JP2001500488A - 宿主vs移植片反応の重篤度をHSP60自己免疫性をダウンレギュレーションすることにより低下させる方法 - Google Patents
宿主vs移植片反応の重篤度をHSP60自己免疫性をダウンレギュレーションすることにより低下させる方法Info
- Publication number
- JP2001500488A JP2001500488A JP10511984A JP51198498A JP2001500488A JP 2001500488 A JP2001500488 A JP 2001500488A JP 10511984 A JP10511984 A JP 10511984A JP 51198498 A JP51198498 A JP 51198498A JP 2001500488 A JP2001500488 A JP 2001500488A
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- Prior art keywords
- hsp60
- residues
- peptide
- seq
- autoimmunity
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.供与体臓器または組織の宿主への移植に伴って、宿主内のhsp60自己免 疫性をダウンレギュレーションすることを含む、宿主vs移植片反応の重篤度を 低下させるための方法。 2.該ダウンレギュレーションする工程が、hsp60自己免疫性をダウンレギ ュレーションするための医薬組成物を投与することを含む、請求項1記載の方法 。 3.該組成物が、寛容性担体またはTH1→TH2シフトを仲介し得る生物学的 に活性な担体、ならびにhsp60、hsp60ペプチド、およびそれらのアナ ログ、塩および機能的誘導体からなる群から選択されるhsp60自己免疫性を ダウンレギュレーションし得る化合物を含む、請求項2記載の方法。 4.該化合物が、SEQ ID NO.1由来の以下のアミノ酸残基:残基31〜50、残 基136〜155、残基151〜170、残基166〜185、残基195〜2 14、残基255〜274、残基286〜305、残基346〜365、残基4 21〜440、残基436〜455、残基437〜460、残基466〜485 、残基511〜530、残基343〜366および残基458〜474に対応す る配列を有するもの、それらの塩および機能的誘導体からなるhsp60ペプチ ドの群から選択される、請求項3記載の方法 5.該化合物が、SEQ TDNO.1の残基437〜460に対応する配列を有する、 請求項4記載の方法。 6.該化合物が、SEQ ID NO.1の残基166〜185に対応する配列を有する、 請求項4記載の方法。 7.該化合物が、SEQ ID NO.1の残基466〜485に対応する配列を有する、 請求項4記載の方法。 8.該化合物が、SEQ ID NO.2、SEQ ID NO.3、SEQ ID NO.4、SEQ ID NO.5、SEQ ID NO.6、SEQ ID NO.7およびSEQ ID NO.8の配列を有するペプチドからなる群か ら選択されるhsp60ペプチドアナログである、請求項3記載の方法。 9.該生物学的に活性な担体が: 10%〜20% 植物および/または動物起源のトリグリセリド; 1.2%〜2.4% 植物および/または動物起源のリン脂質; 2.25%〜4.5% 浸透圧調節物; 0%〜0.05% 抗酸化剤;および 滅菌水 を含む脂肪エマルジョンである、請求項2記載の方法。 10.該投与工程が、該医薬組成物の、経口、鼻内、静脈内、筋肉内、または皮 下投与による、供与体臓器または組織の移植前の宿主への投与を含む、請求項2 記載の方法。 11.該ダウンレギュレーション工程が、宿主に、in vitroでhsp60タンパ ク質、hsp60ペプチド、またはそれらのペプチドアナログ、塩、および機能 的誘導体により活性化されたT細胞を投与することを含む、請求項1記載の方法 。 12.移植片拒絶を予防するか抑制するのに用いられるためのペプチドを選択す る方法であって: 個々のペプチドのパネルを、臓器または組織移植の候補者である個体 の血液から単離された末梢血リンパ球の抗原提示細胞に接触させる工程、ここで このペプチドは検出可能に標識されている; 抗原提示細胞に結合したペプチドを検出する工程; 抗原提示細胞に結合することができる1以上のペプチドを選択する工 程、 を含む方法。 13.hsp60、hsp60ペプチド、ならびにそれらのアナログ、塩および 機能的誘導体から選択された化合物の、宿主内のhsp60自己免疫性をダウン レギュレーションするための医薬組成物の調製のための使用。 14.臓器移植における宿主vs移植片反応の重篤度を低下させるための請求項 13記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/706,209 US5993803A (en) | 1996-08-30 | 1996-08-30 | Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity |
US08/706,209 | 1996-08-30 | ||
PCT/US1997/015294 WO1998008536A2 (en) | 1996-08-30 | 1997-09-02 | Method of reducing the severity of host vs. graft reaction by down-regulating hsp60 autoimmunity |
Publications (3)
Publication Number | Publication Date |
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JP2001500488A true JP2001500488A (ja) | 2001-01-16 |
JP2001500488A5 JP2001500488A5 (ja) | 2005-04-07 |
JP4256474B2 JP4256474B2 (ja) | 2009-04-22 |
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Application Number | Title | Priority Date | Filing Date |
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JP51198498A Expired - Fee Related JP4256474B2 (ja) | 1996-08-30 | 1997-09-02 | 宿主vs移植片反応の重篤度をHSP60自己免疫性をダウンレギュレーションすることにより低下させる方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5993803A (ja) |
EP (1) | EP0921810B1 (ja) |
JP (1) | JP4256474B2 (ja) |
AT (1) | ATE237344T1 (ja) |
AU (1) | AU722576B2 (ja) |
CA (1) | CA2263816C (ja) |
DE (1) | DE69721007T2 (ja) |
DK (1) | DK0921810T3 (ja) |
ES (1) | ES2198594T3 (ja) |
IL (2) | IL128728A0 (ja) |
WO (1) | WO1998008536A2 (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9911772D0 (en) * | 1999-05-21 | 1999-07-21 | Semmelweis University Of Medic | Diagnosis and treatment of atherosclerosis |
NZ519348A (en) * | 1999-12-15 | 2006-04-28 | Develogen Israel Ltd | Fragments and antagonists of heat shock protein 60 |
IL150113A0 (en) * | 1999-12-15 | 2002-12-01 | Peptor Ltd | Fragments and antagonists of heat shock protein 60 |
AU2001249214A1 (en) * | 2000-03-15 | 2001-09-24 | The Brigham And Women's Hospital, Inc. | Suppression of vascular disorders by mucosal administration of heat shock protein peptides |
US7608683B2 (en) * | 2000-08-09 | 2009-10-27 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
US6989146B2 (en) * | 2000-08-09 | 2006-01-24 | The Regents Of The University Of California | Stress proteins and peptides and methods of use thereof |
JP2005503320A (ja) * | 2000-08-25 | 2005-02-03 | イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド | CpG−含有ポリヌクレオチドで自己免疫疾患を処置または防止する方法 |
JP4264257B2 (ja) | 2000-11-01 | 2009-05-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 熱ショックタンパク質に由来する免疫調節ペプチドとその使用 |
WO2003063759A2 (en) * | 2002-01-31 | 2003-08-07 | Peptor Ltd. | Hsp peptides and analogs for modulation of immune responses via antigen presenting cells |
AU2003209623A1 (en) * | 2002-02-19 | 2003-09-09 | Yeda Research And Development Co. Ltd. | Dual-effect ligands comprising anti-inflammatory hsp peptide epitopes for immunomodulation |
WO2003096967A2 (en) | 2002-05-21 | 2003-11-27 | Yeda Research And Development Co. Ltd. | Dna vaccines encoding heat shock proteins |
WO2004090095A2 (en) * | 2003-04-01 | 2004-10-21 | University Of Southern California | Generation of human regulatory t cells by bacterial toxins for the treatment of inflammatory disorders |
EP1687423A4 (en) * | 2003-11-24 | 2007-04-18 | Yeda Res & Dev | HSP60 PEPTIDE FRAGMENT-ENCODING DNA VACCINES FOR THE TREATMENT OF AUTOIMMUNE DISEASES |
CA2595520A1 (en) | 2004-01-28 | 2005-08-11 | Develogen Israel Ltd. | Hsp therapy in conjunction with a low antigenicity diet |
CU23504A1 (es) | 2004-09-24 | 2010-04-13 | Ct Ingenieria Genetica Biotech | Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas |
US8691772B2 (en) | 2005-01-04 | 2014-04-08 | Yeda Research And Development Co. Ltd. | HSP60, HSP60 peptides and T cell vaccines for immunomodulation |
WO2013128453A1 (en) | 2012-03-01 | 2013-09-06 | Yeda Research And Development Co. Ltd. | Regeneration of islet beta cells by hsp60 derived peptides |
AU2013227249A1 (en) | 2012-03-01 | 2014-09-11 | Yeda Research And Development Co. Ltd. | Hsp60 derived peptides and peptide analogs for suppression and treatment of non-autoimmune diabetes |
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IL92629A0 (en) * | 1989-12-10 | 1990-08-31 | Yeda Res & Dev | Direct binding of t-cell epitopes to mhc gene products on intact living antigen presenting cells and the use thereof for identifying epitopes causing autoimmune diseases and pharmaceutical compositions for treating such diseases |
WO1992004049A1 (en) * | 1990-09-06 | 1992-03-19 | Rijksuniversiteit Te Utrecht | Inhibitor of lymphocyte response and immune-related disease |
IL114407A0 (en) * | 1995-06-30 | 1995-10-31 | Yeda Res & Dev | Novel peptides and pharmaceutical compositions comprising them |
IL114458A0 (en) * | 1995-07-05 | 1995-11-27 | Yeda Res & Dev | Therapeutic preparations for treatment of T cell mediated diseases |
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1996
- 1996-08-30 US US08/706,209 patent/US5993803A/en not_active Expired - Lifetime
-
1997
- 1997-09-02 AT AT97940708T patent/ATE237344T1/de not_active IP Right Cessation
- 1997-09-02 AU AU42426/97A patent/AU722576B2/en not_active Ceased
- 1997-09-02 EP EP97940708A patent/EP0921810B1/en not_active Expired - Lifetime
- 1997-09-02 DK DK97940708T patent/DK0921810T3/da active
- 1997-09-02 ES ES97940708T patent/ES2198594T3/es not_active Expired - Lifetime
- 1997-09-02 DE DE69721007T patent/DE69721007T2/de not_active Expired - Lifetime
- 1997-09-02 WO PCT/US1997/015294 patent/WO1998008536A2/en active IP Right Grant
- 1997-09-02 JP JP51198498A patent/JP4256474B2/ja not_active Expired - Fee Related
- 1997-09-02 IL IL12872897A patent/IL128728A0/xx active IP Right Grant
- 1997-09-02 CA CA002263816A patent/CA2263816C/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
ES2198594T3 (es) | 2004-02-01 |
WO1998008536A2 (en) | 1998-03-05 |
WO1998008536A3 (en) | 1998-05-07 |
DE69721007T2 (de) | 2004-02-12 |
DE69721007D1 (de) | 2003-05-22 |
US5993803A (en) | 1999-11-30 |
EP0921810B1 (en) | 2003-04-16 |
ATE237344T1 (de) | 2003-05-15 |
DK0921810T3 (da) | 2003-07-28 |
AU4242697A (en) | 1998-03-19 |
IL128728A (en) | 2006-09-05 |
AU722576B2 (en) | 2000-08-10 |
JP4256474B2 (ja) | 2009-04-22 |
CA2263816C (en) | 2008-12-30 |
IL128728A0 (en) | 2000-01-31 |
CA2263816A1 (en) | 1998-03-05 |
EP0921810A2 (en) | 1999-06-16 |
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