JP2001097858A - ビタミンａ誘導体含有組成物 - Google Patents
ビタミンａ誘導体含有組成物Info
- Publication number
- JP2001097858A JP2001097858A JP27949799A JP27949799A JP2001097858A JP 2001097858 A JP2001097858 A JP 2001097858A JP 27949799 A JP27949799 A JP 27949799A JP 27949799 A JP27949799 A JP 27949799A JP 2001097858 A JP2001097858 A JP 2001097858A
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- derivative
- fat
- oil
- palmitate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000004347 all-trans-retinol derivatives Chemical class 0.000 title claims abstract description 23
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 10
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 9
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N retinyl palmitate group Chemical group C(CCCCCCCCCCCCCCC)(=O)OC\C=C(\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C)/C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 17
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims description 9
- 229940108325 retinyl palmitate Drugs 0.000 claims description 9
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 9
- 239000011769 retinyl palmitate Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 4
- 230000000087 stabilizing effect Effects 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical class OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract description 13
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract description 11
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract description 9
- 235000019155 vitamin A Nutrition 0.000 abstract description 9
- 239000011719 vitamin A Substances 0.000 abstract description 9
- 229940045997 vitamin a Drugs 0.000 abstract description 9
- -1 vitamin A palmitic ester Chemical class 0.000 abstract description 4
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 239000003925 fat Substances 0.000 description 9
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 239000002385 cottonseed oil Substances 0.000 description 5
- 235000012343 cottonseed oil Nutrition 0.000 description 5
- 230000003078 antioxidant effect Effects 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- 150000002148 esters Chemical group 0.000 description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 3
- 229960000984 tocofersolan Drugs 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- 239000002076 α-tocopherol Substances 0.000 description 3
- 235000004835 α-tocopherol Nutrition 0.000 description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 229960000342 retinol acetate Drugs 0.000 description 2
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 2
- 235000019173 retinyl acetate Nutrition 0.000 description 2
- 239000011770 retinyl acetate Substances 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000001140 Night Blindness Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000004300 dark adaptation Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000002168 ethanoic acid esters Chemical class 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27949799A JP2001097858A (ja) | 1999-09-30 | 1999-09-30 | ビタミンａ誘導体含有組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27949799A JP2001097858A (ja) | 1999-09-30 | 1999-09-30 | ビタミンａ誘導体含有組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001097858A true JP2001097858A (ja) | 2001-04-10 |
| JP2001097858A5 JP2001097858A5 (enExample) | 2006-05-18 |
Family
ID=17611882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27949799A Pending JP2001097858A (ja) | 1999-09-30 | 1999-09-30 | ビタミンａ誘導体含有組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001097858A (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009044854A1 (ja) | 2007-10-03 | 2009-04-09 | Asahi Breweries, Ltd. | 顆粒、錠剤およびそれらの製造方法 |
| JP2013256462A (ja) * | 2012-06-12 | 2013-12-26 | Rohto Pharmaceutical Co Ltd | ビタミンａ類を含有する水性組成物 |
| JP2016216509A (ja) * | 2016-09-26 | 2016-12-22 | ロート製薬株式会社 | ビタミンａ類を含有する水性組成物 |
| JP2018168168A (ja) * | 2018-06-12 | 2018-11-01 | ロート製薬株式会社 | ビタミンａ類を含有する水性組成物 |
| JP2020105222A (ja) * | 2020-03-31 | 2020-07-09 | ロート製薬株式会社 | ビタミンａを含有する水性組成物 |
-
1999
- 1999-09-30 JP JP27949799A patent/JP2001097858A/ja active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009044854A1 (ja) | 2007-10-03 | 2009-04-09 | Asahi Breweries, Ltd. | 顆粒、錠剤およびそれらの製造方法 |
| JP2012072190A (ja) * | 2007-10-03 | 2012-04-12 | Asahi Group Holdings Ltd | 顆粒、錠剤およびそれらの製造方法 |
| JP2013256462A (ja) * | 2012-06-12 | 2013-12-26 | Rohto Pharmaceutical Co Ltd | ビタミンａ類を含有する水性組成物 |
| JP2016216509A (ja) * | 2016-09-26 | 2016-12-22 | ロート製薬株式会社 | ビタミンａ類を含有する水性組成物 |
| JP2018168168A (ja) * | 2018-06-12 | 2018-11-01 | ロート製薬株式会社 | ビタミンａ類を含有する水性組成物 |
| JP2020105222A (ja) * | 2020-03-31 | 2020-07-09 | ロート製薬株式会社 | ビタミンａを含有する水性組成物 |
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Legal Events
| Date | Code | Title | Description |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060317 |
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| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060323 |
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| A711 | Notification of change in applicant |
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| A131 | Notification of reasons for refusal |
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