JP2000511929A - 分子薬の光活性化における改善された選択性のための方法 - Google Patents
分子薬の光活性化における改善された選択性のための方法Info
- Publication number
- JP2000511929A JP2000511929A JP10520696A JP52069698A JP2000511929A JP 2000511929 A JP2000511929 A JP 2000511929A JP 10520696 A JP10520696 A JP 10520696A JP 52069698 A JP52069698 A JP 52069698A JP 2000511929 A JP2000511929 A JP 2000511929A
- Authority
- JP
- Japan
- Prior art keywords
- coumarin
- tissue
- light
- photoactive
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 304
- 239000003814 drug Substances 0.000 title claims abstract description 275
- 229940079593 drug Drugs 0.000 title claims abstract description 269
- 230000002186 photoactivation Effects 0.000 title claims description 43
- 230000001976 improved effect Effects 0.000 title description 14
- 230000005284 excitation Effects 0.000 claims abstract description 243
- 241001465754 Metazoa Species 0.000 claims abstract description 87
- 239000000463 material Substances 0.000 claims abstract description 49
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 29
- 201000011510 cancer Diseases 0.000 claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 claims description 92
- 229960000956 coumarin Drugs 0.000 claims description 46
- 235000001671 coumarin Nutrition 0.000 claims description 46
- -1 4-tert - butylphenyl Chemical group 0.000 claims description 42
- 238000011282 treatment Methods 0.000 claims description 41
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 claims description 35
- 230000005281 excited state Effects 0.000 claims description 33
- IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 claims description 33
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 claims description 32
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 229960004469 methoxsalen Drugs 0.000 claims description 27
- HUVXQFBFIFIDDU-UHFFFAOYSA-N aluminum phthalocyanine Chemical compound [Al+3].C12=CC=CC=C2C(N=C2[N-]C(C3=CC=CC=C32)=N2)=NC1=NC([C]1C=CC=CC1=1)=NC=1N=C1[C]3C=CC=CC3=C2[N-]1 HUVXQFBFIFIDDU-UHFFFAOYSA-N 0.000 claims description 25
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims description 25
- 230000005855 radiation Effects 0.000 claims description 24
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 claims description 24
- AFYCEAFSNDLKSX-UHFFFAOYSA-N coumarin 460 Chemical compound CC1=CC(=O)OC2=CC(N(CC)CC)=CC=C21 AFYCEAFSNDLKSX-UHFFFAOYSA-N 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
- YNHJECZULSZAQK-UHFFFAOYSA-N tetraphenylporphyrin Chemical compound C1=CC(C(=C2C=CC(N2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3N2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 YNHJECZULSZAQK-UHFFFAOYSA-N 0.000 claims description 21
- BUNGCZLFHHXKBX-UHFFFAOYSA-N 8-methoxypsoralen Natural products C1=CC(=O)OC2=C1C=C1CCOC1=C2OC BUNGCZLFHHXKBX-UHFFFAOYSA-N 0.000 claims description 19
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 claims description 19
- SXQRATTWLJENLK-UHFFFAOYSA-N [9-(diethylamino)benzo[a]phenoxazin-5-ylidene]-ethylazanium;chloride Chemical compound [Cl-].C12=CC=CC=C2C(=[NH+]CC)C=C2C1=NC1=CC=C(N(CC)CC)C=C1O2 SXQRATTWLJENLK-UHFFFAOYSA-N 0.000 claims description 19
- XHXMPURWMSJENN-UHFFFAOYSA-N coumarin 480 Chemical compound C12=C3CCCN2CCCC1=CC1=C3OC(=O)C=C1C XHXMPURWMSJENN-UHFFFAOYSA-N 0.000 claims description 19
- 239000003446 ligand Substances 0.000 claims description 19
- ZTKQHJHANLVEBM-UHFFFAOYSA-N 2-[3-(ethylamino)-6-ethylimino-2,7-dimethylxanthen-9-yl]benzoic acid Chemical compound C1=2C=C(C)C(NCC)=CC=2OC2=CC(=NCC)C(C)=CC2=C1C1=CC=CC=C1C(O)=O ZTKQHJHANLVEBM-UHFFFAOYSA-N 0.000 claims description 18
- UJKPHYRXOLRVJJ-MLSVHJFASA-N CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C Chemical class CC(O)C1=C(C)/C2=C/C3=N/C(=C\C4=C(CCC(O)=O)C(C)=C(N4)/C=C4\N=C(\C=C\1/N\2)C(C)=C4C(C)O)/C(CCC(O)=O)=C3C UJKPHYRXOLRVJJ-MLSVHJFASA-N 0.000 claims description 18
- MUSLHCJRTRQOSP-UHFFFAOYSA-N rhodamine 101 Chemical compound [O-]C(=O)C1=CC=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MUSLHCJRTRQOSP-UHFFFAOYSA-N 0.000 claims description 18
- OYINILBBZAQBEV-UWJYYQICSA-N (17s,18s)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid Chemical compound N1C2=C(C)C(C=C)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1C(O)=O)=NC1=C(CC(O)=O)C([C@@H](CCC(O)=O)[C@@H]1C)=NC1=C2 OYINILBBZAQBEV-UWJYYQICSA-N 0.000 claims description 16
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims description 16
- LBGCRGLFTKVXDZ-UHFFFAOYSA-M ac1mc2aw Chemical compound [Al+3].[Cl-].C12=CC=CC=C2C(N=C2[N-]C(C3=CC=CC=C32)=N2)=NC1=NC([C]1C=CC=CC1=1)=NC=1N=C1[C]3C=CC=CC3=C2[N-]1 LBGCRGLFTKVXDZ-UHFFFAOYSA-M 0.000 claims description 16
- 229960002045 bergapten Drugs 0.000 claims description 16
- KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 claims description 16
- 235000021286 stilbenes Nutrition 0.000 claims description 16
- COIVODZMVVUETJ-UHFFFAOYSA-N sulforhodamine 101 Chemical compound OS(=O)(=O)C1=CC(S([O-])(=O)=O)=CC=C1C1=C(C=C2C3=C4CCCN3CCC2)C4=[O+]C2=C1C=C1CCCN3CCCC2=C13 COIVODZMVVUETJ-UHFFFAOYSA-N 0.000 claims description 16
- FMHHVULEAZTJMA-UHFFFAOYSA-N trioxsalen Chemical compound CC1=CC(=O)OC2=C1C=C1C=C(C)OC1=C2C FMHHVULEAZTJMA-UHFFFAOYSA-N 0.000 claims description 16
- ZUELZXZJXUXJCH-UHFFFAOYSA-N 3-[10,15,20-tris(3-hydroxyphenyl)-21,23-dihydroporphyrin-5-yl]phenol Chemical compound Oc1cccc(c1)-c1c2ccc(n2)c(-c2cccc(O)c2)c2ccc([nH]2)c(-c2cccc(O)c2)c2ccc(n2)c(-c2cccc(O)c2)c2ccc1[nH]2 ZUELZXZJXUXJCH-UHFFFAOYSA-N 0.000 claims description 15
- 102000004169 proteins and genes Human genes 0.000 claims description 15
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 15
- GZEYLLPOQRZUDF-UHFFFAOYSA-N 7-(dimethylamino)-4-methylchromen-2-one Chemical compound CC1=CC(=O)OC2=CC(N(C)C)=CC=C21 GZEYLLPOQRZUDF-UHFFFAOYSA-N 0.000 claims description 14
- QZXAEJGHNXJTSE-UHFFFAOYSA-N 7-(ethylamino)-4,6-dimethylchromen-2-one Chemical compound O1C(=O)C=C(C)C2=C1C=C(NCC)C(C)=C2 QZXAEJGHNXJTSE-UHFFFAOYSA-N 0.000 claims description 14
- JBNOVHJXQSHGRL-UHFFFAOYSA-N 7-amino-4-(trifluoromethyl)coumarin Chemical compound FC(F)(F)C1=CC(=O)OC2=CC(N)=CC=C21 JBNOVHJXQSHGRL-UHFFFAOYSA-N 0.000 claims description 14
- GLNDAGDHSLMOKX-UHFFFAOYSA-N coumarin 120 Chemical compound C1=C(N)C=CC2=C1OC(=O)C=C2C GLNDAGDHSLMOKX-UHFFFAOYSA-N 0.000 claims description 14
- JBPCDMSEJVCNGV-UHFFFAOYSA-N coumarin 334 Chemical compound C1CCC2=C(OC(C(C(=O)C)=C3)=O)C3=CC3=C2N1CCC3 JBPCDMSEJVCNGV-UHFFFAOYSA-N 0.000 claims description 14
- LGDDFMCJIHJNMK-UHFFFAOYSA-N coumarin 337 Chemical compound C12=C3CCCN2CCCC1=CC1=C3OC(=O)C(C#N)=C1 LGDDFMCJIHJNMK-UHFFFAOYSA-N 0.000 claims description 14
- KCDCNGXPPGQERR-UHFFFAOYSA-N coumarin 343 Chemical compound C1CCC2=C(OC(C(C(=O)O)=C3)=O)C3=CC3=C2N1CCC3 KCDCNGXPPGQERR-UHFFFAOYSA-N 0.000 claims description 14
- VMJKUPWQKZFFCX-UHFFFAOYSA-N coumarin 504 Chemical compound C1CCC2=C(OC(C(C(=O)OCC)=C3)=O)C3=CC3=C2N1CCC3 VMJKUPWQKZFFCX-UHFFFAOYSA-N 0.000 claims description 14
- VBVAVBCYMYWNOU-UHFFFAOYSA-N coumarin 6 Chemical compound C1=CC=C2SC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 VBVAVBCYMYWNOU-UHFFFAOYSA-N 0.000 claims description 14
- 230000005283 ground state Effects 0.000 claims description 14
- LLSRPENMALNOFW-UHFFFAOYSA-N coumarin 106 Chemical compound C12=C3CCCN2CCCC1=CC1=C3OC(=O)C2=C1CCC2 LLSRPENMALNOFW-UHFFFAOYSA-N 0.000 claims description 13
- UIMOXRDVWDLOHW-UHFFFAOYSA-N coumarin 481 Chemical compound FC(F)(F)C1=CC(=O)OC2=CC(N(CC)CC)=CC=C21 UIMOXRDVWDLOHW-UHFFFAOYSA-N 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 13
- 229920001296 polysiloxane Polymers 0.000 claims description 13
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims description 13
- IYBRGZNQCXTXOU-UHFFFAOYSA-L 2-pyridin-2-ylpyridine rhodium(2+) dichloride Chemical compound [Cl-].[Cl-].[Rh++].c1ccc(nc1)-c1ccccn1.c1ccc(nc1)-c1ccccn1.c1ccc(nc1)-c1ccccn1 IYBRGZNQCXTXOU-UHFFFAOYSA-L 0.000 claims description 12
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims description 12
- NRZJOTSUPLCYDJ-UHFFFAOYSA-N 7-(ethylamino)-6-methyl-4-(trifluoromethyl)chromen-2-one Chemical compound O1C(=O)C=C(C(F)(F)F)C2=C1C=C(NCC)C(C)=C2 NRZJOTSUPLCYDJ-UHFFFAOYSA-N 0.000 claims description 12
- XDROKJSWHURZGO-UHFFFAOYSA-N angelicin Chemical compound C1=C2OC=CC2=C2OC(=O)C=CC2=C1 XDROKJSWHURZGO-UHFFFAOYSA-N 0.000 claims description 12
- 239000000126 substance Substances 0.000 claims description 12
- VYXSBFYARXAAKO-WTKGSRSZSA-N chembl402140 Chemical compound Cl.C1=2C=C(C)C(NCC)=CC=2OC2=C\C(=N/CC)C(C)=CC2=C1C1=CC=CC=C1C(=O)OCC VYXSBFYARXAAKO-WTKGSRSZSA-N 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 10
- 229960003569 hematoporphyrin Drugs 0.000 claims description 10
- 230000001443 photoexcitation Effects 0.000 claims description 10
- UPZKDDJKJWYWHQ-UHFFFAOYSA-O [6-amino-9-(2-carboxyphenyl)xanthen-3-ylidene]azanium Chemical compound C=12C=CC(=[NH2+])C=C2OC2=CC(N)=CC=C2C=1C1=CC=CC=C1C(O)=O UPZKDDJKJWYWHQ-UHFFFAOYSA-O 0.000 claims description 9
- HACOCUMLBPNDIN-UHFFFAOYSA-M ac1l2skh Chemical compound [O-]Cl(=O)(=O)=O.C1CCN2CCCC3=C2C1=C1OC2=C(CCC4)C5=[N+]4CCCC5=CC2=C(C#N)C1=C3 HACOCUMLBPNDIN-UHFFFAOYSA-M 0.000 claims description 9
- 150000001413 amino acids Chemical class 0.000 claims description 9
- 239000002738 chelating agent Substances 0.000 claims description 9
- VSSSHNJONFTXHS-UHFFFAOYSA-N coumarin 153 Chemical compound C12=C3CCCN2CCCC1=CC1=C3OC(=O)C=C1C(F)(F)F VSSSHNJONFTXHS-UHFFFAOYSA-N 0.000 claims description 9
- VYXSBFYARXAAKO-UHFFFAOYSA-N ethyl 2-[3-(ethylamino)-6-ethylimino-2,7-dimethylxanthen-9-yl]benzoate;hydron;chloride Chemical compound [Cl-].C1=2C=C(C)C(NCC)=CC=2OC2=CC(=[NH+]CC)C(C)=CC2=C1C1=CC=CC=C1C(=O)OCC VYXSBFYARXAAKO-UHFFFAOYSA-N 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- TUFFYSFVSYUHPA-UHFFFAOYSA-M rhodamine 123 Chemical compound [Cl-].COC(=O)C1=CC=CC=C1C1=C(C=CC(N)=C2)C2=[O+]C2=C1C=CC(N)=C2 TUFFYSFVSYUHPA-UHFFFAOYSA-M 0.000 claims description 9
- CVAVMIODJQHEEH-UHFFFAOYSA-O rhodamine B(1+) Chemical compound C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O CVAVMIODJQHEEH-UHFFFAOYSA-O 0.000 claims description 9
- 229940043267 rhodamine b Drugs 0.000 claims description 9
- OSQUFVVXNRMSHL-LTHRDKTGSA-M sodium;3-[(2z)-2-[(e)-4-(1,3-dibutyl-4,6-dioxo-2-sulfanylidene-1,3-diazinan-5-ylidene)but-2-enylidene]-1,3-benzoxazol-3-yl]propane-1-sulfonate Chemical compound [Na+].O=C1N(CCCC)C(=S)N(CCCC)C(=O)C1=C\C=C\C=C/1N(CCCS([O-])(=O)=O)C2=CC=CC=C2O\1 OSQUFVVXNRMSHL-LTHRDKTGSA-M 0.000 claims description 9
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 9
- 239000011701 zinc Substances 0.000 claims description 9
- KFNLIWIAIPMECU-UHFFFAOYSA-N 1-(1-methyl-2H-pyridin-2-yl)-21,23-dihydro-2H-porphyrin Chemical compound CN1C=CC=CC1C1(C=C2N=C(C=C2)C=C2C=CC(N2)=CC=2C=CC(N=2)=C2)NC2=CC1 KFNLIWIAIPMECU-UHFFFAOYSA-N 0.000 claims description 8
- MHIITNFQDPFSES-UHFFFAOYSA-N 25,26,27,28-tetrazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1(25),2,4,6,8(27),9,11,13,15,17,19,21,23-tridecaene Chemical class N1C(C=C2C3=CC=CC=C3C(C=C3NC(=C4)C=C3)=N2)=CC=C1C=C1C=CC4=N1 MHIITNFQDPFSES-UHFFFAOYSA-N 0.000 claims description 8
- WBIICVGYYRRURR-UHFFFAOYSA-N 3-(aminomethyl)-2,5,9-trimethylfuro[3,2-g]chromen-7-one Chemical compound O1C(=O)C=C(C)C2=C1C(C)=C1OC(C)=C(CN)C1=C2 WBIICVGYYRRURR-UHFFFAOYSA-N 0.000 claims description 8
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 claims description 8
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 8
- 229930003316 Vitamin D Natural products 0.000 claims description 8
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 8
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 8
- QYNCZLPRFXWLEN-UHFFFAOYSA-N [9-(diethylamino)benzo[a]phenothiazin-5-ylidene]-ethylazanium;chloride Chemical compound [Cl-].C12=CC=CC=C2C(=[NH+]CC)C=C2C1=NC1=CC=C(N(CC)CC)C=C1S2 QYNCZLPRFXWLEN-UHFFFAOYSA-N 0.000 claims description 8
- 229940015493 dihematoporphyrin ether Drugs 0.000 claims description 8
- 229910052732 germanium Inorganic materials 0.000 claims description 8
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims description 8
- 239000000906 photoactive agent Substances 0.000 claims description 8
- 229950003776 protoporphyrin Drugs 0.000 claims description 8
- HTNRBNPBWAFIKA-UHFFFAOYSA-M rhodamine 700 perchlorate Chemical compound [O-]Cl(=O)(=O)=O.C1CCN2CCCC3=C2C1=C1OC2=C(CCC4)C5=[N+]4CCCC5=CC2=C(C(F)(F)F)C1=C3 HTNRBNPBWAFIKA-UHFFFAOYSA-M 0.000 claims description 8
- 235000019166 vitamin D Nutrition 0.000 claims description 8
- 239000011710 vitamin D Substances 0.000 claims description 8
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 8
- 229940046008 vitamin d Drugs 0.000 claims description 8
- 229910052725 zinc Inorganic materials 0.000 claims description 8
- IOOMXAQUNPWDLL-UHFFFAOYSA-N 2-[6-(diethylamino)-3-(diethyliminiumyl)-3h-xanthen-9-yl]-5-sulfobenzene-1-sulfonate Chemical compound C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S(O)(=O)=O)C=C1S([O-])(=O)=O IOOMXAQUNPWDLL-UHFFFAOYSA-N 0.000 claims description 7
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 7
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 claims description 7
- HSHNITRMYYLLCV-UHFFFAOYSA-N 4-methylumbelliferone Chemical compound C1=C(O)C=CC2=C1OC(=O)C=C2C HSHNITRMYYLLCV-UHFFFAOYSA-N 0.000 claims description 7
- QXAMGWKESXGGNV-UHFFFAOYSA-N 7-(diethylamino)-1-benzopyran-2-one Chemical compound C1=CC(=O)OC2=CC(N(CC)CC)=CC=C21 QXAMGWKESXGGNV-UHFFFAOYSA-N 0.000 claims description 7
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 7
- KDTAEYOYAZPLIC-UHFFFAOYSA-N coumarin 152 Chemical compound FC(F)(F)C1=CC(=O)OC2=CC(N(C)C)=CC=C21 KDTAEYOYAZPLIC-UHFFFAOYSA-N 0.000 claims description 7
- JRUYYVYCSJCVMP-UHFFFAOYSA-N coumarin 30 Chemical compound C1=CC=C2N(C)C(C=3C4=CC=C(C=C4OC(=O)C=3)N(CC)CC)=NC2=C1 JRUYYVYCSJCVMP-UHFFFAOYSA-N 0.000 claims description 7
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- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/008—Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00057—Light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| US08/739,801 US5829448A (en) | 1996-10-30 | 1996-10-30 | Method for improved selectivity in photo-activation of molecular agents |
| US08/739,801 | 1996-10-30 | ||
| PCT/US1997/019527 WO1998018399A1 (en) | 1996-10-30 | 1997-10-28 | Method for improved selectivity in photo-activation of molecular agents |
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| JP2000511929A true JP2000511929A (ja) | 2000-09-12 |
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| NZ (1) | NZ334190A (cg-RX-API-DMAC7.html) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2004112902A1 (ja) * | 2003-06-20 | 2006-08-31 | 学校法人慶應義塾 | 光線力学的治療装置、光線力学的治療装置の制御方法、および光線力学的治療方法 |
| JP2009037734A (ja) * | 2002-10-10 | 2009-02-19 | Landauer Inc | 酸化アルミニウム単結晶媒体を利用するビット方式光学データ記憶 |
| JP2010523690A (ja) * | 2007-04-08 | 2010-07-15 | イミュノライト・エルエルシー | 細胞増殖障害を治療する方法およびシステム |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US20090117199A1 (en) * | 1998-08-06 | 2009-05-07 | Scott Timothy C | Method of treatment of cancer |
| US8557298B2 (en) | 1998-08-06 | 2013-10-15 | Provectus Pharmatech, Inc. | Medicaments for chemotherapeutic treatment of disease |
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| EP2289549A3 (en) | 1999-10-01 | 2011-06-15 | Immunogen, Inc. | Immunoconjugates for treating cancer |
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| US7897140B2 (en) | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| JP2003519670A (ja) * | 2000-01-12 | 2003-06-24 | ライト サイエンシーズ コーポレイション | 眼疾患の新規処置 |
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| ATE489050T1 (de) * | 2000-02-11 | 2010-12-15 | Gen Hospital Corp | Photochemische gewebeverbindung |
| WO2002019594A2 (en) | 2000-08-02 | 2002-03-07 | Arizona Board Of Regents, Acting On Behalf Of Arizona State University | Scanning fluorescence lifetime microscope: directed evolution |
| JP4659300B2 (ja) * | 2000-09-13 | 2011-03-30 | 浜松ホトニクス株式会社 | レーザ加工方法及び半導体チップの製造方法 |
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| WO2007123518A1 (en) * | 2006-04-21 | 2007-11-01 | Cedars-Sinai Medical Center | Multiple imaging and/or spectroscopic modality probe |
| US20080275432A1 (en) * | 2006-05-11 | 2008-11-06 | Ceramoptec Industries, Inc. | Photodynamic foam composition and sclerosis treatment |
| KR20090097925A (ko) * | 2006-12-12 | 2009-09-16 | 노미어 메디컬 테크놀로지즈, 인크. | 세포의 정상-상태 막 전위의 근적외선 전자기 변형 |
| US20080208295A1 (en) * | 2007-02-28 | 2008-08-28 | Cumbie William E | Phototherapy Treatment and Device to Improve the Appearance of Nails and skin |
| AU2016210665B2 (en) * | 2007-04-08 | 2017-12-07 | Immunolight, Llc | Methods and systems for treating cell proliferation disorders |
| US8951561B2 (en) * | 2007-08-06 | 2015-02-10 | Duke University | Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP) |
| US20140324138A1 (en) * | 2007-05-09 | 2014-10-30 | Massachusetts Institute Of Technology | Wirelessly-powered illumination of biological tissue |
| US20090104212A1 (en) * | 2007-08-06 | 2009-04-23 | Immunolight | Methods and systems for treating cell proliferation disorders using two-photon simultaneous absorption |
| EP2212679A1 (en) | 2007-09-18 | 2010-08-04 | Applied Biosystems Inc. | Methods, systems and apparatus for light concentrating mechanisms |
| CA2705859A1 (en) * | 2007-10-15 | 2009-04-23 | John P. Stokes | Convergent well irradiating plaque for choroidal melanoma |
| US20090104113A1 (en) * | 2007-10-18 | 2009-04-23 | Searete Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8529426B2 (en) | 2007-10-18 | 2013-09-10 | The Invention Science Fund I Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8164074B2 (en) * | 2007-10-18 | 2012-04-24 | The Invention Science Fund I, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US9557635B2 (en) * | 2007-10-18 | 2017-01-31 | Gearbox, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8168958B2 (en) * | 2007-10-18 | 2012-05-01 | The Invention Science Fund I, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8684898B2 (en) * | 2007-10-18 | 2014-04-01 | The Invention Science Fund I Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| US8227204B2 (en) * | 2007-10-18 | 2012-07-24 | The Invention Science Fund I, Llc | Ionizing-radiation-responsive compositions, methods, and systems |
| WO2009086122A2 (en) | 2007-12-21 | 2009-07-09 | Board Of Trustees Of Michigan State University | Control in ultrashort laser systems by a deformable mirror in the stretcher |
| DE102008011811B3 (de) * | 2008-02-29 | 2009-10-15 | Anton Dr. Kasenbacher | Dentales Laserbearbeitungsgerät zur Bearbeitung von Zahnmaterial |
| CL2009000560A1 (es) | 2008-03-11 | 2010-02-19 | Univ Duke | Un metodo para endurecer un medio endurecible por radiacion que comprende colocar una composicion dentro de un objeto para ser endurecido, la aplicacion de al menos uno elegido entre rayos x, rayos gama o haz de electrones a traves del objeto y dentro de la composicion. |
| WO2013009688A1 (en) | 2011-07-08 | 2013-01-17 | Bourke Frederic A | Phosphors and scintillators for light stimulation within a medium |
| CA3095369C (en) | 2008-04-04 | 2023-09-26 | Immunolight, Llc | Non-invasive systems and methods for in-situ photobiomodulation |
| US8770203B2 (en) * | 2008-07-14 | 2014-07-08 | Immunolight, Llc. | Advanced methods and systems for treating cell proliferation disorders |
| DE102009005194B4 (de) * | 2009-01-20 | 2016-09-08 | Anton Kasenbacher | Laserbearbeitungsgerät zur Bearbeitung eines Materials |
| US8675699B2 (en) * | 2009-01-23 | 2014-03-18 | Board Of Trustees Of Michigan State University | Laser pulse synthesis system |
| WO2010141128A2 (en) | 2009-03-05 | 2010-12-09 | Board Of Trustees Of Michigan State University | Laser amplification system |
| SA114350273B1 (ar) | 2009-04-21 | 2016-06-23 | امونولايت، ال ال سي | أنظمة وطرق غير انتشارية للتحويل العلوي للطاقة للتعديل الحيوي الضوئي في الموقع |
| US20110054305A1 (en) * | 2009-08-30 | 2011-03-03 | Stephen Eliot Zweig | Photon upconverting implantable medical devices |
| US20110275686A1 (en) * | 2009-12-11 | 2011-11-10 | Biolitec, Inc. | Nanoparticle carrier systems based on poly(dl-lactic-co-glycolic acid) (plga) for photodynamic therapy (pdt) |
| US8630322B2 (en) * | 2010-03-01 | 2014-01-14 | Board Of Trustees Of Michigan State University | Laser system for output manipulation |
| US9642687B2 (en) | 2010-06-15 | 2017-05-09 | The Procter & Gamble Company | Methods for whitening teeth |
| US9095414B2 (en) * | 2011-06-24 | 2015-08-04 | The Regents Of The University Of California | Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea |
| US9257206B2 (en) * | 2011-12-02 | 2016-02-09 | The Charles Stark Draper Laboratory, Inc. | Adiabatic rapid passage atomic beamsplitter using frequency-swept coherent laser beam pairs |
| US10549112B2 (en) | 2012-07-20 | 2020-02-04 | The General Hospital Corporation | Apparatus for tissue irradiation and methods and kits utilizing the same |
| WO2014015274A1 (en) | 2012-07-20 | 2014-01-23 | The General Hospital Corporation | Methods for tissue passivation |
| WO2014055960A1 (en) | 2012-10-05 | 2014-04-10 | Genelux Corporation | Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes |
| WO2014168734A1 (en) | 2013-03-15 | 2014-10-16 | Cedars-Sinai Medical Center | Time-resolved laser-induced fluorescence spectroscopy systems and uses thereof |
| US11129675B2 (en) * | 2013-04-25 | 2021-09-28 | Koninklijke Philips N.V. | Non-invasive device for treatment of the skin using laser light |
| CA3278502A1 (en) | 2013-07-18 | 2025-10-31 | The General Hospital Corporation | Vessel treatment systems, methods, and kits |
| WO2015108991A2 (en) | 2014-01-17 | 2015-07-23 | Imra America, Inc. | Laser-based modification of transparent materials |
| WO2015112850A2 (en) | 2014-01-23 | 2015-07-30 | Wenle Xia | Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders |
| WO2015166333A1 (en) * | 2014-04-29 | 2015-11-05 | Theralase Technologies, Inc. | Apparatus and method for multiwavelength photodynamic therapy |
| EP3157519B1 (en) | 2014-06-19 | 2021-05-12 | Immunolight, LLC | Methods and systems for treating cell proliferation disorders with psoralen derivatives |
| US11534622B2 (en) * | 2014-08-18 | 2022-12-27 | Immunolight, Llc | Non-invasive systems and methods for selective activation of photoreactive responses |
| SG11201702428PA (en) * | 2014-09-29 | 2017-04-27 | Univ King Abdullah Sci & Tech | Laser-based agriculture system |
| US9897448B2 (en) | 2014-10-31 | 2018-02-20 | The Charles Stark Draper Laboratory, Inc. | Systems and methods for multiple species atom interferometry |
| US10331087B2 (en) | 2014-12-03 | 2019-06-25 | The Charles Stark Draper Laboratory, Inc. | Atom interferometry in dynamic environments |
| US11123366B1 (en) | 2014-12-15 | 2021-09-21 | Children's Hospital Of Orange County | Methods, materials, and systems for treating injuries to the central nervous system using light emitting nanoparticles |
| US20190022221A1 (en) | 2015-01-14 | 2019-01-24 | Immunolight, Llc. | Non-invasive systems and methods for treatment of a host carrying a virus with photoactivatable drugs |
| EP3436805A4 (en) | 2016-04-01 | 2019-12-11 | Black Light Surgical, Inc. | SYSTEMS, DEVICES AND METHODS FOR TIME-RESOLUTION FLUORESCENCE SPECTROSCOPY |
| CN111787918A (zh) | 2017-11-29 | 2020-10-16 | 洛克菲勒大学 | 用于皮肤病学病况增强治疗的局部和全身性治疗的组合 |
| CN112996502B (zh) | 2018-05-16 | 2023-10-31 | 普罗维克图斯药品技术公司 | 卤代呫吨针对难治性小儿实体瘤的体外和异种移植抗肿瘤活性 |
| US11419844B2 (en) | 2019-11-19 | 2022-08-23 | Provectus Pharmatech, Inc. | Halogenated xanthene composition and method for treating hematologic cancers |
| US12064507B2 (en) | 2019-11-19 | 2024-08-20 | Provectus Pharmatech, Inc. | Composition and method for oral treatment of leukemia |
| US11938182B2 (en) | 2020-03-26 | 2024-03-26 | Provectus Pharmatech, Inc. | Halogenated xanthenes as vaccine adjuvants |
| CN115916343B (zh) | 2020-03-26 | 2024-07-02 | 普罗维克图斯药品技术公司 | 卤代呫吨在肿瘤学和病毒学中的新用途 |
| CN111592920A (zh) * | 2020-05-21 | 2020-08-28 | 新沂百川畅银新能源有限公司 | 一种沼气脱硫净化工艺 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4589881A (en) * | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
| US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
| JPS63111886A (ja) * | 1986-10-29 | 1988-05-17 | 呉羽化学工業株式会社 | 光ダイオ−ドを用いた癌治療装置 |
| US5053006A (en) * | 1988-04-19 | 1991-10-01 | Watson Brant D | Method for the permanent occlusion of arteries |
| US4925736A (en) * | 1988-07-06 | 1990-05-15 | Long Island Jewish Medical Center | Topical hematoporphyrin |
| US5654267A (en) * | 1988-12-20 | 1997-08-05 | La Jolla Cancer Research Center | Cooperative combinations of ligands contained within a matrix |
| US5498694A (en) * | 1989-05-25 | 1996-03-12 | La Jolla Cancer Research Foundation | Peptides of the cytoplasmic domain of integrin |
| US4973848A (en) * | 1989-07-28 | 1990-11-27 | J. Mccaughan | Laser apparatus for concurrent analysis and treatment |
| US5121398A (en) * | 1989-09-26 | 1992-06-09 | Excel Technology, Inc. | Broadly tunable, high repetition rate solid state lasers and uses thereof |
| US5034613A (en) * | 1989-11-14 | 1991-07-23 | Cornell Research Foundation, Inc. | Two-photon laser microscopy |
| KR920702820A (ko) * | 1989-12-11 | 1992-10-28 | 루이스 에이. 산타나블랑크 | 전신성 질병에 사용되는 레이저 치료장치 및 방법 |
| US5629291A (en) * | 1992-01-31 | 1997-05-13 | La Jolla Cancer Research Foundation | Methods of modulating fibronectin extracellular matrix assembly |
| US5627263A (en) * | 1993-11-24 | 1997-05-06 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| US5558666A (en) * | 1994-01-14 | 1996-09-24 | Coherent, Inc. | Handpiece for producing highly collimated laser beam for dermatological procedures |
| US5586981A (en) * | 1994-08-25 | 1996-12-24 | Xin-Hua Hu | Treatment of cutaneous vascular and pigmented lesions |
| US5643334A (en) * | 1995-02-07 | 1997-07-01 | Esc Medical Systems Ltd. | Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment |
| US5576013A (en) * | 1995-03-21 | 1996-11-19 | Eastern Virginia Medical School | Treating vascular and neoplastic tissues |
| JP2001520637A (ja) * | 1995-09-06 | 2001-10-30 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 二光子アップコンバーティング色素および応用 |
| US5622699A (en) * | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
| US5759767A (en) * | 1996-10-11 | 1998-06-02 | Joseph R. Lakowicz | Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids |
| US5832931A (en) * | 1996-10-30 | 1998-11-10 | Photogen, Inc. | Method for improved selectivity in photo-activation and detection of molecular diagnostic agents |
-
1996
- 1996-10-30 US US08/739,801 patent/US5829448A/en not_active Expired - Lifetime
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1997
- 1997-10-24 IN IN2408MA1997 patent/IN186854B/en unknown
- 1997-10-28 JP JP10520696A patent/JP2000511929A/ja not_active Ceased
- 1997-10-28 EP EP97946336A patent/EP0977592A4/en not_active Withdrawn
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009037734A (ja) * | 2002-10-10 | 2009-02-19 | Landauer Inc | 酸化アルミニウム単結晶媒体を利用するビット方式光学データ記憶 |
| JPWO2004112902A1 (ja) * | 2003-06-20 | 2006-08-31 | 学校法人慶應義塾 | 光線力学的治療装置、光線力学的治療装置の制御方法、および光線力学的治療方法 |
| JP2010523690A (ja) * | 2007-04-08 | 2010-07-15 | イミュノライト・エルエルシー | 細胞増殖障害を治療する方法およびシステム |
| US9352040B2 (en) | 2007-04-08 | 2016-05-31 | Immunolight, Llc. | Methods and systems for treating cell proliferation disorders |
| US9358292B2 (en) | 2007-04-08 | 2016-06-07 | Immunolight, Llc | Methods and systems for treating cell proliferation disorders |
| US9682146B2 (en) | 2007-04-08 | 2017-06-20 | Immunolight, Llc. | Methods and systems for treating cell proliferation related disorders |
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| AU716507B2 (en) | 2000-02-24 |
| BR9712599A (pt) | 1999-12-21 |
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| CA2252783A1 (en) | 1998-05-07 |
| US5998597A (en) | 1999-12-07 |
| EP0977592A4 (en) | 2001-01-10 |
| US5829448A (en) | 1998-11-03 |
| KR20000035893A (ko) | 2000-06-26 |
| IL128355A0 (en) | 2000-01-31 |
| IN186854B (cg-RX-API-DMAC7.html) | 2001-11-24 |
| WO1998018399A1 (en) | 1998-05-07 |
| NO991492D0 (no) | 1999-03-26 |
| IS5006A (is) | 1999-03-19 |
| EP0977592A1 (en) | 2000-02-09 |
| US6042603A (en) | 2000-03-28 |
| CN1226148A (zh) | 1999-08-18 |
| AU5152898A (en) | 1998-05-22 |
| NO991492L (no) | 1999-05-31 |
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