JP2001500735A - Ｃ型肝炎ウィルスのｎｓ３セリンプロテアーゼの活性を有する可溶性ポリペプチド、およびそれらの製造および単離法 - Google Patents

Ｃ型肝炎ウィルスのｎｓ３セリンプロテアーゼの活性を有する可溶性ポリペプチド、およびそれらの製造および単離法

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Publication number
JP2001500735A
JP2001500735A JP10514467A JP51446798A JP2001500735A JP 2001500735 A JP2001500735 A JP 2001500735A JP 10514467 A JP10514467 A JP 10514467A JP 51446798 A JP51446798 A JP 51446798A JP 2001500735 A JP2001500735 A JP 2001500735A
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JP
Japan
Prior art keywords
polypeptide
hcv
protease
protein
serine protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10514467A
Other languages
English (en)
Japanese (ja)
Inventor
フランセスコ，ラファエル ド
トラモンタノ，アンナ
トメイ，リシア
ナルディ，マリア，チアラ
シュタインキュラー，クリスチアン
ウルバニ，アンドレア
ビタレ，ロザ，レティジア
コルロカ，ステファノ
Original Assignee
イスチチュート デイ リセルシュ デイ バイオロジア モレコラレ ピー．アンジェレッティ ソシエタ ペル アチオニ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by イスチチュート デイ リセルシュ デイ バイオロジア モレコラレ ピー．アンジェレッティ ソシエタ ペル アチオニ filed Critical イスチチュート デイ リセルシュ デイ バイオロジア モレコラレ ピー．アンジェレッティ ソシエタ ペル アチオニ
Publication of JP2001500735A publication Critical patent/JP2001500735A/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP10514467A 1996-09-17 1997-09-17 Ｃ型肝炎ウィルスのｎｓ３セリンプロテアーゼの活性を有する可溶性ポリペプチド、およびそれらの製造および単離法 Pending JP2001500735A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM960632 IT1285158B1 (it) 1996-09-17 1996-09-17 Polipeptidi solubili con l'attivita' di serino-proteasi di ns3 del virus dell'epatite c, e procedimento per la loro preparazione e il
IT96A000632 1996-09-17
PCT/IT1997/000228 WO1998012308A1 (en) 1996-09-17 1997-09-17 Soluble polypeptides with activity of the ns3 serine protease of hepatitis c virus, and process for their preparation and isolation

Publications (1)

Publication Number Publication Date
JP2001500735A true JP2001500735A (ja) 2001-01-23

Family

ID=11404423

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10514467A Pending JP2001500735A (ja) 1996-09-17 1997-09-17 Ｃ型肝炎ウィルスのｎｓ３セリンプロテアーゼの活性を有する可溶性ポリペプチド、およびそれらの製造および単離法

Country Status (6)

Country Link
EP (1) EP0950094A1 (it)
JP (1) JP2001500735A (it)
AU (1) AU4397097A (it)
CA (1) CA2264487A1 (it)
IT (1) IT1285158B1 (it)
WO (1) WO1998012308A1 (it)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500724A (ja) * 2009-07-31 2013-01-10 バクスター・インターナショナル・インコーポレイテッド Ａｄａｍｔｓタンパク質発現のための細胞培養培地

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9806815D0 (en) * 1998-03-30 1998-05-27 Hoffmann La Roche Amino acid derivatives
CA2359971A1 (en) 1999-01-08 2000-07-13 Bristol-Myers Squibb Company Modified forms of hepatitis c virus ns3 protease
PL206255B1 (pl) 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
CZ2003195A3 (cs) 2000-07-21 2003-04-16 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostředek
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
CN1894276B (zh) 2003-10-27 2010-06-16 威特克斯医药股份有限公司 Hcv ns3-ns4a蛋白酶抗药性突变体
US7705138B2 (en) * 2005-11-11 2010-04-27 Vertex Pharmaceuticals Incorporated Hepatitis C virus variants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012992A2 (en) * 1991-01-14 1992-08-06 James N. Gamble Institute Of Medical Research Basic structural immunogenic polypeptides having epitopes for hcv, antibodies, polynucleotide sequences, vaccines and methods
US5843752A (en) * 1995-05-12 1998-12-01 Schering Corporation Soluble active hepatitis C virus protease
IT1277914B1 (it) * 1995-08-22 1997-11-12 Angeletti P Ist Richerche Bio Procedimento per produrre - in forma pura e in quantita' elevate - polipeptidi con l'attivita' proteolitica della proteasi ns3 di hcv, e

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013500724A (ja) * 2009-07-31 2013-01-10 バクスター・インターナショナル・インコーポレイテッド Ａｄａｍｔｓタンパク質発現のための細胞培養培地
US8759026B2 (en) 2009-07-31 2014-06-24 Baxter International Inc. Methods for increasing recovery of an ADAMTS activity from a cell culture supernatant
US9127265B2 (en) 2009-07-31 2015-09-08 Baxalta Incorporated Cell culture medium for ADAMTS protein expression
US9441216B2 (en) 2009-07-31 2016-09-13 Baxalta Incorporated Cell culture medium for ADAMTS protein expression
US10072254B2 (en) 2009-07-31 2018-09-11 Baxalta Incorporated Cell culture methods for expressing ADAMTS13 protein
US10724024B2 (en) 2009-07-31 2020-07-28 Baxalta Incorporated Cell culture methods for expressing ADAMTS protein
US11254921B2 (en) 2009-07-31 2022-02-22 Takeda Pharmaceutical Company Limited ADAMTS13 protein cell culture supernatant

Also Published As

Publication number Publication date
IT1285158B1 (it) 1998-06-03
AU4397097A (en) 1998-04-14
WO1998012308A1 (en) 1998-03-26
ITRM960632A1 (it) 1998-03-17
EP0950094A1 (en) 1999-10-20
CA2264487A1 (en) 1998-03-26

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