JP2001501952A5 - - Google Patents

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Publication number
JP2001501952A5
JP2001501952A5 JP1998517770A JP51777098A JP2001501952A5 JP 2001501952 A5 JP2001501952 A5 JP 2001501952A5 JP 1998517770 A JP1998517770 A JP 1998517770A JP 51777098 A JP51777098 A JP 51777098A JP 2001501952 A5 JP2001501952 A5 JP 2001501952A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1998517770A
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English (en)
Japanese (ja)
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JP2001501952A (ja
JP4118958B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/018323 external-priority patent/WO1998015563A1/en
Publication of JP2001501952A publication Critical patent/JP2001501952A/ja
Publication of JP2001501952A5 publication Critical patent/JP2001501952A5/ja
Application granted granted Critical
Publication of JP4118958B2 publication Critical patent/JP4118958B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP51777098A 1996-10-09 1997-10-09 テトラホスホネート二環式トリス無水物 Expired - Fee Related JP4118958B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2815496P 1996-10-09 1996-10-09
US60/028,154 1996-10-09
US3836097P 1997-02-13 1997-02-13
US60/038,360 1997-02-13
PCT/US1997/018323 WO1998015563A1 (en) 1996-10-09 1997-10-09 Tetraphosphonate bicyclic trisanhydrides

Publications (3)

Publication Number Publication Date
JP2001501952A JP2001501952A (ja) 2001-02-13
JP2001501952A5 true JP2001501952A5 (https=) 2005-08-11
JP4118958B2 JP4118958B2 (ja) 2008-07-16

Family

ID=26703363

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51777098A Expired - Fee Related JP4118958B2 (ja) 1996-10-09 1997-10-09 テトラホスホネート二環式トリス無水物

Country Status (13)

Country Link
US (2) US6326490B1 (https=)
EP (1) EP0934325B1 (https=)
JP (1) JP4118958B2 (https=)
KR (1) KR100560182B1 (https=)
CN (1) CN1113888C (https=)
AT (1) ATE271058T1 (https=)
AU (1) AU4815197A (https=)
BR (1) BR9712285A (https=)
CA (1) CA2268434C (https=)
DE (1) DE69729877T2 (https=)
ES (1) ES2225958T3 (https=)
PT (1) PT934325E (https=)
WO (1) WO1998015563A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9712285A (pt) 1996-10-09 2001-11-20 Pharmasset Ltd Tetrafosfonato bicìclico de trianidridas
CN1262556C (zh) 1997-02-06 2006-07-05 印斯拜尔药品股份有限公司 特定的二核苷酸和它们作为粘膜纤毛清除和纤毛颤动频率调节剂的应用
US7223744B2 (en) 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US20040181078A1 (en) * 1997-10-10 2004-09-16 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
JP2003531111A (ja) 1999-12-17 2003-10-21 アライアッド・ファーマシューティカルズ・インコーポレーテッド プロトンポンプインヒビター
ATE327242T1 (de) * 1999-12-17 2006-06-15 Ariad Pharma Inc Neue purine
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
US6867199B2 (en) 2000-08-21 2005-03-15 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapeutic use
US6555675B2 (en) 2000-08-21 2003-04-29 Inspire Pharmaceuticals, Inc. Dinucleoside polyphosphate compositions and their therapuetic use as purinergic receptor agonists
WO2002048165A2 (en) * 2000-12-15 2002-06-20 Pharmasset Ltd. Antiviral agents for treatment of flaviviridae infections
US7470724B2 (en) 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US7300924B2 (en) 2003-04-25 2007-11-27 Gilead Sciences, Inc. Anti-infective phosphonate analogs
US7432261B2 (en) 2003-04-25 2008-10-07 Gilead Sciences, Inc. Anti-inflammatory phosphonate compounds
US7427636B2 (en) 2003-04-25 2008-09-23 Gilead Sciences, Inc. Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
KR20060022647A (ko) 2003-04-25 2006-03-10 길리애드 사이언시즈, 인코포레이티드 키나아제 억제 포스포네이트 유사체
WO2005002626A2 (en) 2003-04-25 2005-01-13 Gilead Sciences, Inc. Therapeutic phosphonate compounds
EA014685B1 (ru) 2003-04-25 2010-12-30 Джилид Сайэнс, Инк. Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе
US7452901B2 (en) 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
US7407965B2 (en) 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
HUE029877T2 (en) 2003-05-30 2017-04-28 Gilead Pharmasset Llc Modified fluorinated nucleoside analogues
WO2005044279A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Purine nucleoside phosphonate conjugates
WO2005044308A1 (en) 2003-10-24 2005-05-19 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
BRPI0417988A (pt) 2003-12-22 2007-04-27 Gilead Sciences Inc análogos de fosfonato antivirais
DE10361932A1 (de) * 2003-12-30 2005-07-28 Celanese Ventures Gmbh Protonenleitende Membran und deren Verwendung
DE10361832A1 (de) * 2003-12-30 2005-07-28 Celanese Ventures Gmbh Protonenleitende Membran und deren Verwendung
AU2005330489B2 (en) 2004-07-27 2011-08-25 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti HIV agents
AU2006298677A1 (en) * 2005-10-06 2007-04-12 Innate Pharma Phosphoantigen salts of organic bases and methods for their crystallization
WO2008150438A1 (en) * 2007-06-01 2008-12-11 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
CA2714198A1 (en) * 2008-02-15 2009-08-20 Microdose Therapeutx, Inc. Methods of making nucleoside tetraphosphate analogs
US8658617B2 (en) 2008-07-08 2014-02-25 Gilead Sciences, Inc. Salts of HIV inhibitor compounds
EP2447274B1 (en) 2008-10-24 2017-10-04 Ionis Pharmaceuticals, Inc. Oligomeric compounds and methods
WO2011139699A2 (en) 2010-04-28 2011-11-10 Isis Pharmaceuticals, Inc. 5' modified nucleosides and oligomeric compounds prepared therefrom
US9156873B2 (en) 2010-04-28 2015-10-13 Isis Pharmaceuticals, Inc. Modified 5′ diphosphate nucleosides and oligomeric compounds prepared therefrom
EP2601204B1 (en) 2010-04-28 2016-09-07 Ionis Pharmaceuticals, Inc. Modified nucleosides and oligomeric compounds prepared therefrom
JP2016512846A (ja) * 2013-03-13 2016-05-09 ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド Ras阻害剤およびその使用
WO2017120508A1 (en) 2016-01-08 2017-07-13 Arcus Biosciences, Inc. Modulators of 5'-nucleotidase, ecto and the use thereof
WO2018094148A1 (en) * 2016-11-18 2018-05-24 Arcus Biosciences, Inc. Inhibitors of cd73-mediated immunosuppression
SI3661937T1 (sl) 2017-08-01 2021-11-30 Gilead Sciences, Inc. Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb
WO2020210970A1 (en) * 2019-04-16 2020-10-22 Bioardis Llc Imidazotriazine derivatives as cd73 inhibitors
US11633416B1 (en) 2020-03-06 2023-04-25 Arcus Biosciences, Inc. Oral formulations of CD73 compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI89365C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
US5569650A (en) * 1993-06-11 1996-10-29 Sloan-Kettering Institute For Cancer Research C-nucleoside isosters of analogs thereof and pharmaceutical compositions
DE4341161A1 (de) * 1993-12-02 1995-06-08 Michael Prof Dr Zeppezauer Membrangängiger Wirkstoff zur Störung der DNA-Biosynthese
FR2721931B1 (fr) * 1994-06-30 1996-08-02 Commissariat Energie Atomique Conjugues d'analogues de diphosphates ou triphosphates avec des enzymes ou des proteurs antigeniques et dosage immunologique utilisant de tels conjugues
BR9712285A (pt) 1996-10-09 2001-11-20 Pharmasset Ltd Tetrafosfonato bicìclico de trianidridas

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