JP2000512980A5 - - Google Patents

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Publication number
JP2000512980A5
JP2000512980A5 JP1998500803A JP50080398A JP2000512980A5 JP 2000512980 A5 JP2000512980 A5 JP 2000512980A5 JP 1998500803 A JP1998500803 A JP 1998500803A JP 50080398 A JP50080398 A JP 50080398A JP 2000512980 A5 JP2000512980 A5 JP 2000512980A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998500803A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000512980A (ja
Filing date
Publication date
Priority claimed from US08/659,206 external-priority patent/US5922685A/en
Application filed filed Critical
Publication of JP2000512980A publication Critical patent/JP2000512980A/ja
Publication of JP2000512980A5 publication Critical patent/JP2000512980A5/ja
Ceased legal-status Critical Current

Links

JP10500803A 1996-06-05 1997-06-04 腫瘍のil―12遺伝子治療 Ceased JP2000512980A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/659,206 US5922685A (en) 1996-06-05 1996-06-05 IL-12 gene therapy of tumors
US08/659,206 1996-06-05
PCT/US1997/009591 WO1997046263A1 (en) 1996-06-05 1997-06-04 Il-12 gene therapy of tumors

Publications (2)

Publication Number Publication Date
JP2000512980A JP2000512980A (ja) 2000-10-03
JP2000512980A5 true JP2000512980A5 (enExample) 2005-01-13

Family

ID=24644498

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10500803A Ceased JP2000512980A (ja) 1996-06-05 1997-06-04 腫瘍のil―12遺伝子治療

Country Status (6)

Country Link
US (1) US5922685A (enExample)
EP (1) EP0963207B1 (enExample)
JP (1) JP2000512980A (enExample)
DE (1) DE69735643T2 (enExample)
ES (1) ES2262180T3 (enExample)
WO (1) WO1997046263A1 (enExample)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
WO1998041229A1 (en) * 1997-03-19 1998-09-24 F. Hoffmann-La Roche Ag USE OF IL-12p40 AS IMMUNOSTIMULANT
ATE267215T1 (de) 1997-12-08 2004-06-15 Lexigen Pharm Corp Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
AU758860B2 (en) * 1998-04-15 2003-04-03 Merck Patent Gmbh Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor
WO2000015249A1 (en) * 1998-09-15 2000-03-23 Genetics Institute, Inc. Treatment of kaposi's sarcoma with il-12
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
PL202058B1 (pl) 1999-08-09 2009-05-29 Merck Patent Gmbh Wielofunkcyjne białko fuzyjne cytokin i przeciwciała
US20030190305A1 (en) * 1999-09-15 2003-10-09 Wyeth And National Institutes Of Health Treatment of Kaposi's sarcoma with IL-12
US7074210B2 (en) * 1999-10-11 2006-07-11 Felton International, Inc. Universal protector cap with auto-disable features for needle-free injectors
CA2387326A1 (en) 1999-10-11 2001-04-19 Needleless Ventures, Inc. Universal anti-infectious protector for needleless injectors
ES2313907T3 (es) * 1999-10-29 2009-03-16 Anges Mg, Inc. Terapia genica para la isquemia diabetica.
EP1228214A2 (en) 1999-11-12 2002-08-07 MERCK PATENT GmbH Erythropoietin forms with improved properties
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
AU4314801A (en) 2000-02-11 2001-08-20 Lexigen Pharm Corp Enhancing the circulating half-life of antibody-based fusion proteins
US20040213798A1 (en) * 2000-06-08 2004-10-28 Powderject Vaccines, Inc. Spray-dried alum compositions
US20020120228A1 (en) * 2000-06-08 2002-08-29 Yuh-Fun Maa Powder compositions
SK982003A3 (en) * 2000-06-29 2004-05-04 Merck Patent Gmbh Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents
US20020086036A1 (en) 2000-12-05 2002-07-04 Allergan Sales, Inc. Methods for treating hyperhidrosis
US7255865B2 (en) * 2000-12-05 2007-08-14 Allergan, Inc. Methods of administering botulinum toxin
US7148321B2 (en) * 2001-03-07 2006-12-12 Emd Lexigen Research Center Corp. Expression technology for proteins containing a hybrid isotype antibody moiety
US6992174B2 (en) * 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
US6969517B2 (en) * 2001-05-03 2005-11-29 Emd Lexigen Research Center Corp. Recombinant tumor specific antibody and use thereof
CA2349506C (en) * 2001-06-14 2009-12-08 Duke University A method for selective expression of therapeutic genes by hyperthermia
ATE542137T1 (de) * 2001-12-04 2012-02-15 Merck Patent Gmbh Immunocytokine mit modulierter selektivität
KR101086660B1 (ko) * 2002-12-17 2011-11-24 메르크 파텐트 게엠베하 Gd2 에 결합하는 마우스 14.18 항체의 인간화 항체(h14.18) 및 그것의 il-2 와의 융합
AU2005203962C1 (en) * 2004-01-05 2012-11-08 Antisoma Research Limited Interleukin-12 targeted to oncofoetal fibronectin
JP5175214B2 (ja) * 2005-12-30 2013-04-03 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 改良された安定性を有するインターロイキン−12p40変種
US7833754B2 (en) * 2006-01-13 2010-11-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services IL-12 for expression in mammalian cell
CN101883845B (zh) * 2007-10-08 2015-06-10 英特瑞克斯顿股份有限公司 工程树突细胞及其在癌症治疗中的应用
CN102575227A (zh) 2008-10-08 2012-07-11 英特瑞克斯顿股份有限公司 表达多种免疫调节剂的工程改造细胞及其应用
WO2010126766A1 (en) * 2009-04-30 2010-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inducible interleukin-12
WO2010147971A2 (en) * 2009-06-15 2010-12-23 New York University Il23 modified viral vector for recombinant vaccines and tumor treatment
FI3458083T3 (fi) 2016-05-18 2023-03-01 Interleukiini-12:ta (il12) koodittavia polynukleotideja ja niiden käyttötapoja
US11421011B2 (en) 2017-05-18 2022-08-23 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US4945050A (en) * 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5149655A (en) * 1990-06-21 1992-09-22 Agracetus, Inc. Apparatus for genetic transformation
EP0690732B1 (en) * 1994-01-21 2003-01-29 Powderject Vaccines, Inc. Gas driven gene delivery instrument
CA2268276A1 (en) * 1996-10-18 1998-04-30 Jeff Nordstrom Gene expression and delivery systems and uses

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