JP2000514789A5 - - Google Patents

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Publication number
JP2000514789A5
JP2000514789A5 JP1998503446A JP50344698A JP2000514789A5 JP 2000514789 A5 JP2000514789 A5 JP 2000514789A5 JP 1998503446 A JP1998503446 A JP 1998503446A JP 50344698 A JP50344698 A JP 50344698A JP 2000514789 A5 JP2000514789 A5 JP 2000514789A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998503446A
Other languages
English (en)
Japanese (ja)
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JP2000514789A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/010900 external-priority patent/WO1997049286A1/en
Publication of JP2000514789A publication Critical patent/JP2000514789A/ja
Publication of JP2000514789A5 publication Critical patent/JP2000514789A5/ja
Ceased legal-status Critical Current

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JP10503446A 1996-06-27 1997-06-24 Ｉｌ―８受容体拮抗薬 Ceased JP2000514789A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2065596P 1996-06-27 1996-06-27
US60/020,655 1996-06-27
PCT/US1997/010900 WO1997049286A1 (en) 1996-06-27 1997-06-24 Il-8 receptor antagonists

Publications (2)

Publication Number Publication Date
JP2000514789A JP2000514789A (ja) 2000-11-07
JP2000514789A5 true JP2000514789A5 (cg-RX-API-DMAC7.html) 2005-02-10

Family

ID=21799843

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10503446A Ceased JP2000514789A (ja) 1996-06-27 1997-06-24 Ｉｌ―８受容体拮抗薬

Country Status (15)

Country Link
US (1) US6271261B1 (cg-RX-API-DMAC7.html)
EP (1) EP0915651A4 (cg-RX-API-DMAC7.html)
JP (1) JP2000514789A (cg-RX-API-DMAC7.html)
KR (1) KR20000022273A (cg-RX-API-DMAC7.html)
AU (1) AU3499497A (cg-RX-API-DMAC7.html)
BR (1) BR9709938A (cg-RX-API-DMAC7.html)
CO (1) CO4890843A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ425698A3 (cg-RX-API-DMAC7.html)
HU (1) HUP9903922A3 (cg-RX-API-DMAC7.html)
IL (1) IL127667A0 (cg-RX-API-DMAC7.html)
NO (1) NO986109L (cg-RX-API-DMAC7.html)
PL (1) PL330849A1 (cg-RX-API-DMAC7.html)
TR (1) TR199802695T2 (cg-RX-API-DMAC7.html)
WO (1) WO1997049286A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA975671B (cg-RX-API-DMAC7.html)

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JP2000513360A (ja) 1996-06-27 2000-10-10 スミスクライン・ビーチャム・コーポレイション Ｉｌ―８レセプターアンタゴニスト
CA2294064A1 (en) * 1997-07-29 1999-02-11 Smithkline Beecham Corporation Il-8 receptor antagonists
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US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
WO1999036069A1 (en) * 1998-01-16 1999-07-22 Smithkline Beecham Corporation Il-8 receptor antagonists
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
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EP1274415A4 (en) * 2000-03-14 2005-09-07 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6767922B2 (en) 2000-03-14 2004-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
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PT1478358E (pt) 2002-02-11 2013-09-11 Bayer Healthcare Llc Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal
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AU2003210969A1 (en) * 2002-02-11 2003-09-04 Bayer Corporation Aryl ureas with raf kinase and angiogenesis inhibiting activity
AR041834A1 (es) * 2002-10-29 2005-06-01 Smithkline Beecham Corp Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
US20060229335A1 (en) * 2002-12-24 2006-10-12 Bradley Teegarden Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
PL1626714T3 (pl) 2003-05-20 2007-12-31 Bayer Healthcare Llc Diarylowe pochodne mocznika do schorzeń, w których pośredniczy PDGFR
EP1558582B1 (en) 2003-07-22 2005-12-21 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
CN102816113B (zh) 2003-07-23 2015-05-13 拜耳医药保健有限责任公司 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲
ATE548353T1 (de) * 2004-03-23 2012-03-15 Arena Pharm Inc Verfahren zur herstellung von substituierte n- aryl-n'-ä3-(1h-pyrazol-5-yl)phenylü-harnstoffe and intermediate davon.
CN101010315A (zh) * 2004-04-30 2007-08-01 拜耳制药公司 用于治疗癌症的取代的吡唑基脲衍生物
KR20070011475A (ko) 2004-05-12 2007-01-24 쉐링 코포레이션 Ｃｘｃｒ1 및 ｃｘｃｒ2 케모카인 길항제
WO2006043950A1 (en) * 2004-10-20 2006-04-27 Smithkline Beecham Corporation Il-8 receptor antagonists
PE20061130A1 (es) * 2004-11-19 2007-01-05 Arena Pharm Inc Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a
WO2006060762A2 (en) * 2004-12-03 2006-06-08 Arena Pharmaceuticals, Inc. Pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
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CN104761498B (zh) 2006-05-18 2017-12-26 艾尼纳制药公司 5‑ht2a血清素受体的调节剂
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
US9567327B2 (en) 2007-08-15 2017-02-14 Arena Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
NO2364142T3 (cg-RX-API-DMAC7.html) 2008-10-28 2018-06-16
US8980891B2 (en) 2009-12-18 2015-03-17 Arena Pharmaceuticals, Inc. Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
CN109562085A (zh) 2015-06-12 2019-04-02 阿速万科学有限责任公司 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物
KR20180064373A (ko) 2015-07-15 2018-06-14 엑소반트 사이언시즈 게엠베하 신경퇴행성 질환과 관련된 환각의 예방 및 치료에 유용한 5-ht2a 세로토닌 수용체의 조절자로서의 다이아릴 및 아릴헤테로아릴 우레아 유도체

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