JP2000516515A - 脈管内プロテーゼデバイスとその使用方法 - Google Patents
脈管内プロテーゼデバイスとその使用方法Info
- Publication number
- JP2000516515A JP2000516515A JP10510886A JP51088698A JP2000516515A JP 2000516515 A JP2000516515 A JP 2000516515A JP 10510886 A JP10510886 A JP 10510886A JP 51088698 A JP51088698 A JP 51088698A JP 2000516515 A JP2000516515 A JP 2000516515A
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- frame body
- cover
- graft
- catheter
- endovascular
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/848—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/061—Blood vessels provided with means for allowing access to secondary lumens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/065—Y-shaped blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0058—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements soldered or brazed or welded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 脈管内プロテーゼデバイスにおいて、 少なくとも1個の拡張可能な管状フレームボディと、 前記フレームボディに具備された少なくとも1個の耐生物適用材料性のカバー と、 を有し、 前記フレームボディは、脈管部位に導入可能なように小直径に収縮可能 であり、かつ内部ルーメン内で半径方向に大直径に拡張可能であり、 前記カバーは、前記管状フレームボディの内部ルーメンに跨って延び、 かつ2個の開口を有し、前記各開口は、前記フレームボディのより大きな直径以 下の直径を有し、前記カバーは、前記管状フレームボディの拡張により拡大する ことを特徴とする脈管内プロテーゼデバイス。 2. 前記少なくとも1個のカバーは、前記管状ボディが拡張したときに、前記 管状ボディの一端に配置される ことを特徴とする請求の範囲1記載の装置。 3. 前記管状ボディは、そのいずれかの端部において2個の開口を有する1個 のカバーを有する ことを特徴とする請求の範囲1記載の装置。 4. 前記管状ボディは、曲げ部によってその曲げ部の反対側の端部と接続され るエンドレスの輪になったジグザグ構成に形成されたフレキシブルなフィラメン トを有する ことを特徴とする請求の範囲1記載の装置。 5. 前記少なくとも1つのカバーは、前記曲げ部で前記ボディの一端に固着さ れ、 前記管状ボディは、前記ボディの端部間に延びる周囲上にはカバーを有さない ことを特徴とする請求の範囲4記載の装置。 6. メインルーメンと第1と第2のブランチルーメンとを有する動脈系の分岐 点近傍に形成された瘤を治療する脈管内グラフトプロテーゼにおいて、 前記グラフトプロテーゼは、前記メインルーメンと第1と第2のグラフトリム とに配置される少なくとも1個の拡張可能な管状フレームボディを具備する脈管 内プロテーゼデバイスを有し、 前記フレームボディは、瘤の脈管部位の上流側に導入するために小径に収縮し 、内部ルーメンまで大径の半径方向に拡張し、 前記フレームボディは、管状フレームボディの内部ルーメンに跨って延び、2 個の開口を有するカバーを具備し、 前記各開口は、前記フレームボディの大径の以下の直径を有し、 前記第1リムは、前記開口の一方に搭載される頭部と前記第1ブランチルーメ ン内に配置される尾部とを有し、 前記第2リムは、前記開口の他方に搭載される頭部と前記第2ブランチルーメ ン内に配置される尾部とを有し、 前記カバーは、前記フレームボディを通して血液が流れるのを阻止するが、前 記2つの開口に搭載された第1と第2のグラフトリム内には血液が流れる ことを特徴とする脈管内グラフトプロテーゼ。 7. 前記カバーは、前記フレームボディが拡張したときに前記フレームボディ の一端に配置される ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 8. 前記フレームボディは、そのいずれかの端部に2個の開口を有する1つの カバーを有する ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 9. 前記フレームボディは、曲げ部によってその曲げ部の反対側の端部と接続 されるエンドレスの輪になったジグザグ構成に形成されたフレキシブルなフィラ メントを有する ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 10. 前記カバーは、前記曲げ部で前記ボディの一端に固着され、 前記フレームボディは、前記ボディの端部間に延びるその周辺上にはカバーを 具備しない ことを特徴とする請求の範囲9記載の脈管内グラフトプロテーゼ。 11. 前記第1と第2のグラフトリムの各々は、前記頭部において、前記開口 を包囲するカバーを把持する搭載手段を有する ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 12. 前記第1と第2のグラフトリムの各々は、前記プロテーゼデバイスが拡 張され、脈管部位に導入され大きな径になるために小さな直径に収縮する ことを特徴とする請求の範囲11記載の脈管内グラフトプロテーゼ。 13. 前記搭載手段は、前記グラフトリムの頭部から半径方向に前記開口の直 径より大きな直径に拡張する ことを特徴とする請求の範囲12記載の脈管内グラフトプロテーゼ。 14. 前記搭載手段は、前記グラフトリムの頭部開口部を包囲するカラーであ る ことを特徴とする請求の範囲13記載の脈管内グラフトプロテーゼ。 15. 脈管系に展開される前の前記第1と第2のグラフトリムの各々は、16 French以下の外径を有する導入用カテーテル内で、収縮した状態で配置される ことを特徴とする請求の範囲12記載の脈管内グラフトプロテーゼ。 16. 前記脈管系に展開される前の脈管内プロテーゼデバイスは、16French 以下の外径を有する導入用カテーテル内で、収縮した状態で配置される ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 17. 前記脈管系に展開される前の脈管内プロテーゼデバイスは、カテーテル 内に、前記カバーの開口の一方を介して延びる2本の予め搭載したガイドワイヤ とともに収縮して配置される ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 18. 前記フレームボディは、自己拡張型である ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 19. 前記フレームボディは、バーブのような係止手段を具備する ことを特徴とする請求の範囲6記載の脈管内グラフトプロテーゼ。 20. ルーメンと第1と第2の腸骨動脈に分かれる大動脈内の腹部大動脈瘤を 治療する方法において、 (A) 第1カテーテルに、第1と第2の開口を有する少なくとも1つのカバ ーと、このカバーを具備するフレームボディを有する予め搭載された脈管内プロ テーゼデバイスと、前記第1と第2の開口をそれぞれ貫通する第1と第2の予め 搭載されたガイドワイヤとを具備させるステップと、 (B) 前記第1のカテーテルを前記第1の腸骨動脈内に挿入し、そのカテー テルを瘤の上流側の位置まで前進させるステップと、 (C) 前記脈管内プロテーゼデバイスを前記第1カテーテルから開放し、こ のプロテーゼデバイスを拡張して、前記フレームボディの周辺の少なくとも1部 が前記瘤の大動脈の上流側と接触し、前記カバーは、前記フレームボディにおい て、前記大動脈のルーメン内に延び、 (D) 把持手段を具備するワイヤを前記第2の腸骨動脈内に導入し、前記第 2のガイドワイヤを把持してその頭部部分を前記第1の腸骨動脈から前記第2の 腸骨動脈内に引き抜くステップと、 (E) 第2のカテーテルを予め搭載した第1のグラフトリムにより前記第1 のガイドワイヤの上を前記リムの頭部が前記第1開口を通過するまで前進させる ステップと、 (F) 前記第1グラフトリムを前記第2カテーテルから取り出すステップと 、前記リムの頭部は、前記第1開口に搭載され、前記第1グラフトリムの尾部は 、前記第1腸骨動脈内に配置され、第3のカテーテルを予め搭載した第2のグラ フトリムでもって、前記第2のガイドワイヤ上に前記リムの頭部が前記第2開口 を通過するまで前進させるステップと、 (G) 前記第2グラフトリムを前記第3カテーテルから取り出すステップと 、を有し、 前記リムの頭部は、前記第2開口に搭載され、前記第2グラフトリムの頭部は 、前記第2腸骨動脈内に配置される ことを特徴とする腹部の大動脈瘤の治療方法。 21. 前記脈管内プロテーゼデバイスは、前記第1カテーテルの中を前進する 押し出し機を使用することにより前記第1カテーテルから取り出される ことを特徴とする請求の範囲20記載の方法。 22. 前記脈管内プロテーゼデバイスは、把持手段を有するワイヤを使用する ことにより前記第1カテーテルから取り出され、前記ワイヤガイドは、軸方向に 導入され、把持手段が前記プロテーゼデバイスと係合し、前記第1カテーテルか らそれを取り出すのに使用される所にある第1カテーテルまで前進させる ことを特徴とする請求の範囲20記載の方法。 23. 前記脈管内プロテーゼデバイスは、前記フレームボディの各端部に取り 付けられた1個のカバーを有し、かつ前記第1カテーテルに予め搭載され、その 結果各カバーは、前記フレームボディから出て拡張する ことを特徴とする請求の範囲20記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/697,057 US6325819B1 (en) | 1996-08-19 | 1996-08-19 | Endovascular prosthetic device, an endovascular graft prothesis with such a device, and a method for repairing an abdominal aortic aneurysm |
US08/697,057 | 1996-08-19 | ||
PCT/US1997/014539 WO1998007389A1 (en) | 1996-08-19 | 1997-08-19 | Endovascular prosthetic device, and method of use |
Publications (3)
Publication Number | Publication Date |
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JP2000516515A true JP2000516515A (ja) | 2000-12-12 |
JP2000516515A5 JP2000516515A5 (ja) | 2005-04-07 |
JP3968456B2 JP3968456B2 (ja) | 2007-08-29 |
Family
ID=24799621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP51088698A Expired - Lifetime JP3968456B2 (ja) | 1996-08-19 | 1997-08-19 | 脈管内プロテーゼデバイスと脈管内グラフトプロテーゼ |
Country Status (9)
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US (1) | US6325819B1 (ja) |
EP (1) | EP0925043B1 (ja) |
JP (1) | JP3968456B2 (ja) |
KR (1) | KR100521671B1 (ja) |
AU (1) | AU738826B2 (ja) |
CA (1) | CA2263694A1 (ja) |
DE (1) | DE69722940T2 (ja) |
ES (1) | ES2202635T3 (ja) |
WO (1) | WO1998007389A1 (ja) |
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Also Published As
Publication number | Publication date |
---|---|
KR20000068139A (ko) | 2000-11-25 |
DE69722940T2 (de) | 2004-05-13 |
ES2202635T3 (es) | 2004-04-01 |
KR100521671B1 (ko) | 2005-10-17 |
US6325819B1 (en) | 2001-12-04 |
AU738826B2 (en) | 2001-09-27 |
EP0925043B1 (en) | 2003-06-18 |
DE69722940D1 (en) | 2003-07-24 |
EP0925043A1 (en) | 1999-06-30 |
CA2263694A1 (en) | 1998-02-26 |
JP3968456B2 (ja) | 2007-08-29 |
WO1998007389A1 (en) | 1998-02-26 |
AU3985497A (en) | 1998-03-06 |
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