JP2000514307A5 - - Google Patents

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Publication number
JP2000514307A5
JP2000514307A5 JP1998506265A JP50626598A JP2000514307A5 JP 2000514307 A5 JP2000514307 A5 JP 2000514307A5 JP 1998506265 A JP1998506265 A JP 1998506265A JP 50626598 A JP50626598 A JP 50626598A JP 2000514307 A5 JP2000514307 A5 JP 2000514307A5
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JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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JP1998506265A
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English (en)
Japanese (ja)
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JP2000514307A (ja
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Priority claimed from PCT/US1997/012347 external-priority patent/WO1998002582A2/en
Publication of JP2000514307A publication Critical patent/JP2000514307A/ja
Publication of JP2000514307A5 publication Critical patent/JP2000514307A5/ja
Ceased legal-status Critical Current

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JP10506265A 1996-07-16 1997-07-15 増加した標的特異的t▲下m▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法 Ceased JP2000514307A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2181896P 1996-07-16 1996-07-16
US60/021,818 1996-07-16
PCT/US1997/012347 WO1998002582A2 (en) 1996-07-16 1997-07-15 Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008137832A Division JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的tmを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Publications (2)

Publication Number Publication Date
JP2000514307A JP2000514307A (ja) 2000-10-31
JP2000514307A5 true JP2000514307A5 (OSRAM) 2007-08-02

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JP10506265A Ceased JP2000514307A (ja) 1996-07-16 1997-07-15 増加した標的特異的t▲下m▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法
JP2008137832A Expired - Lifetime JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的tmを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

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JP2008137832A Expired - Lifetime JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的tmを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Country Status (11)

Country Link
US (3) US6130038A (OSRAM)
EP (1) EP0912767B1 (OSRAM)
JP (2) JP2000514307A (OSRAM)
KR (1) KR20000023814A (OSRAM)
AT (1) ATE339514T1 (OSRAM)
AU (1) AU726821B2 (OSRAM)
CA (1) CA2260749A1 (OSRAM)
DE (1) DE69736667T2 (OSRAM)
DK (1) DK0912767T3 (OSRAM)
ES (1) ES2270467T3 (OSRAM)
WO (1) WO1998002582A2 (OSRAM)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
ES2324503T3 (es) 1997-04-10 2009-08-07 Stichting Katholieke Universiteit University Medical Centre Nijmegen Pca3, genes pca3 y metodos de uso.
DE69941333D1 (de) 1998-07-02 2009-10-08 Gen Probe Inc Molekulare fackeln
CA2336539A1 (en) 1998-07-31 2000-02-10 Gen-Probe Incorporated Reversible inhibiting probes
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000070093A1 (en) * 1999-05-13 2000-11-23 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
WO2001023620A2 (en) * 1999-09-29 2001-04-05 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
PT1222266E (pt) 1999-09-29 2006-07-31 Diagnocure Inc Arn mensageiro de pca3 em tecidos benignos e malignos da prostata
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
US6924108B2 (en) * 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US7833715B1 (en) * 2000-01-11 2010-11-16 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
CA2405450C (en) 2000-03-31 2011-08-16 Merck & Co., Inc. Dermacentor variabilis gaba-gated chloride channels
JP4950414B2 (ja) * 2000-08-03 2012-06-13 独立行政法人産業技術総合研究所 核酸の測定方法、それに用いる核酸プローブ及びその方法によって得られるデータを解析する方法
EP1315839B9 (en) 2000-09-01 2009-08-12 Gen-Probe Incorporated Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
AU2002211814A1 (en) * 2000-09-12 2002-03-26 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of cryptosporidium organisms in a test sample
ATE312942T1 (de) * 2000-10-25 2005-12-15 Hoffmann La Roche Amplifizierung unter verwendung von modifizierten primern
EP1251183A3 (en) * 2001-04-18 2003-12-10 Exiqon A/S Improved helper probes for detection of a target sequence by a capture oligonucleotide
CA2449011A1 (en) 2001-05-31 2002-12-05 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
US7365175B2 (en) * 2001-06-12 2008-04-29 The Regents Of The University Of California Wit 3.0, a novel gene to control soft tissue wound healing
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
EP1495139A4 (en) * 2002-03-29 2006-06-28 Genentech Inc METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING NUCLEIC ACID ANALYTES
US7211382B2 (en) * 2002-04-09 2007-05-01 Orchid Cellmark Inc. Primer extension using modified nucleotides
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20030235827A1 (en) * 2002-06-25 2003-12-25 Orchid Biosciences, Inc. Methods and compositions for monitoring primer extension and polymorphism detection reactions
EP1573037A4 (en) * 2002-06-28 2007-05-09 Orchid Cellmark Inc METHODS AND COMPOSITIONS FOR ANALYZING WEAKENED SAMPLES USING UNIQUE NUCLEOTIDE POLYMORPHISMS PANELS
US7192700B2 (en) * 2002-12-20 2007-03-20 Orchid Cellmark Inc. Methods and compositions for conducting primer extension and polymorphism detection reactions
CA2497570A1 (en) * 2002-08-02 2004-02-12 Orchid Biosciences, Inc. Methods and compositions for genotyping
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
WO2004067726A2 (en) * 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
CA2513780C (en) 2003-02-07 2014-12-30 Diagnocure Inc. Method to detect prostate cancer from a urine sample
EP2292792B1 (en) 2003-05-19 2013-11-20 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of Trichomonas Vaginalis in a test sample
US20080176220A1 (en) * 2004-02-26 2008-07-24 Thomsen Bioscience Method, Kit and System for Enhanced Nested Pcr
CA2572472C (en) 2004-07-01 2013-08-13 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
AU2005280162B2 (en) 2004-08-27 2012-04-26 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
WO2006121888A2 (en) 2005-05-06 2006-11-16 Gen-Probe Incorporated Methods of nucleic acid target capture
AU2006254891B2 (en) * 2005-06-06 2011-04-14 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of Chlamydophila pneumoniae in a test sample
EP2017356B1 (en) 2006-06-06 2011-12-07 Gen-Probe Incorporated Tagged oliggonucleotides and their use in nucleic acid amplification methods
CA2658105C (en) * 2006-08-01 2016-07-05 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
US8911946B2 (en) 2007-12-21 2014-12-16 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
WO2009135093A2 (en) 2008-04-30 2009-11-05 Integrated Dna Technologies, Inc. Rnase-h-based assays utilizing modified rna monomers
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
AU2009246363B2 (en) * 2008-05-13 2013-10-24 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
AU2009262870B2 (en) 2008-05-30 2014-03-20 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Salmonella
EP2367958B1 (en) 2008-11-25 2017-08-23 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
US8748133B2 (en) 2008-12-30 2014-06-10 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Listeria
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
RU2612521C2 (ru) 2009-07-06 2017-03-09 Онтории, Инк. Новые пролекарства нуклеиновых кислот и способы их применения
US8999675B2 (en) 2009-08-31 2015-04-07 Gen-Probe Incorporated Dengue virus assay
CA2896129C (en) 2010-01-22 2015-12-29 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
US9822397B2 (en) 2010-06-30 2017-11-21 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
BR112013004044A2 (pt) 2010-08-13 2016-07-05 Envirologix Inc composições e métodos para quantificação de uma sequência de ácido nucleico em uma amostra.
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
AU2012236896A1 (en) * 2011-03-25 2013-05-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
BR112014001244A2 (pt) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd métodos para a síntese de ácidos nucléicos funcionalizados
AU2012312169B2 (en) 2011-09-21 2016-01-14 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
ES3011408T3 (en) * 2012-04-09 2025-04-07 Envirologix Inc Compositions and methods for quantifying a nucleic acid sequence in a sample
WO2013158215A1 (en) 2012-04-16 2013-10-24 Life Technologies Corporation Oligonucleotides and methods for the preparationof rna libraries
BR112015000723A2 (pt) 2012-07-13 2017-06-27 Shin Nippon Biomedical Laboratories Ltd adjuvante de ácido nucléico quiral
CN112007045A (zh) 2012-07-13 2020-12-01 波涛生命科学有限公司 手性控制
ES2862073T3 (es) 2012-07-13 2021-10-06 Wave Life Sciences Ltd Grupo auxiliar asimétrico
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
WO2014140165A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof
WO2014140167A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof
US9347095B2 (en) 2013-03-15 2016-05-24 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
EP3066219B1 (en) * 2013-11-08 2018-12-26 Ionis Pharmaceuticals, Inc. Methods for detecting oligonucleotides
EP3095460A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
EP3095459A4 (en) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
CN113278617A (zh) 2014-01-16 2021-08-20 波涛生命科学有限公司 手性设计
WO2015164494A1 (en) 2014-04-22 2015-10-29 Envirologix, Inc. Compositions and methods for enhancing and/or predicting dna amplification
US10793922B2 (en) 2014-10-20 2020-10-06 Envirologix Inc. Compositions and methods for detecting an RNA virus
KR102657306B1 (ko) 2014-12-08 2024-04-12 버그 엘엘씨 전립선암의 진단 및 치료에서 필라민을 포함하는 마커의 용도
CN107849603B (zh) 2015-04-24 2022-01-28 阿提拉生物系统公司 利用有限核苷酸组成的引物扩增
US10329601B2 (en) 2015-12-28 2019-06-25 Ionian Technologies, Inc. Nicking and extension amplification reaction (NEAR) of Streptococcus species
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
EP3914732A1 (en) 2019-01-25 2021-12-01 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
WO2020223576A1 (en) 2019-04-30 2020-11-05 Chondrial Therapeutics, Inc. Frataxin-sensitive markers for determining effectiveness of frataxin replacement therapy
US20220307093A1 (en) 2019-07-03 2022-09-29 Gen-Probe Incorporated Oligonucleotides for use in determining the presence of trichomonas vaginalis in a sample
AU2020335996A1 (en) 2019-08-23 2022-03-31 Gen-Probe Incorporated Compositions, methods and kits for detecting Treponema pallidum
EP4182482A1 (en) 2020-07-17 2023-05-24 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
WO2022216841A1 (en) 2021-04-06 2022-10-13 Berg Llc Protein markers for estrogen receptor (er)-positive luminal a(la)-like and luminal b1 (lb1)-like breast cancer
EP4320441A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
CA3214833A1 (en) 2021-04-06 2022-10-13 Bpgbio, Inc. Protein markers for the prognosis of breast cancer progression
CN119365780A (zh) 2022-04-06 2025-01-24 拉利玛生物医药公司 用于监测共济蛋白替代疗法的共济蛋白敏感性标志物
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2024220373A1 (en) 2023-04-15 2024-10-24 Accent Therapeutics, Inc. Assays for monitoring inhibition of rna helicase dhx9
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087558A (en) 1981-09-25 1992-02-11 Webster John A Jr Method for identifying and characterizing organisms
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
JPS61243182A (ja) * 1985-04-19 1986-10-29 Nitsukan Kogyo Kk 金属メツキされたチタン酸カリウム繊維およびその製造方法
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5091519A (en) * 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
FI891436L (fi) 1987-07-31 1989-03-23 Univ Leland Stanford Junior Selektivt flerfaldigande av targetpolynukleotidsekvenser.
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA2008096A1 (en) * 1989-01-19 1990-07-19 Samuel Rose Nucleic acid amplification using single primer
CA2031536A1 (en) * 1989-04-05 1990-10-06 Kevin R. Kearney Hybridization promotion reagents
IE81145B1 (en) 1989-04-20 2000-05-03 Thomas Gerard Barry Generation of specific probes for target nucleotide sequences
DE69022362T2 (de) * 1989-05-24 1996-05-09 Amoco Corp Nukleinsäuresonden für die detektion von neisseria gonorrhoeae.
US5849504A (en) 1989-08-11 1998-12-15 Amoco Corporation Nucleic acid probes and methods for detecting Pneumocystis carinii
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
CA2025178A1 (en) * 1989-10-02 1991-04-03 William G. Weisburg Nucleic acid probes for the detection of lyme disease spirochetes
CA2069948A1 (en) * 1989-12-01 1991-06-02 Brian Wylie Pontius Promotion of high specificity molecular assembly
US5914396A (en) 1990-01-11 1999-06-22 Isis Pharmaceuticals, Inc. 2'-O-modified nucleosides and phosphoramidites
US5536638A (en) 1990-04-18 1996-07-16 N.V. Innogenetics S.A. Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae
US5811533A (en) 1990-06-11 1998-09-22 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
JPH0874B2 (ja) * 1990-07-27 1996-01-10 アイシス・ファーマシューティカルス・インコーポレーテッド 遺伝子発現を検出および変調するヌクレアーゼ耐性、ピリミジン修飾オリゴヌクレオチド
US5386023A (en) * 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5366988A (en) * 1990-11-29 1994-11-22 Kumiai Chemical Industry Co., Ltd. Benzohydroximoylazole derivatives and insecticide including the same
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5435248A (en) * 1991-07-09 1995-07-25 The Ensign-Bickford Company Extended range digital delay detonator
DE637965T1 (de) * 1991-11-26 1995-12-14 Gilead Sciences Inc Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen.
KR940703846A (ko) * 1991-12-24 1994-12-12 비. 린네 파샬 갭(gap)이 형성된 2′ 변성된 올리고뉴클레오티드(gapped 2′ modifed oligonucleotides)
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
US5652099A (en) * 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
ES2082256T3 (es) * 1992-03-23 1996-03-16 Hoffmann La Roche Metodo de deteccion del adn.
EP1223173B1 (en) * 1992-07-23 2005-07-13 Isis Pharmaceuticals, Inc. Novel 2'-O-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
EP0601889A2 (en) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
WO1994019023A1 (en) * 1993-02-19 1994-09-01 Isis Pharmaceuticals, Inc. Cyclobutyl antisense oligonucleotides, methods of making and use thereof
CA2105364A1 (en) * 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US6156501A (en) * 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5827648A (en) * 1995-12-13 1998-10-27 Chiron Corporation Differential hybridization for relative quantification of variant populations
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
AU2522095A (en) * 1994-05-19 1995-12-18 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
AU693023B2 (en) * 1995-05-05 1998-06-18 Applied Biosystems, Llc Methods and reagents for combined PCR amplification and hybridization probing assay
ATE494394T1 (de) 1995-06-07 2011-01-15 Gilead Sciences Inc Nukleinsäureliganden, die an dna-polymerasen binden und diese inhibieren
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
CA2252048C (en) * 1996-04-12 2008-03-11 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
WO1997044488A2 (en) 1996-05-22 1997-11-27 Gen-Probe Incorporated Compositions and methods for the detection of mycobacterium kansasii
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US6747252B2 (en) * 1996-11-15 2004-06-08 Kenneth J. Herzog Multiple head induction sealer apparatus and method
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6210015B1 (en) * 1999-10-04 2001-04-03 Kenneth Alan Ross Stand for cakes or pastry

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