JP2001017546A - Drug solution dispensing device and method for manufacturing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To carry out dissolving and mixing of a drug by simple operation in a short time without causing contamination and assemble versatilely and simply, without limiting the method of administration or by arranging a gasket clearance of a sealing member. SOLUTION: A flange 23 is formed at the periphery of the base end of a vessel body, and the face of the base end is preferably flat so that a sealing compound 6 may be applied. A nearly columnar gasket 3 formed of an elastic member that can slide tightly along the inside periphery is inserted into the vessel body. The gasket 3, a part of the side of which is adhered to the overall length of the peripheral direction of the inside periphery of the vessel body and provided on the front end side clear or the sealing compound 6. The distance from the sealing compound 6 varies depending on the size of a drug solution injection device, the quantity, bulkiness or the like of a dissolving solution necessary for dissolution, and such that may not break the airtightness of the gasket 3 with the inside periphery of the vessel body during inflow or outflow of a dissolving solution, and that allows a space 25 to secure the quantity of a dissolving solution to make flow in.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid medicine injection device, and more particularly to a liquid medicine injection device used for dissolving and compounding powdered drugs.

[0002]

2. Description of the Related Art Powdered drugs such as antibiotics are dissolved in a dissolving solution and blended as necessary.
To mix such a drug, first, the puncture needle of a syringe (syringe) is pierced into the elastic stopper of the lysis solution bag, the plunger is pulled, the lysis solution in the lysis solution bag is collected in the syringe, and then the puncture is performed. The needle is pierced into the elastic stopper of the container (vial) containing the drug, the collected solution is transferred, the drug is dissolved in the vial, mixed, and then the drug is again mixed with the syringe, and the mixed solution is sucked and collected by the syringe. Then, the puncture needle of the syringe is inserted again into the elastic stopper of the solution bag, and the plunger is pushed to inject the drug mixture into the solution bag. However, the compounding of such a chemical solution requires a complicated operation procedure, takes a long time for the compounding,
There is a drawback that foreign matter is easily contaminated and bacteria are easily contaminated. Recently, a kit product has been developed in which a drug and a solution are separately stored in a multi-chamber container and mixed at the time of use in order to simplify this operation. (JP-A-4-364851) These kits are
Although the operation is simple, there is a problem that the method of use and the amount of the solution are limited. Further, as a method for solving such a problem, for example, a drug injection device such as Japanese Patent Application Laid-Open No. H11-33114 has been devised. However, it is assumed that a gasket is inserted into an outer cylinder and a pressure reducing seal is simultaneously performed. Therefore, a structure is adopted in which the gasket is bonded in advance to a sealing material provided at the rear end opening of the outer cylinder so that the gasket does not move toward the distal end of the outer cylinder during the decompression work. In addition, since the material of the seal material and the material of the gasket are different and do not have adhesiveness, it is necessary to connect a member made of a material having adhesiveness with the sealant to the rear end of the gasket. And the production was complicated.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to dissolve and mix drugs by a simple operation without causing contamination.
It is an object of the present invention to provide a drug solution injection device which can be performed in a short time, has high versatility in which the administration method and the like are not limited, and can be easily assembled.

[0004]

This and other objects are achieved by the present invention which is defined below as (1) to (6). (1) An outer cylinder having a nozzle sealed at the front end and having an open rear end, a gasket disposed in the outer cylinder so as to be slidable in the outer cylinder, and a seal for sealing the rear end of the outer cylinder. A liquid injector having a member and a pressure reduced inside the outer cylinder, wherein the gasket is disposed separately from the sealing member.

(2) An outer cylinder having a nozzle sealed at the front end and having an open rear end, a gasket slidably disposed in the outer cylinder, and a rear end sealed with the outer cylinder In manufacturing a chemical solution injection device having a reduced pressure in the outer cylinder, a gasket is inserted into the outer cylinder so that the internal pressure does not substantially differ between before and after the gasket, and then the rear end opening is formed. A method for manufacturing a drug solution injection device, wherein the pressure is reduced so that a gasket remains at a predetermined position in an outer cylinder when sealing with a sealing member. (3) The method for manufacturing a liquid injector according to the above (2), wherein the nozzle is sealed by a cap and a sealing member covered by the nozzle. (4) The method according to (3), wherein the gasket is inserted before the cap is completely sealed. (5) The gasket according to the above (2) or (3), wherein the gasket is inserted into the outer cylinder by inserting the gasket from the opening at the rear end of the outer cylinder with the side wall of the gasket compressed into the outer cylinder in which the nozzle is sealed. A method for manufacturing a drug solution injection device. (6) The method according to any one of the above (2) to (5), wherein the medicine is stored in an internal space between the nozzle of the outer cylinder and the gasket.

[0006]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a liquid injector according to the present invention. FIG.
1 is a longitudinal sectional view showing an embodiment of a drug solution injector of the present invention. As shown in FIG. 1, the drug solution injection device 1 of the present invention mainly comprises
A container body 2, a gasket 3 slidable along the inner peripheral surface of the container body 2 in a liquid-tight manner, a detachable plunger 4 for sliding the gasket, and a cap 5 as sealing means; It is composed of a sealing material 6, a desiccant 91 and an oxygen scavenger 92 that can be inserted as needed. Hereinafter, these components will be sequentially described with the upper side in the drawing as the leading end and the lower side in the drawing as the base end.

The container body 2 is formed of a bottomed cylindrical body having a bottom with a mouth 21 functioning as a discharge port for a chemical solution protruding at the tip, and is made of a rigid material having a predetermined rigidity. As a constituent material of the container body 2, for example, polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly-
Polyesters such as 4 (4-methylpentene-1), acrylic resin, polyacrylonitrile, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polyethylene naphthalate-polyethylene terephthalate copolymer, and polyolefin. Various resins such as vinylidene chloride, butadiene-styrene copolymer, and cyclic polyolefin, and a mixed resin thereof are exemplified. In order to maintain the decompressed state of the spaces 25 and 26 formed on the distal end side and the base end side of the container body 2 with the gasket 3 as a boundary, the constituent material of the container body 2 is made of gas barrier (gas impermeable). ) Are preferred. Because of its high gas barrier property, the constituent material of the container body 2 is preferably polyethylene terephthalate, polyacrylonitrile, polyvinylidene fluoride, polyethylene naphthalate, or polyethylene naphthalate-polyethylene terephthalate copolymer. When formed of a material having a low gas barrier property, a film having a gas barrier property such as polyvinyl alcohol or an ethylene-vinyl alcohol copolymer may be laminated on the surface (for example, the outer surface) of the container body 2 by coating or the like. preferable. When a light-unstable drug is encapsulated, a light-impermeable film is preferably laminated by coating or the like. The constituent material of the container body 2 is preferably substantially transparent or translucent in order to secure the visibility inside. In order to further improve the gas barrier property, a gas barrier layer (not shown) may be formed on the surface of the container body 2 by, for example, vapor deposition, sputtering, or the like. Examples of the composition of the gas barrier layer include oxides such as silicon oxide, aluminum oxide, and titanium oxide.

A flange 23 is provided on the outer periphery of the base end of the container body 2.
Is formed so that the sealing material 6 can be easily joined.
It is preferable that the base end face is flat. The mouth portion 21 is formed of a cylindrical body having a tapered portion having an outer diameter tapering toward the distal end at least, and a male screw 22 is formed on the outer peripheral surface on the base end side. The space in the mouth 21 communicates with the space 25 in the container body 2. A substantially cylindrical gasket 3 made of an elastic material that can slide in a liquid-tight manner along the inner peripheral surface of the container body 2 is inserted into the container body 2. The gasket 3 has at least a part of the side surface in close contact with the entire length in the circumferential direction of the inner peripheral surface of the container body, and is provided at a position separated from the sealing material 6 on the distal end side. The distance from the sealing material 6 depends on the size of the liquid injector 1, the amount of solution necessary for dissolution, the height of the drug, and the like. The airtightness is not broken, and the amount of the solution to be flowed into the space 25 can be ensured. Specific examples of the constituent material of the gasket 3 include styrene-based elastomers, hydrogenated styrene-based elastomers, and polyolefins such as polyethylene, polypropylene, polybutene, and α-olefin copolymers, and oils such as flow oils and process oils. And a mixture of powdered inorganic substances such as talc, cast, and mica. In addition, various types such as polyvinyl chloride elastomer, olefin elastomer, polyester elastomer, polyamide elastomer, polyurethane elastomer, natural rubber, isoprene rubber, butyl rubber, chloroprene rubber, nitrile-butadiene rubber, styrene-butadiene rubber, and silicone rubber Rubber materials (especially those vulcanized) and mixtures thereof are mentioned.

The gasket 3 is not limited to the whole made of the above-mentioned elastic material, but at least a portion (the projection 31 in this embodiment) in contact with the inner surface of the container body 2 is made of the above-mentioned elastic material. Anything should do. A plurality of ring-shaped projections 31 are formed on the outer peripheral surface of the gasket 3 over the entire circumference. This projection 31 is
When the gasket 3 slides on the container body 2, the liquid tightness is maintained. Also, the protrusion 31
It also has a function of maintaining an appropriate slidability of the gasket 3 necessary for pushing out the internal solution. In order to maintain good liquid tightness of the gasket 3 with respect to the container body 2, it is preferable that the maximum outer diameter of the gasket 3, that is, the outer diameter of the ring-shaped projection 31, be larger than the inner diameter of the container body 2. Further, in order to further improve the liquid tightness and the slidability, a plurality of projections 31 (three in this embodiment) are formed at predetermined intervals along the longitudinal direction of the container body 2 as shown in the figure. It is preferred that In order to enable connection with the plunger 4, a concave portion 32 is formed at a central portion inside the base end side of the gasket 3. The concave portion 32 may have any shape as long as the distal end portion 41 of the plunger 4 can be connected. For example, a female screw is formed in the concave portion 32, and a male screw ( (Not shown), and the female screw and the male screw are screwed together, so that the connection can be made stronger. Also, plunger 4
A handle portion 42 for gripping and operating the plunger 4 by hand is formed at the base end of the plunger 4.

[0010] The sealing material 6 is releasably adhered to a flange 23 provided on the outer periphery of the base end of the container main body 2, and the space 25 in the container main body 2 until the chemical liquid injector 1 is used.
The degree of pressure reduction of 26 is maintained. As for the material of the sealing material 6, it has a high gas barrier property and is easily joined (adhered, fused).
As long as it can be easily peeled or punctured, specifically, a metal foil such as an aluminum foil, an ethylene-vinyl alcohol copolymer, polyvinylidene chloride, polyethylene terephthalate, or any of these and other materials. Examples include a laminated film with a material. In the case where the container body 2 is made of polyethylene terephthalate (PET), it is described in JP-A-5-45262.
From the base end side, an airtight maintenance member such as an aluminum foil for maintaining the reduced pressure state of the container body 2, a resin thin film base film having a function of maintaining the strength of the sealing material 6 such as a stretched PET film, and a container body such as a modified polyester. A laminated film composed of a resin thin film adhesive film which is heat-fusible with the second flange 23 and has easy peelability is preferable. In addition, a cap (sealing means) 5 for hermetically sealing the mouth 21 is provided on the distal end side of the container body 2. The cap 5 has an internal space opened at the distal end and the proximal end, and is detachably mounted (screwed) around the mouth 21, and a seal installed inside the cap main body 51. And a stop member 53. On the inner peripheral surface of the base end portion of the cap body 51, a female screw 52 screwed with the male screw 22 is formed, and the female screw 52 and the male screw 22 are screwed, so that the cap body 51 is Attached around.

The sealing member 53 is formed of a membrane or a plug made of an elastic material such as various rubbers or thermoplastic elastomers as described above, and can be penetrated by a second needle tube 832 described later, and It is airtight in itself.
Further, in order to improve the gas barrier property, the sealing member 53 is used.
A gas barrier layer (not shown) as described above may be formed on the surface of the substrate. When the cap body 51 is screwed into the mouth portion 21 and attached, the tip end surface of the mouth portion 21 comes into close contact (compression bonding) with the sealing member 53, whereby the mouth portion 21 is hermetically sealed and sealed. In cooperation with the material 6, the decompressed state of the spaces 25 and 26 can be maintained. A tapered guide surface 54 whose inner diameter gradually increases toward the distal end is provided on the periphery of the opening on the distal end side of the sealing member 53 of the cap body 51.
Are formed. The guide surface 54 is provided with the second needle tube 8.
When piercing the sealing member 53 with 32, it plays a role of guiding the needle tip 834 of the second needle tube 832 to the center of the sealing member 53. The spaces 25 and 26 in the container main body 2 surrounded by the container main body 2, the sealing material 6, and the sealing member 53 as described above are in a reduced pressure state. In this case, the pressure in the spaces 25 and 26 is preferably about 40 to 600 torr, and 70 to 200 torr.
rr is more preferable. If the pressure in the space 25 is too low,
When the inflow of the liquid into the space 25 is completed, the proportion of the liquid in the space 25 increases (the number of air bubbles decreases), and the solubility when the medicine is dissolved by shaking the container body 2; There is a possibility that the stirring property may be reduced. Also,
If the pressure in the space 25 is too high, the inflow amount when the liquid flows into the space 25 becomes small. When the degree of pressure reduction is defined based on the amount of the inflowing liquid, the inflowing liquid is in the space 25.
It is preferable to reduce the pressure in the space 25 so as to be 70 to 90% of the space 25.

Although not shown, the space 25 contains a medicine, especially a solid medicine (for example, a powder, a granule, a lump, or a gel), as necessary. The type of drug is not particularly limited, and examples thereof include antibiotics, vitamins (multivitamins), various amino acids, antithrombotics such as heparin, insulin, antitumor agents, analgesics, inotropics,
Intravenous anesthetics, antiparkinson agents, ulcer treatment agents, corticosteroids, arrhythmic agents, correcting electrolytes, antiviral agents, immunostimulants, etc. may be used. The form of the drug is not limited to a solid, but may be a liquid. Also,
The drug may be a mixture of two or more. Further, a desiccant 91 and an oxygen scavenger 92 can be accommodated in the space 26 as necessary. Thereby, it is possible to store a temporally unstable drug having hygroscopicity or oxidizing property among the above-mentioned drugs. Examples of the desiccant 91 inserted into the space 26 include those containing silica gel, zeolite, or the like as a component. Examples of the oxygen scavenger 92 include Ageless (manufactured by Mitsubishi Gas Chemical Company), and those using amorphous copper. One or both of the desiccant 91 and the oxygen absorber 92 are inserted depending on the degree of hygroscopicity and oxidizability of the chemical contained in the space 25. The desiccant 91 and the oxygen absorber 92 may be simply inserted into the space 26, but may be adhered or embedded in the base end surface of the gasket 3 or may be adhered to the sealing material 6 (not shown).

The spaces 25 and 26 are under reduced pressure.
The amount of residual moisture and oxygen is small, and the desiccant used 9
1 and the oxygen scavenger 92 need only have a small absorption capacity. Further, storing the desiccant 91 and the oxygen scavenger 92 changes the pressure in the spaces 25 and 26, but does not significantly change the water absorption. Next, the configuration of the holder 8 used by being attached to the drug solution injector 1 will be described. The holder 8 has a cylindrical holder body 81 whose base end is open. The holder main body 81 has a shape and dimensions that allow the cap 5 to be inserted and fitted through the base end opening 811.

On the inner peripheral surface of the tip of the holder body 81,
A female screw 82 is formed. A double-ended needle 83 is attached to the tip of the holder body 81. The double-ended needle 83 connects the first needle tube 831 and the second needle tube 832 to the hub 84 so that their needle tips 833 and 834 face in opposite directions and their lumens communicate with each other.
Is fixed to the The first needle tube 831 and the second needle tube 832 are each made of various metal materials such as stainless steel, titanium, and aluminum.
In addition, various ceramic materials such as glass and alumina,
It may be composed of various hard resins such as polyester, polyphenylene sulfide and polycarbonate. A male screw 85 is formed on the outer periphery of the hub 84,
By screwing the male screw 85 to the female screw 82, the double-ended needle 83 is attached to the holder body 81.
A covering member 87 that covers at least the needle tip 834 is provided around the second needle tube 832. The encapsulating member 87 has a function of preventing contamination of the second needle tube 832 and the like when not in use, maintaining a sterile state, and a function of preventing liquid leakage from the needle tip 834. The enclosing member 87 is preferably made of a film made of an elastic material as described above, and can be easily penetrated by the needle point 834. The distal end of the enclosing member 87 is fitted into a protruding portion 86 protruding from the base end of the hub 84, and is preferably bonded and fixed with an adhesive. The base end of the enclosing member 87 has a hemispherical shape.

Next, a method of assembling the drug solution injector 1 will be described. The cap 5 is attached to the container body 2. This is filled with a drug. The gasket 3 is pressed into the filled medicine by a method such as mechanical tapping until the gasket 3 is slightly slipped. The mechanical tapping here is a tapping method of inserting a gasket into a container in a state where the gasket is pinched and deformed. Further, the gasket may be dropped by a vacuum stopper. Next, the sealing material 6 is joined to the base end of the container body 2 in a reduced pressure state by a reduced pressure sealing machine.
When the pressure is gradually reduced in the pressure reducing sealing machine, the gasket 3 starts to move toward the base end of the container body 2. If the pressure is excessively reduced, the gasket 3 falls off from the base end of the container body 2, so that it is necessary to reduce the pressure appropriately. Since the appropriate degree of decompression varies depending on the position of the gasket when pushed in, that is, the height of the medicine, it is desirable to set the degree of decompression according to the type of medicine.

In the container described in Japanese Patent Application Laid-Open No. H11-33114, a member (positioning member) for connecting the gasket and the sealing material is required in order to hold the gasket at a predetermined position. The container allows the gasket to be placed in place without using these parts, and requires fewer parts and can be manufactured at lower cost.
Further, according to the container assembling method described in Japanese Patent Application Laid-Open No. 11-33114, first, it is necessary to prepare a gasket in which a positioning member is connected, and a sealing material is joined to the positioning member. Therefore, a device for assembling the gasket, the positioning member, and the sealing material is required. On the other hand, the chemical solution injection container according to the present invention can be manufactured very simply without inserting a component assembly step by merely reducing the pressure of the sealing material after inserting the gasket.

Next, an example of a method of using the liquid injector 1 will be described. [1] An unused chemical liquid injector 1 shown in FIG. 1 is prepared. The space 25 maintains a predetermined decompressed state, and a predetermined amount of a solid drug such as a powder is stored in the space 25. [2] On the other hand, a container containing a liquid to be mixed with a drug is prepared. In this embodiment, an infusion bag (not shown) containing a solution is described as an example. Infusion port port of infusion bag (consisting of a plug made of elastic material)
Then, the first needle tube 831 of the double-ended needle 83 of the holder 8 is pierced, and the cap 5 of the drug solution injector 1 is inserted and fitted into the holder main body 81. Thereby, the second needle tube 832 pierces the sealing member 53, and the needle tip 834 intrudes into the lumen of the mouth 21. At this time, the enclosing member 87
The tip is pierced into the second needle tube 832 and pressed by the sealing member 53 and the guide surface 54 so as to be bent toward the tip and folded in a bellows shape. And the needle tube 8
The needle tip 834 of the 31 is guided by the guide surface 54 and guided to the center of the sealing member 53, so that the sealing member 53 can be reliably inserted at an appropriate position. As described above,
When the inside of the infusion bag and the space 25 communicate with each other via the double-ended needle 83, the space 25 is in a depressurized state, so that the lysate in the infusion bag flows into the lumen of the first needle tube 831 and the second needle tube 832. Through the space 25. At this time,
Since the space 26 remains in a reduced pressure state, the gasket 3 moves toward the base end side of the container body 2 until the space 26 returns to normal pressure. Therefore, the volume of the space 25 is increased, and the medicine is easily dissolved.

[3] When the flow of the solution into the space 25 is stopped, the chemical solution injection device 1 is shaken and vibrated as necessary to dissolve the medicine stored in the space 25.
Thereby, a desired chemical solution 10 to be blended is adjusted. [4] Next, the sealing material 6 bonded to the base end of the container body 2 is peeled off. In the exposed recess 32 of the gasket 3,
The plunger 4 is fitted. [5] Subsequently, the plunger 4 is pressed in the distal direction, and the gasket 3 is slid in the same direction. Thereby, the space 2
The drug solution 10 in 5 is sequentially injected into the infusion bag through the lumen of the mouth portion 21, the second needle tube 832, and the first needle tube 831, and is compounded. [6] When the injection of the drug solution into the infusion bag is completed as described above, the holder 8 is removed from the cap 5.
Along with this, the second needle tube 832 is pulled out of the sealing member 53. At this time, the envelope member 87 folded in a bellows shape is instantaneously restored to its original shape by its elastic force, and again envelopes the second needle tube 832.
The liquid is prevented from leaking from and scattering around. And the aseptic condition of the solution in the infusion bag is maintained by the action of resealing of the enclosing member 87 and the mixed injection port.

The following method can be adopted instead of the above steps [4], [5] and [6]. [4 '] After the step [3], the holder 8 is removed from the cap 5, and the cap 5 is further rotated with respect to the container body 2 to remove the cap 5 from the mouth 21. The advantage of removing the holder 8 from the cap 5 is that
The same as described in [6]. [5 ′] On the other hand, a puncture needle (not shown) having a hub that can be fitted (screwed) in a liquid-tight manner with the mouth 21 is prepared in advance, and the hub of the puncture needle is fitted into the mouth 21. I do. [6 '] Next, the puncture needle is punctured into a blood vessel of a patient or a co-injection port of another predetermined container, the plunger 4 is pressed toward the distal end, and the gasket 3 is slid in the same direction. As a result, the drug solution 10 in the space 25 is discharged through the mouth 21 and the puncture needle, and is administered to a patient, or is injected and blended into the container. As described above, the liquid injector according to the present invention has been described with reference to the illustrated embodiments. However, the present invention is not limited to these embodiments. In particular, each component of the liquid injector according to the present invention exhibits the same function. It can be replaced with anything that can.

[0020]

As described above, according to the drug solution injection device and the method of manufacturing the same of the present invention, for example, the injection of a drug solution such as the mixing of a drug solution into a bag can be performed in a short time by a simple operation. A drug solution injection device which can be manufactured, is easy to manufacture, and requires a small number of parts is provided. In particular, since the space surrounded by the container body and the sealing material is in a reduced pressure state, the solution is sucked without performing the operation of pulling the plunger, and the operation can be performed simply and quickly. Furthermore, since the gasket can be provided at a distance from the sealing material, there is no danger that when the gasket is operated by the plunger, the outside air may accidentally enter the space inside the container body and contaminate the dissolved drug. can do. In addition, during the operation, since there is very little chance that various places such as the space inside the container main body come into contact with the outside air, it is possible to prevent bacterial contamination and contamination of foreign matter. Further, by providing the sealing means and the sealing material, the reduced pressure state of the space can be more stably maintained for a long period of time.

In particular, it is possible to maintain a good depressurized state in the container without impairing the slidability of the gasket, and to increase the diameter of the container body and reduce the length of the container body accordingly. By doing so, it is possible to reduce the size of the drug solution injector. In addition, by setting in advance the amount of the drug or the like to be stored in the container body, it is possible to prevent a mixing error.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing one embodiment of a drug solution injector according to the present invention.

Claims (6)

[Claims] 1. An outer cylinder having a nozzle sealed at the front end and having an open rear end, a gasket disposed slidably in the outer cylinder, and sealing a rear end of the outer cylinder. What is claimed is: 1. A chemical injection device, comprising: a sealing member, wherein the inside of an outer cylinder is decompressed, wherein a gasket is disposed separately from the sealing member. 2. An outer cylinder having a nozzle sealed at the front end and having an open rear end, a gasket slidably disposed within the outer cylinder, and a rear end of the outer cylinder sealed. In manufacturing a chemical injection device having a sealing member and a reduced pressure in the outer cylinder, a gasket is inserted into the outer cylinder so that the internal pressure does not substantially differ between before and after the gasket, and then the rear end opening is sealed. A method for manufacturing a chemical injection device, wherein the pressure is reduced so that a gasket stays at a predetermined position in an outer cylinder when sealing with a stop member. 3. The method according to claim 2, wherein the nozzle is sealed with a cap and a sealing member covered by the nozzle. 4. The method according to claim 3, wherein the gasket is inserted before the cap is completely sealed. 5. The chemical solution according to claim 2, wherein the gasket is inserted into the outer cylinder in which the side wall of the gasket is compressed in the outer cylinder in which the nozzle is sealed, by inserting the gasket from the opening at the rear end of the outer cylinder. Manufacturing method of injection device. 6. The method according to claim 2, wherein the medicine is contained in an inner space between the nozzle of the outer cylinder and the gasket.