ATE237344T1 - Senkung der heftigkeit einer host-versus-graft- reaktion durch unterdrueckung der hsp60 autoimmunitaet - Google Patents

Senkung der heftigkeit einer host-versus-graft- reaktion durch unterdrueckung der hsp60 autoimmunitaet

Info

Publication number
ATE237344T1
ATE237344T1 AT97940708T AT97940708T ATE237344T1 AT E237344 T1 ATE237344 T1 AT E237344T1 AT 97940708 T AT97940708 T AT 97940708T AT 97940708 T AT97940708 T AT 97940708T AT E237344 T1 ATE237344 T1 AT E237344T1
Authority
AT
Austria
Prior art keywords
hsp60
host
reducing
autoimmunitacy
violence
Prior art date
Application number
AT97940708T
Other languages
English (en)
Inventor
Irun R Cohen
Ohad Birk
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of ATE237344T1 publication Critical patent/ATE237344T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97940708T 1996-08-30 1997-09-02 Senkung der heftigkeit einer host-versus-graft- reaktion durch unterdrueckung der hsp60 autoimmunitaet ATE237344T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/706,209 US5993803A (en) 1996-08-30 1996-08-30 Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity
PCT/US1997/015294 WO1998008536A2 (en) 1996-08-30 1997-09-02 Method of reducing the severity of host vs. graft reaction by down-regulating hsp60 autoimmunity

Publications (1)

Publication Number Publication Date
ATE237344T1 true ATE237344T1 (de) 2003-05-15

Family

ID=24836651

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97940708T ATE237344T1 (de) 1996-08-30 1997-09-02 Senkung der heftigkeit einer host-versus-graft- reaktion durch unterdrueckung der hsp60 autoimmunitaet

Country Status (11)

Country Link
US (1) US5993803A (de)
EP (1) EP0921810B1 (de)
JP (1) JP4256474B2 (de)
AT (1) ATE237344T1 (de)
AU (1) AU722576B2 (de)
CA (1) CA2263816C (de)
DE (1) DE69721007T2 (de)
DK (1) DK0921810T3 (de)
ES (1) ES2198594T3 (de)
IL (2) IL128728A0 (de)
WO (1) WO1998008536A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911772D0 (en) * 1999-05-21 1999-07-21 Semmelweis University Of Medic Diagnosis and treatment of atherosclerosis
JP2004501061A (ja) * 1999-12-15 2004-01-15 ペプトル・リミテツド 熱ショックタンパク質６０のフラグメントおよびアンタゴニスト
IL150113A0 (en) * 1999-12-15 2002-12-01 Peptor Ltd Fragments and antagonists of heat shock protein 60
WO2001068124A2 (en) * 2000-03-15 2001-09-20 The Brigham And Women's Hospital, Inc. Suppression of vascular disorders by mucosal administration of heat shock protein peptides
US6989146B2 (en) * 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
US7608683B2 (en) * 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
CA2420499A1 (en) * 2000-08-25 2002-02-28 Yeda Research And Development Co. Ltd. Methods of treatment or prevention of autoimmune diseases with cpg-containing polynucleotide
EP1355923B1 (de) 2000-11-01 2012-03-07 The Regents of The University of California Immunsystem-modulierende peptide aus hitzeschock-proteinen und deren verwendungen
WO2003063759A2 (en) * 2002-01-31 2003-08-07 Peptor Ltd. Hsp peptides and analogs for modulation of immune responses via antigen presenting cells
AU2003209623A1 (en) * 2002-02-19 2003-09-09 Yeda Research And Development Co. Ltd. Dual-effect ligands comprising anti-inflammatory hsp peptide epitopes for immunomodulation
ES2433915T3 (es) 2002-05-21 2013-12-13 Irun R. Cohen Vacunas de ADN que codifican proteínas de choque térmico
US7494812B2 (en) * 2003-04-01 2009-02-24 University Of Southern California Generation of human regulatory T cells by bacterial toxins for the treatment of inflammatory disorders
US20090202618A1 (en) * 2003-11-24 2009-08-13 Yeda Research & Development Co. Ltd Dna vaccines encoding hsp60 peptide fragments for treating autoimmune diseases
AU2005207891B2 (en) * 2004-01-28 2010-04-01 Andromeda Biotech Ltd. Hsp therapy in conjunction with a low antigenicity diet
CU23504A1 (es) 2004-09-24 2010-04-13 Ct Ingenieria Genetica Biotech Péptidos y derivados tipo apl de la hsp60 y composiciones farmacéuticas
WO2006072946A2 (en) 2005-01-04 2006-07-13 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Hsp60, hsp60 peptides and t cell vaccines for immunomodulation
CN104244967A (zh) 2012-03-01 2014-12-24 耶达研究与发展有限公司 用于抑制和治疗非自身免疫性糖尿病的Hsp60衍生肽和肽类似物
WO2013128453A1 (en) 2012-03-01 2013-09-06 Yeda Research And Development Co. Ltd. Regeneration of islet beta cells by hsp60 derived peptides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL92629A0 (en) * 1989-12-10 1990-08-31 Yeda Res & Dev Direct binding of t-cell epitopes to mhc gene products on intact living antigen presenting cells and the use thereof for identifying epitopes causing autoimmune diseases and pharmaceutical compositions for treating such diseases
JPH05507501A (ja) * 1990-09-06 1993-10-28 リックスウーニーベルシテイト・テ・ウットレヒト リンパ球応答と免疫関連疾患との阻害剤
IL114407A0 (en) * 1995-06-30 1995-10-31 Yeda Res & Dev Novel peptides and pharmaceutical compositions comprising them
IL114458A0 (en) * 1995-07-05 1995-11-27 Yeda Res & Dev Therapeutic preparations for treatment of T cell mediated diseases

Also Published As

Publication number Publication date
US5993803A (en) 1999-11-30
IL128728A (en) 2006-09-05
JP2001500488A (ja) 2001-01-16
AU4242697A (en) 1998-03-19
ES2198594T3 (es) 2004-02-01
DE69721007D1 (de) 2003-05-22
AU722576B2 (en) 2000-08-10
CA2263816A1 (en) 1998-03-05
JP4256474B2 (ja) 2009-04-22
DK0921810T3 (da) 2003-07-28
DE69721007T2 (de) 2004-02-12
IL128728A0 (en) 2000-01-31
EP0921810A2 (de) 1999-06-16
WO1998008536A2 (en) 1998-03-05
CA2263816C (en) 2008-12-30
EP0921810B1 (de) 2003-04-16
WO1998008536A3 (en) 1998-05-07

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