JP2000512434A - 磁 石 - Google Patents
磁 石Info
- Publication number
- JP2000512434A JP2000512434A JP09517509A JP51750997A JP2000512434A JP 2000512434 A JP2000512434 A JP 2000512434A JP 09517509 A JP09517509 A JP 09517509A JP 51750997 A JP51750997 A JP 51750997A JP 2000512434 A JP2000512434 A JP 2000512434A
- Authority
- JP
- Japan
- Prior art keywords
- magnet
- beads
- magnetic
- cell
- magnetic field
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 title 1
- 239000011324 bead Substances 0.000 claims abstract description 93
- 230000005291 magnetic effect Effects 0.000 claims abstract description 90
- 238000000034 method Methods 0.000 claims abstract description 5
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000010409 thin film Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 17
- 239000003153 chemical reaction reagent Substances 0.000 description 15
- 230000005298 paramagnetic effect Effects 0.000 description 8
- 239000000203 mixture Substances 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 238000005842 biochemical reaction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 239000004593 Epoxy Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000696 magnetic material Substances 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 239000002907 paramagnetic material Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000013019 agitation Methods 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920005597 polymer membrane Polymers 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/02—Permanent magnets [PM]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/02—Permanent magnets [PM]
- H01F7/0273—Magnetic circuits with PM for magnetic field generation
- H01F7/0278—Magnetic circuits with PM for magnetic field generation for generating uniform fields, focusing, deflecting electrically charged particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00468—Beads by manipulation of individual beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/22—Details of magnetic or electrostatic separation characterised by the magnetic field, e.g. its shape or generation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
Landscapes
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Engineering & Computer Science (AREA)
- Power Engineering (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US620295P | 1995-11-03 | 1995-11-03 | |
| US60/006,202 | 1995-11-03 | ||
| PCT/US1996/017398 WO1997016835A1 (en) | 1995-11-03 | 1996-11-01 | Magnet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000512434A true JP2000512434A (ja) | 2000-09-19 |
Family
ID=21719777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09517509A Pending JP2000512434A (ja) | 1995-11-03 | 1996-11-01 | 磁 石 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0876668A1 (OSRAM) |
| JP (1) | JP2000512434A (OSRAM) |
| KR (1) | KR19990067263A (OSRAM) |
| AU (1) | AU7483596A (OSRAM) |
| WO (1) | WO1997016835A1 (OSRAM) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770029A (en) * | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5935401A (en) * | 1996-09-18 | 1999-08-10 | Aclara Biosciences | Surface modified electrophoretic chambers |
| US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
| US6241894B1 (en) * | 1997-10-10 | 2001-06-05 | Systemix | High gradient magnetic device and method for cell separation or purification |
| US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
| US8481268B2 (en) | 1999-05-21 | 2013-07-09 | Illumina, Inc. | Use of microfluidic systems in the detection of target analytes using microsphere arrays |
| US6361958B1 (en) | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| FR2826882B1 (fr) | 2001-07-09 | 2003-09-12 | Bio Merieux | Procede de traitement de particules magnetiques et configurations d'aimants permettant la mise en oeuvre de ce procede |
| EP2407243B1 (en) | 2003-07-31 | 2020-04-22 | Handylab, Inc. | Multilayered microfluidic device |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| WO2005114166A1 (en) | 2004-05-21 | 2005-12-01 | Atonomics A/S | Surface acoustic wave sensor comprising a hydrogel |
| NL1030761C2 (nl) * | 2005-12-23 | 2007-06-29 | Bakker Holding Son Bv | Werkwijze en inrichting voor het scheiden van vaste deeltjes op basis van dichtheidsverschil. |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US20070247968A1 (en) * | 2006-04-21 | 2007-10-25 | V & P Scientific, Inc. | Sandwich magnetic stir elements for stirring the contents of vessels |
| WO2008007270A2 (en) * | 2006-06-21 | 2008-01-17 | Spinomix S.A. | A method for manipulating magnetic particles in a liquid medium |
| US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
| WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| WO2009012185A1 (en) | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| CN106190806B (zh) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法 |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| US10091594B2 (en) | 2014-07-29 | 2018-10-02 | Cochlear Limited | Bone conduction magnetic retention system |
| US10130807B2 (en) | 2015-06-12 | 2018-11-20 | Cochlear Limited | Magnet management MRI compatibility |
| US20160381473A1 (en) | 2015-06-26 | 2016-12-29 | Johan Gustafsson | Magnetic retention device |
| US10917730B2 (en) | 2015-09-14 | 2021-02-09 | Cochlear Limited | Retention magnet system for medical device |
| US11595768B2 (en) | 2016-12-02 | 2023-02-28 | Cochlear Limited | Retention force increasing components |
| EP4215240A1 (en) | 2019-09-27 | 2023-07-26 | Cochlear Limited | Multipole magnet for medical implant system |
| US11701668B1 (en) * | 2020-05-08 | 2023-07-18 | 10X Genomics, Inc. | Methods and devices for magnetic separation |
| US11946038B1 (en) | 2020-05-29 | 2024-04-02 | 10X Genomics, Inc. | Methods and systems including flow and magnetic modules |
| US12263482B1 (en) | 2020-06-03 | 2025-04-01 | 10X Genomics, Inc. | Methods and devices for magnetic separation in a flow path |
| KR102643820B1 (ko) * | 2022-01-28 | 2024-03-06 | 한국기계연구원 | 자기장 제어를 이용한 입자 이동 제어장치 및 이를 이용한 입자 이동 제어방법 |
| CN116020656B (zh) * | 2022-12-30 | 2024-02-02 | 辽宁润兴新材料有限公司 | 一种包覆沥青材料加工用除杂装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB236808A (en) * | 1924-12-02 | 1925-07-16 | Krupp Fried Grusonwerk Ag | Improvements in or relating to zone poles for magnetic separators |
| JPS6253714A (ja) * | 1985-08-30 | 1987-03-09 | Kamata Bio Eng Kk | 流体の磁化浄化装置 |
| US4998083A (en) * | 1989-11-02 | 1991-03-05 | New York University | Yokeless permanent magnet structure and method of construction |
| DE4032616A1 (de) * | 1990-09-29 | 1992-04-02 | Kloeckner Humboldt Deutz Ag | Magnetsystem |
| JP3065781B2 (ja) * | 1992-03-09 | 2000-07-17 | ティーディーケイ株式会社 | 永久磁石磁気回路 |
| EP0589636B1 (en) * | 1992-09-24 | 2000-08-02 | Amersham Pharmacia Biotech UK Limited | Magnetic separation method and apparatus therefor |
| HUT76505A (en) * | 1993-09-07 | 1997-09-29 | Brunsting | Magnetic filter assembly |
-
1996
- 1996-11-01 KR KR1019980703228A patent/KR19990067263A/ko not_active Withdrawn
- 1996-11-01 JP JP09517509A patent/JP2000512434A/ja active Pending
- 1996-11-01 EP EP96937082A patent/EP0876668A1/en not_active Withdrawn
- 1996-11-01 AU AU74835/96A patent/AU7483596A/en not_active Abandoned
- 1996-11-01 WO PCT/US1996/017398 patent/WO1997016835A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997016835A1 (en) | 1997-05-09 |
| EP0876668A4 (OSRAM) | 1998-11-18 |
| KR19990067263A (ko) | 1999-08-16 |
| AU7483596A (en) | 1997-05-22 |
| EP0876668A1 (en) | 1998-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2000512434A (ja) | 磁 石 | |
| US11780984B2 (en) | Integration of ex situ fabricated porous polymer monoliths into fluidic chips | |
| Sia et al. | Microfluidic devices fabricated in poly (dimethylsiloxane) for biological studies | |
| JP4884361B2 (ja) | マイクロビーズを利用した化学反応装置 | |
| Bronzeau et al. | Simultaneous bioassays in a microfluidic channel on plugs of different magnetic particles | |
| US20100055758A1 (en) | Magnetic Device for Isolation of Cells and Biomolecules in a Microfluidic Environment | |
| EP2208531A1 (en) | Distribution of particles in capillary channel by application of magnetic field | |
| JP4852412B2 (ja) | マイクロスケール装置の集積 | |
| US20100279887A1 (en) | Nonlinear magnetophoretic separation of biological substances | |
| US20060102482A1 (en) | Fluidic system | |
| JP2000515978A (ja) | 統合マイクロフルイディック素子 | |
| WO2001083825A3 (en) | Colloid compositions for solid phase biomolecular analytical systems | |
| JP5401724B2 (ja) | 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置 | |
| ATE161104T1 (de) | Verfahren und reagenzien zur ausführung von ioneneinfang-digoxin-assays | |
| Monošík et al. | Utilisation of micro-and nanoscaled materials in microfluidic analytical devices | |
| US20100213136A1 (en) | Apparatus for moving magnetic particles | |
| US20040082766A1 (en) | Method of purifying biological substances, kit for purifying biological substances, and system for analyzing biological substances | |
| Locascio et al. | Liposomes as signal amplification reagents for bioassays in microfluidic channels | |
| WO2012136695A1 (en) | Device comprising rows of magnetic elements in channels and compartments | |
| US20200231961A1 (en) | Device For Facilitating The Isolation Of Targets From A Biological Sample | |
| Abonnenc et al. | Magnetic track array for efficient bead capture in microchannels | |
| CN101372709A (zh) | 一种快速定量评价药物核酸相互作用的方法 | |
| DE10231925A1 (de) | Reaktorsystem zur Durchführung chemischer und biochemischer Prozesse | |
| JP2006247535A (ja) | 回転磁場を利用した反応促進方法 | |
| EP1249499A1 (de) | Verfahren und Vorrichtung zur Bestimmung und Selektion von Molekül-Molekül-Wechselwirkungen |