CA2257296A1 - Composes antiviraux - Google Patents

Composes antiviraux Download PDF

Info

Publication number
CA2257296A1
CA2257296A1 CA002257296A CA2257296A CA2257296A1 CA 2257296 A1 CA2257296 A1 CA 2257296A1 CA 002257296 A CA002257296 A CA 002257296A CA 2257296 A CA2257296 A CA 2257296A CA 2257296 A1 CA2257296 A1 CA 2257296A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
pharmaceutically acceptable
halo
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002257296A
Other languages
English (en)
Inventor
Mark Joseph Tebbe
Wayne Alfred Spitzer
Louis Nickolaus Jungheim
Timothy Alan Shepherd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2257296A1 publication Critical patent/CA2257296A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur une série de composés de benzimidazole inhibant la croissance des picornavirus tels que le rhinovirus, l'entérovirus, le poliovirus, le virus Coxsackie des groupes A et B, l'échovirus, le virus de Mengo, et les flavivirus tels que le virus de l'hépatite C et le virus de la diarrhée bovine.
CA002257296A 1996-06-05 1997-06-05 Composes antiviraux Abandoned CA2257296A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1917096P 1996-06-05 1996-06-05
US60/019,170 1996-06-05

Publications (1)

Publication Number Publication Date
CA2257296A1 true CA2257296A1 (fr) 1997-12-11

Family

ID=21791797

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002257296A Abandoned CA2257296A1 (fr) 1996-06-05 1997-06-05 Composes antiviraux

Country Status (9)

Country Link
EP (1) EP0906097A4 (fr)
JP (1) JP2000511899A (fr)
KR (1) KR20000016346A (fr)
CN (1) CN1220601A (fr)
AU (1) AU3212897A (fr)
BR (1) BR9709528A (fr)
CA (1) CA2257296A1 (fr)
EA (1) EA001316B1 (fr)
WO (1) WO1997046237A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
AU6031898A (en) * 1997-01-22 1998-08-07 Eli Lilly And Company Anti-viral compounds
CA2293508A1 (fr) * 1997-06-04 1998-12-10 Louis Nickolaus Jungheim Composes antiviraux
WO1999059587A1 (fr) * 1998-05-20 1999-11-25 Eli Lilly And Company Composes anti-viraux
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
TR200103147T1 (tr) * 1999-12-27 2002-06-21 Japan Tobacco Inc. Kaynaşık halkalı bileşikler ve bunların ilaç olarak kullanımı.
EP1651631A1 (fr) 2003-08-01 2006-05-03 Genelabs Technologies, Inc. Derives de l'imidazole bicycliques diriges contre les flaviviridae
JP4143669B2 (ja) 2004-02-24 2008-09-03 日本たばこ産業株式会社 ４環縮合複素環化合物及びそのｈｃｖポリメラーゼ阻害剤としての利用
US20070049593A1 (en) 2004-02-24 2007-03-01 Japan Tobacco Inc. Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor
US7659263B2 (en) 2004-11-12 2010-02-09 Japan Tobacco Inc. Thienopyrrole compound and use thereof as HCV polymerase inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434288A (en) * 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US4420479A (en) * 1982-04-08 1983-12-13 Eli Lilly And Company Olefinic benzimidazoles, formulations, and antiviral methods
US4492708A (en) * 1982-09-27 1985-01-08 Eli Lilly And Company Antiviral benzimidazoles

Also Published As

Publication number Publication date
EA001316B1 (ru) 2001-02-26
EA199801078A1 (ru) 1999-04-29
BR9709528A (pt) 1999-08-10
AU3212897A (en) 1998-01-05
KR20000016346A (ko) 2000-03-25
WO1997046237A1 (fr) 1997-12-11
JP2000511899A (ja) 2000-09-12
EP0906097A4 (fr) 2000-12-13
CN1220601A (zh) 1999-06-23
EP0906097A1 (fr) 1999-04-07

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Legal Events

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FZDE Dead