JP2000514307A5 - - Google Patents

Download PDF

Info

Publication number
JP2000514307A5
JP2000514307A5 JP1998506265A JP50626598A JP2000514307A5 JP 2000514307 A5 JP2000514307 A5 JP 2000514307A5 JP 1998506265 A JP1998506265 A JP 1998506265A JP 50626598 A JP50626598 A JP 50626598A JP 2000514307 A5 JP2000514307 A5 JP 2000514307A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998506265A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000514307A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1997/012347 external-priority patent/WO1998002582A2/en
Publication of JP2000514307A publication Critical patent/JP2000514307A/ja
Publication of JP2000514307A5 publication Critical patent/JP2000514307A5/ja
Ceased legal-status Critical Current

Links

JP10506265A 1996-07-16 1997-07-15 増加した標的特異的ｔ▲下ｍ▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法 Ceased JP2000514307A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2181896P 1996-07-16 1996-07-16
US60/021,818 1996-07-16
PCT/US1997/012347 WO1998002582A2 (en) 1996-07-16 1997-07-15 Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008137832A Division JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的ｔｍを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Publications (2)

Publication Number Publication Date
JP2000514307A JP2000514307A (ja) 2000-10-31
JP2000514307A5 true JP2000514307A5 (OSRAM) 2007-08-02

Family

ID=21806324

Family Applications (2)

Application Number Title Priority Date Filing Date
JP10506265A Ceased JP2000514307A (ja) 1996-07-16 1997-07-15 増加した標的特異的ｔ▲下ｍ▼を持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法
JP2008137832A Expired - Lifetime JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的ｔｍを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008137832A Expired - Lifetime JP4527789B2 (ja) 1996-07-16 2008-05-27 増加した標的特異的ｔｍを持つ修飾オリゴヌクレオチドを用いた核酸配列の検出および増幅のための方法

Country Status (11)

Country Link
US (3) US6130038A (OSRAM)
EP (1) EP0912767B1 (OSRAM)
JP (2) JP2000514307A (OSRAM)
KR (1) KR20000023814A (OSRAM)
AT (1) ATE339514T1 (OSRAM)
AU (1) AU726821B2 (OSRAM)
CA (1) CA2260749A1 (OSRAM)
DE (1) DE69736667T2 (OSRAM)
DK (1) DK0912767T3 (OSRAM)
ES (1) ES2270467T3 (OSRAM)
WO (1) WO1998002582A2 (OSRAM)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
ATE426018T1 (de) 1997-04-10 2009-04-15 Stichting Katholieke Univ Pca3, pca3-gene und verfahren zu ihrer verwendung
ES2330812T3 (es) 1998-07-02 2009-12-15 Gen-Probe Incorporated Antorchas moleculares.
EP1100972B1 (en) 1998-07-31 2006-06-14 Gen-Probe Incorporated Reversible inhibiting probes
US6087112A (en) 1998-12-30 2000-07-11 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
WO2000070093A1 (en) * 1999-05-13 2000-11-23 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
JP2003510075A (ja) 1999-09-29 2003-03-18 ディグノキュアー・インコーポレーテッド 良性および悪性の前立腺組織におけるｐｃａ３メッセンジャーｒｎａ種
US6844151B1 (en) 1999-09-29 2005-01-18 Oligos Etc. Inc. Methods for production of arrays with modified oligonucleotide and polynucleotide compositions
WO2001023620A2 (en) * 1999-09-29 2001-04-05 Oligos Etc. Inc. Arrays with modified oligonucleotide and polynucleotide compositions
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
US6924108B2 (en) * 1999-12-21 2005-08-02 Ingeneus Corporation Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
US7833715B1 (en) * 2000-01-11 2010-11-16 Nanogen Recognomics Gmbh Biomolecules having multiple attachment moieties for binding to a substrate surface
CA2405450C (en) 2000-03-31 2011-08-16 Merck & Co., Inc. Dermacentor variabilis gaba-gated chloride channels
JP4950414B2 (ja) * 2000-08-03 2012-06-13 独立行政法人産業技術総合研究所 核酸の測定方法、それに用いる核酸プローブ及びその方法によって得られるデータを解析する方法
AU7104200A (en) 2000-09-01 2002-03-22 Gen Probe Inc Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations
JP2004527221A (ja) * 2000-09-12 2004-09-09 ジェン−プロウブ インコーポレイテッド 試験サンプル中のＣｒｙｐｔｏｓｐｏｒｉｄｉｕｍ生物の存在を決定するための組成物、方法およびキット
ATE312942T1 (de) 2000-10-25 2005-12-15 Hoffmann La Roche Amplifizierung unter verwendung von modifizierten primern
EP1251183A3 (en) * 2001-04-18 2003-12-10 Exiqon A/S Improved helper probes for detection of a target sequence by a capture oligonucleotide
US7208282B2 (en) 2001-05-31 2007-04-24 Merck & Co., Inc. Rhesus monkey, dog and ferret melanin-concentrating hormone type 2 receptor
JP2005517381A (ja) * 2001-06-12 2005-06-16 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｗｉｔ３．０、軟組織創傷治癒を制御する新規遺伝子
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
WO2003083440A2 (en) * 2002-03-29 2003-10-09 Genentech, Inc. Methods and compositions for detection and quantitation of nucleic acid analytes
US7211382B2 (en) * 2002-04-09 2007-05-01 Orchid Cellmark Inc. Primer extension using modified nucleotides
US7199107B2 (en) * 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
US20030235827A1 (en) * 2002-06-25 2003-12-25 Orchid Biosciences, Inc. Methods and compositions for monitoring primer extension and polymorphism detection reactions
AU2003247715B8 (en) * 2002-06-28 2008-06-05 Orchid Cellmark Inc. Methods and compositions for analyzing compromised samples using single nucleotide polymorphism panels
WO2004013346A2 (en) * 2002-08-02 2004-02-12 Orchid Biosciences, Inc. Methods and compositions for genotyping
US7192700B2 (en) * 2002-12-20 2007-03-20 Orchid Cellmark Inc. Methods and compositions for conducting primer extension and polymorphism detection reactions
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
WO2004067726A2 (en) * 2003-01-29 2004-08-12 Keck Graduate Institute Isothermal reactions for the amplification of oligonucleotides
JP4824540B2 (ja) 2003-02-07 2011-11-30 ダイアノキュアー インク． サンプル中の前立腺癌を検出する方法
EP2292792B1 (en) 2003-05-19 2013-11-20 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of Trichomonas Vaginalis in a test sample
US20080176220A1 (en) * 2004-02-26 2008-07-24 Thomsen Bioscience Method, Kit and System for Enhanced Nested Pcr
WO2006007567A2 (en) * 2004-07-01 2006-01-19 Gen-Probe Incorporated Methods and compositions to detect nucleic acids in a biological sample
US7713697B2 (en) * 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
WO2006026388A2 (en) * 2004-08-27 2006-03-09 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
CA2491067A1 (en) 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
EP1877581B1 (en) 2005-05-06 2012-03-28 Gen-Probe Incorporated Methods and products for nucleic acid target capture
EP1896612A2 (en) * 2005-06-06 2008-03-12 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample
DK2017356T3 (da) 2006-06-06 2012-01-30 Gen Probe Inc Mærkede oligonukleotider og anvendelse deraf i fremgangsmåder til amplifikation af nukleinsyrer
EP2765202B1 (en) * 2006-08-01 2017-02-01 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
WO2008021290A2 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
US8183359B2 (en) * 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP1978111B1 (en) 2007-04-02 2013-03-27 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of Pseudomonas aeruginosa
US9689031B2 (en) * 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
WO2009086218A2 (en) 2007-12-21 2009-07-09 Gen-Probe Incorporated Detection of antibiotic-resistant microorganisms
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
AU2009242546B2 (en) 2008-04-30 2015-01-22 Integrated Dna Technologies, Inc. RNase-H-based assays utilizing modified RNA monomers
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
CA2723726C (en) 2008-05-13 2017-09-12 Michael M. Becker Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
WO2009158119A2 (en) 2008-05-30 2009-12-30 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of salmonella
EP2367958B1 (en) 2008-11-25 2017-08-23 Gen-Probe Incorporated Compositions and methods for detecting small rnas, and uses thereof
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
WO2010078374A1 (en) 2008-12-30 2010-07-08 Gen-Probe Incorporated Compositions, kits and related methods for the detection and/or monitoring of listeria
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
JP6057460B2 (ja) 2009-08-31 2017-01-11 ジェン−プローブ・インコーポレーテッド デングウイルスアッセイ
AU2011207406B2 (en) 2010-01-22 2015-01-15 Gen-Probe Incorporated Probes for detecting the presence of Trichomonas vaginalis in a sample
CA2802741C (en) 2010-06-30 2020-07-07 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
CA2810856C (en) 2010-08-13 2022-05-17 Envirologix Inc. Compositions and methods for quantifying a nucleic acid sequence in a sample
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
WO2012135053A2 (en) * 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
JP6128529B2 (ja) 2011-07-19 2017-05-17 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． 官能化核酸の合成のための方法
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
AU2013246080C1 (en) 2012-04-09 2018-03-29 Envirologix Inc. Compositions and methods for quantifying a nucleic acid sequence in a sample
EP2839024B1 (en) 2012-04-16 2017-09-06 Life Technologies Corporation Methods for the preparation of rna libraries
SG10201700283WA (en) 2012-07-13 2017-03-30 Wave Life Sciences Ltd Chiral control
CA2879023C (en) 2012-07-13 2017-03-28 Wave Life Sciences Japan Asymmetric auxiliary group
WO2014010718A1 (ja) 2012-07-13 2014-01-16 株式会社新日本科学 キラル核酸アジュバント
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
WO2014140165A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of paecilomyces byssochlamydoides and uses thereof
WO2014140167A1 (en) 2013-03-14 2014-09-18 Dsm Ip Assets B.V. Cell wall deconstruction enzymes of malbranchea cinnamomea and uses thereof
US9347095B2 (en) 2013-03-15 2016-05-24 Bio-Rad Laboratories, Inc. Digital assays for mutation detection
DK3066219T3 (en) 2013-11-08 2019-03-11 Ionis Pharmaceuticals Inc METHODS FOR DETECTING OIGONUCLEOTIDES
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
WO2015108046A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
KR20230152178A (ko) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 키랄 디자인
UA123387C2 (uk) 2014-04-22 2021-03-31 Інвайролоджикс, Інк. Виділений праймерний олігонуклеотид та спосіб його застосування
CA2965137A1 (en) 2014-10-20 2016-04-28 Envirologix, Inc. Compositions and methods for detecting an rna virus
EP3230314B1 (en) 2014-12-08 2023-05-03 Berg LLC Use of markers including filamin a in the diagnosis and treatment of prostate cancer
WO2016172632A2 (en) 2015-04-24 2016-10-27 Atila Biosystems, Inc Amplification with primers of limited nucleotide composition
US10329601B2 (en) * 2015-12-28 2019-06-25 Ionian Technologies, Inc. Nicking and extension amplification reaction (NEAR) of Streptococcus species
JP2021532808A (ja) 2018-08-08 2021-12-02 ジェン−プローブ・インコーポレーテッド Ｍｙｃｏｐｌａｓｍａ ｇｅｎｉｔａｌｉｕｍを検出するための組成物、方法、およびキット
CA3127620A1 (en) 2019-01-25 2020-07-30 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
CN114127312B (zh) 2019-04-30 2025-11-21 拉利玛生物医药公司 用于测定共济蛋白替代疗法的疗效的共济蛋白敏感性标志物
CN114096683A (zh) 2019-07-03 2022-02-25 简·探针公司 用于确定样品中阴道毛滴虫的存在的寡核苷酸
JP7742830B2 (ja) 2019-08-23 2025-09-22 ジェン－プローブ・インコーポレーテッド Ｔｒｅｐｏｎｅｍａ ｐａｌｌｉｄｕｍを検出するための組成物、方法、およびキット
EP4182482A1 (en) 2020-07-17 2023-05-24 Gen-Probe Incorporated Detection of macrolide-resistant mycoplasma genitalium
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
US20230059578A1 (en) 2021-04-06 2023-02-23 Berg Llc Protein markers for estrogen receptor (er)-positive-like and estrogen receptor (er)-negative-like breast cancer
EP4320443A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for the prognosis of breast cancer progression
US20240402177A1 (en) 2021-04-06 2024-12-05 Bpgbio, Inc. Protein markers for estrogen receptor (er)-positive luminal a (la)-like and luminal b1 (lb1)-like breast cancer
KR20240169114A (ko) 2022-04-06 2024-12-02 라리마 테라퓨틱스, 인코포레이티드 프라탁신 대체 요법 모니터링을 위한 프라탁신 민감성 마커
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
WO2024220373A1 (en) 2023-04-15 2024-10-24 Accent Therapeutics, Inc. Assays for monitoring inhibition of rna helicase dhx9
WO2025155991A2 (en) 2024-01-19 2025-07-24 Bpgbio, Inc. Predictive biomarkers for response to coenzyme q10 treatment in pancreatic cancer

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087558A (en) 1981-09-25 1992-02-11 Webster John A Jr Method for identifying and characterizing organisms
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
JPS61243182A (ja) * 1985-04-19 1986-10-29 Nitsukan Kogyo Kk 金属メツキされたチタン酸カリウム繊維およびその製造方法
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4797355A (en) * 1985-06-13 1989-01-10 Amgen Inc. Methods for attaching polynucleotides to supports
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
EP0232967B1 (en) * 1986-01-10 1993-04-28 Amoco Corporation Competitive homogeneous assay
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5091519A (en) * 1986-05-01 1992-02-25 Amoco Corporation Nucleotide compositions with linking groups
WO1989001050A1 (en) 1987-07-31 1989-02-09 The Board Of Trustees Of The Leland Stanford Junior University Selective amplification of target polynucleotide sequences
US5030557A (en) * 1987-11-24 1991-07-09 Ml Technology Venture Means and method for enhancing nucleic acid hybridization
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA2008096A1 (en) * 1989-01-19 1990-07-19 Samuel Rose Nucleic acid amplification using single primer
CA2031536A1 (en) * 1989-04-05 1990-10-06 Kevin R. Kearney Hybridization promotion reagents
IE81145B1 (en) 1989-04-20 2000-05-03 Thomas Gerard Barry Generation of specific probes for target nucleotide sequences
EP0426843B1 (en) * 1989-05-24 1995-09-13 Amoco Corporation Nucleic acid probes for the detection of neisseria gonorrhoeae
US5849504A (en) 1989-08-11 1998-12-15 Amoco Corporation Nucleic acid probes and methods for detecting Pneumocystis carinii
US5134066A (en) * 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
CA2025178A1 (en) * 1989-10-02 1991-04-03 William G. Weisburg Nucleic acid probes for the detection of lyme disease spirochetes
CA2069948A1 (en) * 1989-12-01 1991-06-02 Brian Wylie Pontius Promotion of high specificity molecular assembly
US5914396A (en) 1990-01-11 1999-06-22 Isis Pharmaceuticals, Inc. 2'-O-modified nucleosides and phosphoramidites
WO1994002501A1 (en) * 1992-07-23 1994-02-03 Isis Pharmaceuticals, Inc. Novel 2'-o-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof
US5536638A (en) 1990-04-18 1996-07-16 N.V. Innogenetics S.A. Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae
US5811533A (en) 1990-06-11 1998-09-22 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to vascular endothelial growth factor (VEGF)
US5386023A (en) * 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
DE69126530T2 (de) * 1990-07-27 1998-02-05 Isis Pharmaceutical, Inc., Carlsbad, Calif. Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5366988A (en) * 1990-11-29 1994-11-22 Kumiai Chemical Industry Co., Ltd. Benzohydroximoylazole derivatives and insecticide including the same
US5641625A (en) * 1992-05-22 1997-06-24 Isis Pharmaceuticals, Inc. Cleaving double-stranded DNA with peptide nucleic acids
US5435248A (en) * 1991-07-09 1995-07-25 The Ensign-Bickford Company Extended range digital delay detonator
AU3222793A (en) * 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5700922A (en) * 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
EP0618925B2 (en) * 1991-12-24 2012-04-18 Isis Pharmaceuticals, Inc. Antisense oligonucleotides
US5652099A (en) * 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
ES2082256T3 (es) * 1992-03-23 1996-03-16 Hoffmann La Roche Metodo de deteccion del adn.
US5445933A (en) * 1992-09-15 1995-08-29 Boehringer Mannheim Corporation Strand displacement assay and complex useful therefor
EP0601889A2 (en) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nucleic acid probes
AU3729493A (en) * 1993-02-19 1994-09-14 Ciba-Geigy Ag Cyclobutyl antisense oligonucleotides, methods of making and use thereof
US5514546A (en) * 1993-09-01 1996-05-07 Research Corporation Technologies, Inc. Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5827648A (en) * 1995-12-13 1998-10-27 Chiron Corporation Differential hybridization for relative quantification of variant populations
SE9400522D0 (sv) * 1994-02-16 1994-02-16 Ulf Landegren Method and reagent for detecting specific nucleotide sequences
JPH10500310A (ja) * 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ
ZA956776B (en) * 1994-08-25 1996-03-20 Akzo Nobel Nv A process for making the product of a nucleic acid amplification reaction incapable of being a target for further amplification a diagnostic assay employing said process a kit and a container suitable for carrying out said process for assay
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5681702A (en) * 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
US6001564A (en) * 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
EP0826066B1 (en) * 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methods and reagents for combined pcr amplification and hybridization probing assay
US5731148A (en) 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
US5747252A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Nucleic acid probes and amplification oligonucleotides for Neisseria species
DE69638318D1 (de) 1995-06-07 2011-02-17 Gilead Sciences Inc Nukleinsäureliganden, die an DNA-Polymerasen binden und diese inhibieren
EP0892808B1 (en) * 1996-04-12 2008-05-14 PHRI Properties, Inc. Detection probes, kits and assays
AU710996B2 (en) 1996-05-22 1999-10-07 Gen-Probe Incorporated Compositions and methods for the detection of mycobacterium kansasii
US5898031A (en) * 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
WO1998002582A2 (en) * 1996-07-16 1998-01-22 Gen-Probe Incorporated Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific t¿m?
US7070925B1 (en) * 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US6747252B2 (en) * 1996-11-15 2004-06-08 Kenneth J. Herzog Multiple head induction sealer apparatus and method
US5846726A (en) * 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6210015B1 (en) * 1999-10-04 2001-04-03 Kenneth Alan Ross Stand for cakes or pastry

Similar Documents

Publication Publication Date Title
JP2000502280A5 (OSRAM)
JP2001508893A5 (OSRAM)
JP2000506993A5 (OSRAM)
JP2000501771A5 (OSRAM)
JP2000501599A5 (OSRAM)
JP2001509661A5 (OSRAM)
JP2000514307A5 (OSRAM)
JP2001506065A5 (OSRAM)
JP2001510377A5 (OSRAM)
JP2000502472A5 (OSRAM)
JP2000501825A5 (OSRAM)
JP2000516371A5 (OSRAM)
JP2000502425A5 (OSRAM)
JP2000502485A5 (OSRAM)
JP2000502568A5 (OSRAM)
JP2000501774A5 (OSRAM)
JP2000516978A5 (OSRAM)
JP2000502570A5 (OSRAM)
JP2001500930A5 (OSRAM)
JP2001500441A5 (OSRAM)
JP2000501876A5 (OSRAM)
JP2000505447A5 (OSRAM)
JP2000501744A5 (OSRAM)
JP2000505355A5 (OSRAM)
JP2000502316A5 (OSRAM)