JP2000516592A5 - - Google Patents
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- Publication number
- JP2000516592A5 JP2000516592A5 JP1998508666A JP50866698A JP2000516592A5 JP 2000516592 A5 JP2000516592 A5 JP 2000516592A5 JP 1998508666 A JP1998508666 A JP 1998508666A JP 50866698 A JP50866698 A JP 50866698A JP 2000516592 A5 JP2000516592 A5 JP 2000516592A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/690,090 US5770687A (en) | 1995-06-07 | 1996-07-31 | Comformationally constrained backbone cyclized somatostatin analogs |
| US08/690,090 | 1996-07-31 | ||
| PCT/IL1997/000261 WO1998004583A1 (en) | 1996-07-31 | 1997-07-30 | Conformationally constrained backbone cyclized somatostatin analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000516592A JP2000516592A (ja) | 2000-12-12 |
| JP2000516592A5 true JP2000516592A5 (cg-RX-API-DMAC7.html) | 2005-02-10 |
| JP4018752B2 JP4018752B2 (ja) | 2007-12-05 |
Family
ID=24771043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50866698A Expired - Fee Related JP4018752B2 (ja) | 1996-07-31 | 1997-07-30 | コンフォメーション的に固定された主鎖環化ソマトスタチン類似体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5770687A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0920446B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4018752B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100477710B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1124282C (cg-RX-API-DMAC7.html) |
| AT (1) | ATE363911T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU711100B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR9710636A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2262778C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69737787T2 (cg-RX-API-DMAC7.html) |
| IL (1) | IL128084A0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ334046A (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998004583A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
| IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
| US6051554A (en) * | 1995-06-07 | 2000-04-18 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| US6841533B1 (en) | 1995-12-07 | 2005-01-11 | Peptor Limited | Conformationally constrained backbone cyclized interleukin-6 antagonists |
| EP0877751B1 (en) * | 1995-12-22 | 2003-10-15 | University Technologies International Inc. | Linker arm for solid support oligonucleotide synthesis and process for production thereof |
| US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| US6602849B1 (en) | 1998-06-16 | 2003-08-05 | Societe De Conseils De Recherche Et D'applications Scientifiques, S.A.S. | Cyclic somatostatin analogs |
| CN1200000C (zh) * | 1998-06-16 | 2005-05-04 | 研究及应用科学协会股份有限公司 | 促生长素抑制素类似物 |
| US7135564B1 (en) * | 1998-07-02 | 2006-11-14 | University Technologies International Inc. | Reusable solid support for oligonucleotide synthesis |
| WO2000010589A1 (en) * | 1998-08-24 | 2000-03-02 | White Jeffrey D | Somatostatin analogs |
| US6465613B1 (en) | 1998-11-19 | 2002-10-15 | Tulane University | Hydrophilic somatostatin analogs |
| US6358491B1 (en) | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
| CA2394504A1 (en) * | 1999-12-15 | 2001-06-21 | Peptor Ltd. | Fragments and antagonists of heat shock protein 60 |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| AU2002341792B2 (en) | 2001-09-21 | 2007-09-06 | The Administrators Of The Tulane Educational Fund | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof |
| WO2003074551A2 (en) * | 2002-03-01 | 2003-09-12 | The Administrators Of The Tulane Educational Fund | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
| IL148921A0 (en) | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
| US7304128B2 (en) | 2002-06-04 | 2007-12-04 | E.I. Du Pont De Nemours And Company | Carbon nanotube binding peptides |
| IL150384A0 (en) * | 2002-06-24 | 2002-12-01 | Peptor Ltd | Radiolabelled somatostatin analogs backbone cyclized through metal complexation |
| US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
| US20050118099A1 (en) * | 2003-03-10 | 2005-06-02 | Braslawsky Gary R. | Thiol-mediated drug attachment to targeting peptides |
| US20070185031A1 (en) * | 2003-07-14 | 2007-08-09 | Northwestern University | Reducing polyglutamine-based aggregation |
| EP1648923B1 (en) * | 2003-07-31 | 2008-12-31 | Tranzyme Pharma Inc. | Spatially-defined macrocycles incorporating peptide bond surrogates |
| GB0318682D0 (en) | 2003-08-08 | 2003-09-10 | Novartis Ag | Organic compounds |
| WO2005018682A2 (en) * | 2003-08-20 | 2005-03-03 | The Regents Of The University Of California | Somatostatin analogs with inhibitory activity to growth hormone release |
| WO2005041901A2 (en) * | 2003-11-03 | 2005-05-12 | Elixir Pharmaceuticals, Inc. | Therapeutics using somatostatin agonists |
| CN101111510B (zh) * | 2004-10-19 | 2011-09-14 | 隆萨股份公司 | 树脂上肽环化 |
| CA2609951A1 (en) * | 2005-05-31 | 2006-12-07 | Yissum Research Development Company Of The Hebrew University Of Jerusale M | Backbone cyclized melanocortin stimulating hormone (.alpha.s) analogs |
| WO2011024175A1 (en) | 2009-08-28 | 2011-03-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection |
| FR2956115B1 (fr) | 2010-02-05 | 2012-04-06 | Isp Investments Inc | Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant |
| EP2604281B1 (en) | 2011-12-14 | 2014-07-30 | Centre National de la Recherche Scientifique (CNRS) | Clicked somatostatin conjugated analogs for biological applications |
| EP2807182A1 (en) | 2012-01-23 | 2014-12-03 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2) |
| WO2015087334A1 (en) | 2013-12-15 | 2015-06-18 | Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. | Viperistatin-derived peptides and uses thereof |
| WO2017212477A1 (en) | 2016-06-07 | 2017-12-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88) |
| EP3684794B1 (en) | 2017-09-19 | 2025-08-06 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Somatostatin prodrugs |
| EP3927737A1 (en) | 2019-02-21 | 2021-12-29 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Par4 derived peptides, analogs and uses thereof |
| WO2022003673A1 (en) | 2020-06-30 | 2022-01-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Humanin analogs and uses thereof |
| WO2025141573A1 (en) | 2023-12-27 | 2025-07-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Calreticulin peptidomimetic inhibitors and prodrugs |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4011182A (en) * | 1975-03-21 | 1977-03-08 | American Home Products Corporation | Cyclic undecapeptide analogs of somatostatin and intermediates |
| US3988304A (en) * | 1975-08-25 | 1976-10-26 | American Home Products Corporation | Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof |
| US4054558A (en) * | 1976-05-24 | 1977-10-18 | American Home Products Corporation | Cyclic dodecapeptide and intermediates therefor |
| SU798098A1 (ru) * | 1977-12-14 | 1981-01-23 | Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp | Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ |
| US4235886A (en) * | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
| US4360516A (en) * | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
| JPS5852259A (ja) * | 1981-09-22 | 1983-03-28 | Shiraimatsu Shinyaku Kk | アミノ酸９個で構成された新規ソマトスタチン類似体 |
| EP0083305B1 (de) * | 1981-12-24 | 1985-07-10 | Ciba-Geigy Ag | Cyclische Octapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung |
| US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
| US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
| EP0334244A3 (en) * | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Bradykinin antagonist peptides |
| AU3534989A (en) * | 1988-04-08 | 1989-11-03 | Scripps Clinic And Research Foundation | Polypeptides stabilized by covalent hydrogen bond replacements |
| IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
| CA2053250A1 (en) * | 1989-04-26 | 1990-10-27 | David H. Coy | Linear somatostatin analogs |
| US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| DE4119544C1 (cg-RX-API-DMAC7.html) * | 1991-06-13 | 1992-10-15 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De | |
| US5364851A (en) * | 1991-06-14 | 1994-11-15 | International Synthecon, Llc | Conformationally restricted biologically active peptides, methods for their production and uses thereof |
| US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
| IL99628A (en) * | 1991-10-02 | 2004-07-25 | Yissum Res Dev Co | Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them |
| US5371070A (en) * | 1992-11-09 | 1994-12-06 | The Salk Institute For Biological Studies | Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins |
| JPH09500625A (ja) * | 1993-07-09 | 1997-01-21 | スミスクライン・ビーチャム・コーポレイション | 環状セミランダムペプチドライブラリー |
| IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
-
1996
- 1996-07-31 US US08/690,090 patent/US5770687A/en not_active Expired - Lifetime
-
1997
- 1997-07-30 WO PCT/IL1997/000261 patent/WO1998004583A1/en not_active Ceased
- 1997-07-30 IL IL12808497A patent/IL128084A0/xx unknown
- 1997-07-30 AU AU36331/97A patent/AU711100B2/en not_active Ceased
- 1997-07-30 DE DE69737787T patent/DE69737787T2/de not_active Expired - Fee Related
- 1997-07-30 JP JP50866698A patent/JP4018752B2/ja not_active Expired - Fee Related
- 1997-07-30 BR BR9710636-4A patent/BR9710636A/pt not_active Application Discontinuation
- 1997-07-30 AT AT97932978T patent/ATE363911T1/de not_active IP Right Cessation
- 1997-07-30 EP EP97932978A patent/EP0920446B1/en not_active Expired - Lifetime
- 1997-07-30 CN CN97198197A patent/CN1124282C/zh not_active Expired - Fee Related
- 1997-07-30 CA CA002262778A patent/CA2262778C/en not_active Expired - Fee Related
- 1997-07-30 NZ NZ334046A patent/NZ334046A/en unknown
- 1997-07-30 KR KR10-1999-7000727A patent/KR100477710B1/ko not_active Expired - Fee Related