JP2000511899A - 抗―ウイルス性化合物群 - Google Patents

抗―ウイルス性化合物群

Info

Publication number
JP2000511899A
JP2000511899A JP10500630A JP50063098A JP2000511899A JP 2000511899 A JP2000511899 A JP 2000511899A JP 10500630 A JP10500630 A JP 10500630A JP 50063098 A JP50063098 A JP 50063098A JP 2000511899 A JP2000511899 A JP 2000511899A
Authority
JP
Japan
Prior art keywords
alkyl
compound
formula
pharmaceutically acceptable
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10500630A
Other languages
English (en)
Japanese (ja)
Inventor
ジュンゲイム，ルイス・エヌ
シェパード，ティモシー・エイ
スピッツァー，ウェイン・エイ
テッブ，マーク・ジェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JP2000511899A publication Critical patent/JP2000511899A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
JP10500630A 1996-06-05 1997-06-05 抗―ウイルス性化合物群 Pending JP2000511899A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1917096P 1996-06-05 1996-06-05
US60/019,170 1996-06-05
PCT/US1997/008848 WO1997046237A1 (fr) 1996-06-05 1997-06-05 Composes antiviraux

Publications (1)

Publication Number Publication Date
JP2000511899A true JP2000511899A (ja) 2000-09-12

Family

ID=21791797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10500630A Pending JP2000511899A (ja) 1996-06-05 1997-06-05 抗―ウイルス性化合物群

Country Status (9)

Country Link
EP (1) EP0906097A4 (fr)
JP (1) JP2000511899A (fr)
KR (1) KR20000016346A (fr)
CN (1) CN1220601A (fr)
AU (1) AU3212897A (fr)
BR (1) BR9709528A (fr)
CA (1) CA2257296A1 (fr)
EA (1) EA001316B1 (fr)
WO (1) WO1997046237A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor
EP2206715A1 (fr) 2004-02-24 2010-07-14 Japan Tobacco, Inc. Composé héterotétracycliques fusionnés et leur utilisation en tant qu'inhibiteurs de la polymérase du HCV
US7977331B1 (en) 2004-02-24 2011-07-12 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
WO1998031363A1 (fr) * 1997-01-22 1998-07-23 Eli Lilly And Company Composes antiviraux
WO1998055120A1 (fr) * 1997-06-04 1998-12-10 Eli Lilly And Company Composes antiviraux
HUP0102117A2 (hu) * 1998-05-20 2001-12-28 Eli Lilly And Co. Imidazo[1,2-a]piridin-származékok és ezeket tartalmazó gyógyászati készítmények
TR200103147T1 (tr) 1999-12-27 2002-06-21 Japan Tobacco Inc. Kaynaşık halkalı bileşikler ve bunların ilaç olarak kullanımı.
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
CA2534649A1 (fr) 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Derives de l'imidazole bicycliques diriges contre les flaviviridae

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2206715A1 (fr) 2004-02-24 2010-07-14 Japan Tobacco, Inc. Composé héterotétracycliques fusionnés et leur utilisation en tant qu'inhibiteurs de la polymérase du HCV
US7977331B1 (en) 2004-02-24 2011-07-12 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor

Also Published As

Publication number Publication date
KR20000016346A (ko) 2000-03-25
EP0906097A1 (fr) 1999-04-07
AU3212897A (en) 1998-01-05
EA199801078A1 (ru) 1999-04-29
EA001316B1 (ru) 2001-02-26
BR9709528A (pt) 1999-08-10
WO1997046237A1 (fr) 1997-12-11
CA2257296A1 (fr) 1997-12-11
EP0906097A4 (fr) 2000-12-13
CN1220601A (zh) 1999-06-23

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