressive disorders and delirium tremens |
WO2019110099A1 (en) | 2017-12-06 | 2019-06-13 | Qrumpharma Inc. | Inhalable clofazimine formulation |
CN112804993A (zh) | 2018-08-23 | 2021-05-14 | 曼金德公司 | 氯法齐明的组合物,含它们的组合,它们的制备方法,含它们的用途和方法 |
US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
JP2022532431A (ja) * | 2019-05-16 | 2022-07-14 | エアロベイト セラピューティクス, インコーポレイテッド | イマチニブ製剤、その製造および使用 |
EP3980373A1 (en) | 2019-06-04 | 2022-04-13 | Thirty Holdings Limited | Methods and compositions for generating nitric oxide and uses thereof |
CA3142109A1 (en) | 2019-06-04 | 2020-12-10 | Thirty Respiratory Limited | Methods and compositions for generating nitric oxide and uses thereof to deliver nitric oxide via the respiratory tract |
EP4009982A4 (en) | 2019-08-05 | 2023-08-09 | Marinus Pharmaceuticals, Inc. | GANAXOLONE FOR USE IN THE TREATMENT OF STATUS EPILEPTICUS |
KR20220134529A (ko) | 2019-12-06 | 2022-10-05 | 마리누스 파마슈티컬스 인코포레이티드 | 복합 결절성 경화증의 치료에 사용하기 위한 가낙솔론 |
WO2021214439A1 (en) | 2020-04-23 | 2021-10-28 | Thirty Respiratory Limited | Methods and compositions for treating and combatting tuberculosis |
GB2610722A (en) | 2020-04-23 | 2023-03-15 | Thirty Respiratory Ltd | Nitric oxide or nitric oxide releasing compositions for use in treating SARS-COV and SARS-COV-2 |
EP4157237A2 (en) | 2020-06-01 | 2023-04-05 | Advent Therapeutics Inc. | Pharmaceutical compositions comprising insoluble active ingredients |
US11220699B1 (en) | 2020-08-12 | 2022-01-11 | Advanced Biocatalytics Corporation | Compositions and methods for enhancing efficiencies of microbial-derived biosurfactants |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
Family Cites Families (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3272700A (en) * | 1963-10-03 | 1966-09-13 | Sterling Drug Inc | Stabilized aqueous solution of tetracaine salt |
DE3013839A1 (de) * | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung |
US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
CA1264566A (en) * | 1984-09-05 | 1990-01-23 | Tetsuji Iwasaki | Biocidal fine powder, its manufacturing method and a suspension for agricultural use containing the above powder |
US4783484A (en) * | 1984-10-05 | 1988-11-08 | University Of Rochester | Particulate composition and use thereof as antimicrobial agent |
GB8432063D0 (en) * | 1984-12-19 | 1985-01-30 | Riker Laboratories Inc | Physically modified steroids |
FR2575678B1 (fr) * | 1985-01-04 | 1988-06-03 | Saint Gobain Vitrage | Ejecteur pneumatique de poudre |
US4727077A (en) * | 1985-02-20 | 1988-02-23 | Ishihara Sangyo Kaisha Ltd. | Benzoyl urea compounds, process for their production, and antitumorous compositions containing them |
US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
US4826821A (en) * | 1985-06-26 | 1989-05-02 | The Regents Of The University Of California | Lung surfactant compositions |
JPS62185013A (ja) * | 1986-02-08 | 1987-08-13 | Green Cross Corp:The | 易吸収性医薬組成物 |
EP0262560A3 (en) * | 1986-09-29 | 1989-07-05 | Ishihara Sangyo Kaisha, Ltd. | Benzoyl urea compound |
EP0264904A3 (en) * | 1986-10-23 | 1988-08-17 | Ishihara Sangyo Kaisha, Ltd. | Pharmaceutical compositions containing benzoyl urea derivatives |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
IT1216570B (it) * | 1988-04-08 | 1990-03-08 | Vectorpharma Int | Composizione farmaceutiche a rilascio controllato e procedimento per la loro preparazione. |
US4825821A (en) * | 1988-04-20 | 1989-05-02 | Outboard Marine Corporation | Carburetor pulse-back damping system for 2-cycle internal combustion engine |
IT1217890B (it) | 1988-06-22 | 1990-03-30 | Chiesi Farma Spa | Dispositivo per l'inalazione di aerosol dosati |
JP2661709B2 (ja) * | 1988-07-08 | 1997-10-08 | ダウ・ケミカル日本株式会社 | 高活性な農薬水和剤の製法 |
US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
US4906476A (en) * | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
JPH02196719A (ja) * | 1989-01-24 | 1990-08-03 | Green Cross Corp:The | 粉末状医薬組成物 |
US5208226A (en) * | 1989-09-08 | 1993-05-04 | Glaxo Group Limited | Medicaments |
GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
JPH05963A (ja) * | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
US5091187A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
GB9024365D0 (en) * | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
US6006745A (en) * | 1990-12-21 | 1999-12-28 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
US5290539A (en) * | 1990-12-21 | 1994-03-01 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
US5316768A (en) * | 1990-12-28 | 1994-05-31 | Murdock International Corporation | Pharmaceutical compositions having antiviral activity against human cytomegalovirus |
US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
US5399363A (en) * | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
MX9201782A (es) * | 1991-04-19 | 1992-10-01 | Sandoz Ag | Particulas de sustancias biologicamente activas, sustancialmente insolubles en agua, proceso para su produccion y composicion farmaceutica que las contiene. |
CA2112905A1 (en) * | 1991-07-05 | 1993-01-21 | Michael R. Violante | Ultrasmall non-aggregated porous particles entrapping gas-bubbles |
GB9120005D0 (en) * | 1991-09-19 | 1991-11-06 | Wellcome Found | Method of administering phospholipid dispersions |
AU675633B2 (en) * | 1991-12-18 | 1997-02-13 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
US5202110A (en) * | 1992-01-22 | 1993-04-13 | Virginia Commonwealth University | Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants |
US5300739A (en) * | 1992-05-26 | 1994-04-05 | Otis Elevator Company | Cyclically varying an elevator car's assigned group in a system where each group has a separate lobby corridor |
US5785049A (en) * | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
GB9216082D0 (en) | 1992-07-28 | 1992-09-09 | Univ Nottingham | Lymphatic delivery composition |
AU660852B2 (en) | 1992-11-25 | 1995-07-06 | Elan Pharma International Limited | Method of grinding pharmaceutical substances |
US5349957A (en) * | 1992-12-02 | 1994-09-27 | Sterling Winthrop Inc. | Preparation and magnetic properties of very small magnetite-dextran particles |
US5298262A (en) * | 1992-12-04 | 1994-03-29 | Sterling Winthrop Inc. | Use of ionic cloud point modifiers to prevent particle aggregation during sterilization |
US5346702A (en) * | 1992-12-04 | 1994-09-13 | Sterling Winthrop Inc. | Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization |
US5260478A (en) * | 1992-12-08 | 1993-11-09 | Sterling Winthrop Inc. | Iodinated aroyloxy carboxamides |
US5302401A (en) * | 1992-12-09 | 1994-04-12 | Sterling Winthrop Inc. | Method to reduce particle size growth during lyophilization |
US5340564A (en) * | 1992-12-10 | 1994-08-23 | Sterling Winthrop Inc. | Formulations comprising olin 10-G to prevent particle aggregation and increase stability |
US5336507A (en) * | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
US5429824A (en) * | 1992-12-15 | 1995-07-04 | Eastman Kodak Company | Use of tyloxapole as a nanoparticle stabilizer and dispersant |
US5322679A (en) * | 1992-12-16 | 1994-06-21 | Sterling Winthrop Inc. | Iodinated aroyloxy esters |
US5352459A (en) * | 1992-12-16 | 1994-10-04 | Sterling Winthrop Inc. | Use of purified surface modifiers to prevent particle aggregation during sterilization |
US5401492A (en) * | 1992-12-17 | 1995-03-28 | Sterling Winthrop, Inc. | Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents |
US5326552A (en) * | 1992-12-17 | 1994-07-05 | Sterling Winthrop Inc. | Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants |
CA2091152C (en) * | 1993-03-05 | 2005-05-03 | Kirsten Westesen | Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof |
NZ263084A (en) * | 1993-03-12 | 1997-08-22 | Arris Pharm Corp | Dipeptide derivatives, treatment of immunomediated inflammatory disorders |
US5264610A (en) * | 1993-03-29 | 1993-11-23 | Sterling Winthrop Inc. | Iodinated aromatic propanedioates |
DE4327063A1 (de) * | 1993-08-12 | 1995-02-16 | Kirsten Dr Westesen | Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften |
US5711934A (en) | 1994-04-11 | 1998-01-27 | Abbott Laboratories | Process for the continuous milling of aerosol pharmaceutical formulations in aerosol propellants |
GB9410222D0 (en) * | 1994-05-21 | 1994-07-06 | Glaxo Wellcome Australia Ltd | Medicaments |
US5718388A (en) * | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
TW384224B (en) | 1994-05-25 | 2000-03-11 | Nano Sys Llc | Method of preparing submicron particles of a therapeutic or diagnostic agent |
US5525328A (en) * | 1994-06-24 | 1996-06-11 | Nanosystems L.L.C. | Nanoparticulate diagnostic diatrizoxy ester X-ray contrast agents for blood pool and lymphatic system imaging |
US5587143A (en) * | 1994-06-28 | 1996-12-24 | Nanosystems L.L.C. | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
DE4440337A1 (de) * | 1994-11-11 | 1996-05-15 | Dds Drug Delivery Services Ges | Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit |
DE4446891A1 (de) * | 1994-12-27 | 1996-07-04 | Falk Pharma Gmbh | Stabile wäßrige Budesonid-Lösung |
US5628981A (en) * | 1994-12-30 | 1997-05-13 | Nano Systems L.L.C. | Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents |
US5466440A (en) * | 1994-12-30 | 1995-11-14 | Eastman Kodak Company | Formulations of oral gastrointestinal diagnostic X-ray contrast agents in combination with pharmaceutically acceptable clays |
US5585108A (en) * | 1994-12-30 | 1996-12-17 | Nanosystems L.L.C. | Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays |
US5662883A (en) * | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5560932A (en) * | 1995-01-10 | 1996-10-01 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents |
US5569448A (en) * | 1995-01-24 | 1996-10-29 | Nano Systems L.L.C. | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
US5571536A (en) * | 1995-02-06 | 1996-11-05 | Nano Systems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
US5560931A (en) * | 1995-02-14 | 1996-10-01 | Nawosystems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
US5622938A (en) * | 1995-02-09 | 1997-04-22 | Nano Systems L.L.C. | Sugar base surfactant for nanocrystals |
US5593657A (en) * | 1995-02-09 | 1997-01-14 | Nanosystems L.L.C. | Barium salt formulations stabilized by non-ionic and anionic stabilizers |
US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5518738A (en) * | 1995-02-09 | 1996-05-21 | Nanosystem L.L.C. | Nanoparticulate nsaid compositions |
US5591456A (en) * | 1995-02-10 | 1997-01-07 | Nanosystems L.L.C. | Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer |
US5500204A (en) * | 1995-02-10 | 1996-03-19 | Eastman Kodak Company | Nanoparticulate diagnostic dimers as x-ray contrast agents for blood pool and lymphatic system imaging |
US5573783A (en) * | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
US5510118A (en) * | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5543133A (en) * | 1995-02-14 | 1996-08-06 | Nanosystems L.L.C. | Process of preparing x-ray contrast compositions containing nanoparticles |
US5580579A (en) * | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
US5718919A (en) * | 1995-02-24 | 1998-02-17 | Nanosystems L.L.C. | Nanoparticles containing the R(-)enantiomer of ibuprofen |
US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
DE69633222T2 (de) | 1995-02-24 | 2005-09-08 | Elan Pharma International Ltd. | Nanopartikel-dispersionen enthaltende aerosole |
US5565188A (en) | 1995-02-24 | 1996-10-15 | Nanosystems L.L.C. | Polyalkylene block copolymers as surface modifiers for nanoparticles |
US5643552A (en) * | 1995-03-09 | 1997-07-01 | Nanosystems L.L.C. | Nanoparticulate diagnostic mixed carbonic anhydrides as x-ray contrast agents for blood pool and lymphatic system imaging |
US5472683A (en) * | 1995-03-09 | 1995-12-05 | Eastman Kodak Company | Nanoparticulate diagnostic mixed carbamic anhydrides as X-ray contrast agents for blood pool and lymphatic system imaging |
US5573749A (en) * | 1995-03-09 | 1996-11-12 | Nano Systems L.L.C. | Nanoparticulate diagnostic mixed carboxylic anhydrides as X-ray contrast agents for blood pool and lymphatic system imaging |
US5521218A (en) * | 1995-05-15 | 1996-05-28 | Nanosystems L.L.C. | Nanoparticulate iodipamide derivatives for use as x-ray contrast agents |
US5573750A (en) * | 1995-05-22 | 1996-11-12 | Nanosystems L.L.C. | Diagnostic imaging x-ray contrast agents |
US5834025A (en) * | 1995-09-29 | 1998-11-10 | Nanosystems L.L.C. | Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions |
FR2742357B1 (fr) * | 1995-12-19 | 1998-01-09 | Rhone Poulenc Rorer Sa | Nanoparticules stabilisees et filtrables dans des conditions steriles |
US5985309A (en) * | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
EP0925061B1 (en) * | 1996-08-22 | 2005-12-28 | Jagotec Ag | Compositions comprising microparticles of water-insoluble substances and method for preparing same |
US6039932A (en) * | 1996-09-27 | 2000-03-21 | 3M Innovative Properties Company | Medicinal inhalation aerosol formulations containing budesonide |
WO1998035666A1 (en) | 1997-02-13 | 1998-08-20 | Nanosystems Llc | Formulations of nanoparticle naproxen tablets |
US6045829A (en) * | 1997-02-13 | 2000-04-04 | Elan Pharma International Limited | Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
SE9701956D0 (sv) * | 1997-05-23 | 1997-05-23 | Astra Ab | New composition of matter |
SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
GB9726543D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel compositions |
US6086376A (en) | 1998-01-30 | 2000-07-11 | Rtp Pharma Inc. | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
ZA991922B (en) | 1998-03-11 | 1999-09-13 | Smithkline Beecham Corp | Novel compositions of eprosartan. |
US6241969B1 (en) | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
US6153225A (en) * | 1998-08-13 | 2000-11-28 | Elan Pharma International Limited | Injectable formulations of nanoparticulate naproxen |
US6165506A (en) * | 1998-09-04 | 2000-12-26 | Elan Pharma International Ltd. | Solid dose form of nanoparticulate naproxen |
IT1303692B1 (it) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US6270806B1 (en) * | 1999-03-03 | 2001-08-07 | Elan Pharma International Limited | Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions |
US6267989B1 (en) * | 1999-03-08 | 2001-07-31 | Klan Pharma International Ltd. | Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions |
US6241696B1 (en) * | 1999-10-20 | 2001-06-05 | Guy Warren York | Hand held massage implement |
EP1318787A2 (en) * | 2000-07-26 | 2003-06-18 | Alcon Inc. | Pharmaceutical suspension compositions lacking a polymeric suspending agent |
US20030129242A1 (en) * | 2002-01-04 | 2003-07-10 | Bosch H. William | Sterile filtered nanoparticulate formulations of budesonide and beclomethasone having tyloxapol as a surface stabilizer |
US20040208833A1 (en) * | 2003-02-04 | 2004-10-21 | Elan Pharma International Ltd. | Novel fluticasone formulations |
BRPI0410767A (pt) * | 2003-05-19 | 2006-07-04 | Baxter Int | formulações farmacêuticas de partìcula pequena de agentes antiataque e antidemência e agentes imunossupressores |
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1996
- 1996-02-23 DE DE69633222T patent/DE69633222T2/de not_active Revoked
- 1996-02-23 CA CA002213638A patent/CA2213638C/en not_active Expired - Lifetime
- 1996-02-23 WO PCT/US1996/002346 patent/WO1996025918A1/en active IP Right Grant
- 1996-02-23 JP JP52579896A patent/JP4484247B2/ja not_active Expired - Lifetime
- 1996-02-23 AT AT96906566T patent/ATE274341T1/de not_active IP Right Cessation
- 1996-02-23 EP EP96906566A patent/EP0810853B1/en not_active Revoked
- 1996-02-23 AU AU49906/96A patent/AU4990696A/en not_active Abandoned
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- 1997-10-09 US US08/948,216 patent/US6264922B1/en not_active Expired - Lifetime
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- 2003-09-23 US US10/667,472 patent/US20040057905A1/en not_active Abandoned
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- 2007-09-05 JP JP2007230718A patent/JP2007314581A/ja not_active Withdrawn
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- 2008-03-19 US US12/051,448 patent/US20080171091A1/en not_active Abandoned
- 2008-04-18 US US12/081,670 patent/US8097282B2/en not_active Expired - Fee Related
- 2008-11-12 US US12/292,092 patent/US20090074873A1/en not_active Abandoned
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004534074A (ja) * | 2001-06-14 | 2004-11-11 | ヤゴテック アーゲー | 新規組成物 |
Also Published As
Publication number | Publication date |
---|---|
WO1996025918A1 (en) | 1996-08-29 |
US8097282B2 (en) | 2012-01-17 |
EP0810853A4 (en) | 1998-09-16 |
CA2213638C (en) | 2004-05-04 |
DE69633222T2 (de) | 2005-09-08 |
US20090074873A1 (en) | 2009-03-19 |
AU4990696A (en) | 1996-09-11 |
US20080171091A1 (en) | 2008-07-17 |
EP0810853B1 (en) | 2004-08-25 |
ATE274341T1 (de) | 2004-09-15 |
US20080274044A1 (en) | 2008-11-06 |
DE69633222D1 (de) | 2004-09-30 |
US20040057905A1 (en) | 2004-03-25 |
CA2213638A1 (en) | 1996-08-29 |
JP2007314581A (ja) | 2007-12-06 |
US20120183476A1 (en) | 2012-07-19 |
US6264922B1 (en) | 2001-07-24 |
JP4484247B2 (ja) | 2010-06-16 |
EP0810853A1 (en) | 1997-12-10 |
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